Reducing False-Positives Due to Urinary Stagnation in the Prostatic Urethra on 18F-DCFPyL PSMA PET/CT With MRI
CONCLUSIONS: Stagnated urine within the prostatic urethra is a potential confounding factor on PSMA PET scans. Integrating PET imaging with T2W MRI can mitigate false-positive calls, especially as PSMA PET/CT continues to gain traction in diagnosing localized prostate cancer.PMID:38651785 | DOI:10.1097/RLU.0000000000005220 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: David G Gelikman Esther Mena Liza Lindenberg William S Azar Nityam Rathi Enis C Yilmaz Stephanie A Harmon Kyle C Schuppe Jessica Y Hsueh Hannah Huth Bradford J Wood Sandeep Gurram Peter L Choyke Peter A Pinto Baris Turkbey Source Type: research
Salvage Reirradiation for Locally Recurrent Prostate Cancer: Results From a Prospective Study With 7.2 Years of Follow-Up
CONCLUSION: Reirradiation with EBRT for locally recurrent PCa after primary curative radiation therapy is clinically feasible and demonstrated a favorable outcome with acceptable toxicity in this prospective study with long-term follow-up.PMID:38652872 | DOI:10.1200/JCO.23.01391 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Christian Ekanger Svein Inge Helle Lars Reis æter Liv Bolstad Hysing Rune Kv åle Alfred Honor é Karsten Gravdal Sara Pilskog Olav Dahl Source Type: research
Reducing False-Positives Due to Urinary Stagnation in the Prostatic Urethra on 18F-DCFPyL PSMA PET/CT With MRI
CONCLUSIONS: Stagnated urine within the prostatic urethra is a potential confounding factor on PSMA PET scans. Integrating PET imaging with T2W MRI can mitigate false-positive calls, especially as PSMA PET/CT continues to gain traction in diagnosing localized prostate cancer.PMID:38651785 | DOI:10.1097/RLU.0000000000005220 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: David G Gelikman Esther Mena Liza Lindenberg William S Azar Nityam Rathi Enis C Yilmaz Stephanie A Harmon Kyle C Schuppe Jessica Y Hsueh Hannah Huth Bradford J Wood Sandeep Gurram Peter L Choyke Peter A Pinto Baris Turkbey Source Type: research
GSE149226 Prognostic classifier for predicting biochemical recurrence in localized prostate cancer patients after radical prostatectomy
Contributors : L Mengual ; J J Lozano ; A AlcarazSeries Type : Expression profiling by arrayOrganism : Homo sapiensAccurate estimation of recurrence risk is needed for optimal treatment of clinically localized prostate cancer (PCa) patients. We combined classical clinicopathological predictors of biochemical recurrence (BCR) and molecular markers into a new risk score for predicting BCR after radical prostatectomy (RP). A retrospective study which included 122 PCa patients who attended our department between 2000 and 2007 was conducted. Total RNA was isolated from formalin-fixed paraffin embedded PCa tissue. Gene express...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Radiomic nomogram based on bi-parametric MRI to predict the International Society of Urological Pathology (ISUP) grading ≥ 3 prostate cancer: a multicenter study
To create a reliable radiomic nomogram for the prediction of the International Society of Urological Pathology (ISUP) grading ≥ 3 PCa patients. (Source: Clinical Radiology)
Source: Clinical Radiology - April 23, 2024 Category: Radiology Authors: Yongsheng Zhang, Zhiping Li, Chen Gao, Liqing Zhang, Yasheng Huang, Hua Qu, Chang Shu, Yuguo Wei, Maosheng Xu, Feng Cui Source Type: research
Prostate-specific Membrane Antigen: Alpha-labeled Radiopharmaceuticals
Novel prostate-specific membrane antigen (PSMA) ligands labeled with α-emitting radionuclides are sparking a growing interest in prostate cancer treatment. These targeted alpha therapies (TATs) have attractive physical properties that deem them effective in progressive metastatic castrate-resistant prostate cancer (mCRPC). Among the PSMA TAT radiopharmaceuticals, [2 25Ac]Ac-PSMA has been used extensively on a compassionate basis and is currently undergoing phase I trials. Notably, TAT has the potential to improve quality of life and has favorable antitumor activity and outcomes in multiple scenarios other than in mCRPC. I...
Source: PET Clinics - April 23, 2024 Category: Radiology Authors: Honest Ndlovu, Kgomotso M.G. Mokoala, Ismaheel Lawal, Louise Emmett, Mike M. Sathekge Source Type: research
Image guided radiotherapy in curative treatment for prostate cancer. 5-year results from a randomized controlled trial (RIC-trial)
Medical advances in health care are in many cases subject to stringent systems of approval including requests for phase III-IV trials prior to implementation in routine clinical practice [1]. By contrast, technological advances are more often subject to non-formal approval and the evidence base for clinical effects is often weaker. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 23, 2024 Category: Radiology Authors: Jo- Åsmund Lund, Stian Lydersen, Bjørg Aksnessæther, Arne Solberg, Anne Wanderås, Christoffer Lervåg, Stein Kaasa, Hanne Tøndel Tags: Original Article Source Type: research
Heterogeneous PSMA ligand uptake inside parotid glands
Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is an imaging procedure primarily used for detecting prostate cancer [1], which quantifies the expression of the PSMA using radiolabeled PSMA ligands. The PSMA is a type II integral membrane protein expressed in all forms of prostate tissue, including cancerous tissue [2], with expression levels being found to increase with the stage and grade of tumours [3,4,5]. PSMA radioligands also accumulate in other body regions such as the major salivary and lacrimal glands [6,7,8], by a process postulated to be at-least partially unrelated to PSMA-mediated...
Source: Physica Medica: European Journal of Medical Physics - April 23, 2024 Category: General Medicine Authors: Caleb M. Sample, Carlos Uribe, Arman Rahmim, Fran çois Bénard, Jonn Wu, Haley Clark Tags: Original paper Source Type: research
The role of multiparametric magnetic resonance ımaging in the diagnosis of granulomatous prostatitis mimicking prostate cancer
ConclusionGranulomatous prostatitis is a rare complication of intravesical BCG. High PSA, abnormal DRE, and PI-RADS ≥ 3 lesions detected after intravesical BCG should suggest granulomatous prostatitis and unnecessary biopsies may be avoided. (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 23, 2024 Category: Radiology Source Type: research
Zeb1-controlled metabolic plasticity enables remodeling of chromatin accessibility in the development of neuroendocrine prostate cancer
Cell Death & Differentiation, Published online: 23 April 2024; doi:10.1038/s41418-024-01295-5Zeb1-controlled metabolic plasticity enables remodeling of chromatin accessibility in the development of neuroendocrine prostate cancer (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - April 23, 2024 Category: Cytology Authors: Deng Wang Genyu Du Xinyu Chen Jinming Wang Kaiyuan Liu Huifang Zhao Chaping Cheng Yuman He Na Jing Penghui Xu Wei Bao Xialian Xi Yingchao Zhang Nan Wang Yiyun Liu Yujiao Sun Kai Zhang Pengcheng Zhang Wei-Qiang Gao Helen He Zhu Source Type: research
Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape
AbstractPurpose of ReviewOur review delves into the progress across urological malignancies and discusses ongoing challenges and future directions in antibody –drug conjugate (ADC) development, emphasising their transformative potential in cancer care.Recent FindingsADCs have advanced from hematologic to solid tumours, notably in breast cancer, and are now pivotal in metastatic urological cancers as both monotherapies and in combination regimens, underscored by the FDA ’s approval of enfortumab vedotin and sacituzumab govitecan for metastatic urothelial cancer. Progress in metastatic prostate cancer, particularly with ...
Source: Current Oncology Reports - April 23, 2024 Category: Cancer & Oncology Source Type: research
Cancer-Related Health and Educational Needs and Faith-Based Health Beliefs in an Urban Muslim Population
AbstractCancer screening behaviors in Muslims are under-researched, and there is limited data on how it relates to their unique cultural and religious beliefs. We assessed cancer prevention and screening-related health needs in the Washington DC area. We developed the needs assessment questionnaires and recruitment strategy in collaboration with key faith leaders from four mosques in our catchment area. A total of 203 participants were recruited through community outreach and engagement approaches and were included in the discussion when developing the needs assessment to ensure questions were religiously and culturally se...
Source: Journal of Cancer Education - April 23, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1622: Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer
ran Mahajan
Advanced localized prostate cancers (PC) recur despite chemotherapy, radiotherapy and/or androgen deprivation therapy. We recently reported HOXB13 lysine (K)13 acetylation as a gain-of-function modification that regulates interaction with the SWI/SNF chromatin remodeling complex and is critical for anti-androgen resistance. However, whether acetylated HOXB13 promotes PC cell survival following treatment with genotoxic agents is not known. Herein, we show that K13-acetylated HOXB13 is induced rapidly in PC cells in response to DNA damage induced by irradiation (IR). It colocalizes with the histone variant &a...
Source: Cancers - April 23, 2024 Category: Cancer & Oncology Authors: Duy T. Nguyen Urvashi Mahajan Duminduni Hewa Angappulige Aashna Doshi Nupam P. Mahajan Kiran Mahajan Tags: Article Source Type: research
Precise prostate cancer diagnosis using fluorescent nanoprobes for detecting PSA and PSMA in serum
Chem. Commun., 2024, Advance Article DOI: 10.1039/D4CC00670D, CommunicationMingyi Ouyang, Ming Jia, Zixuan Chang, Yinian Wang, Keyi Wang, Xiaonan Gao, Bo Tang Novel Au –Se bond-based nanoprobes were designed for concurrent detection of PSA and PSMA in serum samples, aiming to enhance the early diagnosis of prostate cancer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 22, 2024 Category: Chemistry Authors: Mingyi Ouyang Source Type: research
Second primary cancers following radiotherapy for prostate cancer: How many are actually due to the radiotherapy?
Can Urol Assoc J. 2024 Apr;18(4):129-130. doi: 10.5489/cuaj.8760.NO ABSTRACTPMID:38648657 | PMC:PMC11034963 | DOI:10.5489/cuaj.8760 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 22, 2024 Category: Urology & Nephrology Authors: Scott C Morgan Mark T Corkum Source Type: research
