Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
In this study, we included four crucial proteins that perform signalling, receptor, and regulatory action, namely- NUDIX Hydrolases, Dihydrofolate Reductase, HER2/neu Kinase and EGFR and performed multitargeted molecular docking studies against human-approved drugs using HTVS, SP and extra precise algorithms and filtered the poses with MM\GBSA, suggested a benzodiazepine derivative chlordiazepoxide, used as an anxiolytic agent, can be a multitargeted inhibitor with docking and MM\GBSA score ranging from - 4.628 to - 7.877 and - 18.59 to - 135.86 kcal/mol, respectively, and the most interacted residues were 6ARG, 6GLU, 3TRP...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Ahad Amer Alsaiari Amal F Gharib Maha Mahfouz Bakhuraysah Amani A Alrehaili Shatha M Algethami Hayfa Ali Alsaif Norah Al Harthi Mohammed Ageeli Hakami Source Type: research
Icariin ‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling
Exp Ther Med. 2024 Mar 26;27(5):232. doi: 10.3892/etm.2024.12519. eCollection 2024 May.ABSTRACTFerroptosis is a form of regulatory cell death that relies on iron and reactive oxygen species (ROS) to inhibit tumors. The present study aimed to investigate whether icariin-curcumol could be a novel ferroptosis inducer in tumor inhibition. Various concentrations of icariin-curcumol were used to stimulate prostate cell lines (RWPE-2, PC-3, VCAP and DU145). Small interfering negative control (si-NC) and si-nuclear factor erythroid 2-related factor 2 (Nrf2) were used to transfect DU145 cells. Cell viability was determined by using...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Wen Sheng Bonan Li Tiansong Sun Congxu Zhu Yingqiu Li Wenjing Xu Source Type: research
Clinical and Radiological Factors for Predicting Clinically Significant Prostate Cancer in Biopsy-Naive Patients With PI-RADS 3 Lesions
CONCLUSION: The combination of age, prostate-specific antigen density, lesion volume, apparent diffusion coefficient, and digital rectal examination presented a higher diagnostic value for clinically significant prostate cancer than any single parameter in patients with Prostate Imaging Reporting and Data System 3 lesions. Systematic biopsy proved crucial for biopsy-naive patients with Prostate Imaging Reporting and Data System 3 lesions and should not be omitted.PMID:38629205 | DOI:10.1177/15330338241246636 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 17, 2024 Category: Cancer & Oncology Authors: Zhiyu Zhang Can Hu Yuxin Lin Ouyang Song Dongkui Gong Xuefeng Zhang Nan Wang Source Type: research
Management of advanced prostate cancer in the Asia-Pacific region: Summary of the Asia-Pacific Advanced Prostate Cancer Consensus Conference 2023
CONCLUSION: The use of next-generation imaging, genetic testing, and new treatment combinations is increasing the complexity and duration of prostate cancer management. Familiarity with new diagnostic and treatment options is growing in the APAC region. Insights highlight the continued importance of a multidisciplinary approach that includes nuclear medicine, genetic counseling, and quality-of-life expertise. The APAC APCCC meeting provides an important opportunity to share practice and identify APAC-specific issues and considerations in areas of low evidence where clinical experience is growing.PMID:38628049 | DOI:10.1111...
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Edmund Chiong Declan G Murphy Nicholas Buchan Kenneth Chen Sarah S Chen Melvin L K Chua Agus Rizal Hamid Ravindran Kanesvaran Makarand Khochikar Jason Letran Bannakij Lojanapiwat Indranil Mallik Chee Fai Ng Teng Aik Ong Darren M C Poon Yeong-Shiau Pu Marn Source Type: research
A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
CONCLUSION: The safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer.PMID:38630382 | DOI:10.1007/s10147-024-02517-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Katsumasa Nakamura Keiji Nihei Yoshihiro Saito Naoto Shikama Shin-Ei Noda Ryusuke Hara Toshiyuki Imagumbai Takashi Mizowaki Takeshi Akiba Etsuo Kunieda Masanori Someya Saiji Ohga Jiro Kawamori Takuyo Kozuka Yosuke Ota Koji Inaba Takeshi Kodaira Yoshiyuki Source Type: research
A pictorial view on false positive findings of < sup > 68 < /sup > Ga-PSMA-11 PET/CT and their prognostic value in patients with prostate carcinoma after radical prostatectomy and undetectable PSA values
CONCLUSION: The presence of 68Ga-PSMA-11 PET/CT-positive findings in patients after radical prostatectomy and an undetectable PSA had a low predictive value for future progression. The interpretation of 68Ga-PSMA-11 PET/CT should always include a complex assessment of the clinical setting-the risk group, PSA value and degree of PSMA accumulation in the lesions. In these situations, further clarification of PSMA-positive findings is appropriate before deciding to change treatment.PMID:38629815 | DOI:10.1967/s002449912702 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Zhivka Dancheva Sophiya Chausheva Tanya Stoeva Marina Dyankova Tsvetelina Yordanova Borislav Chaushev Rostislav Marinov Viktor Nikolov Pavel Abushev Georgi Todorov Eleonora Dimitrova Aneliya Klisarova Deyan Anakievski Source Type: research
ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance
In this study, we found that SPOP and ELK3 are an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation. Notably, the modulation of SPOP-mediated ELK3 protein stability affected the c-Fos-induced cell proliferation and invasion of PCa cells. The clinical involvement of the SPOP-ELK3 axis in PCa development was confirmed by an immunohistochemical assay on 123 PCa tissues, with an inverse correlation between increased ELK3 and decreased SPOP being present in ~80% of the specimens. This observation was s...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Cheol-Jung Lee Heejung Lee Seo Ree Kim Soo-Bin Nam Ga-Eun Lee Kyeong Eun Yang Guk Jin Lee Sang Hoon Chun Han Chang Kang Joo Young Lee Hye Suk Lee Sung-Jun Cho Yong-Yeon Cho Source Type: research
Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer
J Med Chem. 2024 Apr 17. doi: 10.1021/acs.jmedchem.3c02433. Online ahead of print.ABSTRACTMultitarget medications represent an appealing therapy against the disease with multifactorial abnormalities─cancer. Therefore, simultaneously targeting son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR), two aberrantly expressed proteins crucial for the oncogenesis and progression of prostate cancer, may achieve active antitumor effects. Here, we discovered dual SOS1/EGFR-targeting compounds via pharmacophore-based docking screening. The most prominent compound SE-9 exhibited nanomolar inhibition activity against...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Lufeng Zheng Yuxin Zhang Shuang Mei Tianyuan Xie Yunting Zou Yuting Wang Han Jing Shengtao Xu Pierre Dramou Zhen Xu Jindong Li Yang Zhou Miao-Miao Niu Source Type: research
Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
In this study, we included four crucial proteins that perform signalling, receptor, and regulatory action, namely- NUDIX Hydrolases, Dihydrofolate Reductase, HER2/neu Kinase and EGFR and performed multitargeted molecular docking studies against human-approved drugs using HTVS, SP and extra precise algorithms and filtered the poses with MM\GBSA, suggested a benzodiazepine derivative chlordiazepoxide, used as an anxiolytic agent, can be a multitargeted inhibitor with docking and MM\GBSA score ranging from - 4.628 to - 7.877 and - 18.59 to - 135.86 kcal/mol, respectively, and the most interacted residues were 6ARG, 6GLU, 3TRP...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Ahad Amer Alsaiari Amal F Gharib Maha Mahfouz Bakhuraysah Amani A Alrehaili Shatha M Algethami Hayfa Ali Alsaif Norah Al Harthi Mohammed Ageeli Hakami Source Type: research
LP-184, a novel acylfulvene molecule, exhibits anti-cancer activity against diverse solid tumors with homologous recombination deficiency
Cancer Res Commun. 2024 Apr 17. doi: 10.1158/2767-9764.CRC-23-0554. Online ahead of print.ABSTRACTHomologous recombination (HR) related gene alterations are present in a significant subset of prostate, breast, ovarian, pancreatic, lung and colon cancers rendering these tumors as potential responders to specific DNA damaging agents. A small molecule acylfulvene prodrug, LP-184, metabolizes to an active compound by the oxidoreductase activity of enzyme Prostaglandin Reductase 1 (PTGR1), which is frequently elevated in multiple solid tumor types. Prior work demonstrated that cancer cell lines deficient in a spectrum of (DNA d...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Aditya Kulkarni Jianli Zhou Neha Biyani Umesh Kathad Partha P Banerjee Shiv Srivastava Zsombor Prucsi Kamil Solarczyk Kishor Bhatia Reginald B Ewesuedo Panna Sharma Source Type: research
Icariin ‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling
Exp Ther Med. 2024 Mar 26;27(5):232. doi: 10.3892/etm.2024.12519. eCollection 2024 May.ABSTRACTFerroptosis is a form of regulatory cell death that relies on iron and reactive oxygen species (ROS) to inhibit tumors. The present study aimed to investigate whether icariin-curcumol could be a novel ferroptosis inducer in tumor inhibition. Various concentrations of icariin-curcumol were used to stimulate prostate cell lines (RWPE-2, PC-3, VCAP and DU145). Small interfering negative control (si-NC) and si-nuclear factor erythroid 2-related factor 2 (Nrf2) were used to transfect DU145 cells. Cell viability was determined by using...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Wen Sheng Bonan Li Tiansong Sun Congxu Zhu Yingqiu Li Wenjing Xu Source Type: research
GSE254390 CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE254388 CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [RNA-Seq]
Contributors : Jean C Tien ; Yuping Zhang ; Yu Chang ; Yunhui Cheng ; Rahul Mannan ; Palak Shan ; Xiaoming Wang ; Sanjana Eyunni ; Caleb Cheng ; Brian Magnuson ; Lanbo Xiao ; Marcin Cieslik ; Abhijit Parolia ; Yi Bao ; Shuqin Li ; Alice Xu ; Fengyun Su ; Xuhong Cao ; Yi-Mi Wu ; Dan Robinson ; George Wang ; Ke Ding ; Arul M ChinnaiyanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBiallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of metastatic castration resistant prostate cancer (mCRPC). It remains unclear, however, whether C...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE254387 CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality [scRNA-Seq]
Contributors : Jean C Tien ; Yuping Zhang ; Yu Chang ; Yunhui Cheng ; Rahul Mannan ; Palak Shan ; Xiaoming Wang ; Sanjana Eyunni ; Caleb Cheng ; Brian Magnuson ; Lanbo Xiao ; Marcin Cieslik ; Abhijit Parolia ; Yi Bao ; Shuqin Li ; Alice Xu ; Fengyun Su ; Xuhong Cao ; Yi-Mi Wu ; Dan Robinson ; George Wang ; Ke Ding ; Arul M ChinnaiyanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBiallelic loss of cyclin-dependent kinase 12 (CDK12) defines a unique molecular subtype of metastatic castration resistant prostate cancer (mCRPC). It remains unclear, however, whether C...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Impact of health and digital health literacy on quality of life following radical prostatectomy for prostate cancer: prospective single-center cohort study
ConclusionOur study showed a positive association between self-reported HL/e-HL and QoL, marking the first report on the impact of HL/e-HL on the QoL in men who underwent RP for clinically localized prostate cancer. (Source: World Journal of Urology)
Source: World Journal of Urology - April 17, 2024 Category: Urology & Nephrology Source Type: research
