Global temporal lobe asymmetry as a semi-quantitative imaging biomarker for temporal lobe epilepsy lateralization: A machine learning classification study.
Authors: Peter J, Khosravi M, Werner TJ, Alavi A Abstract OBJECTIVE: The purpose of this study was to evaluate the utility of global semi-quantitative analysis via fluorine-18-flurodeoxyglucose positron emission tomography (18F-FDG PET) at lateralizing seizure foci and diagnosing patients with unilateral temporal lobe epilepsy (TLE). METHODS: Seventeen patients with unilateral TLE (11 right TLE and 6 left TLE) were retrospectively selected for semi-quantitative 18F-FDG PET analysis. Twenty-three control subjects with a Mini Mental State Examination (MMSE) score of 29 or greater were selected for comparison. Glo...
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

T-based tissue segmentation to assess knee joint inflammation and reactive bone formation assessed by 18F-FDG and 18F-NaF PET/CT: Effects of age and BMI.
This study was conducted to determine the role of computed tomography (CT)-based segmentation methodology to semi-quantify the degree of inflammation and reactive bone formation in the knee joints by fluorine-18-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride positron emission tomography/CT (18F-NaF PET/CT) imaging, respectively. Furthermore, we assessed the impact of aging and body mass index (BMI) on these biological responses. SUBJECTS AND METHODS: In this retrospective study, we examined a total of 97 subjects who had undergone both 18F-FDG and 18F-NaF PET/CT scanning. The mean age was 49.3±14.9 (21-75)...
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

More accurate than MRI measurement of tumor size in breast cancer by using the peri-tumoral halo uptake layer method of the 18F-FDG PET/CT scan.
CONCLUSION: A method of tumor size determination, using PHL on 18F-FDG PET/CT, showed more linear relationship and smaller size differences with pathology than MRI (average 0.6 vs. 1.9cm). It provides sufficient reliability and reproducibility for measuring tumor size in breast cancer. PMID: 30006644 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Iodine-125 labeled Australian frog tree host-defense peptides caerin 1.1 and 1.9 better inhibit human breast cancer cells growth than the unlabeled peptides. 125I-caerin 1.9 may better be used for the treatment of breast cancer.
CONCLUSION: Our results from this totally original study indicated that radioactive isotope 125I labeled to caerin peptide 1.9 may be used to treat breast cancer while at the same time the response to treatment may be monitored by simultaneous imaging. PMID: 30006645 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Renal output efficiency and normalized residual activity examined by technetium-99m-DTPA renography have by far greater specificity to diagnose obstructive disease as compared to other conventional parameters of the renogram. First such study of output efficiency.
Authors: Beatović SL, Radulović M, Janković MM, Artiko VM, Ajdinović B, Šobić-Šaranović DP Abstract OBJECTIVE: The aim of this study was to assess the diagnostic ability of renal output efficiency (OE), normalized residual activity (NORA) and conventional interpretation of the diethylene triamine pentaacetic acid (99mTc-DTPA) diuretic renogram (CIR) in diagnosing urine flow obstruction. SUBJECTS AND METHODS: Group A consisted of 73 obstructed kidneys and Group B of 80 kidneys with dilated upper urinary tract. Forty eight kidneys were examined as the control Group C. A 40min acquisition with ...
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

More than the prostate: Intrapancreatic accessory spleen and papillary thyroid cancer detected with 18F-PSMA PET/CT.
CONCLUSION: This is the first case to our knowledge describing both such lesions in one patient and the first case describing the use of 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL)-PSMA PET/CT to detect IPAS. Furthermore we highlight the value of nuclear medicine diagnostic work up in complex cases. PMID: 30006647 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Pituitary gland and bone involvement of Langerhans cell histiocytosis in a boy and brief review of the literature.
Authors: Miao C, Zhang L, Sun M, Ma C Abstract A 3 years old boy was hospitalized with a month's history of polydipsia, polyuria and low fever. There was no relevant family history. This is a rare case of Langerhans cell histiocytosis (LCH) with both bone and pituitary infiltration shown on the technetium-99m methylene diphosphonate (99mTc-MDP) scan and brain magnetic resonance imaging (MRI). Sagittal and coronal T1-weighted images on MRI showed the typical lack of high signal intensity of the posterior pituitary which corresponded to the central signs of diabetes insipidus (DI). The diagnosis of LCH was suspected ...
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Bone scan findings in erythromelalgia.
We present bone scan findings in a case of erythromelalgia in an 18 years old student, in whom the symptoms developed suddenly. No underlying disease could be demonstrated and the patient fully recovered. The scan findings were strikingly similar to those of reflex sympathetic dystrophy. PMID: 30006649 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Erdheim-Chester disease diagnosed by 99mTc-MDP bone scintigraphy and brief literature review.
In conclusion, the authors underline that ECD was diagnosed at a second diagnostic attempt both clinically and by specific staining pathology specimens. PMID: 30006650 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Changes in esophageal mucosal morphology and in growth of breast feeding rats fed with milk of low or high temperature.
Authors: Grammaticos PC, Emmanouil-Nikoloussie E, Trontzos C, Kaidoglou A, Foroglou C Abstract Dear Editor, This rather original investigation was performed some time ago but is still unpublished. Its aim was to estimate the effect of low or high temperature cow's milk given to breast feeding rats in order to study possible influence of this diet to rats, to their physical growth and also esophageal mucosal pathology. Ten white female Wistar rats, 20 days of age were separated from their mothers and divided in 2 groups of 5 members each. Five of them were fed with milk kept at 42oC by using a special warming device...
Source: Hellenic Journal of Nuclear Medicine - July 15, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Brain perfusion defects by SPET/CT and neurostat semi-quantitative analysis in two patients with congenital erythropoietic porphyria.
CONCLUSION: In our opinion, SPET/CT could have a key role in this setting of patients due to its high sensitivity and reliability in mild-to-moderate brain perfusion defects detection. Moreover, the quantitative analysis by using neurostat may allow to recognize even mild brain perfusion alterations, difficult to detect only visually. PMID: 29705816 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - May 2, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Application of the alteration uptake ratio of 99mTc-MIBI scintigraphy for evaluating the efficacy of neoadjuvant chemotherapy in osteosarcoma patients.
Authors: Huang Z, Lou C Abstract BACKGROUND: We aimed to semi-quantitatively evaluate using technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy the efficacy of neoadjuvant chemotherapy in osteosarcoma (OS) patients. SUBJECTS AND METHODS: A hundred and two patients with OS were retrospectively included in this study. All of them underwent 99mTc-MIBI scintigraphy before and after neoadjuvant chemotherapy. Semi-quantitative parameters including the uptake ratio (UR) and alteration of uptake ratio (AUR) were calculated for each patient. According to tumor necrosis rate (TNR), patients were classified...
Source: Hellenic Journal of Nuclear Medicine - May 2, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Effects of age and weight on the metabolic activities of the cervical, thoracic and lumbar spines as measured by fluorine-18 fluorodeoxyglucose-positron emission tomography in healthy males.
This study aimed to explore the age and weight-related metabolic trends in the spines of healthy male subjects using fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging. SUBJECTS AND METHODS: Forty three healthy male subjects (age 23-75 years, weight 50-145kg) were selected from the CAMONA study. A global assessment methodology was applied to the subjects' 18F-FDG 180 minute scans, where each region of the spine (cervical, thoracic and lumbar) was individually encapsulated in a single region of interest, and standardized uptake value (SUVmean) was calculated per respective region. RESU...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Value of 18F-FDG PET/CT in discrimination between indolent and aggressive non-Hodgkin's lymphoma: A study of 328 patients.
Authors: Alobthani G, Romanov V, Isohashi K, Matsunaga K, Watabe T, Kato H, Tatsumi M, Shimosegawa E, Hatazawa J Abstract OBJECTIVE: Non-Hodgkin's lymphoma (NHL) cases with inconclusive biopsy findings are not infrequently referred for fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). We searched for maximum standardized uptake value (SUVmax) cut-off values that could discriminate between indolent and aggressive NHL in conventional non-time of flight (non-TOF) 18F-FDG PET/CT and TOF 18F-FDG PET/CT. SUBJECTS AND METHODS: Retrospectively, 328 patients were selected ...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Tumoricidal effect and pain relief after concurrent therapy by strontium-89 chloride and zoledronic acid for bone metastases.
Authors: Baba K, Kaida H, Hattori C, Muraki K, Kugiyama T, Fujita H, Ishibashi M Abstract OBJECTIVE: The purpose of this study was to investigate the palliative and tumoricidal effects of concurrent therapy of strontium-89 chloride (89SrCl2) and zoledronic acid (ZA) for painful bone metastases. SUBJECTS AND METHODS: Fifty-one patients with painful bone metastases prostate cancer (n=17), lung cancer (n=13), breast cancer (n=12), other cancers (n=9) were treated. Bone metastases was confirmed in all patients by technetium-99m hydroxymethylene diphosphonate (99mTc-HMDP) bone scintigraphy. The numeric rating scale ...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

18F-FDG PET/CT and ultrasonogrpahy in differentiated thyroid carcinoma patients with elevated serum levels of antithyroglobulin antibody, negative Tg and whole body 131I scan.
CONCLUSION: In the 49 DTC patients with elevated serum levels of TgAb but negative findings in serum Tg and in 131I-WBS, neck US and 18F-FDG PET/CT imaging supported the clinical diagnosis and suggested subsequent treatment. PMID: 29550843 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Is there an association between hibernating myocardium and left ventricular mechanical dyssynchrony in patients with myocardial infarction?
This study consisted of 91 patients who had a history of definite prior MI and underwent both technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) gated single photon emission tomography (SPET) myocardial perfusion imaging (MPI) and 18F-FDG positron emission tomography (PET) myocardial metabolic imaging. Left ventricular (LV) functional and LVMD parameters were measured from gated SPET MPI, while myocardial viability was assessed by the integral quantitative analysis of SPET MPI and 18F-FDG PET. Left ventricular MD was defined as>mean+2SD of phase bandwidth (PBW) in the control group. RESULTS: Left ventricular MD w...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Correlations between dual-phase 18F-FDG uptake and clinicopathologic and biological markers of breast cancer.
Authors: Kaida H, Azuma K, Toh U, Kawahara A, Sadashima E, Hattori S, Akiba J, Tahara N, Rominger A, Ishii K, Murakami T, Ishibashi M Abstract OBJECTIVE: To assess the correlations between dual-phase fluorine-18 fluorodeoxyglucose (18F-FDG) uptake and clinicopathological and immunohistochemical prognostic factors in patients with surgically resected breast cancer. SUBJECTS AND METHODS: We retrospectively analyzed the cases of 105 patients. We calculated the maximum standardized uptake value (SUVmax) at 85min (SUV1), SUVmax at 125min (SUV2) and the retention index [RI]. Spearman's rank correlation test, the Krus...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Is there an incremental value to use myocardial perfusion imaging with or without CT attenuation for the diagnosis of coronary artery disease? A study in Chinese patients.
CONCLUSION: Compared to NAC MPI, CTAC improved SPET MPI specificity but decreased sensitivity, leading to no obvious improvement in overall accuracy for the diagnosis of CAD in Chinese patients. However, CTAC might be of value in the subgroups of males and overweight patients and for the RCA territory. In routine clinical application, the integration of NAC and CTAC findings combined with CAD pre-test probability could improve MPI diagnostic performance. PMID: 29550846 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

123I-ioflupane SPET and 123I-MIBG in the diagnosis of Parkinson's disease and parkinsonian disorders and in the differential diagnosis between Alzheimer's and Lewy's bodies dementias.
Authors: Nuvoli S, Palumbo B, Malaspina S, Madeddu G, Spanu A Abstract Nuclear medicine procedures are widely used as "in vivo" biomarkers in a large number of brain diseases, especially in the diagnosis of Parkinson's disease (PD) and of parkinsonian disorders (pD). Furthermore, nuclear medicine is used in the differential diagnosis of dementias especially Alzheimer's disease (AD) and dementia with Lewy's bodies (LBD) which share many clinical symptoms and often LBD is misdiagnosed as AD. The differential diagnosis between these clinical entities is crucial for treatment since LBD also shares some clinic...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Long term quality of life in differentiated thyroid cancer patients after thyroidectomy and high doses of 131I with or without suppressive treatment.
Authors: Giannoula E, Iakovou I, Verburg FA Abstract According to international guidelines, the most frequently applied diagnostic procedures and therapeutic interventions for differentiated thyroid cancer (DTC) patients are those of nuclear medicine. Differentiated thyroid cancer is the most common endocrine malignancy and over the past decades has shown the fastest increasing incidence of all malignancies. This cancer has a detrimental impact on a patients' quality of life (QoL), not very well considered in general practice. In this paper we aimed to review the QoL of DTC patients who received high doses of 131I ...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Simultaneous pulmonary and inferior vena cava tumor thromboembolism secondary to retroperitoneal pleomorphic liposarcoma.
Authors: Chen C, Jiang C, Li L Abstract Retroperitoneal pleomorphic liposarcoma (RPLS) is the least common but the most aggressive subtype of liposarcoma. We herein report a case of tumor embolism (TE) to the inferior vena cava (IVC) and pulmonary arteries in a 54 years old woman with RPLS. The case suggests that fusion fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) can accurately detect occult TE. It also illustrates the usefulness of computed tomography (CT) and high 18F-FDG uptake by PET/CT imaging for diagnosing such findings as filling defect in the veins and b...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Inflammatory myofibroblastic tumor mimicking lymphoma on 18F-FDG PET/CT. Report of a case and review of the literature.
We present a case of a 63 years old woman with left inguinal lymphadenopathy accompanied by low-grade fever. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed abnormal higher 18F-FDG uptake on the neck, axillar, pulmonary hilar, mediastinal, mesenteric, retroperitoneal, pelvic and inguinal lymph nodes. These findings led to an initial misdiagnosis of lymphoma. Final histological diagnosis revealed an IMT. The patient was treated with oral steroids. Ultrasound assessments showed a complete resolution of systemic enlarged lymph nodes at the end of 1 month of therapy. Th...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Andersson's lesion in ankylosing spondylitis diagnosed by 18F-FDG PET/CT.
Authors: Zhang Y, Li B, Yu H, Hou J, Shi H Abstract Ankylosing spondylitis (AS) is a form of arthritis that affects the spine, the sacroiliac joints, and sometimes the hips and shoulders. Andersson lesion (AL), was first described by Andersson in 1937 as a destructive vertebral body and discovertebral portion of the spine in AS. In this case, we report a 50 years old man with medical history of AS diagnosed AL by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). PMID: 29550851 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Differentiated thyroid cancer and selenium supplements for protection of salivary glands from 131I treatment.
In conclusion, the prescription of supplements with organic forms of Se must be preferred against of supplements with inorganic forms of Se among DTC patients for the protection of their salivary glands from 131I treatment and Brazil nuts could be another choice. PMID: 29550852 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Abass Alavi: A giant in Nuclear Medicine turns 80 and is still going strong!
Authors: Abstract Little was written in the stars above the city of Tabriz in Iran on March 15, 1938 indicating that a newborn citizen would immigrate to America and become a master of modern mo-lecular imaging with a sharp focus on 18F-FDG PET to the benefit of millions of people around the world. Nonetheless, that's what happened. A gifted boy who lost his farther early and grew up with his uneducated mother and two siblings in humble circumstances to become a premium student, nationally no. 1 in mathematics while in school, and later a medical doctor before he decided in 1966 to seek his fortune in the US. Here...
Source: Hellenic Journal of Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Effect of hypoparathyroid on bone mineral density of lumber spine in postmenopausal women with differentiated thyroid cancinoma.
CONCLUSION: Transient hypoparathyroid increased BMD at lumbar spine by DXA in postmenopausal DTC patients compared to postmenopausal controls. PMID: 29324909 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Deep brain nucleus targeting in Parkinson's disease and essential tremor by image guided surgery using neuronavigation system with tractography and volume of tissue of activated assessment.
CONCLUSION: IGS using neuronavigation allowed more accurate deep nucleus targeting, minimized intra- and post-operative complications and improved clinical outcome in DBS candidate patients. Our study revealed that increased white matter connections with remote parts of the brain would suggest that isolated deep nucleus stimulation could not explain symptom recovery and that patients' specific white matter stimulation by tractography coupled with IGS should be in priority. PMID: 29324910 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Psychological consideration in patients with cerebral gliomas candidates for intra-operative radiation therapy based on tumor location.
Conclusion: Utilization of IORT is shown to improve survival rate of patients suffering from GBM. However, the psychological status is a major determinating factor for the quality of life of these patients. Our study showed that IORT increased psychological disorders in patients with gliomas located in left parietal, left fronto-temporal and left parieto-temporal lobes and should be considered in pre-operative strategy selection. PMID: 29324911 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Diuresis renography and ultrasonography in children with antenatally detected hydronephrosis can support diagnoses and suggest related surgery treatment.
Authors: Radulović M, Beatović S, Janković M, Šobić-Šaranović D, Artiko V, Ajdinović B Abstract OBJECTIVE: Prenatal ultrasound (US) screening detects the hydronephrosis (HN)-dilatation of fetal renal collecting system in 1%-5% of all pregnancies. In most children, HN is detected by prenatal US screening between 18-20 gestational week. Pelvi- ureteric junction (PUJ) stenosis is the most common etiological factor of prenatal HN and requires postnatal follow-up. Diuresis renography plays important role in the follow-up by complementing morphological information obtained by US with the data about di...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The detection of endocarditis, post implantation grafts, arteritis and other related disorders by 18F-FDG PET/CT.
CONCLUSION: Our results indicate that 18F-FDG PET/CT could be useful diagnostic method for the detection of sights of metabolically active disease in patients with persistent symptoms of infection and inflammation of cardiovascular system, as well as in monitoring therapy response. PMID: 29324913 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The association between Alzheimer's disease and cancer: Systematic review - Meta-analysis.
The objective of the present study was the quantitative assessment of the previously documented inverse relationship between Alzheimer's Disease (AD) and cancer (CA) by conducting a meta-analysis and evaluating systematic differentiations of the aforementioned relationship based on cancer localization. For the purpose of the study all available empirical data of the last decade, which met specific criteria, were included in the analysis by querying PubMed, Web of Science and Cochrane Library databases. Seven studies were included in the analysis, with a total sample of 18,887 (10,859 AD patients, 8,028 non-demented control...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Self-report instruments of cognitive failures as screening tools for Subjective Cognitive Impairment in older adults.
CONCLUSION: Self-report questionnaires of "everyday" cognitive and memory failures seem to be associated with specific objective tests of cognition in aging. Hence, they are useful tools for detecting early cognitive impairment at least in older adults. Their administration together with objective cognitive tasks of high difficulty could substantially help for SCI screening. Given that there is also evidence that the experience of subtle impairment in cognition is related to increased likelihood of biomarker abnormalities indicative of AD pathology, the assessment of subjective estimations is revealed as a useful...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A comparison of 18F-FDG PET/CT findings in HIV positive compared to HIV negative patients with recurrent cervical cancer.
CONCLUSION: By using the 18F-FDG PET/CT scan we showed that the time to recurrence is shorter among HIV seropositive patients with the commonest site of metastatic recurrence being in the lymph nodes. Nodal and liver metastases are significantly higher in HIV seropositive patients compared with seronegative patients. PMID: 29324916 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Sequential 18F-FDG PET/CT imaging parameters for differentiating benign from malignant lymph nodes in head and neck carcinoma.
Authors: Pietrzak A, Kazmierska J, Cholewinski W Abstract OBJECTIVE: The aim of this study was to differentiate between benign and malignant head and neck lymph nodes by sequential imaging. SUBJECTS AND METHODS: The total of 56 retrospectively analysed patients with suspected or histopathologically confirmed head and neck malignancy (nasopharyngeal cancers mainly; 28 patients), before any treatment, underwent sequential fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations for staging purposes. Remaining 28 patients with physiologic and histopathologically...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Specific neck pain algometric measurements and their relation to heart rate and skin humidity.
Authors: Petala E, Mironidou-Tzouveleki M, Nanassis K, Pagkalidou E, Kyriakou C, Kapoukranidou D Abstract Cervical pain is very common in general population but only few methods have been used to evaluate it with objectiveness. There are only few studies which use algometer as a means of neck pain assessment. Studies have shown that algometer could be used in pain evaluation but more studies are necessary to support this. The main purpose of the study was the evaluation of algometer as a means of an objective measurement of pain threshold to people with non-specific neck pain. The study focused on the search of cor...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Synchrotron-Fourier transform infrared maps of ovalbumin-induced murine chronic allergic airways disease: Correlation with conventional histology.
Authors: Mazarakis N, Vongsvivut J, Bambery KR, Snibson KJ, Royce SG, Karagiannis TC Abstract Asthma is a chronic respiratory disease characterised by airway inflammation, remodeling and hyperresponsiveness. The ability to replicate these asthma traits in the well-established ovalbumin induced chronic model of allergic airways disease is an important tool for asthma research and preclinical drug development. Here, spectra derived from focal plane array and Synchrotron-Fourier transform infrared maps were used to analyse biochemical changes in lung tissue from an ovalbumin-induced murine chronic allergic airways dis...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Technetium-99m-dimercaptosuccinic acid renal scintigraphy can guide clinical management in congenital hydronephrosis.
Authors: Bazić-Đorović B, Radulović M, Šišić M, Jauković L, Dugonjić S, Pucar D, Janković Z, Beatović S, Janković M, Krstić Z, Ajdinović B Abstract OBJECTIVE: The purpose of this study was to evaluate damage of the kidney with technetium-99m-dimercaptosuccinic acid (99mTc-DMSA) scintigraphy in children with congenital hydronephrosis (CH) and the influence of other postnatal associated diagnoses on abnormal 99mTc-DMSA findings. SUBJECTS AND METHODS: 99mTc-DMSA scintigraphy in 54 children (17 girls and 37 boys), aged from 2 months to 5 years (median 11 months) with 66 congenital hydronep...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The correlation of Evans index with CSF protein levels and ventriculomegaly.
Authors: Papaoikonomou D, Karypidou E, Megagiannis P, Tsolaki-Tagaraki F, Nenopoulou S, Gkatzima O, Tsolaki M Abstract OBJECTIVE: The role of ventriculomegaly and its interplay between various dementia entities and their pathogenesis, as well as its correlation to the levels of CSF protein markers, remains to be elucidated. Evans index (EI) is a well-established radiological marker in the diagnosis of idiopathic Normal Pressure Hydrocephalus (iNPH), assessing ventricular enlargement. However, there are no previous studies investigating the correlation between EI, age, beta amyloid (Aβ), tau and phosphorylated-...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Autologous free fat transfer in patients with velopharyngeal insufficiency.
CONCLUSION: Augmentation pharyngoveloplasty with autologous free fat transfer in patients with velopharyngeal insufficiency is a safe and innovative alternative, particularly for small to medium degrees of structural velophayngeal dysfunction. PMID: 29324922 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The operation of the Day Care Centre of Alzheimer Hellas "Saint Helen" and of the Memory Clinic of Papanikolaou General Hospital from 2007 to 2017.
CONCLUSION: Women are presented more frequently to primary care services and people with dementia have lower education and greater age. AD continues to be the most common type of dementia. PMID: 29324923 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Mobile phone use for 5 minutes can cause significant memory impairment in humans.
CONCLUSION: MP use has a significant negative impact on working memory performance of human participants. The effect is apparent even for a 5 minute use of the MP. Working memory deficits are greater not only for the 60 years old and above participants but also for individuals with Mild Cognitive Impairment. These results are in agreement with previous studies on animals as well as humans on the effects of MP use on the brain. It is argued that low sensitivity of some of the cognitive tasks used until now and the lack of a validated tool in the form of a cognitive task may account for some of the variability in the literat...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Bone scintigraphy can diagnose osteoporotic vertebral compression fractures better than conventional radiography.
CONCLUSION: Bone scintigraphy has a very high sensitivity for detection of vertebral compression fractures in osteoporotic patients. Conventional radiography showed a much lower sensitivity and could not differentiate acute from old vertebral compression fractures. PMID: 29324925 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Risk stratification and staging in prostate cancer with prostatic specific membrane antigen PET/CTObjective: A one-stop-shop.
CONCLUSION: We found that PSMA PET/CT has potential for initial risk stratifications with reasonable correct estimation for N stage. However, it can underestimate T stage. Hence, we suggest that PSMA PET/CT should be used for staging and initial risk stratification of PC as one-stop-shop with regional MRI in surgically resectable cases. PMID: 29324926 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Hematopoiesis is prognostic for toxicity and survival of 223Radium treatment in patients with metastatic castration-resistant prostate cancer.
Authors: Leisser A, Nejabat M, Hartenbach M, Duan H, Shariat SF, Kramer G, Krainer M, Hacker M, Haug AR Abstract OBJECTIVE: We evaluated the impact of pre-therapeutic hematopoiesis on survival, hematotoxicity (HT) and number of 223Radium (223Ra) treatments in patients with metastatic castration-resistant prostate cancer. SUBJECTS AND METHOD: Hemoglobin-levels (Hb), the number of platelets (Plts), leukocytes (Leuk), and survival data were collected in 56 patients treated with 223Ra. Pre-therapeutic hematopoiesis as well as adverse events during and after therapy were scored (grade 0-4) according to the CTCAE rec...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Individual kidney depth determination is mandatory to assess split renal function in nephrography irrespective of age.
Authors: Sinzinger H, Brammen L Abstract Nephrography having been introduced more than 60 years ago still now is one of the most frequently used and informative procedures in Nuclear Medicine. Although being considered a well standardized method, a worldwide study in 34 centers in 21 countries revealed that determination of split kidney function shows unacceptable high variation, particularly in patients with a relative kidney function below 30%. Furthermore, kidney depth usually is not considered. The calculation of kidney depth by various formulas available, each claiming to be more predictive, is different in ra...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Our solution for fusion of simultaneusly acquired whole body scintigrams and optical images, as usesful tool in clinical practice in patients with differentiated thyroid carcinomas after radioiodine therapy. A useful tool in clinical practice.
CONCLUSION: Based on our first results during clinical testing of our system, we can conclude that our system can improve diagnostic possibility of whole body scintigraphy to detect thyroid remnant tissue in patients with DTC after radioiodine therapy. PMID: 29324929 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Characteristics, socioeconomic status and ethnic variations of primary idiopathic macular hole repair in vitreoretinal centers in the United Kingdom.
CONCLUSION: Asian and Afro-Caribbean patients present with larger IMH than European Caucasians. In addition to IMH base diameter, black origin and lower socioeconomic status are independent risk factors for surgical failure. This study presents a large population-based data analysis on ethnic variation in macular holes and may assist in the management and predicting the surgical outcome. PMID: 29324930 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Vitrectomy with fibrovascular membrane delamination for proliferative diabetic retinopathy with or without preoperative Avastin.
CONCLUSION: Pre-operative Avastin reduces the risk of intraoperative and postoperative complications and results in better postoperative anatomic and functional outcomes in fibrovascular delamination surgery for patients with PDR. PMID: 29324931 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The neurophysiological and evolutionary considerations of close combat: A modular approach.
Authors: Dervenis K, Tsialogiannis E Abstract Close Combat may be identified as a physical confrontation involving armed or unarmed fighting, lethal and/or non-lethal methods, or even simply escape from and/or de-escalation of the confrontation. Our model hypothesizes that distinct areas of the brain are utilized for specific levels of violence, based on evolutionary criteria, and that these levels of violence bring into effect distinct physiological criteria and kinesiology. This model is outlined similar to Paul D. MacLean's triune brain theory, but incorporates distinct processes inherent to the autonomic nervou...
Source: Hellenic Journal of Nuclear Medicine - January 14, 2018 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research