Large Malignant Testicular/Paratesticular Tumors in Adolescence: Assessment of Gross Tumor Size in a Vulnerable Age Group
CONCLUSION: This adolescent cohort with malignant testicular and paratesticular tumors showed a high proportion (11.8%) of very large (≥10 cm) tumors. Although the reasons are unknown and likely multifactorial, this study suggests that adolescents, particularly the 11-13 year age group, are a vulnerable population.PMID:38514050 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Ava G Stechschulte Andrea C Bakker Jasmine Steele Sara O Vargas Source Type: research
GSE249431 Neopetrotaurines A-C, Isoquinoline Alkaloids with an Unprecedented Taurine-Bridged Isoquinoline Quinone Moiety from the Sponge Neopetrosia sp.
Contributors : Yong Y Kim ; Javed Khan ; Dongdong Wang ; Kirk R GustafsonSeries Type : Expression profiling by high throughput sequencingOrganism :Neopetrotaurines A-C, isoquinoline quinone-linked isoquinoline alkaloids that possess a unique taurine bridge connecting the two bicyclic components, were isolated from a Neopetrosia sp. marine sponge. These new compounds have proton-deficient scaffolds, so their structure elucidation was facilitated by utilizing LR-HSQMBC and HMBC NMR experiments optimized to detect 4- and 5-bond long-range 1H-13C heteronuclear correlations. Neopetrotaurines A-C showed potent inhibition of tr...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient: a case report and review of the literature
J Int Med Res. 2024 Mar;52(3):3000605241234755. doi: 10.1177/03000605241234755.ABSTRACTRhabdomyosarcoma of the prostate is a rare mesenchymal tumor that originates from undifferentiated mesenchymal cells. Spindle cell rhabdomyosarcoma is a variant of embryonal rhabdomyosarcoma. The vast majority of these two pathological types occur in children, with only a few adult cases reported to date, and both are associated with poor clinical outcomes. We herein report a case involving a man in his early 40s with spindle cell embryonal rhabdomyosarcoma of the prostate. His chief complaint was difficult urination. The diagnosis was c...
Source: Cell Research - March 19, 2024 Category: Cytology Authors: Hanwen Luo Xiangtao Weng Zibin Zhong Xiongwei Shan Wenli Lin Siyi Li Chiming Gu Source Type: research
P53 Overexpression May Represent an Early Marker of Clinicopathologic Progression in Vasculogenic Mesenchymal Lesions of Germ Cell Tumor Origin
AbstractVasculogenic mesenchymal lesions (VMLs) of germ cell tumor origin are thought to originate in postpubertal-type yolk sac tumor components and include a spectrum of lesions from teratoma with vasculogenic stroma (TVS), to low and high-grade vasculogenic mesenchymal tumors (VMTs). VMLs exhibit rudimentary to well-developed neoplastic vessels within primitive mesenchyme, being considered a neoplastic reiteration of embryonic vasculogen esis in the splanchnic mesoderm of the yolk sac. They occur in patients with primary mediastinal germ cell tumors after chemotherapy, and a subset progresses to “somatic-type” sar...
Source: Virchows Archiv - March 19, 2024 Category: Pathology Source Type: research
Pediatric orbital lesions: neoplastic extraocular soft-tissue lesions
AbstractPediatric neoplastic extraocular soft-tissue lesions in the orbit are uncommon. Early multimodality imaging work-up and recognition of the key imaging features of these lesions allow narrowing of the differential diagnoses in order to direct timely management. In this paper, the authors present a multimodality approach to the imaging work-up of these lesions and highlight the use of ocular ultrasound as a first imaging modality where appropriate. We will discuss vascular neoplasms (congenital hemangioma, infantile hemangioma), optic nerve lesions (meningioma, optic nerve glioma), and other neoplastic lesions (plexi...
Source: Pediatric Radiology - March 14, 2024 Category: Radiology Source Type: research
Adult head and neck rhabdomyosarcoma: radiotherapy- based treatment, outcomes, and predictors of survival
Adult head and neck rhabdomyosarcoma (HNRMS) is an exceptionally rare malignancy, and there is a paucity of data and research dedicated to understanding its characteristics and management in adult populations.... (Source: BMC Cancer)
Source: BMC Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Dan Zhao, Fang Zhou, Weixin Liu, Zhou Huang, Xiaolong Xu, Baomin Zheng, Changqing Liu, Chujie Bai, Jiayong Liu, Yan Sun, Weihu Wang and Shaowen Xiao Tags: Research Source Type: research
Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)
Cancers (Basel). 2024 Feb 29;16(5):998. doi: 10.3390/cancers16050998.ABSTRACTThe Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) clinical trial is an overarching, multinational study for children and adults with rhabdomyosarcoma (RMS). The trial, developed by the European Soft Tissue Sarcoma Study Group (EpSSG), incorporates multiple different research questions within a multistage design with a focus on (i) novel regimens for poor prognostic subgroups, (ii) optimal duration of maintenance chemotherapy, and (iii) optimal use of radiotherapy for local control and widespread metastatic disease. Additional sub-studies focus...
Source: Cancer Control - March 13, 2024 Category: Cancer & Oncology Authors: Julia Chisholm Henry Mandeville Madeleine Adams Veronique Minard-Collin Timothy Rogers Anna Kelsey Janet Shipley Rick R van Rijn Isabelle de Vries Roelof van Ewijk Bart de Keizer Susanne A Gatz Michela Casanova Lisa Lyngsie Hjalgrim Charlotte Firth Keith Source Type: research
New Dual Inducible Cellular Model to Investigate Temporal Control of Oncogenic Cooperating Genes
bioRxiv [Preprint]. 2024 Feb 27:2024.02.23.581802. doi: 10.1101/2024.02.23.581802.ABSTRACTThe study of cooperating genes in cancer can lead to mechanistic understanding and identifying potential therapeutic targets. To facilitate these types of studies, we developed a new dual-inducible system utilizing the tetracycline- and cumate-inducible systems driving HES3 and the PAX3::FOXO1 fusion-oncogene, respectively, as cooperating genes from fusion-positive rhabdomyosarcoma. With this new model, we can independently induce expression of either HES3 or PAX3::FOXO1, as well as simultaneously induce expression of both genes. This...
Source: Cancer Control - March 11, 2024 Category: Cancer & Oncology Authors: Matthew R Kent Amanda N Jay Genevieve C Kendall Source Type: research
Management of a pure uterine corpus rhabdomyosarcoma in a postmenopausal patient: A rare case report and review of the literature
Key Clinical MessageRhabdomyosarcoma of the female genital tract often involves the vagina and cervix. It usually occurs in infants and children. Such tumors are uncommon in the uterus, especially in adults. Treatment options are based on studies of younger individuals.AbstractRhabdomyosarcoma (RMS) is a malignant mesenchymal neoplasm with a tendency to differentiate into skeletal muscle cells. RMS is an aggressive tumor that tends to develop in children and younger patients. A vast majority of genital tract RMSs occur in the vagina and cervix. Such tumors rarely occur in adults. Usually, these tumors either occur as a com...
Source: Clinical Case Reports - March 7, 2024 Category: General Medicine Authors: John Lugata,
Caleigh Smith,
Onesmo Mrosso,
Doris Rwenyagila,
Baraka Shao,
Alex Mremi Tags: CASE REPORT Source Type: research
Small bowel metastasis from embryonal rhabdomyosarcoma of the extremity- a case report
We report an unusual case of ileal metastases from an upper extremity rhabdomyosarcoma in a 17-year-old male who presented with abdominal pain during a routine follow-up visit. Laparotomy and ileocecectomy for a perforated ileal mass confirmed metastatic embryonal rhabdomyosarcoma with 1 out of 14 positive lymph node metastases. This case demonstrates that, although rare, intra-abdominal metastases should be considered when patients with a rhabdomyosarcoma present with abdominal complaints.PMID:38450697 (Source: South African Journal of Surgery)
Source: South African Journal of Surgery - March 7, 2024 Category: Surgery Authors: P Joubert M Mihalik Source Type: research
