Is PSMA PET disrupting traditional prostate cancer staging and treatment?
Can J Urol. 2024 Apr;31(2):11814-11815.NO ABSTRACTPMID:38642457 (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 20, 2024 Category: Urology & Nephrology Authors: Leonard G Gomella Source Type: research
The Role of Extracellular Vesicles in the Treatment of Prostate Cancer
This review summarizes the pivotal role of extracellular vesicles (EVs) in the treatment of prostate cancer (PCa) comprehensively, including but not limited to promising marker and robust modulator to guide treatment tailoring for PCa, potential target for therapeutic modalities, and promising therapeutic vehicle. It elaborates the opportunities and challenges of EVs in PCa treatment, bringing new insights for researchers. AbstractProstate cancer (PCa) has become a public health concern in elderly men due to an ever-increasing number of estimated cases. Unfortunately, the available treatments are unsatisfactory because of ...
Source: Small - April 20, 2024 Category: Nanotechnology Authors: Cong Hu,
Qi Chen,
Tianyang Wu,
Xinxing Du,
Yanhao Dong,
Zehong Peng,
Wei Xue,
Vijaya Sunkara,
Yoon ‐Kyoung Cho,
Liang Dong Tags: Review Source Type: research
Pharmacokinetic study of capivasertib and the CYP3A4 substrate midazolam in patients with advanced solid tumors
ConclusionThe up to 1.75-fold increase in midazolam exposure indicates capivasertib is a weak CYP3A inhibitor at 400 mg BID on an intermittent schedule. Capivasertib was well tolerated; exploratory efficacy analysis demonstrated evidence of clinical activity in this heavily pre-treated population.ClinicalTrials.gov: NCT04958226. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - April 20, 2024 Category: Cancer & Oncology Source Type: research
Psychosocial Factors Associated with Cognitive Function in Prostate Cancer Survivors on Hormonal Treatments: A Systematic Review
AbstractHormonal treatments (HT) for prostate cancer (e.g., androgen deprivation therapy) yield clinical and survival benefits, yet adverse cognitive changes may be a side effect. Since psychosocial factors are largely modifiable, interventions targeting these factors may help mitigate these adverse cognitive effects. This systematic review aimed to identify a range of psychosocial factors associated with cognitive function in individuals with prostate cancer undergoing HT and to determine whether these factors mitigate or exacerbate this effect. Applying PRISMA guidelines, a comprehensive search of relevant databases cond...
Source: Neuropsychology Review - April 20, 2024 Category: Neuroscience Source Type: research
Single-port robot-assisted radical prostatectomy
ConclusionBased on the existing literature, the introduction of SP-RARP not only enriched the repertoire of minimally-invasive surgical treatment options for prostate cancer but also provided the opportunity for urologists to develop new techniques that can improve perioperative outcomes and postoperative quality of life. Given the limited number of patients and heterogeneity in the patient selection and reporting of postoperative outcomes, further research remains necessary to better understand the different benefits and improve patient selection algorithms for the different techniques. (Source: World Journal of Urology)
Source: World Journal of Urology - April 20, 2024 Category: Urology & Nephrology Source Type: research
The effects of different positions on lower extremity hemodynamics during robot-assisted laparoscopic radical prostatectomy for prostate cancer
This study aimed to investigate the effects of two different positions on lower extremity hemodynamics during robot-assisted laparoscopic radical prostatectomy (RARP) for prostate cancer. (Source: BMC Urology)
Source: BMC Urology - April 20, 2024 Category: Urology & Nephrology Authors: Zheng Wang, Xinyu Wang and Xiaofen Yu Tags: Research Source Type: research
Prostatectomy in oligometastatic prostate cancer: a call for high-quality evidence
Prostate Cancer and Prostatic Diseases, Published online: 20 April 2024; doi:10.1038/s41391-024-00838-8Prostatectomy in oligometastatic prostate cancer: a call for high-quality evidence (Source: Prostate Cancer and Prostatic Diseases)
Source: Prostate Cancer and Prostatic Diseases - April 20, 2024 Category: Urology & Nephrology Authors: Tanya Dorff Sheetal R. Kashid Vedang Murthy Riccardo Lombardo Cosimo De Nunzio Source Type: research
Correction: A multidisciplinary approach to address unmet needs in the management of patients with non-metastatic castration-resistant prostate cancer
Prostate Cancer and Prostatic Diseases, Published online: 20 April 2024; doi:10.1038/s41391-024-00835-xCorrection: A multidisciplinary approach to address unmet needs in the management of patients with non-metastatic castration-resistant prostate cancer (Source: Prostate Cancer and Prostatic Diseases)
Source: Prostate Cancer and Prostatic Diseases - April 20, 2024 Category: Urology & Nephrology Authors: Neal D. Shore Emmanuel S. Antonarakis Ashley E. Ross Catherine H. Marshall Kelly L. Stratton Adanma Ayanambakkam Michael S. Cookson Rana R. McKay Alan H. Bryce Marina D. Kaymakcalan Source Type: research
Correction to: Surgical Management and Considerations for Patients with Localized High-Risk Prostate Cancer
(Source: Current Treatment Options in Oncology)
Source: Current Treatment Options in Oncology - April 20, 2024 Category: Cancer & Oncology Source Type: research
HBO regulates the Warburg effect of hypoxic HCC cells through miR-103a-3p/TRIM35
ConclusionThese findings reveal that HBO regulates the Warburg effect of hypoxic HCC cells through miR-103a-3p/TRIM35 and inhibits tumor growth. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 20, 2024 Category: Cancer & Oncology Source Type: research
Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer
ConclusionWe identified ERLIN2 and CDK5RAP3 as ERS-related genes with important prognostic and immunologic values, and classified patients between high- and low-risk subgroups, which provided new prognostic markers, immunotherapeutic targets, and basis for prognostic assessments. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research
Precise Prostate Cancer Diagnosis with Fluorescent Nanoprobes for Detecting PSA and PSMA in Serum
Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC00670D, CommunicationMingyi Ouyang, Ming Jia, Zixuan Chang, Yinian Wang, Keyi Wang, Xiaonan Gao, Bo Tang The novel Au-Se bonded nanoprobes were designed for concurrent detection of PSA and PSMA in serum samples, aiming to enhance the early diagnosis of prostate cancer. The probe demonstrates robust... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 19, 2024 Category: Chemistry Authors: Mingyi Ouyang Source Type: research
[Corrigendum] Cripto ‑1 promotes epithelial‑mesenchymal transition in prostate cancer via Wnt/β‑catenin signaling
Oncol Rep. 2024 Jun;51(6):75. doi: 10.3892/or.2024.8734. Epub 2024 Apr 19.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that the β‑actin control blots featured in Figs. 5A and 6A appeared to be strikingly similar. Upon examining their original data, the authors have realized that the β‑actin blots for Fig. 5A were inadvertently chosen incorrectly. The corrected version of Fig. 5 is shown opposite. Note that the error made in uploading the incorrect version of this figure did not affect the overall conclusions reported in the paper. All the authors agree wi...
Source: Oncology Reports - April 19, 2024 Category: Cancer & Oncology Authors: Yan Liu Zhenbang Qin Kuo Yang Ranlu Liu Yong Xu Source Type: research
Singlet oxygen-based photoelectrochemical detection of miRNAs in prostate cancer patients' plasma: A novel diagnostic tool for liquid biopsy
Bioelectrochemistry. 2024 Apr 4;158:108698. doi: 10.1016/j.bioelechem.2024.108698. Online ahead of print.ABSTRACTDysregulation of miRNA expression occurs in many cancers, making miRNAs useful in cancer diagnosis and therapeutic guidance. In a clinical context using methods such as polymerase chain reaction (PCR), the limited amount of miRNAs in circulation often limits their quantification. Here, we present a PCR-free and sensitive singlet oxygen (1O2)-based strategy for the detection and quantification of miRNAs in untreated human plasma from patients diagnosed with prostate cancer. A target miRNA is specifically captured...
Source: Bioelectrochemistry - April 19, 2024 Category: Biochemistry Authors: Saranya Thiruvottriyur Shanmugam Rui Campos Stanislav Trashin Elise Daems Diogo Carneiro Avelino Fraga Ricardo Ribeiro Karolien De Wael Source Type: research
