GSE208146 PAX3-FOXO1 directs CBP/P300 via its activation domain to build RNA Pol2 clusters
Contributors : Gryder E.Berkley ; Hyunmin Kim ; Issra OsmanSeries Type : Expression profiling by high throughput sequencing ; Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensActivation of oncogenic gene expression from long-range enhancers is initiated by the assembly of DNA-binding transcription factors (TF), leading to recruitment of co-activators such as CBP/p300 to modify the local genomic context and facilitate RNA-Polymerase 2 (Pol2) binding. Yet, most TF-to-coactivator recruitment relationships remain unmapped. Here, studying the oncogenic fusion TF PAX3-FOXO1 (P3F) ...
Source: GEO: Gene Expression Omnibus - December 25, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 16, Pages 43: Congenital Tumors & mdash;Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers, Vol. 16, Pages 43: Congenital Tumors—Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers doi: 10.3390/cancers16010043
Authors:
Kwasniewicz
Wieczorek-Pastusiak
Romaniuk-Doroszewska
Bekiesinska-Figatowska
Congenital tumors are rare and, owing to this rarity, there is limited information on many of them. A total of 839 fetal and postnatal MRI studies performed in the first 3 months of life were retrospectively reviewed. They were performed with the use of 1.5 T scanners. Seventy-six tumors were diagnosed based on fetal MRI between 20 and 37 gestational weeks, and 27 were ...
Source: Cancers - December 20, 2023 Category: Cancer & Oncology Authors: Kwasniewicz Wieczorek-Pastusiak Romaniuk-Doroszewska Bekiesinska-Figatowska Tags: Article Source Type: research
Non ‑syndromic first case of pediatric rhabdomyosarcoma originating from the umbilical left medial ligament: A case report
Oncol Lett. 2023 Dec 1;27(1):38. doi: 10.3892/ol.2023.14171. eCollection 2024 Jan.ABSTRACTRhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. The present study reports the case of a 2-year-old female who presented with abdominal pain and a palpable abdominal mass. Radiological investigations failed to reveal the tissue origin of the mass and a tru-cut biopsy confirmed the diagnosis of embryonal RMS. Surgical excision was performed after neo-adjuvant chemotherapy. The pelvic end of the mass was observed to continue with the left medial umbilical ligament. The patient's postoperative course was unevent...
Source: Oncology Letters - December 18, 2023 Category: Cancer & Oncology Authors: Meltem Kaba Çetin Ali Karadağ Serkan Odaba şi Dildar Bahar Gen ç Source Type: research
Smyd1: Implications for novel approaches in rhabdomyosarcoma therapy
Exp Cell Res. 2023 Dec 12:113863. doi: 10.1016/j.yexcr.2023.113863. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS), a tumor that consists of poorly differentiated skeletal muscle cells, is the most common soft-tissue sarcoma in children. Despite considerable progress within the last decades, therapeutic options are still limited, warranting the need for novel approaches. Recent data suggest deregulation of the Smyd1 protein, a sumoylation target as well as H3K4me2/3 methyltransferase and transcriptional regulator in myogenesis, and its binding partner skNAC, in RMS cells. Here, we show that despite the fact that most...
Source: Cell Research - December 14, 2023 Category: Cytology Authors: Janine Berkholz Angelika Schmitt Annunziata Fragasso Anna-Celina Schmid Barbara Munz Source Type: research
Smyd1: Implications for novel approaches in rhabdomyosarcoma therapy
Exp Cell Res. 2023 Dec 12:113863. doi: 10.1016/j.yexcr.2023.113863. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS), a tumor that consists of poorly differentiated skeletal muscle cells, is the most common soft-tissue sarcoma in children. Despite considerable progress within the last decades, therapeutic options are still limited, warranting the need for novel approaches. Recent data suggest deregulation of the Smyd1 protein, a sumoylation target as well as H3K4me2/3 methyltransferase and transcriptional regulator in myogenesis, and its binding partner skNAC, in RMS cells. Here, we show that despite the fact that most...
Source: Experimental Cell Research - December 14, 2023 Category: Cytology Authors: Janine Berkholz Angelika Schmitt Annunziata Fragasso Anna-Celina Schmid Barbara Munz Source Type: research
Smyd1: Implications for novel approaches in rhabdomyosarcoma therapy
Exp Cell Res. 2023 Dec 12:113863. doi: 10.1016/j.yexcr.2023.113863. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS), a tumor that consists of poorly differentiated skeletal muscle cells, is the most common soft-tissue sarcoma in children. Despite considerable progress within the last decades, therapeutic options are still limited, warranting the need for novel approaches. Recent data suggest deregulation of the Smyd1 protein, a sumoylation target as well as H3K4me2/3 methyltransferase and transcriptional regulator in myogenesis, and its binding partner skNAC, in RMS cells. Here, we show that despite the fact that most...
Source: Experimental Cell Research - December 14, 2023 Category: Cytology Authors: Janine Berkholz Angelika Schmitt Annunziata Fragasso Anna-Celina Schmid Barbara Munz Source Type: research
