Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Multimodality Imaging Evaluation of Nasal Rhabdomyosarcoma in Adults: A Case Report and Literature Review
CONCLUSION: Sinus ARMS is notably malignant and associated with a dismal prognosis. Accurate diagnosis depends on histopathological and immunohistochemical evaluation, complemented by genetic analysis for specific chromosomal translocations and fusion genes. Imaging techniques, including CT, MRI, and PET/CT, are crucial for assessing lesion extent and metastasis, supporting disease diagnosis, informing treatment choices, facilitating surgical planning, and monitoring response to therapy.PMID:38644703 | DOI:10.2174/0118744710288830240405090932 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 22, 2024 Category: Radiology Authors: Lujiao Chen Bo Chen Shanlu Yu Zhenhua Zhao Liyijing Shen Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Multimodality Imaging Evaluation of Nasal Rhabdomyosarcoma in Adults: A Case Report and Literature Review
CONCLUSION: Sinus ARMS is notably malignant and associated with a dismal prognosis. Accurate diagnosis depends on histopathological and immunohistochemical evaluation, complemented by genetic analysis for specific chromosomal translocations and fusion genes. Imaging techniques, including CT, MRI, and PET/CT, are crucial for assessing lesion extent and metastasis, supporting disease diagnosis, informing treatment choices, facilitating surgical planning, and monitoring response to therapy.PMID:38644703 | DOI:10.2174/0118744710288830240405090932 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 22, 2024 Category: Radiology Authors: Lujiao Chen Bo Chen Shanlu Yu Zhenhua Zhao Liyijing Shen Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Multimodality Imaging Evaluation of Nasal Rhabdomyosarcoma in Adults: A Case Report and Literature Review
CONCLUSION: Sinus ARMS is notably malignant and associated with a dismal prognosis. Accurate diagnosis depends on histopathological and immunohistochemical evaluation, complemented by genetic analysis for specific chromosomal translocations and fusion genes. Imaging techniques, including CT, MRI, and PET/CT, are crucial for assessing lesion extent and metastasis, supporting disease diagnosis, informing treatment choices, facilitating surgical planning, and monitoring response to therapy.PMID:38644703 | DOI:10.2174/0118744710288830240405090932 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 22, 2024 Category: Radiology Authors: Lujiao Chen Bo Chen Shanlu Yu Zhenhua Zhao Liyijing Shen Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Multimodality Imaging Evaluation of Nasal Rhabdomyosarcoma in Adults: A Case Report and Literature Review
CONCLUSION: Sinus ARMS is notably malignant and associated with a dismal prognosis. Accurate diagnosis depends on histopathological and immunohistochemical evaluation, complemented by genetic analysis for specific chromosomal translocations and fusion genes. Imaging techniques, including CT, MRI, and PET/CT, are crucial for assessing lesion extent and metastasis, supporting disease diagnosis, informing treatment choices, facilitating surgical planning, and monitoring response to therapy.PMID:38644703 | DOI:10.2174/0118744710288830240405090932 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 22, 2024 Category: Radiology Authors: Lujiao Chen Bo Chen Shanlu Yu Zhenhua Zhao Liyijing Shen Source Type: research
Mosaic RASopathies concept: different skin lesions, same systemic manifestations?
Conclusion
This review delineates genotype/phenotype correlations of syndromic epidermal nevi with somatic RAS and BRAF pathogenic variants and may help improve their follow-up. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - April 19, 2024 Category: Genetics & Stem Cells Authors: Morren, M.-A., Fodstad, H., Brems, H., Bedoni, N., Guenova, E., Jacot-Guillarmod, M., Busiah, K., Giuliano, F., Gilliet, M., Atallah, I. Tags: Genotype-phenotype correlations Source Type: research
Non-surgical fertility spearing management of cervical embryonal rhabdomyosarcoma
J Obstet Gynaecol Can. 2024 Apr 15:102462. doi: 10.1016/j.jogc.2024.102462. Online ahead of print.NO ABSTRACTPMID:38631432 | DOI:10.1016/j.jogc.2024.102462 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - April 17, 2024 Category: OBGYN Authors: Nesrine Souayeh Manel Ben Ghalia Hadhemi Rouis Hajer Bettaieb Source Type: research
