The effect of baseline O < sub > 2 < /sub > conditions on the response of prostate cancer cells to hypoxia
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00155.2024. Online ahead of print.ABSTRACTThe transcriptional response to hypoxia is largely regulated by the hypoxia-inducible factors (HIFs), which induce the expression of genes involved in glycolysis, angiogenesis, proliferation, and migration. Virtually all cell culture-based hypoxia experiments have used near-atmospheric (18% O2) oxygen levels as baseline for comparison to hypoxia. However, this is hyperoxic compared to mammalian tissue microenvironments, where oxygen levels range from 2-9% O2 (physioxia). Thus, these experiments actually compare hyperoxia ...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Ricardo Alva Jacob E Wiebe Jeffrey A Stuart Source Type: research
Network pharmacology and molecular docking-based strategy for predicting anti-tumour mechanism of linarin
Nat Prod Res. 2024 Apr 22:1-9. doi: 10.1080/14786419.2024.2343920. Online ahead of print.ABSTRACTThe aim was to explore the anti-tumour mechanism of linarin (LIN) based on network pharmacology and molecular docking. PharmMapper database and GeneCards database were used to screen anti-tumour related targets of LIN. Enrichment analysis of GO and KEGG was conducted to predict the key targets and pathways. At last, LIN was docked with the key targets. ESR1, ESR2, EGFR, AR, TGFBR2, F2, MAPK10, MAPK14, CDK2 and HSP90AA1 were identified as the key targets. The key pathways included pathways in cancer, prostate cancer, pancreatic ...
Source: Natural Product Research - April 22, 2024 Category: Biochemistry Authors: Jun Wang Jingjing Cheng Source Type: research
Precise prostate cancer diagnosis using fluorescent nanoprobes for detecting PSA and PSMA in serum
Chem Commun (Camb). 2024 Apr 22. doi: 10.1039/d4cc00670d. Online ahead of print.ABSTRACTNovel Au-Se bond-based nanoprobes were designed for concurrent detection of PSA and PSMA in serum samples, aiming to enhance the early diagnosis of prostate cancer. These probes demonstrate robust stability, specificity and accuracy, underscoring their potential as non-invasive tools for diagnosis.PMID:38647078 | DOI:10.1039/d4cc00670d (Source: Chemical Communications)
Source: Chemical Communications - April 22, 2024 Category: Chemistry Authors: Mingyi Ouyang Ming Jia Zixuan Chang Yinian Wang Keyi Wang Xiaonan Gao Bo Tang Source Type: research
Second primary cancers following radiotherapy for prostate cancer: How many are actually due to the radiotherapy?
Can Urol Assoc J. 2024 Apr;18(4):129-130. doi: 10.5489/cuaj.8760.NO ABSTRACTPMID:38648657 | DOI:10.5489/cuaj.8760 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 22, 2024 Category: Urology & Nephrology Authors: Scott C Morgan Mark T Corkum Source Type: research
Inguinal hernia repair in patients with artificial urinary sphincter after radical prostatectomy
CONCLUSION: IHA has its own characteristics, and multidisciplinary knowledge thereof will help surgeons safely perform IH surgery.PMID:38649504 | DOI:10.1007/s10029-024-03040-w (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Y Yatabe T Tanioka Y Waseda K Yamaguchi T Ogo H Fujiwara K Okuno K Kawada S Haruki M Tokunaga Y Fujii Y Kinugasa Source Type: research
Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
In this study, we use in vitro and in vivo preclinical MDA PCa PDX models of resistant human prostate cancer to determine molecular mechanisms of cross-resistance between anti-androgen therapy and taxane chemotherapy, underlying the therapeutically resistant phenotype. Transcriptomic profiling revealed that resistant and sensitive prostate cancer C4-2B cells have a unique differential gene signature response to cabazitaxel. Gene pathway analysis showed that sensitive cells exhibit increase in DNA damage, while resistant cells express genes associated with protein regulation in response to cabazitaxel. These PDX specimens a...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Maddison Archer Diane Begemann Edgar Gonzalez-Kozlova Prerna R Nepali Estefania Labanca Peter Shepherd Navneet Dogra Nora Navone Natasha Kyprianou Source Type: research
The effect of baseline O < sub > 2 < /sub > conditions on the response of prostate cancer cells to hypoxia
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00155.2024. Online ahead of print.ABSTRACTThe transcriptional response to hypoxia is largely regulated by the hypoxia-inducible factors (HIFs), which induce the expression of genes involved in glycolysis, angiogenesis, proliferation, and migration. Virtually all cell culture-based hypoxia experiments have used near-atmospheric (18% O2) oxygen levels as baseline for comparison to hypoxia. However, this is hyperoxic compared to mammalian tissue microenvironments, where oxygen levels range from 2-9% O2 (physioxia). Thus, these experiments actually compare hyperoxia ...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Ricardo Alva Jacob E Wiebe Jeffrey A Stuart Source Type: research
The effect of baseline O < sub > 2 < /sub > conditions on the response of prostate cancer cells to hypoxia
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00155.2024. Online ahead of print.ABSTRACTThe transcriptional response to hypoxia is largely regulated by the hypoxia-inducible factors (HIFs), which induce the expression of genes involved in glycolysis, angiogenesis, proliferation, and migration. Virtually all cell culture-based hypoxia experiments have used near-atmospheric (18% O2) oxygen levels as baseline for comparison to hypoxia. However, this is hyperoxic compared to mammalian tissue microenvironments, where oxygen levels range from 2-9% O2 (physioxia). Thus, these experiments actually compare hyperoxia ...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Ricardo Alva Jacob E Wiebe Jeffrey A Stuart Source Type: research
GSE232552 FOXA2/AP-1 drives prostate cancer lineage plasticity [ChIP-seq]
In this study, we show that FOXA2 binds to distinct chromatin regions in multiple AR-null PCa models with different molecular subtypes and that its binding is dependent on an epigenetic factor, LSD1. More importantly, we demonstrate that FOXA2 can function as a major pioneer factor of JUN and govern the chromatin binding of AP-1 complex in PCa exhibiting lineage plasticity. Mechanistically, differential reprogramming of JUN activates lineage-specific super-enhancers that may promote PCa progression by enhancing cell state transitions to multiple lineages. Overall, our study reveals a pivotal function of the LSD1-FOXA2 axis...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE232554 FOXA2/AP-1 drives prostate cancer lineage plasticity [RNA-seq]
In this study, we show that FOXA2 binds to distinct chromatin regions in multiple AR-null PCa models with different molecular subtypes and that its binding is dependent on an epigenetic factor, LSD1. More importantly, we demonstrate that FOXA2 can function as a major pioneer factor of JUN and govern the chromatin binding of AP-1 complex in PCa exhibiting lineage plasticity. Mechanistically, differential reprogramming of JUN activates lineage-specific super-enhancers that may promote PCa progression by enhancing cell state transitions to multiple lineages. Overall, our study reveals a pivotal function of the LSD1-FOXA2 axis...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE232555 FOXA2/AP-1 drives prostate cancer lineage plasticity
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE232553 FOXA2/AP-1 drives prostate cancer lineage plasticity [PDX ChIP-seq]
In this study, we show that FOXA2 binds to distinct chromatin regions in multiple AR-null PCa models with different molecular subtypes and that its binding is dependent on an epigenetic factor, LSD1. More importantly, we demonstrate that FOXA2 can function as a major pioneer factor of JUN and govern the chromatin binding of AP-1 complex in PCa exhibiting lineage plasticity. Mechanistically, differential reprogramming of JUN activates lineage-specific super-enhancers that may promote PCa progression by enhancing cell state transitions to multiple lineages. Overall, our study reveals a pivotal function of the LSD1-FOXA2 axis...
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Inguinal hernia repair in patients with artificial urinary sphincter after radical prostatectomy
ConclusionIHA has its own characteristics, and multidisciplinary knowledge thereof will help surgeons safely perform IH surgery. (Source: Hernia)
Source: Hernia - April 22, 2024 Category: Sports Medicine Source Type: research
The role of urology and radiology in prostate biopsy: current trends and future perspectives
ConclusionThere is no evidence to suggest that prostate biopsy should be solely performed by a specific specialty. The most important factor remains knowledge of the relevant anatomy and sufficient volume of cases to develop and maintain skills. (Source: World Journal of Urology)
Source: World Journal of Urology - April 22, 2024 Category: Urology & Nephrology Source Type: research
Inguinal hernia repair in patients with artificial urinary sphincter after radical prostatectomy
ConclusionIHA has its own characteristics, and multidisciplinary knowledge thereof will help surgeons safely perform IH surgery. (Source: Hernia)
Source: Hernia - April 22, 2024 Category: Sports Medicine Source Type: research
