Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
Changes in Physiological Traits, Gene Expression and Phytochemical Profile of Mentha piperita in Response to Elicitor
The objective of this research is to investigate the expression of essential genes in the menthol pathway of Mentha piperita, including Pulegone reductase (Pr), Menthofuran synthase (Mfs), and limonene synthase (Ls) using qPCR, physiological analysis and essential oil composition in response to methyl jasmonate (MeJA) (0.5 mM) elicitation. Physiological analysis showed that 0.5 mM MeJA triggers defensive responsiveness in Mentha piperita by increasing superoxide dismutase (SOD) and Peroxidase (POD) enzymes activity. The highest transcript levels of Pr and Mfs genes were observed during 8 and 12 h after treatment respective...
Source: Biochemical Genetics - April 23, 2024 Category: Genetics & Stem Cells Authors: Soheila Afkar Ghasem Karimzadeh Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
Treatment Patterns and Clinical Outcomes Among Patients With Metastatic Prostate Cancer Harboring Homologous Recombination Repair Mutations
CONCLUSIONS: Treatment patterns identified in this study were similar to those among patients with mCRPC regardless of tumor HRR mutation status in the literature.PMID:38653037 | DOI:10.1016/j.clgc.2024.102080 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Priyanka J Bobbili Jasmina Ivanova David B Solit Niharika B Mettu Shannon J McCall Mallika Dhawan Maral DerSarkissian Bhakti Arondekar Jane Chang Alexander Niyazov Jocelyn Lee Risha Huq Michelle Green Michelle Turski Phu Lam Aruna Muthukumar Tracy Guo Man Source Type: research
Salvage Reirradiation for Locally Recurrent Prostate Cancer: Results From a Prospective Study With 7.2 Years of Follow-Up
CONCLUSION: Reirradiation with EBRT for locally recurrent PCa after primary curative radiation therapy is clinically feasible and demonstrated a favorable outcome with acceptable toxicity in this prospective study with long-term follow-up.PMID:38652872 | DOI:10.1200/JCO.23.01391 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Christian Ekanger Svein Inge Helle Lars Reis æter Liv Bolstad Hysing Rune Kv åle Alfred Honor é Karsten Gravdal Sara Pilskog Olav Dahl Source Type: research
Reducing False-Positives Due to Urinary Stagnation in the Prostatic Urethra on 18F-DCFPyL PSMA PET/CT With MRI
CONCLUSIONS: Stagnated urine within the prostatic urethra is a potential confounding factor on PSMA PET scans. Integrating PET imaging with T2W MRI can mitigate false-positive calls, especially as PSMA PET/CT continues to gain traction in diagnosing localized prostate cancer.PMID:38651785 | DOI:10.1097/RLU.0000000000005220 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: David G Gelikman Esther Mena Liza Lindenberg William S Azar Nityam Rathi Enis C Yilmaz Stephanie A Harmon Kyle C Schuppe Jessica Y Hsueh Hannah Huth Bradford J Wood Sandeep Gurram Peter L Choyke Peter A Pinto Baris Turkbey Source Type: research
Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Changes in Physiological Traits, Gene Expression and Phytochemical Profile of Mentha piperita in Response to Elicitor
The objective of this research is to investigate the expression of essential genes in the menthol pathway of Mentha piperita, including Pulegone reductase (Pr), Menthofuran synthase (Mfs), and limonene synthase (Ls) using qPCR, physiological analysis and essential oil composition in response to methyl jasmonate (MeJA) (0.5 mM) elicitation. Physiological analysis showed that 0.5 mM MeJA triggers defensive responsiveness in Mentha piperita by increasing superoxide dismutase (SOD) and Peroxidase (POD) enzymes activity. The highest transcript levels of Pr and Mfs genes were observed during 8 and 12 h after treatment respective...
Source: Biochemical Genetics - April 23, 2024 Category: Genetics & Stem Cells Authors: Soheila Afkar Ghasem Karimzadeh Source Type: research
Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
