The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review

Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710268127231020083505. Online ahead of print.ABSTRACTCrocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in treating some hypoxia-related diseases. Moreover, experimental and clinical studies have reported no adverse effects following TSC treatment, even at high doses. The current study will discuss the potential role of TSC in hemorrhagic shock, ischemia, brain tumor radiotherapy, and others.PMID:37877507 | DOI:10.2174/0118744710268127231020083505

Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Natalia S Klunko Harun Achmad Tamara Muayad Abdullah Sami Mohammed Indranil Saha Khulood Saadoon Salim Rasha Fadhel Obaid Rosario Mireya Romero-Parra Shaker Shanawa Al-Hasnawi Wissam Hamid Al-Janabi Bagher Farhood Source Type: research