Symmetric breasts metastatic prostate cancer shown by 68Ga-PSMA PET/CT scan.
Authors: Mokoala K, Lawal IO, Lengana T, Vorster M, Sathekge MM PMID: 30968861 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 12, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Radioiodine hot feet sign on post-ablation high dose of 131I of whole-body scan.
Authors: Huang CK, Chao KH, Wu J PMID: 30968862 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 12, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

68Ga tagged dendrimers for molecular tumor imaging in animals.
Authors: Wei X, Liu Z, Zhao Z Abstract Dear Editor, Angiogenesis is an essential physiological process that involves formation of new blood vessels from the pre-existing ones and is one of the fundamental processes required for normal growth and development. The ability to non-invasively evaluate angiogenesis might provide new insights into cancer biology pathway. This approach might lead to opportunities to more appropriately select patients likely to respond to anti-angiogenic drugs. Polyamidoamine dendrimers are a member of a versatile, new class of dendritic polymers and are the most well characterized and wide...
Source: Hellenic Journal of Nuclear Medicine - April 12, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Retrogenetic models of working memory: Preliminary multi-group analysis.
CONCLUSION: When we "keep" the educational level equal (low) for all, the hypothesis of retrogenesis is confirmed. Cognitive reserve appears to be protective, keeping differentiated WM's components in every age group other than that of kindergarten students. The results support the "retrogenetic" hypothesis, mainly due to the finding of a delay in WM components' development in the group of kindergarten students, and their dedifferentiation in the low-educated young-old and old-old adults. PMID: 30877719 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Differences between professional and non-professional drivers with cognitive disorders.
CONCLUSION: People with cognitive disorders and previous professional experience were better at driving than the inexperienced ones. PMID: 30877720 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Naringin nanoparticles against neurodegenerative processes: A preliminary work.
Authors: Nday CN, Eleftheriadou D, Jackson G Abstract It is well established that during Alzheimer disease (AD), gradual loss of neuronal networks occurs in the brain, consequently, affecting cognition and memory tasks of the patients. Among other causative factors, oxidative stress induces changes that are eventually accompanied by an irreversible disruption of synaptic connectivity and death of neurons. Moreover, aging and oxidative stress cause alterations to the blood brain barrier, leading to increased permeability, which are thought to further aggravate the underlying pathology. Up to date, no effective treat...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Magnetic chrysin silica nanomaterials behavior in an amyloidogenic environment.
Authors: Nday CN, Eleftheriadou D, Jackson G Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with brain damage induced by β-amyloid and tau accumulation. One of the hallmarks of amyloidogenesis, is the aggregation of amyloid proteins into a specific cross-β sheet structure, which alters their biological activity thereby affecting neuronal connectivity and function. Despite significant progress in the management of AD over the recent years, the early diagnostic and treatment options still remain limited. Recently, great attention has been focused on the advancement ...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Callosal Angle and Evans Index predict beta amyloid and tau protein in patients with dementia.
This study aims to investigate the correlation between EI, CA, Aβ and total tau in order to outline a basis of diagnostic evaluation for the patient's CSF biomarker profile. METHODS: Sixty-two (62) patients who presented with dementia symptoms participated in this study. Aβ and total tau levels in their CSF as well as CA and EI values from their MRIs were measured. Multiple regression was employed to predict Aβ and total tau values from EI and CA. From the Durbin-Watson analysis (d1=2.057, d2=1.881) we can assume that there is no first order linear auto-correlation in our multiple linear regression data....
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Health, Memory Complaints and Cognitive Performance in Older Adults: Relationship Analysis.
CONCLUSION: It seems that multimorbidity is related to the verbal fluency directly, but it was also found to be related to self-rated health which was also related to the cognitive performance. However, it doesn't seem to be related to the subjective performance. PMID: 30877724 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Cognitive decline in Multiple Sclerosis patients.
We present the results from the two-phases of our prospective study on cognitive decline in MS patients using the data collected from the A' Neurologic clinic at AHEPA hospital, Thessaloniki, Greece. Most of the patients of the present study revealed mild cognitive impairment with mild influence on the everyday function. We found weak correlation between cognitive deficit and the duration of MS, as well as the physical disability status and moderate correlation between cognitive impairment and the type of the disease as well as MRI findings (atrophy and lesion load). Our results also indicate that the currently available b...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Future strategies of management of Alzheimer's Disease. The role of homotaurine.
Authors: Tsolaki M Abstract Dementia and Alzheimer's Disease (AD) particularly will become in future one of the major problems that healthcare systems will have to face with in developed but also in developing countries, because of the progressive aging of the population and the age-associated increase in their incidence. There is a rapid increasing in life expectancy and in elderly percentage. Unfortunately, improvements in lifespan have not been matched by improvements in mental health span. In recent years, there has been a growing interest, supported by a large number of experimental, epidemiological and clinic...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Hereditary causes of ischemic cerebral small vessel disease.
Authors: Paraskevas GP Abstract Hereditary types of ischemic cerebral subcortical small vessel disease (SSVD) are rare, usually autosomal dominant, diseases, due to an abnormality in vessel wall synthesis. They may present with various combinations of migraine with aura, ischemic events (transient ischemic attacks, lacunar strokes) and progressively worsening ischemic lesion load in brain imaging. Eventually, vascular cognitive impairment (usually of the frontal-subcortical type) develops, frequently accompanied by behavioral-psychiatric symptoms and bilateral pyramidal and pseudobulbar signs leading to severe disa...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Cognitive functions and social cognition in multiple sclerosis: An overview.
Authors: Giazkoulidou A, Messinis L, Nasios G Abstract Cognitive decline has been widely reported in patients with multiple sclerosis (MS) despite its clinical heterogeneity, at all stages and in all subtypes of the disease. Deficits are most commonly present in attention, processing speed, working memory, verbal fluency and executive function. However, MS patients also show decreased performance in tasks related to social cognition, i.e. mental operations thatdrive interpersonal skills such as social perception, empathy and theory of mind. Social cognitive deficits are an underestimated but important aspect of imp...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Comparison of two electronic screening tests (culturally neutral & culturally customized) for major and minor neurocognitive disorders.
Comparison of two electronic screening tests (culturally neutral & culturally customized) for major and minor neurocognitive disorders. Hell J Nucl Med. 2019 Jan-Apr;22 Suppl:111-122 Authors: Solias AA, Chaldogeridis AE, Batzikosta AV, Tsolaki M Abstract INTRODUCTION: While attempting to test the population for Mild and Major Neurocognitive Disorders (M. - M. N.D.) there are tests in conventional and electronic form which are applied. However, a large proportion of elderly avoids being tested as the process itself causes stress and fatigue. The structure of the tests is often irrelevant to the expe...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Ageing and Down syndrome: Neurocognitive characteristics and pharmacological treatment.
Authors: Malegiannaki AC, Katsarou D, Liolios A, Zisi V Abstract Individuals with Down Syndrome (DS) are commonly characterized by unique neurocognitive and neurobehavioural profiles that emerge within specific stages in the developmental continuum. A plethora of studies have confirmed DS's relationship to premature aging and subsequent cognitive decline. Due to having three copies of the amyloid precursor protein (APP) gene which results in amyloid-beta plaque deposition, the cognitive decline often resembles the decline observed in Alzheimer's disease. More specifically, as individuals with DS mature in age (>...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Speech and language intervention for language impairment in patients in the FTD-ALS spectrum.
Authors: Kiousi V, Arnaoutoglou M, Printza A Abstract Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease that belongs to the group of motor neuron diseases. Motor deficits like reduce in tongue strength, may coexist with cognitive deficits compatible with frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD). FTD is a neurodegenerative syndrome with two main clinical variants: behavioral (bvFTD) and language or Primary Progressive Aphasia (PPA). ALS and FTD have significant clinical and neuropathological overlapping so that for some researchers they are ...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Robust regional cerebral blood flow perfusion deficits in relapsing-remitting multiple sclerosis patients with executive function impairment.
CONCLUSION: Cerebral hypoperfusion is an integral feature of MS pathology. Executive dysfunction is associated with robust cerebral perfusion deficits in the frontal and prefrontal cortex of cognitively impaired RRMS patients. PMID: 30877732 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Are left angular gyrus and amygdala volumes important for financial capacity in mild cognitive impairment?
CONCLUSION: Financial capacity in Greek aMCI patients strongly correlates with right amygdala and left angular gyrus volumes, a finding that supports that emotion as well arithmetic skills are involved in financial capacity, while the importance of MMSE as the only neuropsychological test with the strongest positive correlation is discussed. PMID: 30877733 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Removing muscle artifacts from EEG data of people with cognitive impairment using high order statistic methods.
CONCLUSION: The proposed method overcomes with the need of removing muscle artifacts on both realistic simulated EEG data and brain activity from people with cognitive impairment. PMID: 30877734 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Cerebellar pathology in Alzheimer's disease.
Authors: Mavroudis I Abstract Alzheimer's disease (AD) is one of the main causes of dementia in the western world. It is clinically characterized by memory impairment, deterioration of intellectual faculties and loss of professional skills. AD brains exhibit significant atrophy, predominantly in the temporal and parietal lobes, while light microscopy reveals deposition of senile plaques and neurofibrillary degeneration initially in the entorhinal cortex, the hippocampus, and in the acoustic and visual cortices, in the frontal lobe and the cerebellum in the advanced stages. Dendritic and spinal pathology, as well as...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The self in Alzheimer's Disease' A Case Study with Implications for Life Quality.
Authors: Sarafidou S Abstract In neurodegenerative disorders such as dementia of the Alzheimer's type the person gradually loses skills and aspects of everyday living. Does that indicate that he/ she lose the self? In the past it was widely accepted that the self diminishes in dementia, until it is lost in the latest stage, yet in the recent years this premise has been challenged. Accepting that the self is "lost" can be problematic theoretically in the approach of self-hood, and practically in the care of individuals. Currently a novel perspective is "gaining ground" supporting the existence of...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Biochemical diagnosis of vascular cognitive impairment associated with subcortical small vessels disease.
Authors: Liakakis G Abstract Subcortical small-vessel disease (SSVD) is a disorder that has been fully described in clinical, neuropathological and imaging aspects. It is considered as the most prevalent ischemic CNS disorder and has been associated to arterial hypertension, diabetes mellitus, dyslipidemia and obstructive sleep apnea. The hallmark of SSVD is the ischemic white matter lesions which can be presented as lacunar infracts and global brain hypoperfusion in a common and homogeneous subtype of vascular cognitive impairment (VCI) which is often unrecognized. The special nature and course of SSVD offers the ...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

[Technical characteristics of Alzheimer model based on organ technology (organoid)].
Authors: Tzekaki E, Tsolaki M, Pantazaki A Abstract Alzheimer's disease (AD) is a serious neurodegenerative disorder that manifests itself as progressive damage to memory and knowledge and is the main cause of dementia in the elderly. AD is characterized by extracellular deposition of amyloid-β plate (Aβ) and by the formation of neurofibrillary tangles, composed of hyperphosphorylated Tau protein. These modifications lead to neuronal cell death, vascular dysfunction and inflammatory disorders. Described as "elderly disease", AD is an escalating threat to developed countries as life expectancy is...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

[Bioinks and in vitro neurovascular unit production - New prospects in Alzheimer's disease research].
Authors: Lougiaki P, Tsolaki M, Pantazaki A Abstract Neurovascular dysfunction is a central process in the pathogenesis of the stroke and most neurodegenerative diseases, including Alzheimer's disease. The multi-cell neurovascular unit (NVU) combines the components of the neural, vascular and extracellular matrix (ECM) into an important interface whose proper function is critical to maintaining brain health. Tissue engineering now offers new tools and information to promote understanding of NVU's operation. A promising area for the development of NVU models is their bio-production through 3D bio-printing to produce...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Sickle cell diseases: What can nuclear medicine offer?
Authors: Niccoli Asabella A, Altini C, Nappi AG, Lavelli V, Ferrari C, Marzullo A, Loiodice A, Rubini G Abstract Sickle cell disease (SCD) is the best known haemoglobinopathy, caused by a mutation substituting valina for glutamic acid at position 6 of the beta-globin chain of adult hemoglobin A, resulting in hemoglobin S (HbS). The homozygous HbS disease (HbSS), an autosomal recessive disorder, is the most common form and the Mediterranean area, along with sub-Saharian African and India, have the highest prevalence (1%-15%). In particular, Sicily with a prevalence of 2%-5%, is among the most interested regions. How...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The role of 18F-FDG PET in the assessment of a benign hematological disorder: polycythemia.
Authors: Ayubcha C, Hosoya H, Seraj SM, Zadeh MZ, Werner T, Alavi A Abstract Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging was conceived in the early 1970 by investigators at the University of Pennsylvania as a research technique to measure brain metabolism and function by employing a non-invasive imaging approach. Soon after the introduction of whole-body PET instruments, 18F-FDG was utilized in the assessment of a variety of solid tumors and certain hematological malignancies. Yet, the role of 18F-FDG in assessing benign and uncommon malignant disorders of the bone marrow has n...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

More advantages in detecting bone and soft tissue metastases from prostate cancer using 18F-PSMA PET/CT.
Authors: Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE Abstract Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Imaging of BM is important not only for localization and characterization, but also to evaluate their size and number, as well as to follow-up the disease during and after therapy. Bone metastases format...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Circulatory system and neurosciences. Some perspectives in diagnosis and treatment.
Authors: Grammaticos PC, Baloyiannis SJ, Kokkas V Abstract This paper aims to describe how radial artery obstruction can support blood circulation in an ischemic area. A dramatic case is described. Furthermore aims to describe that fatigue, atherosclerosis and toxic substances like in alcoholism may reduce blood flow and energy supply in the cortex and other brain areas and thus unconsciously modify our usual civilized behavior. Intense mental and physical fatigue was described as: "vital exhaustion". PMID: 30843004 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta.
Authors: Arani LS, Gharavi MH, Zadeh MZ, Raynor WY, Seraj SM, Constantinescu CM, Gerke O, Werner TJ, Høilund-Carlsen PF, Alavi A Abstract OBJECTIVE: We aimed to assess the feasibility of quantifying fluorine-18-fluorodexoglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) uptake in abdominal aorta and examine their association with age and cardiovascular risk factors. SUBJECTS AND METHODS: Our study comprised 123 subjects (48±14 years of age, 62 men) including 78 healthy volunteers and 45 patients with chest pain syndrome, who originally enrolled in the CAMONA study in Odense, Denmark (NCT01724749...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Investigation of appropriate semi-quantitative index for assessment of esophageal and breast cancer treatment response in Japanese patients using 18F-FDG PET/CT findings.
Authors: Tsuchitani T, Takahashi Y, Maeda Y, Oda M, Enoki T, Kotoura N, Kitajima K Abstract OBJECTIVE: To examine the correlation of the quantitative indexes standardized uptake value (SUV), SUV corrected for lean body mass (SUL) and SUV corrected for Japanese lean body mass (SULj) with body weight to develop an appropriate quantitative index independent of body weight fluctuation for assessment of response to cancer treatment in Japanese patients. SUBJECTS AND METHODS: Fifty-six males with esophageal cancer and 30 females with breast cancer underwent fluorine-18-fluoro-2-deoxy-D-glucose (18F-FDG) positron emis...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Prognostic value of 18F-FDG PET/CT prior to breast cancer treatment. Comparison with magnetic resonance spectroscopy and diffusion weighted imaging.
Authors: Kitajima K, Yamano T, Miyoshi Y, Katsuura T, Enoki T, Yamakado K Abstract OBJECTIVE: To investigate the prognostic value of pretreatment fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), magnetic resonance spectroscopy (MRS), and diffusion weighted imaging (DWI) in breast cancer patients. SUBJECTS AND METHODS: Eighty-three patients who had a tumor larger than 2cm shown by 18F-FDG PET/CT and by 3-Tesla breast MRI, received neoadjuvant chemotherapy (NAC) and subsequent surgical resection. Relationships of PET parameters, including maximum standardized uptak...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Comparison of ultrasound and digital mammography plus tomosynthesis in determining benign and malignant breast lesions using pathology as a gold standard, in 102 Chinese women.
This study was to evaluate performance characteristics of ultrasonography (US) and a combined two-and three-dimensional (2D+3D) digital mammography in identifying breast tumors in Chinese women. SUBJECTS AND METHODS: One hundred and two women with suspected breast tumors were examined using diagnostic imaging techniques of US and a combined 2D+3D imaging protocol. Detection of breast tumors in women with and without dense breasts was validated according to the features of image-detected breast tumors which were proven by histological exam in this study cohort. RESULTS: Breast US was superior to 2D+3D imaging in ass...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Stimulation of antioxidant machinery in rats by low dose ionizing radiation: a concept of radiation hormesis.
CONCLUSION: Low doses of X-rays exposure may afford radiation hormesis by providing protection to organs from oxidative injury and support immune reaction. PMID: 30843009 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Semi-quantification of the minimum detectable difference of imaging quality of gamma camera SPET for four radionuclides via an innovative PMMA phantom with a V-shaped slit: interpretation of a feasibility study.
CONCLUSION: The proposed new combination of PMMA phantom with a V-slit and the revised Student's t-test proved to be instrumental in the MDD of SPET optimization analysis. PMID: 30843010 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The importance in diagnosing patients with conflicting observational data for post surgery radioiodinated ablation.
CONCLUSION: If a patient has ≤6.57ng/mL pre-ablative Tg, follow-up intervals of patients with "COD for PSRIA" may be extended due to lower recurrence/relapse rates. However, if a patient has>12.7ng/mL pre-ablative Tg, these patients should be followed-up more frequently in order to determine SIR earlier. This approach may enable more efficient use of medical facility and healthcare system resources and a more scientific planning of their follow-up treatment. This approach seems to have the potential to contribute significantly to cost-effectiveness. PMID: 30843011 [PubMed - as supplied by publisher] (So...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Factors suggesting relapse of Grave's disease after first radioiodine therapy. Analysis of 607 cases.
Authors: Li J, Zhang L, Zhang Z, Liu J, Zhang H, Lin X, Jiang N Abstract OBJECTIVE: Despite the effectiveness of radioiodine therapy (RIT), a few patients are refractory and show relapse, warranting repeated RIT (RRIT). The purpose of this study is to explore the risk factors for RRIT. SUBJECTS AND METHODS: We retrospectively analyzed 607 cases treated with iodine-131 (131I) between January 2013 and June 2016. Patients were categorized into two groups: RRIT (n=76) or non-RRIT (n=531). Univariate analysis and a final multivariate model were used to determine the risk factors for RRIT. P0.05). Anti-thyroid drug (...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Diagnostic utility of 18F-FDG PET/CT with very high SUV levels in patients with FUO end-stage renal disease and treated with renal replacement therapy.
CONCLUSION: About half of the 18F-FDG-PET/CT scans (22/46) identified the cause of FUO in patients on RRT for ESRD. The clinical utility of 18F-FDG PET/CT in this group of patients is comparable to its average performance in the unselected patients' population evaluated for FUO. A higher CRP level was predictive of a positive 18F-FDG PET/CT outcome. PMID: 30843013 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Unsuspected reduced radiochemical purity of the 18F-FDG may decrease image resolution, SUV reliability and diagnostic accuracy.
Authors: Kim ST, Yong CS, Han EO Abstract OBJECTIVE: Our aim was to identify the conditions required to stably maintain the radiochemical purity of fluorine-18-fluorodeoxyglucose (18F-FDG) above the Korean Pharmacology (KP) and United States Pharmacology (USP) standards for expiration time (time from the end of synthesis (EOS), 8h even at a high radioactive concentration exceeding 7.4GBq/mL. SUBJECTS AND METHODS: The changes in the radiochemical purity of 18F-FDG were assessed according to the changes in radioactive concentration, ethanol (EtOH) concentration, amount of water for dilution storage temperature, a...
Source: Hellenic Journal of Nuclear Medicine - December 12, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Equilibrium radionuclide ventriculography: still a clinically useful method for the assessment of cardiac function?
Authors: Sachpekidis C, Sachpekidis V, Moralidis E, Arsos G Abstract 18 The non-invasive assessment of left ventricular function with simple indices, such as left ventricular volumes and ejection fraction (LVEF), offers significant diagnostic and prognostic implications in the entire spectrum of cardiac diseases. Equilibrium radionuclide ventriculography (RNV) is a well validated technique for this purpose. Based on the principle that the amount of radioactivity emitted by technetium-99m (99mTc)-pertechnate labeled erythrocytes in the cardiac chambers is proportional to the amount of bloodcontained, reproducible an...
Source: Hellenic Journal of Nuclear Medicine - December 12, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Is fluorine-18-fluorocholine PET/CT suitable for the detection of skeletal involvement of multiple myeloma?
Authors: Meckova Z, Lambert L, Spicka I, Kubinyi J, Burgetova A Abstract Our limited experience suggests that fluorine-18-fluorocholine (18F-FCH) may perform better in the detection of skeletal involvement by multiple myeloma compared to fluorine-18-fluorodeoxyglucose (18F-FDG) and that standard uptake ratio (SUR) might be considered in the semi-quantitative comparison of tracer uptake. PMID: 30411725 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Comparison of atherosclerotic inflammation and calcification in subjects with end stage renal disease (ESRD) on hemodialysis to normal controls utilizing 18F-FDG PET/CT.
Authors: Bural GG, Torigian DA, Sözmen M, Houseni M, Alavi A Abstract OBJECTIVE: Subjects with end stage renal disease (ESRD) are exposed to increased morbidity and mortality due to cardiovascular events. The primary underlying mechanism has been suggested as accelerated atherosclerosis in these patients. Our aim was to compare the atherosclerotic inflammation and calcification in subjects with ESRD on hemodialysis to that in normal controls utilizing fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT). SUBJECTS AND METHODS: Forthy two subjects who under...
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Normal patterns of regional brain 18F-FDG uptake in normal aging.
This study was part of the cardiovascular molecular calcification assessed by 18F-sodium fluoride (NaF) (CAMONA) PET/computed tomography (CT) study. This study was approved by the Danish National Committee on Health Research Ethics registered at ClinicalTrials.gov (NCT01724749). Forty normal healthy subjects were prospectively recruited in group A (22-32 years) and B (56-75 years) and underwent 18F-FDG PET/CT. Static images were obtained 180 minutes following 18F-FDG injection. Supratentorial (including individual measurements for frontal, parieto-occipital and temporal lobes) and cerebellar 18F-FDG uptakes were measured b...
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Efficacy of 18F-FDG and 18F-NaF PET/CT imaging: A novel semi-quantitative assessment of the effects of age and obesity on hip joint inflammation and bone degeneration.
CONCLUSION: Body mass index had a significant impact on 18F-FDG and 18F-NaF uptake, whereas age had no correlation with either tracer uptake. Obesity increases the mechanical forces applied on weight-bearing joints such as the hip. Body mass index was related to increased joint inflammation and bone degeneration. These findings further support the studies explaining the role of adipose tissue in promoting OA. PMID: 30411728 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

18F-FDG PET/CT in therapy response and in predicting responders or non-responders in malignant pleural mesothelioma patients, by using semi-quantitative mRECIST and EORTC criteria.
CONCLUSION: The semi-quantitative analysis of 18F-FDG PET/CT has an important role in MPM therapy response assessment and has a predictive role in distinguishing responders and non-responders. PMID: 30411729 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An overview of the neurosurgical implications, pathophysiology, diagnosis and recent treatment strategies for Grade IV idiopathic osteolysis, also known as Gorham-Stout or phantom bone disease.
CONCLUSION: We included early in the investigation protocols a total body fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) scan that was extremely helpful to promptly rule out malignant or infective nature of osteolysis. An update on the diagnostic and management options available for GSD, with particular reference to the role of nuclear medicine and the latest clinical trials from international patients registries and classification of idiopathic osteolysis is provided. PMID: 30411730 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Tc-99m-PSMA imaging allows successful radioguided surgery in recurrent prostate cancer.
Authors: Kratzik C, Dorudi S, Schatzl M, Sinzinger H Abstract OBJECTIVE: The introduction of the prostate specific membrane antigen (PSMA) offers the possibility to discover prostate cancer recurrences being frequently so small that they cannot be detected by conventional imaging modalities, such as magnetic resonance or computed tomography. SUBJECTS AND METHODS: A 78 years old patient after radical prostatectomy and lymphadenectomy suffered from recurrence of the disease and galium-68-PSMA (68Ga-PSMA) showed a single hot spot. Therefore, the first time in this indication in Austria radioguided surgery was perf...
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Osteoarticular tuberculosis in children. A fast reappearing disease diagnosed by 18F-FDG PET/CT and other modalities. The cover page of Nicholas Andry booklet L' Orthopedie.
Authors: Xia Y, Papadopoulos N, Chen Y, Zhao Y Abstract Osteoarticular tuberculosis (OAT) is not uncommon in children. Early diagnosis and treatment are essential to avoid ultimately long-term disabilities. Nicolas Andry (1658-1742) gave for the first time the name of the specialty of Orthopedics (L'Orthopedie) and its symbol of the crooked tree, in a paper in which he suggested how to avoid and to treat rachitis in children. We review the correlative-imaging findings and provide insights regarding the strengths and limitations of the conventional imaging modalities and those of nuclear medicine for the diagnosis o...
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Images in two prostate cancer patients of second primary cancers: Hodgkin's lymphoma and lung adenocarcinoma.
Authors: Cegla P, Wierzchoslawska E, Marszalek A, Gwozdz S, Cholewinski W Abstract Hodgkin's lymphoma and lung adenocarcinoma as second primary cancers in prostate cancer (PC) patients although are rare should be considered as important for the future of the PC patients. PMID: 30411733 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 11, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Technetium-99m-pertechnetate whole-body SPET/CT scan in thyroidectomized differentiated thyroid cancer patients is a useful imaging modality in detecting remnant thyroid tissue, nodal and distant metastases before 131I therapy. A study of 416 patients.
CONCLUSION: Our findings suggested that 99mTc WBS is a useful imaging modality in detecting remnant thyroid tissue, nodal and distant metastases before 131I therapy. The additional SPET/CT scan when needed in 18 cases supported the 99mTc WBS diagnosis. PMID: 30089313 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - August 12, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Whole body bone SPET/CT can successfully replace the conventional bone scan in breast cancer patients. A prospective study of 257 patients.
Authors: Mavriopoulou E, Zampakis P, Smpiliri E, Spyridonidis T, Rapti E, Haberkorn U, Makatsoris T, Apostolopoulos DJ Abstract OBJECTIVE: Single photon emission tomography/computed tomography (SPET/CT) is usually recommended after ambiguous whole body bone scan (WBS) findings. We investigated the value of routine 2-field ("near" whole-body) SPET/CT application in breast cancer (BC) patients. SUBJECTS AND METHODS: In this prospective study planar WBS and 2-field SPET/CT was performed in 257 consecutive BC patients referred for a bone scan. Whole body scan and SPET/CT were interpreted separately. Addit...
Source: Hellenic Journal of Nuclear Medicine - August 12, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research