In-hospital management of elderly patients undergoing myocardial perfusion scintigraphy.
Authors: Štalc M, Jerman N, Trampuš M, Dolenc Novak M, Gužič Salobir B Abstract OBJECTIVE: To investigate the impact of myocardial perfusion scintigraphy results on the decision for invasive coronary angiography in elderly patients (≥75 years) with suspected coronary artery disease hospitalized in a single tertiary medical center. SUBJECTS AND METHODS: In the retrospective study, data of 276 (136 elderly) consecutive hospitalized patients referred to myocardial perfusion imaging were analyzed. The clinical characteristics, myocardial perfusion scintigraphy results, invasive coronary angiograp...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Baseline quality of life predicts overall survival in patients with mCRPC treated with 223Ra-dichloride.
Authors: Frantellizzi V, De Feo MS, Di Rocco A, Pontico M, Pani A, Farcomeni A, Cosma L, Lazri J, De Vincentis G Abstract OBJECTIVE: The prognostic value of baseline clinical parameters in predicting the survival prolonging effect of radium-223-dichloride (223Ra)-therapy in metastatic castration resistant prostate cancer (mCRPC) patients is still an open issue. The aim of this study was investigating the impact of baseline quality of life (QoL) on overall survival (OS) in mCRPC patients treated with 223Ra. The present study also evaluated the trend of patient-reported QoL during both 223Ra-treatment and post-therap...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Comparison of 99mTc-MIBI planar scintigraphy, SPET/CT and ultrasonography in detection of parathyroid adenoma in patients with primary hyperparathyroidism.
CONCLUSION: The combined use of US and SPET/CT has incremental value in accurately localizing PA over either technique alone. In the preoperative assessment of patients with PHPT combination of imaging methods allows selection of patients who would be suitable for minimally invasive surgery. PMID: 32222728 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Investigating the theragnostic potential of 131I-caerin peptide in thyroid cancer.
CONCLUSION: Iodine-131-Caerin can inhibit the cell viability of thyroid cancer and hold certain promise as a theragnostic tool for human thyroid cancers. PMID: 32222729 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Diffusion-weighted MRI, 11C-choline PET/CT, and 18F-FDG PET/CT for predicting the Gleason score in prostate cancer.
CONCLUSION: Carbon-11-choline PET was found have a greater correlation with Gleason score than DWI and is considered to be more useful to predict a higher score in patients with prostate cancer. Fluorine-18-FDG PET was limited because of low sensitivity. PMID: 32222730 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Typical and atypical PET/CT findings in non-cancerous conditions.
Authors: Altini C, Lavelli V, Ruta R, Ferrari C, Nappi AG, Pisani A, Sardaro A, Rubini G Abstract Nuclear Medicine multimodality imaging, such as positron emission tomography/computed tomography PET/CT, refers to metabolic tissue characteristics integrated with anatomical details. Fluorine-18-fluorodeoxyglucose (18F-FDG) is the most diffuse radiopharmaceutical and its application is spreading beyond the area of oncology. The causes of high 18F-FDG uptake that were once considered false positives have been identified and the new knowledge about them led to non-cancerous pathologies that can be studied by 18F-FDG PET...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

18F-FDG PET/CT in treatment response evaluation of Burkitt lymphoma: complete remission of a peritoneal super scan.
Authors: Sachpekidis C, Exadaktylou P, Katsampoukas D, Moralidis E, Arsos G Abstract Peritoneal lymphomatosis, defined as the disseminated intraperitoneal lymphomatous infiltration, is a rare presentation usually of non-Hodgkin lymphoma and is associated with aggressive histological subtypes of the malignancy. Recently, the term "peritoneal super scan" has been introduced in positron emission tomography/computed tomography (PET/CT) in a patient with Burkitt lymphoma to describe hypermetabolic lymphomatous involvement of the entire peritoneum, leading to suppression of tracer uptake in organs with otherwis...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

All that glitters is not prostate cancer: incidental finding of PSMA-avid meningioma.
We present a case of a 79 year old patient with a medical history of unilateral nerve-sparing radical prostatectomy due to a pT3aN0 (Gleason score 7) prostate carcinoma. Because of slightly elevated prostate specific antigen (PSA) level (0.35ng/dL), a fluorine-18-prostate specific membrane antigen (18F-PSMA)-1007 positron emission tomography/computed tomography (PET/CT) scan was performed, showing no signs of malignant recurrence. However, a moderately PSMA-avid nodular lesion was observed in the left occipital region with homogeneous contrast enhancement, suggestive for a meningioma, which was confirmed on magnetic resona...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A case of jejunal neurofibroma in von Recklinghausen's disease with active hemorrhage, detected and located with gastrointestinal bleeding scintigraphy: A case report with literature review.
Authors: Stević M, Vlajković M, Veličković F, Stanojević G, Nestorović M, Petrović F Abstract A 69 year old patient was admitted to hospital with massive gastrointestinal hemorrhage. The clinical presentation of the patient, except for bleeding, was dominated by the presence of neurofibromatosis type 1 - Von Recklinghausen disease. The patient was referred to multislice computed tomography (CT) angiography, magnetic resonance imaging (MRI), esophagogastroduodenoscopy and colonoscopy, which were performed without successful detection of the bleeding site. The MRI examination showed the existence of a tumor lo...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A rare primary pleural squamous cell carcinoma demonstrated on 18F-FDG PET/CT.
We presented a rare case of primary pleural squamous cell carcinoma (SCC) on fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). It manifested as multiple pleural nodules with moderate 18F-FDG uptake and massive pleural effusion on PET/CT. The pathology result supported the primary squamous cell carcinoma. Our case highlighted the SCC should be included as differential diagnosis of the multiple pleural lesions and other differential diagnosis consisted of mesothelioma, solitary fibrous tumor, metastases. PMID: 32222735 [PubMed - as supplied by publisher] (Source: Hellenic J...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Synchronous bilateral clear cell renal cell carcinoma and prostate gland carcinoma on 18F-FDG PET/CT in one patient.
We present a case of synchronous bilateral renal cell carcinoma and prostate carcinoma in a 62 year old man. In a fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) scan, the left renal mass showed intense 18F-FDG uptake with maximum standardized uptake volume (SUVmax) of 8.12, while uptake in the right renal mass was minimal with SUVmax of 2.99. Fluorine-18-FDG uptake in the prostate gland lesion was moderate with SUVmax of 4.19. Histopathologically, both renal tumors were clear cell renal cell carcinoma with International Society of Urological Pathology (ISUP) Grade 2 and 3 for the right and left k...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Intense uterine activity on whole body 18F-FDG PET/CT due to attenuation artifact.
Authors: Cheng J, Ou X PMID: 32222737 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

131I accumulation in oligodendroglioma: before and after surgery.
Authors: Cao L, Yang F, Li S, Xie J PMID: 32222738 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Glucose and lipid abnormalities in patients with adrenal incidentalomas.
Authors: Vukomanovic VR, Ignjatovic VD, Mihaljevic O, Vuleta K, Matovic MD Abstract Adrenal incidentalomas (AI), defined as masses detected during imaging procedures of non-adrenal disorders, have become a common clinical problem that appear to have impairment of glucose and lipid metabolism. PATIENTS AND METHODS: One hundred and ten patients (mean 53.5 age; 24-72), who were diagnosed with functioning and non-functioning AI, were assessed. Patients with hormone-secreting AI underwent biochemical evaluation regarding metabolic disorders. Data about hormone status (cortisol profile and DEX screening test), lipid ...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Analyzing social cognition and understanding of social inferences in patients with multiple sclerosis. A comparative study.
CONCLUSION: The level of Theory of Mind in the form of sarcasm understanding decreases significantly in MS patients compared with healthy group potentially mirroring impairment in ToM in general. The results indicate that MS group is not resilient to understand metaphoric speech. More specifically, their pathology seems to be able to affect complex ToM abilities. PMID: 31802039 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Think big - Plastic surgical treatment of complicated large sacral ulcerations: A case comparison.
CONCLUSION: Using a fillet flap of the lower extremity to cover large sacral ulcers is often the last possibility of surgical treatment. Though many complications can occur, full rehabilitation and social participation is possible after fillet flap surgery even with loss of both legs. Depending on patient's motivation and availability of orthopedic technology like special electric wheel chairs and other tools full mobility can be achieved. PMID: 31802040 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A critical survey of a dedicated craniofacial surgery outpatient's clinic within a public health service structure.
Authors: Foroglou P, Farmakis G, Antoniou A, Demiri E Abstract The management of craniofacial conditions, especially in the setting of a large general hospital, is ideally achieved by a focused team in a multidisciplinary clinic. The purpose of this article was to present the design, modus operandi and outcomes of a newly formed dedicated craniofacial multidisciplinary outpatients' clinic at the first year of operation endpoint within a public healthcare structure. PMID: 31802041 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Cardiotoxicity among adult survivors suffered from childhood malignancies.
Authors: Petropoulos AC, Moschovi M Abstract Late cardiotoxicity following treatment of malignancy diseases has been long established. Cancer therapeutics-related cardiac dysfunction (CTRCD), acute arrhythmias, pericardial disease, valvopathies and early atherosclerotic Cardiovascular Disease (CVD), are the clinical presentations of cardiotoxicity. Although these clinical modalities can affect adults treated for malignancies, they are more common to present in the pediatric survivors as improvement of prognosis, nowadays exists. Studies have shown that CVD can present earlier than thirty years, post treatment. If a...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A study about neck pain on active population who visit Primary Health Centers.
Authors: Petala E, Mironidou-Tzouveleki M, Nanassis K, Pagkalidou E, Kyriakou C, Kapoukranidou D Abstract BACKGROUND: Cervical pain is very common among population and several methods have been used until now in order to evaluate it. The main aim of this study is to estimate the prevalence of non-specific neck pain and the special features of it through its relation to demographic agents, habits and physiology parameters. Additionally, this study aims to select the most valid and objective methods for neck pain evaluation, which could also be useful in Primary Health Care and could give new prospectives. METHOD...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Factors influencing corneal predescemetic endothelial keratoplasty (PDEK) graft creation: It's all in a bubble.
CONCLUSION: In young donors pneumatic (air) graft dissection leads to PDEK in a high proportion. This percentage is reduced when transport medium is tried after unsuccessful air injection. Injection of transport medium increases the percentage of grafts harvested but also increases the ratio of Type II and III DMEK grafts created. PMID: 31802044 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Functional and anatomic results of up to 24 months aflibercept treatment for diabetic macular edema in real-life setting.
CONCLUSION: Aflibercept resulted in significant functional and anatomic improvement after 12- and 24-month treatment in diabetic macular edema eyes in a real-life setting. The majority of the eyes completed the 2-year treatment regimen of aflibercept. PMID: 31802045 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Visual and anatomic outcomes of aflibercept treatment in treatment-naive patients with neovascular age-related macular degeneration; real-life data over 24 months.
CONCLUSION: Treatment with intravitreal injections of aflibercept in a real life setting resulted in a significant improvement in BCVA at 12 months and in a significant anatomic restoration throughout the 24-month follow-up. PMID: 31802046 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

New application of membrane blue-dual dye for retinal or iatrogenic break staining in retinal detachment surgery.
CONCLUSIONS: The greatest advantage of use of this "heavy" dye solution membrane blue-dual is improved intraoperative identification of ILM at the edges of retinal breaks and the discrimination of them from surrounding intraocular structures. Due to its increased molecular weight and viscosity properties it eliminates the need for fluid-air exchange, injection of PFCL or subretinal injection. PMID: 31802047 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Novel smartphone assisted device for neurotargeting.
CONCLUSIONS: This smartphone application coupled with targeting device can be used in various settings such as EVD placement in hydrocephalus and in other brain targeting candidates in emergency settings. Also, it may be used in any emergency or neurosurgery department centers with no access to advanced neuro-imaging facilities, only using patient's simple cranial measures to achieve acceptable and highly accurate brain targeting compared with conventional, time consuming and costly techniques. We plan to expand this study to clinical trials for further evaluation. PMID: 31802048 [PubMed - in process] (Source: Hellenic...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Conscientious objection in health care: A principlism-based compromise position.
CONCLUSION: On the basis of the bioethical principle of mutuality the paper provides a proposal in two steps for obtaining a normatively reasonable (if not true) compromise position. PMID: 31802049 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The importance of postoperative analgesia after major thoracic surgery interventions, protocols, applications, and the following evaluation of the patient's quality of life.
CONCLUSIONS: The measure of a "QoL" index is widely taken into account as one of the most accurate indicators of a patient's health evolution. The results supply us with significant information which is added to the initial management strategy, mainly regarding pain symptomatology and eventual complications and discomforts, while they indicate us towards a thorough realization of each patient's "follow up" individually and the achievement of an optimal Quality of Life level. PMID: 31802050 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Glial and neuroaxonal biomarkers in a multiple sclerosis (MS) cohort.
We present normally distributed variables using means and standard deviations and non-normally distributed variables using medians along with their ranges. Spearman's correlation coefficients were used to analyse correlations between the CSF's biomarker concentrations, and both unadjusted and Bonferroni adjusted p-values are reported. Orthogonal projection to latent structure discriminant analysis (OPLS-DA) was also used to find differences in terms of CSF metabolites between the relapsing and remitting patients [CIS, RR, PR versus PP, SP patients]. The OPLS-DA algorithm finds the projection direction, score vector, that g...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Elders and mental capacity: Using a qualitative approach to examine views on independence and protection across the Balkans.
CONCLUSION: The similarities and differences among these three ethnic groups are discussed, which according to the interviewees discourse reveal peculiar cultural understandings about subordinate themes such as power and its relationship to the self and superordinate themes on emotional control, choice, and individualism. PMID: 31802052 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Impact of reconstruction parameters on quantitative bone SPECT imaging: A novel thoracic spine phantom study.
CONCLUSION: Our results indicated that the quantitative accuracy of bone SPECT images was affected by reconstruction parameters. It is important to optimize the reconstruction parameters, and improve quantitative accuracy in bone SPECT imaging. PMID: 31802053 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Basic study of random sampling for compressed sensing using MRI simulator.
CONCLUSION: The method of numerical simulation with the MRI simulator using a phase map was close to the actual conditions and was considered to be useful for the validation of new sampling methods. The random sampling method using GH is expected to be useful for the highly efficient acquisition of data under ideal conditions; however, more accurate phase correction is necessary to apply the actual measurement data. PMID: 31802054 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Use of amyloid PET/CT with 18F-Florbetaben in the management of patients with Alzheimer's disease.
CONCLUSION: The low agreement between amyloid PET/CT and previous clinical and instrumental assessments that we found in our study suggests that the amyloid PET/CT provides additional and early information. To perform an early and differential diagnosis of AD could have a great impact on the patient's management and cost of care in order to perform the correct therapeutic interventions and to allow family members to manage adequately the patient's demanding care. PMID: 31802055 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Impact of pre-treatment variables on the completion of 223radium-dichloride therapy in mCRPC patients with bone metastases.
CONCLUSION: Our preliminary analysis demonstrates that the high tumor burden represents the most important pre-treatment factor that could affect treatment completion and that needs to be considered before starting 223Ra-therapy to achieve a better outcome in mCRPC patients. PMID: 31802056 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The paleoradiology importance in the study of relics: the unique densitometric analysis of a bone relic of Saint Nicholas.
CONCLUSION: For this first DXA analysis of the rib relic of Saint Nicholas was necessary a long and complex experimental work to modify standard technique procedure to particular and unusual sample and Create specific supports and complementary instruments. Perform DXA analysis on relics permit to obtain additional information to living conditions, economical situation, behaviours, diet, diseaes, conservations conditions of remains, change of life style in different age. Our experimental work, the first of its kind, creates the way to analyze precious relics that often include only few bone fragments and data obtained by o...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Will Rogers phenomenon in the oesophageal cancer patients staging - CT versus 18F-FDG PET/CT: retrospective study.
CONCLUSION: In this material, the 18F-FDG PET/CT seems to be more accurate in terms of staging in case of the oesophageal cancer TNM classification. PMID: 31802058 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Administration of the extra virgin olive oil (EVOO) in mild cognitive impairment (MCI) patients as a therapy for preventing the progress to AD.
CONCLUSION: We demonstrated that EVOO therapy may prevent the risk of patients with MCI to progress to AD via decreasing fibrinolytic factors PAI-1 and a2 antiplasmin that reflecting in the diminution of the hallmarks proteins of AD, tau and Aβ amyloid as well and in a biomarker of oxidative stress, MDA. PMID: 31802059 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Predicting oligonucleotide therapeutic efficacy at the population level.
Authors: Theotokis PI, Usher L, Kortschak CK, Schwalbe E, Moschos SA Abstract BACKGROUND: DNA-directed RNA interfering (RNAi) mediators that follow the classic Watson-Crick base pairing to bind to their molecular targets and exert their silencing capacities have been identified to be relatively insensitive to single nucleotide polymorphisms (SNPs). The experimental evaluation of a few putative genomic SNPs in a quasi-species population is the only approach scientists have been employing so far for the experimental validation of the efficacy of oligonucleotide drugs on a given population. These studies are inherentl...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Benchtop systems for in vivo molecular screening of labeled compounds, as a tool to speed up drug research.
Authors: Loudos G, Georgiou M, Rouchota M, Papadimitroulas P, Fysikopoulos E Abstract BACKGROUND: For every new drug,>10,000 candidate molecules are tested for ~15 years. This is the daily mission of thousands research teams worldwide. It is well proven that small animal imaging speeds up this work, increases accuracy and decreases costs. However, commercial imaging systems have high purchase cost, require high service contracts, special facilities and trained staff. Thus, they are affordable to only few large research centres and not to the majority of small and medium research teams internationally. There are ...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Correlation between cervical carcinogenesis and tobacco use by sexual partners.
CONCLUSION: Since the almost exclusively cause of cervical neoplasms is due to the presence and carcinogenic activity of HPV, the harmful/synergistic effect of smoking, passive smoking and partner smoking cannot be attributed to the direct carcinogenic effect of nicotine but to the overall damage of the immune system as we as the reduction of cervical self-defense making it more vulnerable to the carcinogenic nature of HPV, in particular the increased pathogenic types 16 and 18. Lastly, another potential correlation that could be further examined is the potential effects of tobacco constituents in cervical fluids on the se...
Source: Hellenic Journal of Nuclear Medicine - December 6, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Principles and current trends in the correlative evaluation of glioma by advanced MRI techniques and PET.
Authors: Tsiouris S, Bougias C, Fotopoulos A Abstract Cerebral gliomas comprise a heterogeneous group of primary neoplasms of the central nervous system, representing a significant cause of cancer morbidity and mortality. Contrast-enhanced magnetic resonance imaging (MRI) is paramount for identifying structural brain abnormalities related to the development of gliomas. Although morphological MRI remains the current standard of care for initial diagnostic workup, surgical planning, monitoring therapy response and surveillance during follow-up, it is rather difficult to define tumor grade and boundaries and to assess...
Source: Hellenic Journal of Nuclear Medicine - October 29, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Cardiac amyloidosis. Two main subtypes and diagnosis by Nuclear Medicine: SPET tracer revival.
Authors: Valsamaki PN, Zissimopoulos A Abstract PMID: 31587024 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Utility of 18 F-FDG PET/CT in pre-surgical risk stratification of patients with breast cancer.
CONCLUSION: The pre-treatment tumor SUVmax could be utilized as an independent imaging biomarker of the tumor aggressiveness and poor prognosis. Risk stratification based on this index could play a pivotal role in alteration of treatment planning, such as neoadjuvant chemotherapy (precision oncology). PMID: 31587025 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

99mTc-MIBI scintimammography and digital mammography in the diagnosis of multicentric breast cancer.
Authors: Novikov SN, Chernaya AV, Krzhivitsky PI, Kanaev SV, Krivorotko PV, Artemyeva AS, Popova NS Abstract OBJECTIVE: To compare diagnostic accuracy of scintimammography (SMG) and digital mammography (DS) in the diagnosis of multicentric breast cancer. SUBJECTS AND METHODS: Three hundred and sixty seven women with histologically confirmed breast cancer were included in this analysis. All patients were candidates for conservative breast surgery and had cT1-3N0-1 stage of disease. Scintimammography was performed in prone position 5-10min after intravenous injection of 740MBq of technetium-99m-methoxy-isobtyl-is...
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Independent brain 18F-FDG PET attenuation correction using a deep learning approach with Generative Adversarial Networks.
CONCLUSION: Independent AC of brain 18F-FDG PET is feasible with high accuracy using the proposed, easy to implement deep learning framework. Further evaluation in clinical cohorts will be necessary to assess the clinical performance of this method. PMID: 31587027 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

How often suspected pulmonary embolism is diagnosed and its main diagnostic characteristics, in an emergency nuclear medicine service? Four years experience.
We present our 4 years experience on this subject. SUBJECTS AND METHODS: We retrospectively studied 2178 lung perfusion scintigraphies (LPS). Of them 1846 were performed to patients suspected for APE admitted to the emergency departments of the University Polyclinic of Bari and examined immediately by our Nuclear Medicine Department. Contingency tables and odds ratio (OR) were used to estimate the relation between symptoms, risk factors, D-dimers dosage, other imaging diagnostic tools and LPS results. RESULTS: Lung perfusion scintigraphy was positive for APE in 309/1846 (16.7%) patients which then were treated succ...
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Memory performance associates with serotonin transporter in midbrain and pons in healthy subjects.
CONCLUSION: In conclusion, we demonstrated that SERT availability was associated with memory function in healthy females from the PPMI database. Further studies are needed to clarify underlying mechanisms of this phenomenon. PMID: 31587029 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Quality of radiochemical purity in multiple samples of various fractionated cold kits: Testing a cost & time effective technique.
CONCLUSION: Fractionation of cold kits using standardised technique is a time and cost-effective method and does not deteriorate the quality of labelling in commonly used pharmaceuticals in our study. We have used fractionated aliquots up to 3 days of preparation in patients with clinically usable radiochemical purity. Deep frozen fractions can be used up to 15 days in our experience. PMID: 31587030 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Castleman's disease. Large retroperitoneal masses and multiple calcifications detected by 18F-FDG PET/CT.
Authors: Xiao L, Zhu HM, Li L Abstract An 18 years old man was admitted to our hospital for intractable oral ulcer and abdominal discomfort. Bulky soft-tissue masses were found in pathology speciments in the retroperitoneum from the twelfth thoracic vertebra to the fifth lumbar vertebra during an abdominal computed tomography (CT) scan. Then he was referred for fluorine-18-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) due to suspicion of paraneoplastic pemphigus. On the maximum intensity projection image, a large, elongated mass was displayed in the right abdomen near the spine with slightly i...
Source: Hellenic Journal of Nuclear Medicine - October 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Ear-lobe anthropometric signs do not relate to longevity. Ear length relates to age.
Authors: Grammaticos PC, Petrou I, Papadopoulos N, Christodoularas S Abstract Dear Editor, During the last 30 years we are collecting various photographs which showed the face of persons who died at various ages during their lifetime. We so collected more than 235 photographs. After strict selection of these photographs, so that we could see well the ear and the ear-lobe we chose 57 of them and studied the following parameters: the vertical length of the ear till the lobe, the vertical length of the earlobe, the total ear length, the width of the ear-lobe and the area of the lobe, in order to relate them to longevi...
Source: Hellenic Journal of Nuclear Medicine - July 24, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Pathophysiological interrelated deactivation/activation processes in the exhausted brain after whiplash injury.
Authors: Otte A Abstract In this paper pathophysiological interrelated deactivation/activation phenomena are set out in the example of whiplash injury. These phenomena could have been underestimated in previous positron emission tomography studies as their focus was on hypoperfusion rather than hyperperfusion. In addition, statistical parametric mapping analysis of cerebral studies is normally not fine-tuned to special interesting areas rather than to obvious clusters of difference. PMID: 31273349 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

High standardized uptake values of 18F-FDG PET/CT imaging but not MRI correlates to pathology findings in patients with cervical cancer.
CONCLUSION: An increased SUVmax suggests lymph node metastases or distant metastases, low differentiation and FIGO stage III-IV. A low negative correlation was observed between the SUVmax and ADCmin, while we observed no correlation between the ADCmin and the clinical pathological characteristics of cervical cancer. PMID: 31273350 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 7, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research