Clinical and histopathological spectrum of cranial small round cell tumors: An experience from a tertiary care center
CONCLUSIONS: SRCTs have a variable age of presentation. Their incidence in CNS is low as compared to other organ systems. On light microscopy, the histopathology of these lesions is overlapping, posing a great diagnostic dilemma for the pathologist. The use of ancillary techniques like immunohistochemistry helps in arriving at the correct diagnosis. Treatment strategy and tumor prognosis also vary along the entire spectrum of SRCT, thus making exact characterization essential for proper management.PMID:38554327 | DOI:10.4103/jcrt.jcrt_383_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Pooja Gupta Fouzia Siraj K B Shankar Manish Rawat Dipanker S Mankotia Vivek Yadav Amit Dagar Source Type: research
CRISPR-Cas9-Mediated Bioluminescent Tagging of Endogenous Proteins by Fluorescent Protein-Assisted Cell Sorting
Methods Mol Biol. 2024;2779:273-286. doi: 10.1007/978-1-0716-3738-8_12.ABSTRACTOncogenic fusion genes are attractive therapeutic targets because of their tumor-specific expression and central "driver" roles in various human cancers. However, oncogenic fusions involving transcription factors such as PAX3-FOXO1 in alveolar fusion gene-positive rhabdomyosarcoma (FP-RMS) have been difficult to inhibit due to the apparent lack of tractable drug-like binding sites comparable to that recognized by Gleevec (imatinib mesylate) on the BCR-ABL1 tyrosine kinase fusion protein. Toward the identification of novel small molecules that se...
Source: Mol Biol Cell - March 25, 2024 Category: Molecular Biology Authors: Robert G Hawley Teresa S Hawley Source Type: research
CRISPR-Cas9-Mediated Bioluminescent Tagging of Endogenous Proteins by Fluorescent Protein-Assisted Cell Sorting
Methods Mol Biol. 2024;2779:273-286. doi: 10.1007/978-1-0716-3738-8_12.ABSTRACTOncogenic fusion genes are attractive therapeutic targets because of their tumor-specific expression and central "driver" roles in various human cancers. However, oncogenic fusions involving transcription factors such as PAX3-FOXO1 in alveolar fusion gene-positive rhabdomyosarcoma (FP-RMS) have been difficult to inhibit due to the apparent lack of tractable drug-like binding sites comparable to that recognized by Gleevec (imatinib mesylate) on the BCR-ABL1 tyrosine kinase fusion protein. Toward the identification of novel small molecules that se...
Source: Mol Biol Cell - March 25, 2024 Category: Molecular Biology Authors: Robert G Hawley Teresa S Hawley Source Type: research
Nomogram to predict prognosis of head and neck rhabdomyosarcoma patients in children and adolescents
ConclusionWe constructed a prognostic nomogram model for predicting the OS in HNRMS patients in children and adolescents and this model presented practical and applicable clinical value to predict survival when choosing treatment strategies. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Intraoperative radiation therapy for pediatric sarcomas and other solid tumors
CONCLUSION: Our study represents the largest and most recent analysis of efficacy and safety of IORT in pediatric patients with ST. Less than one quarter of all patients failed locally with acceptable toxicities. Overall, IORT is an effective and safe technique to achieve local control in patients with challenging circumstances.PMID:38520048 | DOI:10.1002/pbc.30949 (Source: Cancer Control)
Source: Cancer Control - March 23, 2024 Category: Cancer & Oncology Authors: Brianna Conte Dana L Casey Kathryn R Tringale Michael P LaQuaglia J Ted Gerstle Leonard Wexler Michael V Ortiz Suzanne L Wolden Source Type: research
Primary alveolar rhabdomyosarcoma of the brain: a case report
ConclusionThe standard of care for managing this rare type of brain tumor involves surgery with adjuvant chemoradiotherapy. Further studies should be conducted for a better diagnostic and therapeutic understanding. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 23, 2024 Category: General Medicine Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
