Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Bisphenol S enhances the cell proliferation ability of prostate cancer cells by regulating the expression of SDS
Toxicol In Vitro. 2024 Apr 22:105827. doi: 10.1016/j.tiv.2024.105827. Online ahead of print.ABSTRACTRecent times have witnessed an increase in both incidence and mortality rates of prostate cancer. While some individuals with localized or metastatic cancer may progress slowly with a lower mortality risk, those with intermediate or high-risk cancer often face a higher likelihood of death, despite treatment. Bisphenol A (BPA) has been linked to various cancers, including prostate and breast cancer, yet the relationship between bisphenol S (BPS) and human health remains underexplored. In our study, we employed ssGSEA analysis...
Source: Toxicology in Vitro - April 24, 2024 Category: Toxicology Authors: Guanqun Ju Xiangyang Zhan Xinglin Chen Tongtong Zhang Xinyu Zhai Chuanmin Chu Mingyue Tan Dongliang Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Bisphenol S enhances the cell proliferation ability of prostate cancer cells by regulating the expression of SDS
Toxicol In Vitro. 2024 Apr 22:105827. doi: 10.1016/j.tiv.2024.105827. Online ahead of print.ABSTRACTRecent times have witnessed an increase in both incidence and mortality rates of prostate cancer. While some individuals with localized or metastatic cancer may progress slowly with a lower mortality risk, those with intermediate or high-risk cancer often face a higher likelihood of death, despite treatment. Bisphenol A (BPA) has been linked to various cancers, including prostate and breast cancer, yet the relationship between bisphenol S (BPS) and human health remains underexplored. In our study, we employed ssGSEA analysis...
Source: Toxicology in Vitro - April 24, 2024 Category: Toxicology Authors: Guanqun Ju Xiangyang Zhan Xinglin Chen Tongtong Zhang Xinyu Zhai Chuanmin Chu Mingyue Tan Dongliang Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Prostate-specific Membrane Antigen: Alpha-labeled Radiopharmaceuticals
PET Clin. 2024 Apr 23:S1556-8598(24)00018-X. doi: 10.1016/j.cpet.2024.03.003. Online ahead of print.ABSTRACTNovel prostate-specific membrane antigen (PSMA) ligands labeled with α-emitting radionuclides are sparking a growing interest in prostate cancer treatment. These targeted alpha therapies (TATs) have attractive physical properties that deem them effective in progressive metastatic castrate-resistant prostate cancer (mCRPC). Among the PSMA TAT radiopharmaceuticals, [225Ac]Ac-PSMA has been used extensively on a compassionate basis and is currently undergoing phase I trials. Notably, TAT has the potential to improve qua...
Source: Clinical Prostate Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Honest Ndlovu Kgomotso M G Mokoala Ismaheel Lawal Louise Emmett Mike M Sathekge Source Type: research
Comparison of novel PSMA-targeting [ < sup > 177 < /sup > Lu]Lu-P17-087 with its albumin binding derivative [ < sup > 177 < /sup > Lu]Lu-P17-088 in metastatic castration-resistant prostate cancer patients: a first-in-human study
CONCLUSION: [177Lu]Lu-P17-088 and [177Lu]Lu-P17-087 displayed different pharmacokinetics but excellent PSMA-targeting dose delivery in mCRPC patients. These two agents are promising RLT agents for personalized treatment of mCRPC. Further studies with increased dose and frequency of RLT are warranted to evaluate the potential therapeutic efficacy.TRIAL REGISTRATION: 177Lu-P17-087/177Lu-P17-088 in Patients with Metastatic Castration-resistant Prostate Cancer (NCT05603559, Registered at 25 October, 2022). URL OF REGISTRY: https://classic.CLINICALTRIALS: gov/ct2/show/NCT05603559 .PMID:38658392 | DOI:10.1007/s00259-024-06721-x ...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Linlin Li Jiarou Wang Guochang Wang Rongxi Wang Wenbin Jin Jie Zang Huimin Sui Chenhao Jia Yuanyuan Jiang Haiyan Hong Lin Zhu David Alexoff Karl Ploessl Hank F Kung Zhaohui Zhu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Bisphenol S enhances the cell proliferation ability of prostate cancer cells by regulating the expression of SDS
Toxicol In Vitro. 2024 Apr 22:105827. doi: 10.1016/j.tiv.2024.105827. Online ahead of print.ABSTRACTRecent times have witnessed an increase in both incidence and mortality rates of prostate cancer. While some individuals with localized or metastatic cancer may progress slowly with a lower mortality risk, those with intermediate or high-risk cancer often face a higher likelihood of death, despite treatment. Bisphenol A (BPA) has been linked to various cancers, including prostate and breast cancer, yet the relationship between bisphenol S (BPS) and human health remains underexplored. In our study, we employed ssGSEA analysis...
Source: Toxicology in Vitro - April 24, 2024 Category: Toxicology Authors: Guanqun Ju Xiangyang Zhan Xinglin Chen Tongtong Zhang Xinyu Zhai Chuanmin Chu Mingyue Tan Dongliang Xu Source Type: research
The Added Value of Prostate Magnetic Resonance Imaging to Patient Selection
CONCLUSIONS: Increased utilization of prostate MRI has been associated with a higher proportion of biopsies with high PI-RADS and Gleason scores consistent with improved patient selection in this integrated health system.PMID:38654626 | DOI:10.7812/TPP/23.178 (Source: The Permanente journal)
Source: The Permanente journal - April 24, 2024 Category: General Medicine Authors: Erin M Jyo Hyo-Chun Yoon Bradford Burton Source Type: research
Prostate-specific Membrane Antigen: Alpha-labeled Radiopharmaceuticals
PET Clin. 2024 Apr 23:S1556-8598(24)00018-X. doi: 10.1016/j.cpet.2024.03.003. Online ahead of print.ABSTRACTNovel prostate-specific membrane antigen (PSMA) ligands labeled with α-emitting radionuclides are sparking a growing interest in prostate cancer treatment. These targeted alpha therapies (TATs) have attractive physical properties that deem them effective in progressive metastatic castrate-resistant prostate cancer (mCRPC). Among the PSMA TAT radiopharmaceuticals, [225Ac]Ac-PSMA has been used extensively on a compassionate basis and is currently undergoing phase I trials. Notably, TAT has the potential to improve qua...
Source: Clinical Prostate Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Honest Ndlovu Kgomotso M G Mokoala Ismaheel Lawal Louise Emmett Mike M Sathekge Source Type: research
AZGP1 deficiency promotes angiogenesis in prostate cancer
CONCLUSION: AZGP1 is a negative regulator of angiogenesis, such that loss of AZGP1 promotes angiogenesis in prostate cancer. AZGP1 likely exerts heterotypical effects on cells in the tumor microenvironment, such as stromal and endothelial cells. This study sheds light on the anti-angiogenic characteristics of AZGP1 in the prostate and provides a rationale to target AZGP1 to inhibit prostate cancer progression.PMID:38659028 | DOI:10.1186/s12967-024-05183-x (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Ru M Wen Zhengyuan Qiu G Edward W Marti Eric E Peterson Fernando Jose Garcia Marques Abel Bermudez Yi Wei Rosalie Nolley Nathan Lam Alex LaPat Polasko Chun-Lung Chiu Dalin Zhang Sanghee Cho Grigorios Marios Karageorgos Elizabeth McDonough Chrystal Chadwic Source Type: research
Physiotherapy for continence and muscle function in prostatectomy: a randomised controlled trial
CONCLUSION: Supervised PFMT can improve postoperative UI and PFM function after RARP. Further studies are needed to confirm whether intra-anal pressure reflects PFM function and affects continence status in UI in men who have undergone RARP.PMID:38658057 | DOI:10.1111/bju.16369 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Mifuka Ouchi Takeya Kitta Hiroki Chiba Madoka Higuchi Yui Abe-Takahashi Mio Togo Naohisa Kusakabe Sachiyo Murai Hiroshi Kikuchi Ryuji Matsumoto Takahiro Osawa Takashige Abe Nobuo Shinohara Source Type: research
ACSM1 and ACSM3 regulate fatty acid metabolism to support prostate cancer growth and constrain ferroptosis
Cancer Res. 2024 Apr 24. doi: 10.1158/0008-5472.CAN-23-1489. Online ahead of print.ABSTRACTSolid tumors are highly reliant on lipids for energy, growth, and survival. In prostate cancer, the activity of the androgen receptor (AR) is associated with reprogramming of lipid metabolic processes. Here, we identified acyl-CoA synthetase medium chain family members 1 and 3 (ACSM1 and ACSM3) as AR-regulated mediators of prostate cancer metabolism and growth. ACSM1 and ACSM3 were upregulated in prostate tumors compared to non-malignant tissues and other cancer types. Both enzymes enhanced proliferation and protected prostate cancer...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Raj Kumar Shrestha Zeyad D Nassar Adrienne R Hanson Richard Iggo Scott L Townley Jonas Dehairs Chui Yan Mah Madison Helm Mohammadreza Alizadeh-Ghodsi Marie Pickering Bart Ghesquiere Matthew J Watt Lake-Ee Quek Andrew J Hoy Wayne D Tilley Johannes V Swinne Source Type: research
