The Nobel Prize; An Exclamation Point For Urologic Practice.
Authors: Loughlin KR PMID: 32333731 [PubMed - as supplied by publisher] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Legends in Urology.
Authors: Clayman RV PMID: 32333732 [PubMed - as supplied by publisher] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Aquablation for benign prostatic hyperplasia in large prostates (80-150 cc): 2-year results.
Authors: Desai M, Bidair M, Bhojani N, Trainer A, Arther A, Kramolowsky E, Doumanian L, Elterman D, Kaufman RP, Lingeman J, Krambeck A, Eure G, Badlani G, Plante M, Uchio E, Gin G, Goldenberg L, Paterson R, So A, Humphreys MR, Roehrborn CG, Kaplan S, Motola J, Zorn KC Abstract INTRODUCTION: To report 2-year safety and effectiveness of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume 80-150 cc prostates. MATERIALS AND METHODS: Between September-December 2017, 101 men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc under...
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Charlson Comorbidity score influence on prostate cancer survival and radiation-related toxicity.
Authors: Ghanem AI, Khalil RM, Khedr GA, Tang A, Elsaid AA, Chetty IJ, Movsas B, Elshaikh MA Abstract INTRODUCTION: In addition to survival endpoints, we explored the impact of Charlson Comorbidity-Index (CCI) on the acute and late toxicities in men with localized prostate cancer who received dose-escalated definitive radiotherapy (RT). MATERIALS AND METHODS: CCI scores at diagnosis and survival outcomes were identified for men with intermediate/high-risk prostate cancer treated with RT (1/2007-12/2012). Study-cohort was accordingly grouped into no, mild and severe comorbidity (CCI-0, 1 or 2+). CCI-groups were ...
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Phyllanthus niruri (stone breaker) herbal therapy for kidney stones; a systematic review and meta-analysis of clinical efficacy, and Google Trends analysis of public interest.
CONCLUSIONS: Limited clinical evidence supports modest efficacy of P. niruri in reducing stone burden, pending further study. Public interest in P. niruri is growing within the United States, possibly reflecting a rising demand. PMID: 32333735 [PubMed - as supplied by publisher] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

The role of FSH and LH in prostate cancer and cardiometabolic comorbidities.
CONCLUSIONS: Patients with cardiovascular risk factors who require ADT may benefit from the better control of FSH provided by GnRH antagonists. ADT itself appears to heighten CV risk, and data suggest that FSH may at least partly drive this risk by promoting inflammation, atherosclerosis, insulin resistance, adipocyte rearrangement and plaque instability. PMID: 32333736 [PubMed - as supplied by publisher] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Guidewire type and prior use affects ureteral stent insertion force.
Authors: Ewald J, Hodgson H, Thomas J, Khater N, Keheila M, Alsyouf M, Arenas JL, Hajiha M, Baldwin DD Abstract INTRODUCTION: To improve the success rate and safety of ureteral stent insertion, we sought to identify the effect of guidewire type and prior use upon the force needed to advance a 6Fr ureteral stent over various guidewires. MATERIALS AND METHODS: Two-hundred forty stent insertion trials were performed in an ex vivo porcine urinary tract model. Ten trials were randomly performed over 12 new and 12 used guidewires. For each trial, the force required to advance a 6Fr Cook double-pigtail ureteral stent ...
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Prednisone after vasectomy reversal may improve semen parameters: one institution's experience.
Authors: Machen GL, Doolittle J, Sandlow JI Abstract INTRODUCTION: Patients with suboptimal semen parameters following vasectomy reversal represent a diagnostic and therapeutic challenge. This may be caused by either partial or complete anastomotic obstruction. Despite the relatively common clinical use of corticosteroids in this patient population, data remain sparse. Thus, we set out to evaluate the safety and efficacy of prednisone after vasectomy reversal. MATERIALS AND METHODS: A chart review was performed from January 1, 2008 to September 30, 2018 to identify men in which prednisone was used for suspected...
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

How I Do It - MRI-ultrasound fusion prostate biopsy using the Fusion MR and Fusion Bx systems.
We describe our group's early experience with the Fusion MR and Fusion Bx systems (Focal Healthcare, Toronto, ON, Canada). These products are designed with elastic fusion technology that is user-friendly, intuitive and accurate. The Fusion MR contouring system is straightforward and allows for contouring with several MRI sequences simultaneously. The Fusion Bx biopsy system has a semi-robotic arm that accounts for prostate deformation and patient movement and allows for freehand-like access, which is a seamless transition from SPB for clinicians. There were 68 lesions targeted in the first 51 patients. The overall cancer d...
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Cavernous hemangioma of the adrenal gland mimicking a hepatic hemangioma.
We report a case of a 62-year-old male who presented with right upper quadrant and flank pain. Physical examination revealed a fullness of the right upper quadrant. Both computed tomography and magnetic resonance imaging suggested a hemangioma originating from the liver. During angiography with the intent of embolization, it was discovered that the vascular supply was consistent with an adrenal mass rather than a hepatic origin. The patient was referred to Urology and underwent curative right open adrenalectomy and nephrectomy. Histopathology confirmed the diagnosis of an adrenal cavernous hemangioma. PMID: 32333740 [P...
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Gas in the inferior vena cava from severe emphysematous pyelonephritis.
We present the case of a 54-yearold female who was found to have a large volume of air in her renal vein and inferior vena cava from severe emphysematous pyelonephritis. In this case report, the medical and operative management of this patient are reviewed, and the literature on the management of emphysematous pyelonephritis is summarized. PMID: 32333741 [PubMed - as supplied by publisher] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 26, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

The Primary Care Provider (Family Physician and Nurse Practitioner)-Specialist: Partnership.
Authors: Barkin J PMID: 32101693 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 28, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Diagnosis of prostate cancer: the implications and proper utilization of PSA and its variants; indications and use of MRI and biomarkers.
Authors: Law KW, Nguyen DD, Barkin J, Zorn KC Abstract Prostate cancer screening remains highly controversial in medicine. The College of Family Physicians of Canada currently endorses positions that recommend against prostate-specific antigen (PSA) screening in men of all ages, while the Canadian Urological Association recommends shared and informed decision making for PSA screening in men 50-70 years old. Unfortunately, these opposing stances have left Family Physicians responsible for interpreting the appropriate course of action for their patients. Recent studies demonstrating an increase in incidence of metast...
Source: Canadian Journal of Urology - February 28, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Androgen deprivation therapy: indications, methods of utilization, side effects and their management.
Authors: Magee DE, Singal RK Abstract Our objective is to provide an up-to-date summary of current literature on the indications for androgen deprivation therapy (ADT), ways in which ADT is used, and the main side effects associated with its use. MEDLINE (Pubmed) was searched for relevant papers published from database inception to May 1, 2019 for studies evaluating the use of ADT and its associated adverse events. ADT is a mainstay in the treatment of prostate cancer and is used throughout the disease course. While predominantly used in the metastatic setting, ADT has a role in the treatment of localized disease a...
Source: Canadian Journal of Urology - February 28, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Management of erectile dysfunction and LUTS/incontinence: the two most common, long-term side effects of prostate cancer treatment.
Authors: Shabataev V, Saadat SH, Elterman DS Abstract The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. While surgery is mostly associated with SUI and radiation mostly results in UUI, there can be an overlap. Incontinence rates after cryotherapy and high in...
Source: Canadian Journal of Urology - February 28, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Boosting Free Testosterone With OTC Natural Supplements: Be Careful What You Wish For.
Authors: Gomella LG PMID: 32065859 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Legends in Urology.
Authors: Hautmann RE PMID: 32065860 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Three-year outcomes after Aquablation therapy compared to TURP: results from a blinded randomized trial.
CONCLUSIONS: Three-year BPH symptom reduction and urinary flow rate improvement were similar after TURP and Aquablation therapy. No subjects required surgical retreatment beyond 20 months postoperatively. (ClinicalTrials.gov number, NCT02505919). PMID: 32065861 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Assessment of high-grade prostate cancer risk using prostate cancer biomarkers.
Authors: Stanton WN, Crawford ED, Arangua PB, La Rosa FG, van Bokhoven A, Lucia MS, Poage WL, Partin A, Maroni P, Werahera PN Abstract INTRODUCTION: To identify patients at risk of high-grade prostate cancer using prostate cancer biomarkers. MATERIALS AND METHODS: A total of 601 men were screened for prostate cancer in 2012, 2015, and 2016 using prostate cancer biomarkers: prostate health index (phi), 4KScore, and SelectMDx. The first two are blood tests that incorporate several PSA isoforms; SelectMDx measures mRNA levels of homeobox C6 and distal-less homeobox 1 in post-digital rectal examination urine sample...
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Secondary screening tests for prostate cancer: is more information better? Which test is best?
Authors: Moul JW PMID: 32065863 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Implementing a patient safety culture survey to identify and target process improvements in academic ambulatory urology practices: a multi-institutional collaborative.
CONCLUSIONS: The SOPS is a clinically useful tool to identify issues impacting a practice's safety culture. Substantial variability was observed within each composite domain at the levels of practice site and respondent role. Comparing composite domain results between clinics will allow leadership to identify gaps and evaluate policies and resources of higher performing peer sites. PMID: 32065864 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Continent cutaneous ileocecal cystoplasty in the treatment of refractory bladder neck contracture and urinary incontinence after prostate cancer treatment.
CONCLUSIONS: CCIC is an effective means of treating refractory bladder neck contractures and/or urinary incontinence. While morbidity rates are high, subjective patient satisfaction is high. PMID: 32065865 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Hospital-specific antibiograms and antibiotic prophylaxis for prostate biopsies: a reexamination of AUA recommendations.
Authors: Mann M, Calio BP, Mark JR, Chelluri R, Hufnagel E, Reese A, Lallas CD, Trabulsi EJ, Chandrasekar T, Shenot PJ, Halpern E, Gomella LG Abstract INTRODUCTION: To assess whether standard American Urological Association (AUA) and other recommendations for prostate biopsy prophylaxis provide sufficient coverage of common urinary organisms responsible for post biopsy infections by comparing local antibiograms in Philadelphia-area hospitals. MATERIALS AND METHODS: De-identified culture results derived from antibiograms were collected from six academic and community hospitals in the Philadelphia region. Analysi...
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Considerations and alternative approaches to antibiotic prophylaxis for prostate biopsy.
Authors: Kim EH, Andriole GL PMID: 32065867 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Mirabegron improves sleep measures, nocturia, and lower urinary tract symptoms in those with urinary symptoms associated with disordered sleep.
Authors: Petrossian RA, Dynda D, Delfino K, El-Zawahry A, McVary KT Abstract INTRODUCTION: The role of organized sleep in overall health and quality-of-life (QoL) is critical. Nocturia necessarily disrupts the normal sleep cycle and negatively impacts one's health, work productivity, and QoL. We investigated, for the first time in an exploratory pilot, the effectiveness of mirabegron for improving sleep disturbance and nocturia. MATERIALS AND METHODS: This was a prospective, open-label 12-week trial evaluating the efficacy of mirabegron in 34 men and women with disordered sleep and lower urinary tract symptoms ...
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Urinary leak following partial nephrectomy: a contemporary review of 975 cases.
Authors: Peyton CC, Hajiran A, Morgan K, Azizi M, Tang D, Chipollini J, Gilbert SM, Poch M, Sexton WJ, Spiess PE Abstract INTRODUCTION: To describe the incidence, contemporary management, risk factors and outcomes of urinary leak following open and robotic partial nephrectomy at a tertiary care, comprehensive cancer center. MATERIALS AND METHODS: We reviewed 975 patients who underwent partial nephrectomy at Moffitt Cancer Center from January 2009 to May 2017. Patient demographic, perioperative and follow up data was recorded and compared stratified for postoperative urine leak. Fisher's exact and Wilcoxon sum-r...
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Injection location does not impact botulinum toxin A efficacy in interstitial cystitis/bladder pain syndrome patients.
CONCLUSIONS: BTX-A treatment using either a trigone-sparing or trigone-including injection template resulted in significant, but not location-dependent, improvement in IC/BPS symptom scores at 30 and 90 day points post-procedure with no significant difference in post-treatment complication profiles. PMID: 32065870 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Safety of retrograde pyelography for infected ureteral stones.
CONCLUSION: The use of RGP prior to ureteral stent placement for an obstructing ureteral stone with concomitant UTI was not associated with unfavorable clinical outcomes in our retrospective series. While these findings support the safety of RGP in this setting, prospective trials are warranted. PMID: 32065871 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Testicular torsion in brothers.
Authors: Tabakin AL, Farber NJ, Barone J Abstract Testicular torsion is a common pediatric emergency. Predisposing factors and other risk factors for testicular torsion have not been fully elucidated. This case report highlights teenage brothers who each experienced right-sided testicular torsion at nearly the same age, just 1 year apart. Because of their parents' urgency in seeking medical attention, the affected testicles in both patients were salvaged. We also review the current literature in regards to etiology, inheritance, and patient and parental education. PMID: 32065872 [PubMed - in process] (Source: C...
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Life-threatening gross hematuria: case report of renal artery aneurysm.
We report a case of a young male with no prior genitourinary history who presents to an emergency department with sudden onset gross hematuria, clot retention, and right-sided flank pain. On evaluation, he was found to have a renal artery aneurysm bleeding into his collecting system and underwent renal artery embolization and rapid resolution of his hematuria. Renal vascular pathology should be considered in the differential diagnosis and timely diagnosis of this condition is imperative as surgical interventions have proven to be life-saving. PMID: 32065873 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - February 19, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Evidence-Based Urology, 2nd Edition.
Authors: Chung PH PMID: 31860414 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Are You A Hedgehog Or A Fox?
Authors: Loughlin KR PMID: 31860415 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Legends in Urology.
Authors: Hanno P PMID: 31860416 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Extramammary Paget's disease: what do we know and how do we treat?
CONCLUSIONS: Significant developments in understanding the pathogenesis of EMPD have been made, especially of the genomic aberrations associated with EMPD. This has allowed for the development and use of therapeutic options which may improve outcomes for patients with EMPD. PMID: 31860417 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Attitudes towards child life specialists and their utilization within pediatric urology.
CONCLUSIONS: This survey illuminates that the majority of providers interact with CCLS in clinical settings and believe their involvement is beneficial. However, CCLSs are under-utilized during invasive urological procedures where patient anxiety is high. By understanding perceptions of providers and their practice patterns we can overcome barriers to CCLS use and improve their quality of life. PMID: 31860418 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

An unusual presentation of testicular torsion in children: a single - centre retrospective study.
CONCLUSION: Testicular torsion, particulary in regard to torsion in the inguinal canal or presenting dominantly with abdominal pain can be easily misdiagnosed, but needs to be recognized on time, to salvage the affected testicle. The complete physical examination, including the genital examination, needs to be performed in each male patient presenting with lower abdominal or groin pain. PMID: 31860419 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Characterization of a learning curve for robotic cystectomy with intracorporeal urinary diversion at two institutions using the cumulative sum (CUSUM) method.
CONCLUSION: In RCID, approximately 10 cases were required by robotically trained new faculty to reach a steady-state level of performance. PMID: 31860420 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Satisfaction and surgical outcomes in patients undergoing penile prosthesis implantation for drug-refractory erectile dysfunction: mid-term results in a single center French cohort.
CONCLUSION: PP implantation is a safe and satisfactory treatment for ED. However, patient selection remains crucial in determining the post-surgical success of this procedure. PMID: 31860421 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Cost-effectiveness analysis of metformin with enzalutamide in the metastatic castrate-resistant prostate cancer setting.
CONCLUSIONS: Enza + Met is unlikely to be CE at WTP thresholds less than $100 000/QALY; these results make sense because a therapy that is not CE at these WTP thresholds by itself is unlikely to be CE with an adjuvant therapy that keep a patient on such a treatment for even longer. Finally, our model suggests that the mCRPC setting is not the optimal place to trial adding Met as the relative costs are high and utility values low. PMID: 31860422 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Alpha-dystroglycan staining pattern and mortality in patients undergoing radical prostatectomy with lymph node positive prostate cancer.
Authors: Alzubaidi AN, Nepple KG, Vollstedt A, Dahmoush L, Ma D, Henry MD, Brown JA Abstract INTRODUCTION: Dystroglycan (DG) is a cell surface receptor for extracellular matrix proteins involved in tissue mechanical stability and matrix organization. Initial work has demonstrated that alpha-DG expression is decreased in many types of adenocarcinoma, including prostate, and potentially associated with the development of metastatic disease. However, the consistency between prostate and lymph node alpha-DG staining has not been previously reported. In addition, identification of an immunohistochemical marker associate...
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Endoscopic diagnosis of renal pseudoaneurysm following ureteroscopy.
Authors: Pelzman DL, Semins MJ Abstract Renal pseudoaneurysm following ureteroscopy is a rare cause of hematuria usually diagnosed and treated with angiography and embolization. Here we present a case of a small pseudoaneurysm causing intermittent flank pain and gross hematuria associated with clot retention initially diagnosed during ureteroscopy and subsequently treated with a combined endourologic and endovascular approach. PMID: 31860424 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Primary extragonadal yolk sac tumor originating from adrenal gland.
We present an extragonadal yolk sac tumor that presented as an adrenal carcinoma and required left adrenalectomy, nephrectomy, and significant IVC thrombectomy. This case, to our knowledge, is the first documented case of extragonadal yolk sac tumor originating from the adrenal gland. PMID: 31860425 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Introduction to the 2019 Philadelphia Prostate Cancer Consensus Program: 'Implementation of Genetic Testing for Inherited Prostate Cancer'.
This article outlines the key elements of our 2017 consensus meeting and discusses the rationale and design of our follow up 2019 Philadelphia Prostate Cancer Consensus titled the 'Implementation of Genetic Testing for Inherited Prostate Cancer.' PMID: 31629412 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Urology perspective on the expanding world of germline testing for prostate cancer.
Authors: Cookson MS Abstract The management of high-risk prostate cancer is evolving. Currently, most decisions are based on traditional factors such as tumor grade and stage. However, we are in a state of evolution. A new understanding of the value of both genetic and somatic germline testing is upon us. Perhaps even more exciting is the recognition that genomic testing can and should be moved up in certain high-risk patients so more effective and targeted therapy can be applied earlier in the disease state. PMID: 31629413 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Natural history and imaging in men with high genetic risk for developing prostate cancer.
Authors: Dahut WL, Couvillon A, Pinto PA, Turkbey B, Karzai F Abstract Prostate cancer is the most common malignancy and the second leading cause of cancer related deaths in the United States. Established risk factors for prostate cancer incidence include older age, African-American race, and positive family history. Prostate cancer has substantial inherited predisposition and certain genetic variants are associated with increased risk of disease. Screening and imaging should target high-risk populations based on their genetic predisposition. PMID: 31629414 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Advances in germline genetics for prostate cancer funded by the Prostate Cancer Foundation.
Authors: Soule HR, Miyahira AK Abstract The Prostate Cancer Foundation (PCF) is the world's largest non-profit organization that funds patient-centric prostate cancer research. PCF has funded numerous critical studies surrounding the identification, biology, and clinical significance of prostate cancer germline and somatic genetic alterations, and is accelerating the application of these findings to improving outcomes for patients and their families. PMID: 31629415 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

DNA repair genes: contributions to prostate cancer predisposition and aggressiveness.
Authors: Boyle J, Cooney KA Abstract Germline pathogenic mutations in DNA repair genes have been linked to prostate cancer risk and aggressiveness. This observation was facilitated by tumor sequencing of men with advanced prostate cancer and has important implications for clinical management. In addition, cascade testing will identify at-risk individuals who should be assessed for cancer risk. PMID: 31629416 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Updated insights into genetic contribution to prostate cancer predisposition: focus on HOXB13.
Authors: Isaacs WB, Cooney KA, Xu J Abstract This presentation for the Philadelphia Prostate Cancer Consensus 2019 will focus on recent findings regarding the role of HOXB13 as a prostate cancer susceptibility gene. Factors affecting the frequency of HOXB13 mutations in different prostate cancer populations will be reviewed. A number of these factors are relevant for prostate cancer susceptibility genes in general. PMID: 31629417 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Considerations of multigene test findings among men with prostate cancer - knowns and unknowns.
Authors: AlDubayan SH Abstract Germline genetic testing has become an increasingly informative tool in the management of cancer patients. Over the past few years, the landscape of germline testing of prostate cancer patients has evolved significantly with the introduction of several multi-gene panel tests. Here, we dissect the clinically available prostate cancer-specific multi-gene panels and explore their performance on clinical series of prostate cancer patients from different ethnic groups. PMID: 31629418 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Polygenic risk scores for prostate cancer: testing considerations.
Authors: Toland AE Abstract Genome-wide association studies (GWAS) have identified more than 170 single nucleotide variants (SNVs) associated with prostate cancer risk. Each variant is associated with only small increases in risk and is not predictive of an individuals' overall risk of developing prostate cancer. Polygenic risk scores (PRS) combining these variants are now clinically available and may improve predictive value of other factors such as PSA. This overview reviews the current state of PRS for prostate cancer including testing considerations. PMID: 31629419 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - October 21, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research