Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)
Cancers (Basel). 2024 Feb 29;16(5):998. doi: 10.3390/cancers16050998.ABSTRACTThe Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) clinical trial is an overarching, multinational study for children and adults with rhabdomyosarcoma (RMS). The trial, developed by the European Soft Tissue Sarcoma Study Group (EpSSG), incorporates multiple different research questions within a multistage design with a focus on (i) novel regimens for poor prognostic subgroups, (ii) optimal duration of maintenance chemotherapy, and (iii) optimal use of radiotherapy for local control and widespread metastatic disease. Additional sub-studies focusing on biological risk stratification, use of imaging modalities, including [18F]FDG PET-CT and diffusion-weighted MRI imaging (DWI) as prognostic markers, and impact of therapy on quality of life are described. This paper forms part of a Special Issue on rhabdomyosarcoma and outlines the study background, rationale for randomisations and sub-studies, design, and plans for utilisation and dissemination of results.PMID:38473359 | DOI:10.3390/cancers16050998
Source: Cancer Control - Category: Cancer & Oncology Authors: Julia Chisholm Henry Mandeville Madeleine Adams Veronique Minard-Collin Timothy Rogers Anna Kelsey Janet Shipley Rick R van Rijn Isabelle de Vries Roelof van Ewijk Bart de Keizer Susanne A Gatz Michela Casanova Lisa Lyngsie Hjalgrim Charlotte Firth Keith Source Type: research
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