Precise Prostate Cancer Diagnosis with Fluorescent Nanoprobes for Detecting PSA and PSMA in Serum
Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC00670D, CommunicationMingyi Ouyang, Ming Jia, Zixuan Chang, Yinian Wang, Keyi Wang, Xiaonan Gao, Bo Tang The novel Au-Se bonded nanoprobes were designed for concurrent detection of PSA and PSMA in serum samples, aiming to enhance the early diagnosis of prostate cancer. The probe demonstrates robust... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 19, 2024 Category: Chemistry Authors: Mingyi Ouyang Source Type: research
Recent Updates on Applications of Artificial Intelligence for Nuclear Medicine Professionals: Prostate Cancer and PET/CT
Nucl Med Mol Imaging. 2024 May;58(3):97-100. doi: 10.1007/s13139-024-00856-3. Epub 2024 Feb 24.NO ABSTRACTPMID:38633291 | PMC:PMC11018562 | DOI:10.1007/s13139-024-00856-3 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Ki-Seong Park Source Type: research
Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [ < sup > 177 < /sup > Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer
CONCLUSION: We successfully implemented same-day post-therapy SPECT/CT after [177Lu]Lu-PSMA-617 infusions. Quantitation of 1-2 h post-therapy SPECT/CT images is a promising method for assessing treatment response. However, the approach is currently limited by its suboptimal detection of small tumor lesions and the necessity of incorporating a third-cycle SPECT/CT to mitigate the effects of any potential treatment-related flare-up. Further investigation in a larger patient cohort and prospective validation is essential to confirm these findings and to explore the role of SPECT/CT as a potential adjunct to PSMA PET/CT in man...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Hong Song Maria Isabel Leonio Valentina Ferri Heying Duan Carina Mari Aparici Guido Davidzon Benjamin L Franc Farshad Moradi Jagruti Shah Colin P Bergstrom Alice C Fan Sumit Shah Ali Raza Khaki Sandy Srinivas Andrei Iagaru Source Type: research
Discordant Molecular Imaging Findings with 2-[ < sup > 18 < /sup > F]FDG and [ < sup > 68 < /sup > Ga]Ga-PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer
We present a case of double primary cancer involving the bladder and prostate, where the prostatic primary showed intense [68Ga]Ga-PSMA uptake with non-avid skeletal and pulmonary metastases, which showed intense 2-[18F]FDG uptake, thus showing discordance due to different clonal origins.PMID:38633286 | PMC:PMC11018560 | DOI:10.1007/s13139-024-00839-4 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Aparna Mahalik Jasim Jaleel Sambit Sagar Dikhra Khan Shobhana Raju Rakesh Kumar Source Type: research
Current state of theranostics in metastatic castrate ‐resistant prostate cancer
SummaryProstate cancer remains one of the leading causes of cancer-related death in the world. There have been significant advances in chemotherapy, hormonal therapy and targeted therapy options for patients with castrate-resistant disease. However, these systemic treatments are often associated with unwanted toxicities. Targeted therapy with radiopharmaceuticals has become of key interest to limit systemic toxicity and provides a more precision oncology approach to treatment. Strontium-89, Samarium-153 EDTMP and Radium-223 have been trialled with mixed results. Strontium-89 and Samarium-153 EDTMP have shown benefits in pa...
Source: Journal of Medical Imaging and Radiation Oncology - April 18, 2024 Category: Radiology Authors: Udit Nindra,
Peter Lin,
Therese Becker,
Tara L Roberts,
Wei Chua Tags: Medical Imaging —Review Article Source Type: research
Health-related quality of life following salvage radical prostatectomy for recurrent prostate cancer after radiotherapy or focal therapy
ConclusionssRP impacts HRQOL in patients with PCa after RT and FT with no significant differences. Comparison with HRQOL and BRFS of treatment alternatives is paramount to counsel patients for appropriate treatments. (Source: World Journal of Urology)
Source: World Journal of Urology - April 18, 2024 Category: Urology & Nephrology Source Type: research
Aggressive variant prostate cancer with multiple subcutaneous metastases: a case report
AbstractA 71-year-old man with bone metastasis of hormone-sensitive prostate cancer was treated with androgen deprivation therapy and apalutamide. Radium-223 and radiation therapy were administered after it become castration resistant. Although prostate-specific antigen levels remained low, multiple subcutaneous metastases of neuroendocrine prostate cancer were observed. A review of the pre-treatment prostate needle biopsy revealed a small component with features suggestive of neuroendocrine differentiation. Phosphatase and tensine homolog loss and tumor protein p53 overexpression were observed, confirming the diagnosis of...
Source: International Cancer Conference Journal - April 18, 2024 Category: Cancer & Oncology Source Type: research
Design and navigation method of a soft robot for single-port transvesical radical prostatectomy
ConclusionsThe designed soft robot system, due to its soft structure, good flexibility, and accurate navigation, is expected to improve surgical safety and precision, thereby exhibiting significant potential for STRP. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - April 18, 2024 Category: Intensive Care Source Type: research
Cancers, Vol. 16, Pages 1549: Prostate Tissue Microbiome in Patients with Prostate Cancer: A Systematic Review
er A. Warlick
Some researchers have speculated that the prostatic microbiome is involved in the development of prostate cancer (PCa) but there is no consensus on certain microbiota in the prostatic tissue of PCa vs. healthy controls. This systematic review aims to investigate and compare the microbiome of PCa and healthy tissue to determine the microbial association with the pathogenesis of PCa. We searched MEDLINE, Embase, and Scopus databases. Articles were screened by two independent and blinded reviewers. Literature that compared the prostatic tissue microbiome of patients with PCa with benign controls was included...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Daniela F. Ward Grados Onuralp Ergun Carly D. Miller Petr Gaburak Nana A. Frimpong Oluwatobi Shittu Christopher A. Warlick Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1547: Peritoneal Flap Following Lymph Node Dissection in Robotic Radical Prostatectomy: A Novel & ldquo;Bunching & rdquo; Technique
Conclusion: We have demonstrated a modified technique for a peritoneal flap (PBFB) with the initial elimination of postoperative symptomatic lymphoceles and promising short-term outcomes. (Source: Cancers)
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Ahmed Gamal Marcio Covas Moschovas Abdel Rahman Jaber Shady Saikali Marco Sandri Ela Patel Evan Patel Travis Rogers Vipul Patel Tags: Article Source Type: research
Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression (CREATINE-52): a protocol for a double-blind randomized controlled trial
Muscle mass is important for metastatic prostate cancer survival and quality of life (QoL). The backbone of treatment for men with metastatic castration sensitive prostate cancer (mCSPC) is androgen deprivatio... (Source: BMC Cancer)
Source: BMC Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Adriana M Coletta, Lea Haverbeck Simon, Kelsey Maslana, Sarah Taylor, Kish Larson, Pamela A Hansen, Vinay Mathew Thomas, Cornelia M Ulrich, Manish Kohli, Jonathan Chipman, Umang Swami, Sumati Gupta, Benjamin L Maughan and Neeraj Agarwal Tags: Study Protocol Source Type: research
Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer
ConclusionWe successfully implemented same-day post-therapy SPECT/CT after [177Lu]Lu-PSMA-617 infusions. Quantitation of 1 –2 h post-therapy SPECT/CT images is a promising method for assessing treatment response. However, the approach is currently limited by its suboptimal detection of small tumor lesions and the necessity of incorporating a third-cycle SPECT/CT to mitigate the effects of any potential treatment-rela ted flare-up. Further investigation in a larger patient cohort and prospective validation is essential to confirm these findings and to explore the role of SPECT/CT as a potential adjunct to PSMA PET/CT in ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 16, Pages 1538: From Diabetes to Oncology: Glucagon-like Peptide-1 (GLP-1) Receptor Agonist & rsquo;s Dual Role in Prostate Cancer
Cancers, Vol. 16, Pages 1538: From Diabetes to Oncology: Glucagon-like Peptide-1 (GLP-1) Receptor Agonist’s Dual Role in Prostate Cancer
Cancers doi: 10.3390/cancers16081538
Authors:
Abdulrahman Alhajahjeh
Raad Al-Faouri
Hisham F. Bahmad
Taima’ Bader
Ryan W. Dobbs
Ahmed A. Abdulelah
Wassim Abou-Kheir
Elai Davicioni
David I. Lee
Mohammed Shahait
Glucagon-like peptide-1 (GLP-1), an incretin hormone renowned for its role in post-meal blood sugar regulation and glucose-dependent insulin secretion, has gained attention as a novel treatment for diabetes through GLP-1 receptor agonists (GLP-1...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Abdulrahman Alhajahjeh Raad Al-Faouri Hisham F. Bahmad Taima ’ Bader Ryan W. Dobbs Ahmed A. Abdulelah Wassim Abou-Kheir Elai Davicioni David I. Lee Mohammed Shahait Tags: Review Source Type: research
Racial Differences in Germline Genetic Testing Completion Among Males With Pancreatic, Breast, or Metastatic Prostate Cancers
CONCLUSIONS: Overall rates of guideline-recommended genetic testing are low in males with pancreatic, breast, or metastatic prostate cancers. Racial disparities in genetic testing among males exist in a commercially insured population, mediated by net worth and household income; these disparities are not seen in the equal-access Veterans Health Administration. Alleviating financial and access barriers may mitigate racial disparities in genetic testing.PMID:38631387 | DOI:10.6004/jnccn.2023.7105 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 17, 2024 Category: Cancer & Oncology Authors: Jeffrey W Shevach Danielle Candelieri-Surette Julie A Lynch Rebecca A Hubbard Patrick R Alba Karen Glanz Ravi B Parikh Kara N Maxwell Source Type: research
Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
In this study, we included four crucial proteins that perform signalling, receptor, and regulatory action, namely- NUDIX Hydrolases, Dihydrofolate Reductase, HER2/neu Kinase and EGFR and performed multitargeted molecular docking studies against human-approved drugs using HTVS, SP and extra precise algorithms and filtered the poses with MM\GBSA, suggested a benzodiazepine derivative chlordiazepoxide, used as an anxiolytic agent, can be a multitargeted inhibitor with docking and MM\GBSA score ranging from - 4.628 to - 7.877 and - 18.59 to - 135.86 kcal/mol, respectively, and the most interacted residues were 6ARG, 6GLU, 3TRP...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Ahad Amer Alsaiari Amal F Gharib Maha Mahfouz Bakhuraysah Amani A Alrehaili Shatha M Algethami Hayfa Ali Alsaif Norah Al Harthi Mohammed Ageeli Hakami Source Type: research
