A challenging case of drug ‐related acute fibrinous and organizing pneumonia: A rare case report
We present a case of AFOP probably induced by anti-prostate cancer medications. AbstractA 65-year-old man presented with intermittent fever and progressive shortness of breath. He responded poorly to antibiotics and corticosteroids (methylprednisolone 40 mg/d). Chest computed tomography scans showed diffuse consolidations and ground glass density patchy opacities in both lungs and these lesions progressed rapidly. The diagnosis of acute fibrinous and organizing pneumonia (AFOP) was confirmed through transbronchial cryobiopsy. This patient had pro state cancer with bone metastasis for 4 months and took the anti-prostat...
Source: Respirology Case Reports - April 24, 2024 Category: Respiratory Medicine Authors: Chenxia Guo,
Wei Wu,
Xiang Zhu,
Qingtao Zhou,
Ying Liang Tags: CASE REPORT Source Type: research
Clinical Pathology Conference: Case 4: An exophytic gingival mass of the right anterior mandible
An 83-year-old male presented to a community oral maxillofacial surgeon with a tender, pink, pedunculated exophytic tumor measuring 2 × 1.5 cm involving the right anterior mandible adjacent to tooth #27 (Figure 1A). His medical history was significant for hypertension, congestive heart failure, atrial fibrillation, and prostate cancer treated with radiation and androgen deprivation chemotherapy. The patient had been taking a miodarone, metoprolol, digoxin, rivaroxaban, furosemide, bicalutamide, and leuprorelin injections. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Safia Durab, Ida A. Varghese, Laith Mahmood, Nadarajah Vigneswaran Source Type: research
AZGP1 deficiency promotes angiogenesis in prostate cancer
Loss of AZGP1 expression is a biomarker associated with progression to castration resistance, development of metastasis, and poor disease-specific survival in prostate cancer. However, high expression of AZGP1... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 24, 2024 Category: Research Authors: Ru M. Wen, Zhengyuan Qiu, G. Edward W. Marti, Eric E. Peterson, Fernando Jose Garcia Marques, Abel Bermudez, Yi Wei, Rosalie Nolley, Nathan Lam, Alex LaPat Polasko, Chun-Lung Chiu, Dalin Zhang, Sanghee Cho, Grigorios Marios Karageorgos, Elizabeth McDonoug Tags: Research Source Type: research
Limited prognostic role of routine serum markers (AP, CEA, LDH and NSE) in oligorecurrent prostate cancer patients undergoing PSMA-radioguided surgery
ConclusionThe assessment of AP, CEA, LDH, and NSE before salvage PSMA-RGS showed no prognostic impact. Further studies are needed to identify possible predictors that will optimize patient selection for salvage PSMA-RGS. (Source: World Journal of Urology)
Source: World Journal of Urology - April 24, 2024 Category: Urology & Nephrology Source Type: research
Quantification of biochemical PSA dynamics after radioligand therapy with [177Lu]Lu-PSMA-I & T using a population pharmacokinetic/pharmacodynamic model
There is an unmet need for prediction of treatment outcome or patient selection for [177Lu]Lu-PSMA therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). Quantification of the tumor exp... (Source: EJNMMI Physics)
Source: EJNMMI Physics - April 24, 2024 Category: Radiology Authors: Hinke Siebinga, Berlinda J. de Wit-van der Veen, Daphne M. V. de Vries-Huizing, Wouter V. Vogel, Jeroen J. M. A. Hendrikx and Alwin D. R. Huitema Tags: Original research Source Type: research
Alternative splicing in prostate cancer progression and therapeutic resistance
Oncogene, Published online: 24 April 2024; doi:10.1038/s41388-024-03036-xAlternative splicing in prostate cancer progression and therapeutic resistance (Source: Oncogene)
Source: Oncogene - April 24, 2024 Category: Cancer & Oncology Authors: Chitra Rawat Hannelore V. Heemers Source Type: research
Real-world experience of water vapour therapy (Rezum) in patients with benign prostatic enlargement: a retrospective single-center study
Prostate Cancer and Prostatic Diseases, Published online: 24 April 2024; doi:10.1038/s41391-024-00836-wReal-world experience of water vapour therapy (Rezum) in patients with benign prostatic enlargement: a retrospective single-center study (Source: Prostate Cancer and Prostatic Diseases)
Source: Prostate Cancer and Prostatic Diseases - April 24, 2024 Category: Urology & Nephrology Authors: Mathias Wolters Martin Krastel Thorben Winkler Hamza Idais Mehrdad Mazdak Hossein Tezval Markus A. Kuczyk Christoph-A. J. von Klot Source Type: research
Methodological considerations in the use of a large database to estimate incidence of prostate cancer in transgender women in the US
Prostate Cancer and Prostatic Diseases, Published online: 24 April 2024; doi:10.1038/s41391-024-00839-7Methodological considerations in the use of a large database to estimate incidence of prostate cancer in transgender women in the US (Source: Prostate Cancer and Prostatic Diseases)
Source: Prostate Cancer and Prostatic Diseases - April 24, 2024 Category: Urology & Nephrology Authors: Alison M. Berner Devon Buchanan Leighton Seal Stewart O ’Callaghan Source Type: research
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and a displaced single-stranded DNA, that frequently form during transcription and may be attributed to genomic stabili... (Source: Molecular Cancer)
Source: Molecular Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Yufan Ying, Yuqing Wu, Fenghao Zhang, Yijie Tang, Jiahe Yi, Xueyou Ma, Jiangfeng Li, Danni Chen, Xiao Wang, Xiaoyan Liu, Ben Liu, Jindan Luo, Xiangyi Zheng and Liping Xie Tags: Research Source Type: research
Real-world treatment patterns and medical costs of prostate cancer patients in Switzerland – a claims data analysis
Prostate cancer (PC) is the most prevalent cancer in men in Switzerland. However, evidence on the real-world health care use of PC patients is scarce. The aim of this study is to describe health care utilization, treatment patterns, and medical costs in PC patients over a period of five years (2014-2018). (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Michael Stucki, Stephanie Dosch, Markus Gn ädinger, Sereina M. Graber, Carola A. Huber, Golda Lenzin, Räto T. Strebel, Daniel R. Zwahlen, Aurelius Omlin, Simon Wieser Tags: Original Research Source Type: research
Biparametric MRI in prostate cancer during active surveillance: is it safe?
AbstractActive surveillance (AS) is the preferred option for patients presenting with low-intermediate-risk prostate cancer. MRI now plays a crucial role for baseline assessment and ongoing monitoring of AS. The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations aid radiological assessment of progression; however, current guidelines do not advise on MRI protocols nor on frequency. Biparametric (bp) imaging without contrast administration offers advantages such as reduced costs and increased throughput, with similar outcomes to multiparametric (mp) MRI shown in the biopsy na...
Source: European Radiology - April 24, 2024 Category: Radiology Source Type: research
Nutritional supplement with fermented soy in men with an elevated risk of prostate cancer and negative prostate biopsies: General and oncological results from the prospective PRAECAP trial
To investigate the effect of a dietary supplement containing fermented soy on PSA, IPSS, changes in prostate volume and prostate cancer development after a 6-month challenge in men at increased risk of prostate cancer and negative previous biopsies. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Hans Van Der Eecken, Bram Vansevenant, Ga ëtan Devos, Eduard Roussel, Alexander Giesen, Jochen Darras, Filip Ameye, Lodewijk Van Wynsberge, Lieven Goeman, Marc Claessens, Dieter Ost, Steven Joniau Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
