Abscisic acid signaling through LANCL2 and PPAR γ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells
Oncol Rep. 2024 Mar;51(3):39. doi: 10.3892/or.2024.8698. Epub 2024 Jan 12.ABSTRACTProstate cancer (PCa) is one the most common malignancies in men. The high incidence of bone metastasis years after primary therapy suggests that disseminated tumor cells must become dormant, but maintain their ability to proliferate in the bone marrow. Abscisic acid (ABA) is a stress response molecule best known for its regulation of seed germination, stomal opening, root shoot growth and other stress responses in plants. ABA is also synthesized by mammalian cells and has been linked to human disease. The aim of the present study was to exam...
Source: Oncology Reports - April 16, 2024 Category: Cancer & Oncology Authors: Keshab Raj Parajuli Younghun Jung Russell S Taichman Source Type: research
Prostate Cancer, Version 3.2024
J Natl Compr Canc Netw. 2024 Apr;22(3):140-150. doi: 10.6004/jnccn.2024.0019.ABSTRACTThe NCCN Guidelines for Prostate Cancer include recommendations for staging and risk assessment after a prostate cancer diagnosis and for the care of patients with localized, regional, recurrent, and metastatic disease. These NCCN Guidelines Insights summarize the panel's discussions for the 2024 update to the guidelines with regard to initial risk stratification, initial management of very-low-risk disease, and the treatment of nonmetastatic recurrence.PMID:38626801 | DOI:10.6004/jnccn.2024.0019 (Source: Journal of the National Comprehens...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 16, 2024 Category: Cancer & Oncology Authors: Edward M Schaeffer Sandy Srinivas Nabil Adra Yi An Rhonda Bitting Brian Chapin Heather H Cheng Anthony Victor D'Amico Neil Desai Tanya Dorff James A Eastham Thomas A Farrington Xin Gao Shilpa Gupta Thomas Guzzo Joseph E Ippolito R Jeffrey Karnes Michael R Source Type: research
Abscisic acid signaling through LANCL2 and PPAR γ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells
Oncol Rep. 2024 Mar;51(3):39. doi: 10.3892/or.2024.8698. Epub 2024 Jan 12.ABSTRACTProstate cancer (PCa) is one the most common malignancies in men. The high incidence of bone metastasis years after primary therapy suggests that disseminated tumor cells must become dormant, but maintain their ability to proliferate in the bone marrow. Abscisic acid (ABA) is a stress response molecule best known for its regulation of seed germination, stomal opening, root shoot growth and other stress responses in plants. ABA is also synthesized by mammalian cells and has been linked to human disease. The aim of the present study was to exam...
Source: Oncology Reports - April 16, 2024 Category: Cancer & Oncology Authors: Keshab Raj Parajuli Younghun Jung Russell S Taichman Source Type: research
Transrectal versus transperineal prostate biopsy for cancer detection in patients with gray-zone prostate-specific antigen: a multicenter, real-world study
Asian J Androl. 2024 Apr 16. doi: 10.4103/aja20241. Online ahead of print.ABSTRACTKnowledge about the effect of different prostate biopsy approaches on the prostate cancer detection rate (CDR) in patients with gray-zone prostate-specific antigen (PSA) is limited. We performed this study to compare the CDR among patients who underwent different biopsy approaches and had rising PSA levels in the gray zone. Two hundred and twenty-two patients who underwent transrectal prostate biopsy (TRB) and 216 patients who underwent transperineal prostate biopsy (TPB) between June 2016 and September 2022 were reviewed in this study. In ad...
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Jun-Xiao Liu Ze-Yuan Wang Shao-Xi Niu Xiao-Yong Sai Xu Zhang Xue-Pei Zhang Xin Ma Source Type: research
Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer
This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer (mHSPC). PubMed, EMBASE, and the Cochrane Library were comprehensively searched for eligible randomized controlled trials (RCTs) published from inception to October 2023. Interventions included abiraterone, apalutamide, enzalutamide, docetaxel, darolutamide, and androgen deprivation therapy (ADT), either as doublet or triplet therapies. The outcomes examined were overall survival (OS), progression-free survival (PFS), castration-resistant prostate cancer (CRPC)-free survival, time to symptomat...
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Shan-Shan Wang Xiao-Jie Bian Jun-Long Wu Bei-He Wang Sheng Zhang Ding-Wei Ye Source Type: research
