The modifications brought about by the COVID-19 pandemic to Nuclear Medicine practice.
Authors: Chatzipavlidou V Abstract Nearly 19.9 million cases and more than 730 thousand disease-related deaths have been confirmed in the months that followed WHO's assessment that the novel coronavirus COVID-19, first emerged in Wuhan China on December 2019, could be characterized as a pandemic. The aforementioned coronavirus affected 188 countries as of 8.10.2020. Despite the continually increasing number of COVID-19 cases reported to CDC, at national level, the percentage of visits to outpatient providers and emergency departments has decreased and mortality rates attributed to COVID-19 have declined compared to...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

SARS-CoV2: Diagnostic tests available to the clinician.
Authors: Hadweh P, Orfanidou T, Tsiamita M, Timologos G, Papadopoulos T Abstract On December 2019, a new coronavirus disease (COVID-19) emerged in China and spread worldwide, causing acute severe respiratory syndrome. Due to the increased transmission rate of the virus, it became of great importance the early diagnosis of the disease. The coronavirus pandemic led to the development of numerous tests in order to mass screening population for active viral load and for the identification of antibodies for epidemiological purposes. This review summarizes the different diagnostic tests available to the clinicians for th...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The consequences of COVID-19 pandemic in the routine of Nuclear Medicine Departments.
Authors: Papanastasiou E Abstract The outbreak and spreading of the COVID-19 pandemic have affected billions of people around the world, severely disrupting many aspects of their lives. Although not at the frontline of the pandemic response, Nuclear Medicine departments have to adopt their clinical routine to the new environment. A series of protective measures, including among others spatial arrangements to promote social distancing, meticulous hand hygiene and use of personal protective equipment, workload reduction, patient screening at admission and examination protocol adjustments, have to be adopted in order ...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Challenges and priorities in skeletal, gastrointestinal, hepatobiliary, genitourinary and lung scintigraphy during the COVID-19 pandemic.
Authors: Koutsikos J, Angelidis G Abstract On December 29, 2019, a hospital in the City of Wuhan, Hubei Province, in Central China, admitted four individuals with pneumonia. The hospital reported this occurrence to the local center for disease control (CDC), which lead Wuhan CDC staff to initiate a field investigation with a retrospective search for pneumonia patients. On December 31, 2019, the World Health Organization (WHO) was alerted by the Chinese authorities for several cases of pneumonia of unknown origin in the City of Wuhan. On January 7, 2020, a novel virus was identified as the causative agent, belonging...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nuclear Cardiology practice in COVID-19 era.
Authors: Paschali A, Anagnostopoulos C Abstract The Coronavirus Disease 2019 (COVID-19) pandemic is the biggest shock in decades to the well developed healthcare system and resources worldwide. Although there was a wide variation in the level of preparedness, the transition was tough even for the most renowned healthcare systems. Increasing the capacity and adapting healthcare for the needs of COVID-19 patients is described by the WHO as a fundamental outbreak response measure. However, while the system is preoccupied with a pandemic infection, patients suffering from other illnesses are in high risk to get infecte...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

COVID-19 pandemic: Implications for radionuclide therapy in Nuclear Medicine departments.
Authors: Koukouraki S, Kapsoritakis N, Bourogianni O Abstract The global COVID-19 health and economic crisis has forced people to adopt challenging rules of social distancing and self-isolation. Health care staff has been advised to change working routines to keep themselves and their patients safe. Radionuclide therapy has had an increasing role in clinical practice. Most therapeutic radionuclide procedures have applications in oncology. Cancer patients are an especially fragile and vulnerable population with higher risk due to co morbidities and immunosuppression. COVID-19 is another risk that must be considered ...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nuclear Medicine and Oncology in the COVID-19 pandemic era.
Authors: Panagiotidis E Abstract The coronavirus disease 2019 (COVID-19) global pandemic poses a significant challenge to the national health systems. Not only China, the first country that experienced the health crisis since last December, but the rest of the world, is facing an unprecedented global health crisis, the most serious crisis in a century, with social and economic impact. However, the most important impact of the new pandemic is the human impact. Till 4th of June 2020, coronavirus SARS-CoV-2, causing COVID-19 disease, has infected more than 65000.000 people and has been responsible for more than 386000...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nuclear thyroidology in pandemic times: The paradigm shift of COVID-19.
The objective of the current paper is to provide guidance on how diagnostic and therapeutic management of patients with thyroid diseases can be safely and effectively adjusted during pandemic, in nuclear medicine settings. PMID: 32862214 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Non-Oncological PET/CT imaging during SARS-CoV-2 pandemic.
Authors: Exadaktylou P, Papadopoulos N, Chatzipavlidou V, Giammarile F Abstract In December 2019 a new β-CoV, Severe Acute Respiratory Coronavirus- 2 (SARS-CoV-2), has been identified in Wuhan Hubei Province, China. Within a few months it spread rapidly to more than 114 countries and the disease, Coronavirus disease 2019 (COVID-19), was declared pandemic on 11th February 2020 by the World Health Organization (WHO). Until 20 June 2020 8:09 am, 8,465,085 cases of COVID-19 were confirmed globally, with 454,258 deaths. The first incidence in Greece was documented on 26 February 2020 in Thessaloniki and up to 20 Ju...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Recommendations for nuclear neuroimaging of patients with neurological disorders in the COVID-19 era.
Authors: Valotassiou V, Angelidis G, Georgoulias P Abstract The novel coronavirus disease 2019 (COVID-19) pandemic has changed people's normal lives in a very short time causing extensive infections and mortality, which required the national health systems to be adapted to new situation. Changes in healthcare services included modifications of standard procedures in nuclear medicine departments in order to limit COVID-19 spreading and protect patients and personnel. Here, we recommend management of patients with neurological diseases and especially dementia and movement disorders, who are referred for neuroimaging ...
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

COVID-19 and cancer: Revisiting "The comfort zone".
COVID-19 and cancer: Revisiting "The comfort zone". Hell J Nucl Med. 2020 May-Aug;23 Suppl:65-69 Authors: Retsas S PMID: 32862217 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The modifications brought about by the COVID-19 pandemic to Nuclear Medicine practice.
Authors: Chatzipavlidou V Abstract Nearly 19.9 million cases and more than 730 thousand disease-related deaths have been confirmed in the months that followed WHO's assessment that the novel coronavirus COVID-19, first emerged in Wuhan China on December 2019, could be characterized as a pandemic. The aforementioned coronavirus affected 188 countries as of 8.10.2020. Despite the continually increasing number of COVID-19 cases reported to CDC, at national level, the percentage of visits to outpatient providers and emergency departments has decreased and mortality rates attributed to COVID-19 have declined compared to...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

SARS-CoV2: Diagnostic tests available to the clinician.
Authors: Hadweh P, Orfanidou T, Tsiamita M, Timologos G, Papadopoulos T Abstract On December 2019, a new coronavirus disease (COVID-19) emerged in China and spread worldwide, causing acute severe respiratory syndrome. Due to the increased transmission rate of the virus, it became of great importance the early diagnosis of the disease. The coronavirus pandemic led to the development of numerous tests in order to mass screening population for active viral load and for the identification of antibodies for epidemiological purposes. This review summarizes the different diagnostic tests available to the clinicians for th...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The consequences of COVID-19 pandemic in the routine of Nuclear Medicine Departments.
Authors: Papanastasiou E Abstract The outbreak and spreading of the COVID-19 pandemic have affected billions of people around the world, severely disrupting many aspects of their lives. Although not at the frontline of the pandemic response, Nuclear Medicine departments have to adopt their clinical routine to the new environment. A series of protective measures, including among others spatial arrangements to promote social distancing, meticulous hand hygiene and use of personal protective equipment, workload reduction, patient screening at admission and examination protocol adjustments, have to be adopted in order ...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Challenges and priorities in skeletal, gastrointestinal, hepatobiliary, genitourinary and lung scintigraphy during the COVID-19 pandemic.
Authors: Koutsikos J, Angelidis G Abstract On December 29, 2019, a hospital in the City of Wuhan, Hubei Province, in Central China, admitted four individuals with pneumonia. The hospital reported this occurrence to the local center for disease control (CDC), which lead Wuhan CDC staff to initiate a field investigation with a retrospective search for pneumonia patients. On December 31, 2019, the World Health Organization (WHO) was alerted by the Chinese authorities for several cases of pneumonia of unknown origin in the City of Wuhan. On January 7, 2020, a novel virus was identified as the causative agent, belonging...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nuclear Cardiology practice in COVID-19 era.
Authors: Paschali A, Anagnostopoulos C Abstract The Coronavirus Disease 2019 (COVID-19) pandemic is the biggest shock in decades to the well developed healthcare system and resources worldwide. Although there was a wide variation in the level of preparedness, the transition was tough even for the most renowned healthcare systems. Increasing the capacity and adapting healthcare for the needs of COVID-19 patients is described by the WHO as a fundamental outbreak response measure. However, while the system is preoccupied with a pandemic infection, patients suffering from other illnesses are in high risk to get infecte...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

COVID-19 pandemic: Implications for radionuclide therapy in Nuclear Medicine departments.
Authors: Koukouraki S, Kapsoritakis N, Bourogianni O Abstract The global COVID-19 health and economic crisis has forced people to adopt challenging rules of social distancing and self-isolation. Health care staff has been advised to change working routines to keep themselves and their patients safe. Radionuclide therapy has had an increasing role in clinical practice. Most therapeutic radionuclide procedures have applications in oncology. Cancer patients are an especially fragile and vulnerable population with higher risk due to co morbidities and immunosuppression. COVID-19 is another risk that must be considered ...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nuclear Medicine and Oncology in the COVID-19 pandemic era.
Authors: Panagiotidis E Abstract The coronavirus disease 2019 (COVID-19) global pandemic poses a significant challenge to the national health systems. Not only China, the first country that experienced the health crisis since last December, but the rest of the world, is facing an unprecedented global health crisis, the most serious crisis in a century, with social and economic impact. However, the most important impact of the new pandemic is the human impact. Till 4th of June 2020, coronavirus SARS-CoV-2, causing COVID-19 disease, has infected more than 65000.000 people and has been responsible for more than 386000...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nuclear thyroidology in pandemic times: The paradigm shift of COVID-19.
The objective of the current paper is to provide guidance on how diagnostic and therapeutic management of patients with thyroid diseases can be safely and effectively adjusted during pandemic, in nuclear medicine settings. PMID: 32860396 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Non-Oncological PET/CT imaging during SARS-CoV-2 pandemic.
Authors: Exadaktylou P, Papadopoulos N, Chatzipavlidou V, Giammarile F Abstract In December 2019 a new β-CoV, Severe Acute Respiratory Coronavirus- 2 (SARS-CoV-2), has been identified in Wuhan Hubei Province, China. Within a few months it spread rapidly to more than 114 countries and the disease, Coronavirus disease 2019 (COVID-19), was declared pandemic on 11th February 2020 by the World Health Organization (WHO). Until 20 June 2020 8:09 am, 8,465,085 cases of COVID-19 were confirmed globally, with 454,258 deaths. The first incidence in Greece was documented on 26 February 2020 in Thessaloniki and up to 20 Ju...
Source: Hellenic Journal of Nuclear Medicine - August 30, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Absorbed dose estimation to cohabitants and co-travelers of patients treated with radioiodine for differentiated thyroid carcinoma.
CONCLUSION: Provided necessary precautions are followed, radiation burden to the family members and co-travelers of DTC patients treated with radioiodine following thyroidectomy can be kept well below the corresponding dose limits and constraints. PMID: 32830204 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - August 26, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

99mTc-MAA total body imaging of patent right-to-left shunt with invisible brain activity.
Authors: Son HJ, Ryu JS Abstract Generally, the presence of brain activity in technetium-99m macro aggregated albumin (99mTc-MAA) total-body imaging is considered a hallmark sign of patent right-to-left shunt. Herein, we present a unique case of a patient with Eisenmenger syndrome, whose 99mTc-MAA total-body imaging showed increased extrapulmonary activities only in the abdomen, pelvis, and both lower extremities and no activity was observed in the brain and upper extremities. The patient previously underwent a Potts shunt operation, which is a surgical approach to perform a side-to-side anastomosis between the lef...
Source: Hellenic Journal of Nuclear Medicine - August 26, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Correlations of the 68Ga-PSMA PET/CT derived primary prostate tumor PSMA expression parameters and metastatic patterns in patients with Gleason Score > 7 prostate cancer.
CONCLUSION: The PSMA-TV and TL-PSMA values are strong markers for metastasis prediction in patients with GS>7 PCa but no other PSMA expression parameters can distinguish between N1M0 and M1 groups. PMID: 32716402 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Automatic characterization of myocardial perfusion imaging polar maps employing deep learning and data augmentation.
CONCLUSION: The proposed deep learning model with data augmentation techniques performed better than the conventional semi-quantitative polar map analysis and competed with doctor's expertise in this particular patient cohort and image set. The model could potentially serve as an assisting tool to support interpretation of MPI studies or could be used for teaching purposes. PMID: 32716403 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Quantitative bone SPECT/CT applications for cartilaginous bone neoplasms.
CONCLUSION: Standardized uptake value obtained with bone SPECT/CT may be useful to differentiate benign from malignant cartilaginous bone neoplasms, thus helping the orthopedic surgeon towards the most appropriate treatment procedure. PMID: 32716404 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

CT guided mediastinal biopsy facilitated by PET/CT imaging: Our experience.
Authors: Exarhos D, Athanasiou S, Lazaridou E, Stefanou D, Aslanidi C, Samartzis A, Rondogianni P, Datseris I Abstract The purpose of this retrospective study is to assess the efficacy of mediastinal tumor biopsies guided by computed tomography (CT) and facilitated by positron emission tomography (PET)/CT in our hospital. We also wanted to prove the use of PET/CT in performing such biopsies. Fifty-two patients were biopsied under CT guidance with PET/CT visual co-registration (35) and facilitated PET/CT registration (17). In 49 patients, a diagnosis from the guided biopsy performed was successful and in 3 patients ...
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Diagnostic value of clinical parameters and parathyroid scintigraphy for asymptomatic primary hyperparathyroidism.
Authors: Ning Y, Chen D, Huang Z, Lou C Abstract OBJECTIVE: The purpose of this study was to evaluate the diagnostic value of clinical parameters and parathyroid scintigraphy for asymptomatic primary hyperparathyroidism (aPHPT), including quantitative parameter of laboratory and semiquantitative parameters derived from technetium-99m- metoxyisobutylisonitrile (99mTc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT). SUBJECTS AND METHODS: Two hundred and fourteen patients who had been diagnosed as PHPT and underwent surgical treatment were enrolled in this study. All patients were d...
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An easy method for the evaluation of visual tumor heterogeneity of 18F-FDG PET/CT using 10-step color scale: A correlative study in patients with lung cancer.
CONCLUSION: In this study, we provide a new visual assessment criterion of TH with a strong inter-observer agreement. The visual analysis using the PHL method could be a potential marker for evaluating heterogeneous tumors. PMID: 32716407 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Additive evidence of the competence of pregnancy-adapted YEARS algorithm in reducing the need for CTPA, Q and/or V/Q scintiscan.
Authors: Al Oweidat K, Al Ryalat SA, Al Husban N, Alhawari H, Ghareeb R, Ribie M, Jwaied S, Al Yasjeen S, Juweid ME Abstract OBJECTIVE: To determine whether a pregnancy-adapted clinical and D-dimer-based algorithm, termed the "YEARS algorithm," can reduce the need for radiological imaging, including lung scintigraphy in pregnant women with suspected pulmonary embolism (PE). PATIENTS AND METHODS: This retrospective study included all pregnant women with suspected PE between January 2014 and September 2019 who have undergone D-dimer testing and radiological imaging (computed tomography pulmonary angiogr...
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Radionuclide techniques for the detection of vesicoureteral reflux and their clinical significance.
Authors: Likartsis C, Printza N, Notopoulos A Abstract We discuss and try to evaluate the detection of vesicoureteral reflux (VUR) by radionuclide techniques and especially direct radionuclide cystography (DRC). Direct radionuclide cystography is applied for more than half a century mainly in children. Vesicoureteral reflux has a complex pathology not yet completely understood and is often related to urinary tract infection (UTI) and renal parenchyma scarring that can lead to long-term renal function impairment. Since there is no consensus on the optimal imaging algorithm after the first febrile urinary tract infec...
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Comparison of gallium-68 somatostatin receptor and 18F-fluorodeoxyglucose positron emission tomography in the diagnosis of neuroendocrine tumours: A systematic review and meta-analysis.
CONCLUSION: The 68Ga-SSTR PET has highly sensitive and had a greater diagnostic value than 18F-FDG PET for patients with NET. Fluorine-18-FDG PET, however, had significant specificity than 68Ga-SSTR PET. The 68Ga-SSTR has high sensitivity in G1/G2 NET, while 18F-FDG has a low positive rate. In G3 NET, however, the opposite is true. Therefore, the 68Ga-SSTR PET and 18F-FDG PET modalities are complementary rather than substitutive in clinical practice. PMID: 32716410 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Importance of combined use of preoperative 18F-FDG PET/CT imaging and intraoperative 18F-FDG handheld gamma probe detection in recurrent papillary thyroid cancer.
We describe a case of RTC whose serum thyroglobulin (Tg) level was 5.6ng/mL. Preoperative fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed two focal abnormalities in the anterior tracheal and right upper mediastinal regions and a handheld gamma probe was used intraoperatively to identify the hot areas seen on PET scan. Postoperative 18F-FDG PET/CT imaging after tumor excision was normal. This case shows that recurrent tumor can be localized correctly using 18F-FDG PET/CT and a surgical gamma probe. PMID: 32716411 [PubMed - as supplied by publisher] (Source: Helle...
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An unusual false-positive uptake of radioiodine caused by pulmonary vasculature: The usefulness of SPECT/CT.
Authors: Yang F, Cao L, Zhang C Abstract There are numerous conditions that may cause false-positive findings on iodine scintigraphy, such as vascular structure, mediastinum, bronchiectasis, cystic lesions and mature cystic teratoma; however, many of their mechanisms remain to be elucidated. Single photon emission tomography/computed tomography (SPECT/CT) imaging can be conducive to avoiding potential pitfalls. In addition, the nuclear physicians have to bear in mind that iodine-131 (131I) uptake in pulmonary vasculature can be a possible cause of false-positive uptake when they interpret 131I whole body scan (WBS)...
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An intrathoracic schwannoma case in 18F-FDG PET/CT scan.
Authors: Gültekin A, Aydoğmuş Ü, Arifoğlu H, Bir F, Yaylalı O Abstract Positron emission tomography /CT images showed a moderately increased 18F-FDG uptake in the mass of left lung lower lobe superior segment (SUVmax: 2.71). No pathological 18F-FDG involvement was detected in another region of the whole body scan. The patient underwent tru-cut biopsy. Since histopathological diagnosis could not be made, thoracotomy was performed. Schwannomas are the second most common benign peripheral nerve sheath originated tumor. Due to its development from Schwann cells, it can be seen in all organs or tissues dur...
Source: Hellenic Journal of Nuclear Medicine - July 29, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A new era for nuclear medicine.
Authors: Chatzipavlidou V Abstract The coronavirus COVID-19 pandemic is the defining global health crisis of our time. Health care systems globally are amid an unprecedented challenge. Since its emergence in December 2019 in Wuhan, China, the virus has spread to 185 countries worldwide, with more than 2.63 million cases confirmed and more than 183 thousand related deaths (as of 23/04/2020). According to current evidence, the novel coronavirus is transmitted from human-to-human mainly via respiratory droplets of different sizes, contact with bodily fluids, or from contaminated surfaces. In the context of COVID-19, a...
Source: Hellenic Journal of Nuclear Medicine - May 5, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Clinical trials and the COVID-19 pandemic.
Authors: Retsas S Abstract "...but why think? Why not try the experiment?..." John Hunter (1728-1793), in a letter to Edward Jenner. August 2nd, 1775. When Galen of Pergamum (2nd c. A.D.), physician, philosopher and experimentalist, sought to ascertain the therapeutic properties of Theriac, an antidote of repute against poisons, he resorted to an experiment. Theriac or Theriaca was a compound drug, containing in some versions used in antiquity numerous components; Galen's own composition included over 70 ingredients! One of its uses was as an antidote against snakebites, a frequent peril for the Roman arm...
Source: Hellenic Journal of Nuclear Medicine - May 5, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Associations of volumetric whole-body 18F-FDG PET/CT parameters with the CA 19-9 level and haemogram parameters in pancreatic adenocarcinoma.
Authors: Araç E, Can C, Kömek H Abstract OBJECTIVE: The present study compared metabolic and volumetric fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) parameters [metabolic tumour volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax)] with carbohydrate antigen (CA) 19-9 tumour marker levels and haemogram parameters [(neutrophil-lymphocyte ratio, mean platelet volume (MPV), and platelet-lymphocyte ratio] as prognostic and diagnostic markers of pancreatic cancer. MATERIAL AND METHODS: A total of 66 patients who u...
Source: Hellenic Journal of Nuclear Medicine - May 5, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Quality & safety aspects of nuclear medicine practice: Definitions and review of the current literature.
Quality & safety aspects of nuclear medicine practice: Definitions and review of the current literature. Hell J Nucl Med. 2020 Jan-Apr;23(1):60-66 Authors: Giannoula E, Panagiotidis E, Katsikavelas I, Chatzipavlidou V, Sachpekidis C, Bamidis P, Raftopoulos V, Iakovou I Abstract Current literature records a glaring discrepancy between the rapid developments and progress of medicine and the simultaneous deterioration of the quality and safety of the provided health care services. Bibliographic data as far as perceptions of quality and safety in nuclear medicine departments are concerned, are limited ...
Source: Hellenic Journal of Nuclear Medicine - May 5, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Spectrum of false positive 18F-sodium fluoride (NaF) bone PET/CT findings in Oncology imaging; A narrative pictorial review of cases from a single institution.
Authors: Usmani S, Ahmed N, Muzaffar S, Esmail A, Gnanasegaran G, Van den Wyngaert T Abstract Fluorine-18-sodium fluoride (18F-NaF) is a positron emission tomography (PET) bone imaging agent mainly used for oncology staging but may also be used in the evaluation of benign bone and joint pathology conditions. Fluorine-18-NaF is an excellent bone-seeking agent with high bone uptake owing to favorable biodistribution with rapid single-pass extraction, limited plasma protein binding and prompt renal clearance. Fluorine-18-NaF PET/computed tomography (CT) is highly sensitive in identifying both sclerotic and lytic bone ...
Source: Hellenic Journal of Nuclear Medicine - May 5, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Associating radioiodine therapy in hyperthyroidism with cancer mortality: robust or random results of a statistical analysis?
Authors: Iakovou I, Giannoula E, Chatzipavlidou V, Sachpekidis C Abstract Dear Editor, Recently, Kitahara et al. (2019) published an article in JAMA Internal Medicine entitled "Association of radioactive iodine treatment with cancer mortality in patients with hyperthyroidism". This publication was based on organ dosimetry calculations from 18,805 patients with hyperthyroidism treated with radioiodine treatment (RAI) followed for nearly 7 decades. The results of the work suggest that solid cancer mortality increases in hyperthyroid patients treated with RAI, with greater absorbed doses to exposed organs be...
Source: Hellenic Journal of Nuclear Medicine - May 5, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

[Comparative evaluation of Iterative and FORE-Iterative reconstruction algorithms for PET/CT].
In this study, the properties of the reconstruction algorithm Iterative in comparison with the FORE-Iterative using 18F-FDG PET/CT data were evaluated. The study was conducted in the Department of Nuclear Medicine of Evangelismos Athens General Hospital, in which data from 9 patients were collected and reconstructed with both algorithms, Iterative and FORE-Iterative. For each patient, the image quality was assessed using parameters such as SUVmax, SUVpeak, SUVmean, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). Regions of interest were defined based on medical expertise focusing on the tumor areas. Based on...
Source: Hellenic Journal of Nuclear Medicine - May 5, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

In-hospital management of elderly patients undergoing myocardial perfusion scintigraphy.
Authors: Štalc M, Jerman N, Trampuš M, Dolenc Novak M, Gužič Salobir B Abstract OBJECTIVE: To investigate the impact of myocardial perfusion scintigraphy results on the decision for invasive coronary angiography in elderly patients (≥75 years) with suspected coronary artery disease hospitalized in a single tertiary medical center. SUBJECTS AND METHODS: In the retrospective study, data of 276 (136 elderly) consecutive hospitalized patients referred to myocardial perfusion imaging were analyzed. The clinical characteristics, myocardial perfusion scintigraphy results, invasive coronary angiograp...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Baseline quality of life predicts overall survival in patients with mCRPC treated with 223Ra-dichloride.
Authors: Frantellizzi V, De Feo MS, Di Rocco A, Pontico M, Pani A, Farcomeni A, Cosma L, Lazri J, De Vincentis G Abstract OBJECTIVE: The prognostic value of baseline clinical parameters in predicting the survival prolonging effect of radium-223-dichloride (223Ra)-therapy in metastatic castration resistant prostate cancer (mCRPC) patients is still an open issue. The aim of this study was investigating the impact of baseline quality of life (QoL) on overall survival (OS) in mCRPC patients treated with 223Ra. The present study also evaluated the trend of patient-reported QoL during both 223Ra-treatment and post-therap...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Comparison of 99mTc-MIBI planar scintigraphy, SPET/CT and ultrasonography in detection of parathyroid adenoma in patients with primary hyperparathyroidism.
CONCLUSION: The combined use of US and SPET/CT has incremental value in accurately localizing PA over either technique alone. In the preoperative assessment of patients with PHPT combination of imaging methods allows selection of patients who would be suitable for minimally invasive surgery. PMID: 32222728 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Investigating the theragnostic potential of 131I-caerin peptide in thyroid cancer.
CONCLUSION: Iodine-131-Caerin can inhibit the cell viability of thyroid cancer and hold certain promise as a theragnostic tool for human thyroid cancers. PMID: 32222729 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Diffusion-weighted MRI, 11C-choline PET/CT, and 18F-FDG PET/CT for predicting the Gleason score in prostate cancer.
CONCLUSION: Carbon-11-choline PET was found have a greater correlation with Gleason score than DWI and is considered to be more useful to predict a higher score in patients with prostate cancer. Fluorine-18-FDG PET was limited because of low sensitivity. PMID: 32222730 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Typical and atypical PET/CT findings in non-cancerous conditions.
Authors: Altini C, Lavelli V, Ruta R, Ferrari C, Nappi AG, Pisani A, Sardaro A, Rubini G Abstract Nuclear Medicine multimodality imaging, such as positron emission tomography/computed tomography PET/CT, refers to metabolic tissue characteristics integrated with anatomical details. Fluorine-18-fluorodeoxyglucose (18F-FDG) is the most diffuse radiopharmaceutical and its application is spreading beyond the area of oncology. The causes of high 18F-FDG uptake that were once considered false positives have been identified and the new knowledge about them led to non-cancerous pathologies that can be studied by 18F-FDG PET...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

18F-FDG PET/CT in treatment response evaluation of Burkitt lymphoma: complete remission of a peritoneal super scan.
Authors: Sachpekidis C, Exadaktylou P, Katsampoukas D, Moralidis E, Arsos G Abstract Peritoneal lymphomatosis, defined as the disseminated intraperitoneal lymphomatous infiltration, is a rare presentation usually of non-Hodgkin lymphoma and is associated with aggressive histological subtypes of the malignancy. Recently, the term "peritoneal super scan" has been introduced in positron emission tomography/computed tomography (PET/CT) in a patient with Burkitt lymphoma to describe hypermetabolic lymphomatous involvement of the entire peritoneum, leading to suppression of tracer uptake in organs with otherwis...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

All that glitters is not prostate cancer: incidental finding of PSMA-avid meningioma.
We present a case of a 79 year old patient with a medical history of unilateral nerve-sparing radical prostatectomy due to a pT3aN0 (Gleason score 7) prostate carcinoma. Because of slightly elevated prostate specific antigen (PSA) level (0.35ng/dL), a fluorine-18-prostate specific membrane antigen (18F-PSMA)-1007 positron emission tomography/computed tomography (PET/CT) scan was performed, showing no signs of malignant recurrence. However, a moderately PSMA-avid nodular lesion was observed in the left occipital region with homogeneous contrast enhancement, suggestive for a meningioma, which was confirmed on magnetic resona...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A case of jejunal neurofibroma in von Recklinghausen's disease with active hemorrhage, detected and located with gastrointestinal bleeding scintigraphy: A case report with literature review.
Authors: Stević M, Vlajković M, Veličković F, Stanojević G, Nestorović M, Petrović F Abstract A 69 year old patient was admitted to hospital with massive gastrointestinal hemorrhage. The clinical presentation of the patient, except for bleeding, was dominated by the presence of neurofibromatosis type 1 - Von Recklinghausen disease. The patient was referred to multislice computed tomography (CT) angiography, magnetic resonance imaging (MRI), esophagogastroduodenoscopy and colonoscopy, which were performed without successful detection of the bleeding site. The MRI examination showed the existence of a tumor lo...
Source: Hellenic Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research