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About an energy functioning by fusion, independently.
Authors: Melfou F, Lambrianidis C, Grammaticos PC Abstract An innovative biological energy has been observed related to the eye sight and fusing with another energy over tap water through a small metallic chain. The fused energy has been repeatedly described under standard conditions and it is characteristics vary according to the condition of the eye sight and the water content. This energy may be called: "EFI" (energy functioning, by fusion, independently). PMID: 29244884 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 16, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Semi-quantitative assessment of pulmonary arterial hypertension associated with congenital heart disease through myocardial perfusion imaging.
Authors: Liu M, Qin C, Xia X, Li M, Wang Y, Wang L, Shang X, Lan X Abstract OBJECTIVE: The study aimed to use myocardial perfusion imaging (MPI) as a semi-quantitative method to assess the clinical severity of pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD). SUBJECTS AND METHODS: A total of 24 patients with PAH related to CHD (PAH-CHD) who received interventional or medical treatment were included. All patients underwent physical examination, cardiac function evaluation, biochemical test, echocardiography, right heart catheterization (RHC), and MPI with 99mTc-methoxyisobuty...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Cell and gene therapy with reporter gene imaging in myocardial ischemia.
Authors: Qin C, Xia X, Pei Z, Zhang Y, Lan X Abstract OBJECTIVE: Reporter gene/probe systems have proved to be reliable for monitoring gene/cell therapy. We sought to evaluate whether a reporter gene/probe system, namely the human estrogen receptor ligand binding domain (hERL)/16α-18F fluoro-17β-estradiol (18F-FES), could be used for monitoring vascular endothelial growth factor (VEGF) gene expression and response to bone marrow mesenchymal stem cell (MSCs) therapy in ischemic heart disease. ANIMALS AND METHODS: Reporter gene hERL and therapeutic gene VEGF165 were linked through internal ribosome ent...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Errors in the absorbed and the administered 131I therapeutic dose in patients with Graves' disease. A suggested more precise technique.
This study included 45 patients with Graves' disease 12 men and 33 women; age 44.1±12.8 years. Thyroid mass (TM) was measured using ultrasound. Uptake of 131I (RAIU) was tested at 2, 4-6, 24, 48-72, and 96-168h after its administration and the half-life (T1/2eff) and resident time (RT) of 131I were computed. According to the sQMHF, a prescribed TD of 75Gy required 3.7MBq/g of 131I, correction based on the RAIU24h and T1/2eff. Subsequently, the therapeutic TD was computed according to the SOPD and the RE was recorded. The data were analyzed using t-tests. RESULTS: The TM, RAIU24h, therapeutic TD, and RE were 36.5...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Assessment of segmental left ventricular thickening in diabetic type II obese patients with normal myocardial perfusion scan.
Authors: Al-Makhamreh HK, AlSharif AA, Abujbara MA, Al-Ibraheem AN, Obeidat OS, AlKawaleet YI, Darawsheh A, Liswi MI, Ajlouni KM Abstract OBJECTIVE: The aim of this study is to investigate whether gated single photo emission tomography (gSPET) can be used to detect subclinical left ventricular systolic dysfunction (LVSD) in obese diabetic type II patients. SUBJECTS AND METHODS: We retrospectively reviewed gSPET images of 190 patients with diabetes mellitus type II (DM II) (137 females and 53 males) with normal myocardial perfusion and normal ejection fraction (EF). Standardized twenty segment polar maps of thic...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Is 18F-FDG PET/CT a valuable diagnostic tool for verifying accelerated atherosclerosis secondary to diabetes mellitus on insulin in the aortic segments and large arteries?
CONCLUSION: Our results show that inflammatory component of atherosclerosis was more severe in all aortic segments in subjects with IDDM compared to those of controls. Presence of macroscopic calcification also detected to be more frequently encountered in the descending thoracic and abdominal aorta in subjects with IDDM. Fluorine-18-FDG PET/CT is a valuable diagnostic tool for detecting and semi-quantifying accelerated atherosclerotic inflammatory and calcific changes secondary to diabetes mellitus treated with insulin in the aortic segments and large arteries. PMID: 29177258 [PubMed - as supplied by publisher] (Sourc...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The influence of adipose tissue volume can significantly affect the metabolic activity of reference organs in 18F-FDG PET/CT studies of a normal healthy population.
This study investigated whether fluorine-18-fluorodeoxyglucose (18F-FDG) uptake of reference organs can be affected by subjects' factors in positron emission tomography/computed tomography (PET/CT) in a healthy population. SUBJECTS AND METHODS: A total of 208 normal healthy subjects without diabetes or dyslipidemia were included. Adipose tissue volume was measured by CT images from a dedicated PET/CT scan. Uptake of 18F-FDG of reference organs was measured from liver, blood pool, and muscle, and was normalized by lean body anthropometric data and adipose tissue volume. RESULTS: Of 208 participants, 118 were metabol...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Radioiodine associated de novo Graves' opthalmopathy in an Asian cohort.
In this report, we describe five individuals who required extensive ophthalmic treatment for post-RAI de novo GO. PMID: 29177260 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Performance and safety profile of regadenoson myocardial perfusion imaging: first experience in Greece.
CONCLUSION: Our findings support previously published data indicating the optimal safety profile of regadenoson MPI, even in the group of patients suffering from chronic obstructive pulmonary disease. PMID: 29177261 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Metabolic activity in bone metastases of breast and prostate cancer were similar as studied by 18F-FDG PET/CT. The role of 99mTc-MDP.
Authors: Pietrzak A, Czepczynski R, Wierzchoslawska E, Cholewinski W Abstract OBJECTIVE: The aim of this study was to compare the metabolic activity of metastatic foci from breast and prostate cancer patients as scanned by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and by technetium-99m methyl diphosphonate (99mTc-MDP) bone scan (BS). SUBJECTS AND METHODS: Forty one patients were studied, divided into 2 groups based on histologically confirmed diagnosis: a) Breast cancer group, 23 women, mean age: 61±12 years, range: 37-79 years and, b) Prostate cance...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Primary radiation dosimetry of a novel PET radiopharmaceutical 68Ga-NODAGA-glycine in comparison with 99mTc-DTPA in renal studies.
CONCLUSION: The results showed that 68Ga-NODAGA-glycine delivers lower dose to the patients. Also due to its application in PET (which offers higher sensitivity and spatial resolution compared to planar or SPET), 68Ga-NODAGA-glycine would be a superior choice than 99mTc-DTPA for renography and impose less radiation doses to patients. PMID: 29177263 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Results of performing or not cardiac resynchronization therapy for live assessment of LV function and mechanical systole synchrony using gated myocardial perfusion imaging and real-time three-dimensional echocardiography. Seven months follow-up.
Authors: Yang L, Wang J, Wang Y, Zhang X Abstract We studied a 50 years old male patient who underwent cardiac resynchronization therapy on and off (CRT-on and CRT-off) for assessment of left ventricular (LV) function and mechanical systole synchrony using gated myocardial perfusion imaging (gMPI) and real-time three-dimensional echocardiography (RT3DE). The patient was reexamined after seven months. The comparison of these two modalities showed consistent results on assessing both the CRT-on and CRT-off conditions. This result may indicate that an immediate synchronization parameter change during CRT-on may be val...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Metastatic melanoma response to combination therapy with ipilimumab and vemurafenib.
We report on a stage IV metastatic melanoma patient with the BRAF V600 mutation and a large tumor burden initially treated with two cycles of ipilimumab. Due to dramatic disease progression, demonstrated on interim 18F-FDG PET/CT, vemurafenib was added in the patient's therapeutical scheme. After completion of the concurrent ipilimumab and vemurafenib administration, a third 18F-FDG PET/CT showed an impressive metabolic remission of the metastatic disease, reflecting the potential role of the modality in treatment response evaluation of melanoma patients receiving combination therapies. PMID: 29177265 [PubMed - as supp...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Atypical Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis simulating lymphadenitis on 18F-FDG PET/CT and its differential diagnosis.
Authors: Lu J, Fang Q, Ma C, Su F, Chen G, Huang M, Wang W, Su X Abstract Diagnosis of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is challenging as its clinical presentation is atypical. Here we present a case of atypical EBV-HLH simulating lymphadenitis on fluorrine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), with a view to consider this kind of EBV-HLH as a possible differential diagnosis in lymphadenitis. A 68 years old male who had episodic fever accompanied by weight loss and weakness for two weeks was studied. Finally, biopsies in bo...
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Primary and secondary hyperparathyroidism among vitamin D deficient Hashimoto's thyroiditis patients and the need for a parathyroid scan.
Authors: Mazokopakis E, Papadomanolaki M, Skarakis SN, Tsekouras K Abstract The patients with Hashimoto thyroiditis must be investigated mainly for secondary hyperparathyroidism due to vitamin D deficiency/insufficiency. Parathyroid scintigraphy has no place in the diagnosis of primary, secondary or tertiary hyperparathyroidism or in the decision for surgical treatment. Parathyroid scintigraphy is a useful preoperative technique for the localization of the pathological parathyroid glands. PMID: 29177267 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Endless research II. The genomic era. Neohippocratic Medicine.
Authors: Grammaticos PC, Antoniou DE Abstract The great progress of genetics research, during 2015-2017, will certainly influence all medical specialties including nuclear medicine. In nuclear medicine there are still problems to solve as to differentiate between infection, inflammation and cancer etc. Furthermore, in dosimetry and radiation protection there are worldwide problems. It has been reported that (64) Cu-cetuximab immune-PET represented EGFR expression levels in ESCC tumors and that (177) Lu-cetuximab radioimmunotherapy effectively inhibited the tumor growth. Recent important research findings and few re...
Source: Hellenic Journal of Nuclear Medicine - August 6, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The effect of scatter correction on planar and tomographic semiquantitative (123)I cardiac imaging. A phantom study.
CONCLUSION: In cardiac (123)I imaging with a LE collimator the use of TEW scatter correction provides a semi-quantitative assessment comparable to that attained with ME collimation and may moderate inter-institutional inconsistencies. PMID: 28777833 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - August 6, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Whiplash Syndrome- a disorder of the brain?
Authors: Biendara J, Otte A Abstract In the past two decades much has been published on whiplash injury, yet both the confusion regarding the condition, and the medicolegal discussion about it have increased. In this paper, functional imaging research results are summarized using MRIcroGL 3D visualization software and assembled in an image comprising regions of cerebral activation and deactivation. PMID: 28697186 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Can semiquantitative measurements of SUVmax and cut-off values differentiate malignant from benign colorectal cancer?
CONCLUSION: Semi-quantitative measurements of SUVmax and cut-off values proved inadequate for differentiating colorectal malignancies from benign findings. While integrated measures, e.g. cTLG, are potentially better indicators of disease severity and extent, more optimal segmentation and PVC methods are required. PMID: 28697187 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Impact of tall cell variant histology on predicting relapse and changing the management of papillary thyroid carcinoma patients.
Authors: Gunalp B, Okuyucu K, Ince S, Ayan A, Alagoz E Abstract OBJECTIVE: There has been much discussion recently about the risk category of tall cell variant (TVC) histology and its effects on the management of papillary thyroid carcinoma (PTC). We, therefore, undertook a retrospective study to compare stage-matched risk factors and recurrence rates between classical PTC (cPTC) patients and patients with TCV histology. SUBJECTS AND METHODS: A total of 3128 well-differentiated thyroid carcinoma patients who were treated and followed-up for more than 5 years in our clinic from 1995 to 2016 were included in this...
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Gallium-68-dotatate PET/CT is better than CT in the management of somatostatin expressing tumors: First experience in Africa.
CONCLUSION: Gallium-68-dotatate PET/CT was better than CT in detecting primary sites of the disease and highly sensitive and specific for diagnosis and treatment of NET and other SSTR expressing tumors. PMID: 28697189 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

(18)F-FDG PET/CT and histology for diagnosing recurrent/remnant tumors in head and neck cancer patients treated with radiotherapy.
CONCLUSION: (18)F-FDG PET/CT might aid the diagnosis of locoregional residual/recurrent tumors in patients with HNC previously treated with RT. Inflammation was the main cause of false positives regardless of the interval between RT and PET/CT, even several years after RT. Therefore, histological verification of positive PET/CT findings should be conducted during follow-up of HNC patients treated with RT. PMID: 28697190 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An innovative method for precise lymph node detection before surgical treatment.
CONCLUSION: We found this integrated SPET/MSCT 3D model to be much faster and easier to use as compared with the "classic" method, which was based on a radioactivity detection probe. In addition, our method was reproducible, accurate and of low cost. In other words, the method described in this paper could be very useful for health facilities with modest budget, because it obviates the need for buying expensive integrated SPET/MSCT hybrid imaging systems while detecting SNLs more accurately and in shorter time. PMID: 28697191 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A prototype PET/SPECT/X-rays scanner dedicated for whole body small animal studies.
CONCLUSION: A compact tri-modal system was successfully built and evaluated for planar mode operation. The system has an efficient performance, allowing accurate and informative anatomical and functional imaging, as well as semi-quantitative results. Compared to other available systems, it provides a moderate but comparable performance, at a fraction of the cost and complexity. It is fully open, scalable and its main purpose is to support groups on a national and regional level and provide an open technological platform to study different detector components and acquisition strategies. PMID: 28697192 [PubMed - as suppl...
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The value of (18)FDG PET/CT parameters, hematological parameters and tumor markers in predicting KRAS oncogene mutation in colorectal cancer.
CONCLUSION: We observed that in patients with colorectal cancers, we cannot predict KRAS gene mutations using PET/CT parameters (SUVmax, MTV, TLG), hematological parameters (NLR, PLR) or tumor marker CA 19-9. We detected a significant but not very strong association only between CEA and KRAS mutations. PMID: 28697193 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Enhancing contrast agents and radiotracers performance through hyaluronic acid-coating in neuroradiology and nuclear medicine.
Authors: Ganau M, Syrmos NC, D'Arco F, Ganau L, Chibbaro S, Prisco L, Ligarotti GKI, Ambu R, Soddu A Abstract The use of hyaluronic acid nanoshells has been proposed to encapsulate prodrugs and exploit the mechanisms of interactions between living cells, like endocytes or cancer cells and hyaluronic acid, which is a natural component of the extracellular matrix. In this review we describe the potential and the limits of this promising research trend and discuss the theoretical advantages of such an engineering approach. Is it a possible scalability to increase the efficacy and biodegradability of molecules like con...
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Fluorine-18-FDG PET/CT in a patient with angiomyolipoma: Response to mammalian target of rapamycin inhibitor therapy.
We report on a 27 years old female patient who was referred to our department for whole-body as well as dynamic positron emission tomography/computed tomography (dPET/CT) scan of the upper and middle abdomen with fluorine-18-fluorodeoxy glucose ((18)F-FDG), for further evaluation of a mass in the left adrenal gland region. Positron emission tomography showed a suspicious, enlarged, hypermetabolic mass with an average standardized uptake value (SUV) of 4.5 and a maximum SUV of 5.9. The patient was referred for biopsy, which revealed an angiomyolipoma, a perivascular epithelioid cell tumor (PEComa) of the adrenal gland. Peri...
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Fluorine-18-fluorodeoxyglucose positron emission tomography/ computed tomography findings in a pediatric mucoepidermoid carcinoma and differential diagnosis.
Authors: Xie J, Ma C, Tang J Abstract An 11 years old boy was referred to our hospital. He complained for the last three months for intermittent cough and shortness of breath after exercise which worsened recently. Airways computed tomography (CT) showed an abnormal endobronchial tumor, obstructing the right main bronchus and also atelectasis in the upper lobe of the right lung. Bronchoscopy showed a wet on its surface mass obstructing the right main bronchus. Biopsy showed a mucoepidermoid carcinoma (MEC). The fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan s...
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Increased and normalized uptake of (18)F-FDG in a case of bone periprosthetic infection treated by antibiotics.
CONCLUSION: In the case we report, since we found no otnt focal areas in the lumbar spine where due to age-related bone deformities including some Schmorl's nodes. The inflammation in the bone prosthesis and the subcutaneous wound responded almost totally to the antibiotic treatment we applied. PMID: 28697197 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Unusual diffuse liver (18)F-FDG uptake in melanoma patient treated by ipilimumab.
We present herein a case of unusual (18)F-FDG PET-CT diffuse hypermetabolic liver uptake in melanoma patient treated by ipilimumab. PMID: 28697198 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Negative (18)F-FDG PET and positive CT and MRI findings in multifocal splenic hamartoma.
CONCLUSION: The normal :F-FDG PET/CT findings suggested that, at least in this patient, splenic hamartoma may display a similar :F-FDG avidity when compared to normal splenic tissue. Alternatively, due to the infra-centrimeric size of the hamartoma and spill-over from :F-FDG activity from neighbouring normal tissue, the true (18)F-FDG avidity of the hamartomas present might also be overestimated. PMID: 28697199 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 12, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Medical History in the Hellenic Journal of Nuclear Medicine.
Authors: Otte A, Ahn BC Abstract The Hellenic Journal of Nuclear Medicine is about to celebrate its 20th anniversary end of 2017. On board of the editorial team since 2003, this journal has influenced me like a good friend over the many past years. From time to time, the journal has published interesting and valuable historical notes. They show that nuclear medicine has a history and that medicine is its basis. They also teach us today, and some of the ancient perspectives and approaches are still valid. The reader of HJNM may be interested in these historical contributions, as they are timeless. Therefore, it was ...
Source: Hellenic Journal of Nuclear Medicine - April 22, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Multimodality-multiparametric brain tumors evaluation.
Authors: Tsitsia V, Svolou P, Kapsalaki E, Theodorou K, Vassiou K, Valotassiou V, Georgoulias P, Fezoulidis I, Tsougos I Abstract Brain tumors represent a vast group of lesions, originating from different neuronal cells with different degrees of aggressiveness. Despite some technological advances either pre or post-treatment, these tumors may share similar imaging findings and properties, rendering diagnosis/prognosis, an ambiguous process. Gadolinium-enhanced magnetic resonance imaging remains the gold standard for providing detailed morphologic information, but presents several limitations due to the overlap of f...
Source: Hellenic Journal of Nuclear Medicine - April 22, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Postoperative radioactive iodine-131 ablation is not necessary among patients with intermediate-risk differentiated thyroid carcinoma: a population-based study.
Authors: Zhang H, Cai Y, Zheng L, Zhang Z, Jiang N Abstract OBJECTIVE: To assess the effectiveness of radioactive iodine (RAI) ablation among patients with intermediate-risk differentiated thyroid cancer (DTC) following surgery. SUBJECTS AND METHODS: This population based study obtained information from the Surveillance, Epidemiology, and End Results (SEER) Program Research Data (1973-2013). National Cancer Institute, DCCPS, Surveillance Research Programme, Surveillance Systems Branch, released April 2016, based on the November 2015 submission. A total of 93,530 patients with primary thyroid cancer were identif...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Reconsideration of the primary and secondary diagnostic criteria of Meckel's diverticulum scintigraphy. A study of 93 confirmed cases.
CONCLUSION: Location in the right lower quadrant and round shape of the lesions are not the primary diagnostic factors for Meckel's diverticulum. The establishment of the diagnosis of MD requires careful consideration of other imaging characteristics such as: a) The onset of lesions' radioactivity to correspond with the onset of the gastric activity and b) The lesions' radioactivity to gradually increase during the scan procedure. PMID: 28315903 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Prognostic value of bone marrow (18)F-FDG uptake on PET/CT in lymphoma patients with negative bone marrow involvement.
Authors: Lee JW, Lee SC, Kim HJ, Lee SM Abstract OBJECTIVE: The study evaluated the significance of 18F fluorodeoxyglucose ((18)F-FDG) uptake of bone marrow (BM) for predicting progression-free survival (PFS) in lymphoma patients without BM involvement. SUBJECTS AND METHODS: Ninety-five patients with histopathologically proven lymphoma, 7 Hodgkin's lymphoma and 88 non-Hodgkin's lymphoma, who underwent (18)F-FDG positron emission tomography/computed tomography (PET/CT) and BM biopsy for staging work-up and 40 normal subjects were retrospectively enrolled. Maximal (18)F-FDG uptake of lymphoma (Lmax), mean (18)F-F...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Breast-specific gamma camera imaging with (99m)Tc-MIBI has better diagnostic performance than magnetic resonance imaging in breast cancer patients: A meta-analysis.
CONCLUSION: The results of our meta-analysis indicated that compared with MRI, BSGI has similar sensitivity, higher specificity, better diagnostic performance, and can be widely used in clinical practice. PMID: 28315905 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nineteen cases with synchronous multiple primary cancers studied by (18)F-FDG PET/CT.
CONCLUSION: In our center, SMPC most commonly involved the gastrointestinal tract and adenocarcinomas were the most common pathology type. (18)F-FDG PET/CT was useful in the diagnosis of SMPC and the ΔSUVmax indicates different pathological origins of the synchronous cancers. PMID: 28315906 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Can preoperative CEA and CA19-9 serum concentrations suggest metastatic disease in colorectal cancer patients?
This study was designed to investigate the efficiency of preoperative serum carcinoembryonic antigen (CEA) and carbohydrate cancer antigen (CA19-9) levels for diagnosing synchronous liver metastases and lymph node in colorectal carcinoma (CRC) patients. SUBJECTS AND METHODS: A total of 300 patients with histologically diagnosed CRC were included in this study between May 2014 and March 2015. The data were obtained prospectively from patient's medical records: medical history, demographics, tumor location, differentiation (grade), depth of the tumor (T), lymph node metastases (N), distant metastases (M), lymphatics, ven...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Positive (99m)Tc-MIBI and the subtraction parathyroid scan are related to intact parathyroid hormone but not to total plasma calcium in primary hyperparathyroidism.
CONCLUSION: In patients with pHPT, the (99m)Tc-MIBI PS and the subtraction PS showed a strong correlation to iPTH (P=0.003) but not to total plasma calcium levels indicating the importance of both the (99m)Tc-MIBI and the subtraction parathyroid scans to indicate pHPT. PMID: 28315908 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation.
Authors: Liontiris MI, Mazokopakis EE Abstract Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. The additional role of diet for the management of HT is usually overlooked. A literature search regarding ...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Effect of selenium supplementation for protection of salivary glands from iodine-131 radiation damage in patients with differentiated thyroid cancer.
Authors: Son H, Lee SM, Yoon RG, Lee H, Lee I, Kim S, Chung WY, Lee JW Abstract OBJECTIVE: In the current study, we examined whether selenium supplementation during iodine-131 ((131)I) treatment had a radio-protective effect on salivary glands. SUBJECTS AND METHODS: Sixteen patients with differentiated thyroid cancer were prospectively enrolled in the study. Patients after total thyroidectomy, before (131)I treatment, were divided into two groups; 8 patients in the selenium group and 8 patients in the control group. Patients in the selenium group received 300νg of selenium orally for 10 days, from 3 days bef...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Reproducibility of a semi-quantitative lobar pulmonary ventilation and perfusion technique using SPET and CT.
CONCLUSION: Our method of lobar VQ SPET with CT quantitation has high inter- and intra- observer concordance and in this preliminary data set seems to be a reliable and reproducible test for semi-quantitation of differential volume, ventilation and perfusion of the lobes of the lungs. PMID: 28315911 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An imaging target TGF- β1 for hepatocellular carcinoma in mice.
CONCLUSION: This pilot study provides an experimental basis for further exploration of the feasibility of TGF-β1 receptor as a target in HCC imaging and in other cancers. PMID: 28315912 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Does dual-time-point (18)F-FDG PET/CT scan add in the diagnosis of hepatocellular carcinoma?
Authors: Wu B, Zhao Y, Zhang Y, Tan H, Shi H Abstract OBJECTIVE: The aim of this study was to evaluate the usefulness of dual-time-point (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for patients with hepatocellular carcinoma (HCC). SUBJECTS AND METHODS: The 150 patients with clinically suspected liver malignancies underwent dual-time-point (18)F-FDG PET/CT imaging. The maximum standardized uptake value (SUVmax) was calculated at both time points of PET imaging. The change in SUVmax (retention index, RI) was defined as the ratio of incr...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The beginning of using X-rays and the evolution of equipment for the treatment of ocular cancer.
Authors: Laios K, Zozolou M, Generalis G, Lymperi M, Koutsandrea C, Moschos MM Abstract Until the early 20(th)century enucleation of the eyeball or its partial excision were the basic treatments for ocular cancer. The discovery of X-rays by Wilhelm Conrad Röntgen (1845-1923) offered new possibilities to the treatment of ocular cancer either as mono or as adjuvant therapy. Nowdays this treatment is more sophisticated. PMID: 28315914 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Four patients with gastrointestinal bleeding identified by a modified in vivo technique with labeled red blood cells sedimentation.
CONCLUSION: The modified in vivo method with sedimentation is a simple and effective way to increase the labeling efficiency and thus the diagnosis for the detection of gastrointestinal bleeding. PMID: 28315915 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Muscular damage in a patient with hepatitis B induced by beta-l-2'-deoxythymidine and detected by (18)F-FDG PET/CT.
Authors: Zi J, Xu C, Zhang X Abstract A 58 years old man under 2'-Deoxy-L-thymidine treatment for his hepatitis B was admitted to our hospital complaining for the last 2 months of recurrent upper abdomen discomfort, fatigue and weight loss of 10 kilograms and general muscular soreness, for 2 weeks. He had elevated creatine kinase (CK), myoglobin, CK-MB and other related or common laboratory findings. Fluorine-18- fluorodeoxyglucose positron emission tomography/ computed tomography ((18)F-FDG PET/CT) showed a diffuse, homogenous, moderately elevated glucose uptake in all muscle groups. Muscular damage induced by 2'-...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A pediatric hypophosphatemic rickets on MRI, (99m)Tc-MDP bone scan and (18)F-FDG PET/CT.
We present a case of a 13 years old boy who was hospitalized with a 10 months history of progressive pain and weakness in his lower extremities. The laboratory tests revealed slightly decreased phosphate and 25-hydroxyvitamin D3, high alkaline phosphatase, normal calcium and parathyroid hormone (PTH). Magnetic resonance imaging (MRI) showed multiple patchy lesions indicating bone destruction in the metaphyses and epiphyses of the left knee. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) revealed a generalized decrease of bone density in axial bones with slightly increased...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Fluorrine-18-fluorodeoxyglucose positron emission tomography/computed tomography of adult liver Langerhans cell histiocytosis.
CONCLUSION: We describe this case, to highlight the importance of (18)F-FDG PET/CT in differential diagnosis for the primary disease and the multiple liver nodules. PMID: 28315918 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research