Development and validation of a clinical-radiomics model for prediction of prostate cancer: a multicenter study
ConclusionThis study presents a clinical-radiomics model that incorporates age, fPSA/PSA, PI-RADS, and radiomics score, which can be conveniently used to facilitate individualized prediction of prostate cancer before prostate biopsy. (Source: World Journal of Urology)
Source: World Journal of Urology - April 30, 2024 Category: Urology & Nephrology Source Type: research
Assessment of the deep learning-based gamma passing rate prediction system for 1.5 T magnetic resonance-guided linear accelerator
This study collected 125 verification plans [reference plan (RP), 100; adapted plan (AP), 25] from patients with prostate cancer treated using Elekta Unity. Based on our previous study, we employed a convolutional neural network that predicted the GPRs of nine pairs of gamma criteria from 1%/1 mm to 3%/3 mm. First, we trained and tested the DL model using RPs (n = 75 andn = 25 for training and testing, respectively) for its optimization. Second, we tested the GPR prediction accuracy using APs to determine whether the DL model could be applied to APs. The mean absolute error (MAE) and correlation coefficient (r) of t...
Source: Radiological Physics and Technology - April 30, 2024 Category: Physics Source Type: research
Enhancing prostate MRI expertise: educational strategies for radiologists
AbstractThe adoption of multiparametric MRI (mpMRI) and the Prostate Imaging Reporting and Data System has significantly changed prostate cancer diagnosis and management. These advancements, alongside novel biomarkers and updated International Society of Uropathology grade groups, have improved cancer detection and prognostication. Despite this progress, varying levels of expertise in mpMRI among radiologists have resulted in inconsistent assessments, potentially leading to unnecessary procedures and diminished confidence in the modality. This review assesses the educational landscape for prostate MRI, highlighting availab...
Source: Abdominal Imaging - April 30, 2024 Category: Radiology Source Type: research
Spatial Pattern of Intraprostatic Recurrence after Definitive External-Beam Radiation Therapy for Prostate Cancer: Implications for Focal Boost to Intraprostatic Dominant Lesion
CONCLUSIONS: Local intraprostatic recurrence after definitive EBRT often occurs at the same site or at a partially overlapping site adjacent to the primary intraprostatic dominant lesion. Our results support the merit of focal dose-escalation for intraprostatic dominant lesions in definitive EBRT.PMID:38681892 | PMC:PMC11043806 | DOI:10.1016/j.adro.2024.101489 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Rihito Aizawa Tomoaki Otani Takashi Ogata Yusaku Moribata Aki Kido Shusuke Akamatsu Takayuki Goto Kimihiko Masui Takayuki Sumiyoshi Yuki Kita Takashi Kobayashi Yuji Nakamoto Takashi Mizowaki Source Type: research
Contemporary trends in the incidence and timing of spinal metastases: A population-based study
CONCLUSIONS: The incidence of spinal metastases has increased in recent years, particularly among older patients. The incidence and timing vary substantially among different primary cancer types. These findings contribute to the understanding of disease trends and emphasize a growing population of patients who require subspecialty care.PMID:38680988 | PMC:PMC11046986 | DOI:10.1093/noajnl/vdae051 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Husain Shakil Armaan K Malhotra Jetan H Badhiwala Vishwathsen Karthikeyan Ahmad Essa Yingshi He Michael G Fehlings Arjun Sahgal Nicolas Dea Alex Kiss Christopher D Witiw Donald A Redelmeier Jefferson R Wilson Source Type: research
A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration-Resistant Prostate Cancer
CONCLUSIONS: Adding ipilimumab to AAPA did not improve outcomes in men with androgen responsive mCRPC. Despite the addition of carboplatin+cabazitaxel, men in the Unsatisfactory group had shortened survivals. Adaptive designs can enrich for biologically and clinically relevant disease subgroups, to contribute to the development of marker-informed, risk-adapted therapy strategies in men with prostate cancer.PMID:38683200 | DOI:10.1158/1078-0432.CCR-23-3740 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 29, 2024 Category: Cancer & Oncology Authors: Ana M Aparicio Rebecca S S Tidwell Shalini S Yadav Jiun-Sheng Chen Miao Zhang Jingjing Liu Shuai Guo Patrick G Pilie Yao Yu Xingzhi Song Haswanth Vundavilli Sonali Jindal Keyi Zhu Paul V Viscuse Justin M Lebenthal Andrew W Hahn Rama Soundararajan Paul G C Source Type: research
A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration-Resistant Prostate Cancer
CONCLUSIONS: Adding ipilimumab to AAPA did not improve outcomes in men with androgen responsive mCRPC. Despite the addition of carboplatin+cabazitaxel, men in the Unsatisfactory group had shortened survivals. Adaptive designs can enrich for biologically and clinically relevant disease subgroups, to contribute to the development of marker-informed, risk-adapted therapy strategies in men with prostate cancer.PMID:38683200 | DOI:10.1158/1078-0432.CCR-23-3740 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Ana M Aparicio Rebecca S S Tidwell Shalini S Yadav Jiun-Sheng Chen Miao Zhang Jingjing Liu Shuai Guo Patrick G Pilie Yao Yu Xingzhi Song Haswanth Vundavilli Sonali Jindal Keyi Zhu Paul V Viscuse Justin M Lebenthal Andrew W Hahn Rama Soundararajan Paul G C Source Type: research
Extreme hypofractionated stereotactic radiotherapy for localized prostate Cancer: Efficacy and late urinary toxicity according to transurethral resection of the prostate history
CONCLUSION: Extreme hypofractionated SBRT is effective for localized prostate cancer with a low risk of late toxicity. A history of TURP is associated with a higher risk of late urinary toxicity. These findings may contribute to the optimal management of patients treated with this regimen, particularly those with a history of TURP.PMID:38681137 | PMC:PMC11047194 | DOI:10.1016/j.ctro.2024.100779 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Maxime Galienne S éverine Risbourg Thomas Lacornerie Alexandre Taillez Eric Lartigau Ma ël Barthoulot David Pasquier Source Type: research
Temporal trend in risk of prostate cancer death in men with favourable-risk prostate cancer
CONCLUSION: Men diagnosed in 2011-2016 with low-risk and favourable intermediate-risk PCa have a similar relative benefit but smaller absolute benefit of curative treatment compared to men diagnosed in 2000-2005.PMID:38682731 | DOI:10.2340/sju.v59.34015 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - April 29, 2024 Category: Urology & Nephrology Authors: Frederik F Thomsen Hans Garmo Lars Egevad P är Stattin Klaus Brasso Source Type: research
Antiproliferative and Apoptotic Effects of Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and Tapereb á (Spondias mombin L.) Extracts in Human Prostate Cell Line (PC-3)
CONCLUSION: These results open a series of perspectives on the use of these bioactive extracts in the prevention and treatment of prostate cancer.PMID:38679995 | DOI:10.31557/APJCP.2024.25.4.1339 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Thuane Oliveira Do Amaral Muxfeldt Paim Nayara Frauches Simas Joel Pimentel Abreu Lana Rosa Thuane Passos Barbosa Lima Anderson Junger Teodoro Source Type: research
Spatial Pattern of Intraprostatic Recurrence after Definitive External-Beam Radiation Therapy for Prostate Cancer: Implications for Focal Boost to Intraprostatic Dominant Lesion
CONCLUSIONS: Local intraprostatic recurrence after definitive EBRT often occurs at the same site or at a partially overlapping site adjacent to the primary intraprostatic dominant lesion. Our results support the merit of focal dose-escalation for intraprostatic dominant lesions in definitive EBRT.PMID:38681892 | PMC:PMC11043806 | DOI:10.1016/j.adro.2024.101489 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Rihito Aizawa Tomoaki Otani Takashi Ogata Yusaku Moribata Aki Kido Shusuke Akamatsu Takayuki Goto Kimihiko Masui Takayuki Sumiyoshi Yuki Kita Takashi Kobayashi Yuji Nakamoto Takashi Mizowaki Source Type: research
Contemporary trends in the incidence and timing of spinal metastases: A population-based study
CONCLUSIONS: The incidence of spinal metastases has increased in recent years, particularly among older patients. The incidence and timing vary substantially among different primary cancer types. These findings contribute to the understanding of disease trends and emphasize a growing population of patients who require subspecialty care.PMID:38680988 | PMC:PMC11046986 | DOI:10.1093/noajnl/vdae051 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Husain Shakil Armaan K Malhotra Jetan H Badhiwala Vishwathsen Karthikeyan Ahmad Essa Yingshi He Michael G Fehlings Arjun Sahgal Nicolas Dea Alex Kiss Christopher D Witiw Donald A Redelmeier Jefferson R Wilson Source Type: research
Antiproliferative and Apoptotic Effects of Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and Tapereb á (Spondias mombin L.) Extracts in Human Prostate Cell Line (PC-3)
CONCLUSION: These results open a series of perspectives on the use of these bioactive extracts in the prevention and treatment of prostate cancer.PMID:38679995 | DOI:10.31557/APJCP.2024.25.4.1339 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Thuane Oliveira Do Amaral Muxfeldt Paim Nayara Frauches Simas Joel Pimentel Abreu Lana Rosa Thuane Passos Barbosa Lima Anderson Junger Teodoro Source Type: research
Extreme hypofractionated stereotactic radiotherapy for localized prostate Cancer: Efficacy and late urinary toxicity according to transurethral resection of the prostate history
CONCLUSION: Extreme hypofractionated SBRT is effective for localized prostate cancer with a low risk of late toxicity. A history of TURP is associated with a higher risk of late urinary toxicity. These findings may contribute to the optimal management of patients treated with this regimen, particularly those with a history of TURP.PMID:38681137 | PMC:PMC11047194 | DOI:10.1016/j.ctro.2024.100779 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Maxime Galienne S éverine Risbourg Thomas Lacornerie Alexandre Taillez Eric Lartigau Ma ël Barthoulot David Pasquier Source Type: research
A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease
CONCLUSION: CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease.PMID:38680575 | PMC:PMC11053306 | DOI:10.1016/j.ajur.2022.03.017 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid Rapoport Nirmish Singla Eric Barret Elena Poddubskaya Maria Borodina Georg Salomon Juan Gomez Rivas Dmitry Enikeev Source Type: research
