The impact of mpMRI-targeted vs systematic biopsy on the risk of prostate cancer downgrading at final pathology
ConclusionsDowngrading rates are highest when PCa is present in TBx only and, especially when the highest grade PCa is diagnosed by TBx cores only. Conversely, downgrading rates are lowest when PCa is identified with the same ISUP through both SBx and TBx. The presence of clinically significant disease at SBx + TBx may indicate a more reliable assessment of the disease at the time of biopsy potentially reducing the risk of downgrading at final pathology. (Source: World Journal of Urology)
Source: World Journal of Urology - April 22, 2024 Category: Urology & Nephrology Source Type: research
Author Correction: Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
Nature, Published online: 22 April 2024; doi:10.1038/s41586-024-07393-1Author Correction: Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer (Source: Nature AOP)
Source: Nature AOP - April 22, 2024 Category: Research Authors: Lanbo Xiao Abhijit Parolia Yuanyuan Qiao Pushpinder Bawa Sanjana Eyunni Rahul Mannan Sandra E. Carson Yu Chang Xiaoju Wang Yuping Zhang Josh N. Vo Steven Kregel Stephanie A. Simko Andrew D. Delekta Mustapha Jaber Heng Zheng Ingrid J. Apel Lisa McMurry Fen Source Type: research
Cancers, Vol. 16, Pages 1602: Robot-Assisted Radical Prostatectomy Performed with the Novel Surgical Robotic Platform Hugo & trade; RAS: Monocentric First Series of 132 Cases Reporting Surgical, and Early Functional and Oncological Outcomes at a Tertiary Referral Robotic Center
Conclusions: Our initial experience highlights the reliability of the HugoTM RAS system in performing RARP. Additionally, we also list problems and solutions found in our daily work. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Angelo Totaro Eros Scarciglia Filippo Marino Marco Campetella Carlo Gandi Mauro Ragonese Riccardo Bientinesi Giuseppe Palermo Francesco Pio Bizzarri Antonio Cret ì Simona Presutti Andrea Russo Paola Aceto Pierfrancesco Bassi Francesco Pierconti Marco Rac Tags: Article Source Type: research
AAT resistance-related AC007405.2 and AL354989.1 as novel diagnostic and prognostic markers in prostate cancer
CONCLUSIONS: In this study, we have discovered the clinical significance of AC007405.2 and AL354989.1 in predicting the prognosis and diagnosing PCa patients. Furthermore, we have confirmed their correlation with various clinical features. These findings provide potential targets for PCa treatment and a novel diagnostic and predictive indicator for precise PCa diagnosis.PMID:38643469 | DOI:10.18632/aging.205754 (Source: Aging)
Source: Aging - April 21, 2024 Category: Biomedical Science Authors: Yuanzhong Deng Chunlin Zhang Haitao Yu Guo Chen Xiang Peng Yang Li Zhenwei Feng Wei Shi Xuesong Bai Xin Gou Nian Liu Source Type: research
Efficacy and safety of metronomic cyclophosphamide combined with abiraterone and dexamethasone in heavily pretreated metastatic castration resistant prostate cancer ：A retrospective, real-world study
Asian J Surg. 2024 Apr 20:S1015-9584(24)00576-1. doi: 10.1016/j.asjsur.2024.03.149. Online ahead of print.NO ABSTRACTPMID:38644125 | DOI:10.1016/j.asjsur.2024.03.149 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 21, 2024 Category: Surgery Authors: Lulu Zhang Lijia Zhou Yanxia Shi Xin An Source Type: research
Cancer on motors: How kinesins drive prostate cancer progression?
Biochem Pharmacol. 2024 Apr 19:116229. doi: 10.1016/j.bcp.2024.116229. Online ahead of print.ABSTRACTProstate cancer causes numerous male deaths annually. Although great progress has been made in the diagnosis and treatment of prostate cancer during the past several decades, much about this disease remains unknown, especially its pathobiology. The kinesin superfamily is a pivotal group of motor proteins, that contains a microtubule-based motor domain and features an adenosine triphosphatase activity and motility characteristics. Large-scale sequencing analyses based on clinical samples and animal models have shown that sev...
Source: Biochemical Pharmacology - April 21, 2024 Category: Drugs & Pharmacology Authors: Jia-Ming Wang Feng-Hao Zhang Zi-Xiang Liu Yi-Jie Tang Jiang-Feng Li Li-Ping Xie Source Type: research
Gastrin Releasing Peptide Receptors-targeted PET Diagnostics and Radionuclide Therapy for Prostate Cancer Management: Preclinical and Clinical Developments of the Past 5 Years
PET Clin. 2024 Apr 20:S1556-8598(24)00019-1. doi: 10.1016/j.cpet.2024.03.004. Online ahead of print.ABSTRACTEach tumor has its own distinctive molecular identity. Treatment, therefore, should be tailored to this unique cancer phenotype. Theragnostics uses the same compound for targeted imaging and treatment, radiolabeled to an appropriate radionuclide, respectively. Gastrin-releasing peptide receptors (GRPRs) are overexpressed in prostate cancer, and radiolabeled GRPR antagonists have shown high diagnostic performance at staging and biochemical recurrence. Several GRPR-targeting theragnostic compounds have been developed p...
Source: Clinical Prostate Cancer - April 21, 2024 Category: Cancer & Oncology Authors: Simone Dalm Heying Duan Andrei Iagaru Source Type: research
Radiographic Progression at Castration-Resistant Prostate Cancer Diagnosis: A Prognostic Indicator of Metastatic Hormone-Sensitive Prostate Cancer
CONCLUSION: Radiographic progression at the point of CRPC diagnosis independently predicts a shorter OS post-CRPC in patients with mHSPC. Therefore, assessing radiographic changes at the time of CRPC diagnosis could be instrumental in managing CRPC in patients with mHSPC.PMID:38643665 | DOI:10.1016/j.clgc.2024.102075 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 21, 2024 Category: Cancer & Oncology Authors: Kojiro Tashiro Shoji Kimura Shunsuke Tsuzuki Fumihiko Urabe Wataru Fukuokaya Keiichiro Mori Koichi Aikawa Masaya Murakami Hiroshi Sasaki Kenta Miki Jun Miki Tatsuya Shimomura Hiroki Yamada Kenichi Hata Hideomi Nishikawa Hirokazu Abe Ken Watanabe Takahiro Source Type: research
Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society
ConclusionThe present findings suggest that higher total protein intake may not be associated with the risk of colorectal and breast cancer, while conclusions on protein intake in relation to risks of other types of cancer are restricted due toinsufficient evidence. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 21, 2024 Category: Nutrition Source Type: research
Gastrin Releasing Peptide Receptors-targeted PET Diagnostics and Radionuclide Therapy for Prostate Cancer Management
Each tumor has its own distinctive molecular identity. Treatment, therefore, should be tailored to this unique cancer phenotype. Theragnostics uses the same compound for targeted imaging and treatment, radiolabeled to an appropriate radionuclide, respectively. Gastrin-releasing peptide receptors (GRPRs) are overexpressed in prostate cancer, and radiolabeled GRPR antagonists have shown high diagnostic performance at staging and biochemical recurrence. Several GRPR-targeting theragnostic compounds have been developed preclinically. Their translation into clinics is underway with 4 clinical trials recruiting participants with...
Source: PET Clinics - April 21, 2024 Category: Radiology Authors: Simone Dalm, Heying Duan, Andrei Iagaru Source Type: research
Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society
ConclusionThe present findings suggest that higher total protein intake may not be associated with the risk of colorectal and breast cancer, while conclusions on protein intake in relation to risks of other types of cancer are restricted due toinsufficient evidence. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 21, 2024 Category: Nutrition Source Type: research
Molecules, Vol. 29, Pages 1891: Effects of Red Sorghum-Derived Deoxyanthocyanidins and Their O- & beta;-D-Glucosides on E-Cadherin Promoter Activity in PC-3 Prostate Cancer Cells
Molecules, Vol. 29, Pages 1891: Effects of Red Sorghum-Derived Deoxyanthocyanidins and Their O-β-D-Glucosides on E-Cadherin Promoter Activity in PC-3 Prostate Cancer Cells
Molecules doi: 10.3390/molecules29081891
Authors:
Nathalie Mora
Maxence Rosa
Mohamed Touaibia
Luc J. Martin
Although much less common than anthocyanins, 3-Deoxyanthocyanidins (3-DAs) and their glucosides can be found in cereals such as red sorghum. It is speculated that their bioavailability is higher than that of anthocyanins. Thus far, little is known regarding the therapeutic effects of 3-DAs and their O-β-D-glucosi...
Source: Molecules - April 21, 2024 Category: Chemistry Authors: Nathalie Mora Maxence Rosa Mohamed Touaibia Luc J. Martin Tags: Article Source Type: research
Application of Lightweight Deep Learning Model-Based Shear Wave Elastic Imaging with Abdominal Probe to Diagnose Prostate Cancer: A Biomedical Approach
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 20, 2024 Category: Nanotechnology Authors: Xu, Jing Gao, Shuai Tags: research-article Source Type: research
Holmium laser enucleation of the prostate for a case of transition zone prostate cancer
We present a case of transition zone prostate cancer that was treated with holmium laser enucleation of the prostate, a procedure that is normally reserved for the management of benign prostatic hyperplasia.PMID:38642466 (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 20, 2024 Category: Urology & Nephrology Authors: Michelle K Li Orlando Diaz Jonathan E Katz Source Type: research
Optimizing outcomes in men with prostate cancer: the cardiovascular event lowering (CaELo) pathways
CONCLUSIONS: Prostate cancer patients receiving ADT with or without ATT need to be more zealously assessed for prevention and aggressively managed to reduce cardiovascular events. This can and should include participation from the entire multidisciplinary healthcare team.PMID:38642459 (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - April 20, 2024 Category: Urology & Nephrology Authors: David E Crawford David Albala Marc B Garnick Andrew W Hahn Paul Maroni Rana R McKay Martin Miner Peter Orio Ⅲ Kshitij Pandit Scott Sellinger Evan Y Yu Robert H Eckel Source Type: research
