Incidental finding of silent appendicitis on (18)F-FDG PET/CT in a patient with small cell lung adenocarcinoma.
We report the incidental diagnosis of acute asymptomatic appendicitis on a fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG PET/CT) performed for staging of a non small cell lung carcinoma. The patient was asymptomatic and laboratory tests were normal. The case illustrates: a) the possibility to diagnose appendicitis on (18)F-FDG PET/CT and b) the possibility of silent acute appendicitis, although this is a rare occurrence. PMID: 27331212 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - June 23, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A rare case of coronary fistula evaluated by first-pass radionuclide angiography.
We report a case of CAF in a 77 years old woman with dyspnea on exertion. Using coronary angiography and cardiac multidetector computed tomography, this patient was diagnosed with CAF draining into the left bronchial arteries. First-pass radionuclide angiography (FPRNA) showed early pulmonary recirculation through a left to right shunt. The pulmonary to systemic blood flow ratio was 1.24. The patient received supportive care with vasodilator and antiplatelet therapy. First-pass radionuclide angiography was used to provide physiologic informations, to plan the treatment course for this patient. PMID: 27331213 [PubMed - ...
Source: Hellenic Journal of Nuclear Medicine - June 23, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Clinical, pathological and (18)F-FDG PET/CT findings in synchronous primary vaginal and endometrial cancers.
In this report, we describe the clinical, pathological and fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) findings of a patient with synchronous primary vaginal and endometrial cancers. To our knowledge, this is the first such case described in the literature. PMID: 27331214 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - June 23, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Multiple liver focal fat sparing lesions with unexpectedly increased (18)F-FDG uptake mimicking metastases examined by ultrasound (18)F-FDG PET/CT and MRI.
CONCLUSION: Histopathology diagnosed focal fatty sparing lesions in the liver. This pattern presented difficult diagnostic challenge. The pathogenesis of multifocal fat deposition and the reasons of the higher accumulation of (18)F-FDG in the liver fat lesions have not been up to now fully explained. PMID: 27331215 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - June 23, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

A pulmonary chondromatous hamartoma resembling multiple metastases in the (18)F-FDG PET/CT scan.
Authors: Li L, Jiang C, Tian R Abstract Multiple pulmonary hamartomas (PH) occur rarely, are mostly seen in females, and are usually leiomyomatous hamartomas. Here, we report an extremely rare case of a 30 years old male patient diagnosed as multiple pulmonary chondromatous hamartomas. He was admitted on May 2015 to our hospital for a 3 months history of cough. Multiple nodules in the right lung were detected on chest X-rays during a routine checkup 9 months ago and in a subsequent chest computed tomography (CT). However, he abandoned medical follow-up because he was asymptomatic. Nine months later, rare and atypic...
Source: Hellenic Journal of Nuclear Medicine - June 23, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The value of (18)F-FDG PET/CT in the diagnosis of uterine intravenous leiomyomatosis extended into the right atrium.
Authors: Xiao J, Liu G, Cheng D, Wang H, Shi H Abstract Intravenous leiomyomatosis (IVL) of the uterus is a rare neoplasm which usually occurs after hysterectomy. Due to its rarity and non-specific clinical manifestations, IVL is commonly misdiagnosed as malignant thrombus or thrombosis and treated inappropriately. Herein, we report an unusual case of a 51 years old woman with IVL without hysterectomy or abdominal manifestations. The IVL was detected in the right atrium. This case highlights the usefulness of (18)F-FDG PET/CT in the diagnosis of IVL. PMID: 27331217 [PubMed - as supplied by publisher] (Source: H...
Source: Hellenic Journal of Nuclear Medicine - June 23, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Neuroendocrine tumors: Peptide receptors radionuclide therapy (PRRT).
Authors: Otte A Abstract Receptor-mediated radioimmunotherapy (RIT) has become an exciting field in nuclear medicine. In some indications we are succesful. Many concepts are experimental, although in use since many years, and only few, as e.g. (90)Y-ibritumomab tiuxetan, have gone to market but still pose a number of challenges. In this context, the review by Papamichail et al. in the Greek section of the Jan-Apr 2016 issue of the HJNM on receptor-mediated RIT regimens in neuroendocrine tumors including somatostatine analogues radiolabelled with (111)In, (90)Y, (177)Lu, and (213)Bi is most timely. The perception of...
Source: Hellenic Journal of Nuclear Medicine - June 23, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Can calcified pulmonary metastases detected by (18)F-FDG PET/CT suggest the primary tumor?
Authors: Hong CM, Ahn BC Abstract Many calcified nodules are encountered on the (18)F-FDG PET/CT scan and even though most of them are benign, the possibility of calcified pulmonary metastases (CPM) should be considered. The CT portion can often differentiate benign diseases due to their morphology. Measuring SUVmax is very important. Understanding the mechanism of calcification in malignant metastatic pulmonary lesions may be useful to suggest their origin. PMID: 27035906 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Johann Sebastian Bach's "Goldberg variations" to treat insomnia from renal lithiasis pain. Sleep research in Nuclear Medicine.
In conclusion, insomnia is an interesting research field-however neglected by modern neuroimaging. Especially nuclear medicine provides the researcher with tools which offer a better spatial resolution and patient comfort than does the current gold standard EEG. Why not look at it-of course, with Bach's "Goldberg variations" in your minds? PMID: 27035907 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Echocardiography versus (201)Tl semi-quantitative gated single photon emission tomography for the evaluation of cardiac disease associated with late stage Duchenne muscular dystrophy.
CONCLUSION: Although our patients were few we indicated that in DMD patients, aged older than 20 years, at an advanced stage of the disease, the EF values calculated by EC were lower than those by (201)Tl SQGS possibly due to thoracic deformity. PMID: 27035908 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

[Neuroendocrine tumors: Peptide receptors radionuclide therapy (PRRT)].
Authors: Papamichail DG, Arahata PE, Chatzipavlidou VD Abstract Neuroendocrine tumors (neuroendocrine tumors-NET) are a heterogeneous group of neoplasms with a common embryological origin and diverse biological behavior, derived from cells of the neuroendocrine system, the system APUD (amine precursor uptake and decarboxylation). They are characterized by overexpression of all five somatostatin receptors (SSTR1-SSTR5), particularly type 2 (SST2). Surgical resection of the tumor is the treatment option, with a possibility of complete remission in patients with limited disease. Somatostatin analogs (octreotide and la...
Source: Hellenic Journal of Nuclear Medicine - April 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An endless research for 2016.
Authors: Grammaticos PC, Antoniou D Abstract In a moment of reflection of the past year of 2015, as to what we have achieved in medical research and what we need to do in the future we realize that although we have performed an enormous progress in medical research in the past we still have to do much more. In nuclear medicine there are many problems to solve like, how can we differentiate between infection, inflammation and cancer or between lymphomas and adenocarcinomas. In bone scans we need to differentiate traumatic lesions acute or chronic and lesions from another origin. Dosimetry and radiation burden is ano...
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

(18)F-FDG PET/CT imaging in granulomatosis with polyangiitis.
Authors: De Geeter F, Gykiere P Abstract The paper gives an overview of the literature data on uptake of fluorine-18-fluorodeoxyglucose ((18)F-FDG) into the different tissue lesions which may occur in granulomatosis with polyangiitis (formerly called Wegener's syndrome). It discusses the cellular mechanisms of such (18)F-FDG uptake, which provide a basis for its interpretation in the context of (18)F-FDG positron emission tomography (PET) for inflammatory conditions. PMID: 26929934 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Causes of (18)F-FDG uptake on white adipose tissue.
Authors: Hwang DY, Lee JW, Lee SM, Kim S Abstract White adipose tissue usually shows negligible fluorine-18-fluorodeoxyglucose ((18)F-FDG) uptake. In certain clinical conditions this (18)F-FDG uptake has been reported to be increased like in HIV patients under treatment, in exogenous Cushing's syndrome, in cases related to premedication and other cases. PMID: 26929935 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Towards tracer dose reduction in PET studies: Simulation of dose reduction by retrospective randomized undersampling of list-mode data.
CONCLUSION: Simulation of PET tracer dose reduction is possible with retrospective undersampling of list-mode data. Resulting simulated low-dose images have equivalent characteristics with PET images actually measured at lower doses and can be used to derive optimal tracer dose regimes. PMID: 26929936 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Challenges and strategies on radioiodine treatment for differentiated thyroid carcinoma.
CONCLUSION: The indications of (131)I ablation continue to be refined with a better understanding of the risks and benefits. For pre-treatment TSH stimulation, recombinant human thyrotropin presents a better choice as it improves the quality of life, but is indicated only for ablation of the thyroid remnant and follow-up. Decreased doses of (131)I seem to be more appropriate in patients without gross residual disease or metastases, but maximal doses are suggested in patients with advanced disease. Imaging procedures contributing to decision-making for patients with advanced DTC also continue to be modified. As for the (131...
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Current status and future challenges of brain imaging with (18)F-DOPA PET for movement disorders.
CONCLUSION: (18)F-DOPA PET imaging is still the best diagnostic tool for the diagnosis of PD and other movement disorders. Fluorine-18-FDG PET can play a role in the differential diagnosis between PD and other PS. The hybrid (18)F-DOPA PET/MRI seems to be able to play an important additional role in early diagnosis of the above syndromes. PMID: 26929938 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

(18)F-FDG PET/CT imaging in systemic lupus erythematosus related autoimmune haemolytic anaemia and lymphadenopathy.
CONCLUSIONS: A symmetrically increased (18)F-FDG uptake in small lymph nodes with multiple serous cavity effusion helped the differential diagnosis between SLE related AIHA and lymphoma. In addition, PET/CT can visualize not only the degree of disease activity or the "burden of inflammation" but also the distribution of the disease in the entire body. PMID: 26929939 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Missed causative tumors in diagnosing tumor-induced osteomalacia with (18)F-FDG PET/CT: a potential pitfall of standard-field imaging.
CONCLUSION: Once patients are suspected to have TIO, a whole-body nuclear imaging study such as (18)F-FDG PET/CT should be performed, in order not to miss the hidden causative tumor, especially occurring in the distal extremities. PMID: 26929940 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Increased pertechnetate and radioiodine uptake in the thyroid gland with subacute thyroiditis and concurrent Graves' disease.
CONCLUSION: This case indicated that the measurement of TSHRAb is useful in understanding the clinical course of patients with SAT when thyroid function tests including the (99m)Tc and (131)I uptake are not compatible with the diagnosis. In such cases, GD should be suspected. The mechanism of high (99m)Tc and/or (131)I uptake in patients with simultaneous SAT and GD may be due to the inflammatory process which was detected by FNA in a small part of the left thyroid lobe inducing the stimulating effects of elevated TSHRAb on the undamaged follicular cells. PMID: 26929941 [PubMed - as supplied by publisher] (Source: Hell...
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

(18)F-FDG PET imaging of granulomatosis with polyangiitis -Wegener's Syndrome.
CONCLUSION: None of the findings on PET are specific for GPA, but in a given clinical context, they may contribute to early diagnosis. They may guide biopsy taking, and may determine the extent of the disease. During and after treatment, PET can be used to monitor disease activity. PMID: 26929942 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The role of PET/CT in diagnosing generalized lymphadenopathy in asymptomatic secondary syphilis.
CONCLUSION: We report a case of a secondary syphilis in a patient with generalized lymphadenopathy detected by fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) images without any clinical symptom. Clinical examination found an ulcer on his penis and serologic tests set the diagnosis of an early stage of secondary syphilis. PMID: 26929943 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Nuclear Medicine and its promising applications in gynecological cancers.
Authors: Lioupis M, Syrmos NC Abstract Nuclear medicine is defined as: "the scientific and clinical discipline in which free radionuclides and radionuclide compounds, redistributed in vivo or in vitro by physical or chemical mechanisms, are used for diagnostic, therapeutic or investigative purposes". It seems that the above definition of Nuclear Medicine well includes the fact that Nuclear Medicine embraces into very important areas such as molecular imaging, cellular imaging and tissue imaging. Related to the interesting papers of Çerçi S. S. et al in HJNM, we may additionally state the fol...
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

An early case of intravascular large B-cell lymphoma of bilateral adrenals detected by (18)F-FDG PET/CT.
CONCLUSION: We describe this case, to highlight the importance of (18)F-FDG-PET/CT in early diagnosis of IVLBCL in bilateral adrenals confirmed by pathology and in differentiating a malignant from a benign tumor. PMID: 26929945 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

[Radiation treatment of head and neck carcinomas as a risk factor for thyroid carcinomas].
Authors: Giannoula E, Gkantaifi A, Iakovou I Abstract OBJECTIVE: Cancer of the thyroid is a relatively rare malignant neoplasm with an increasing incidence in the last decades. Ionizing radiation is the best documented risk factor for thyroid malignant neoplasms, in current medical literature. An increase in the global annual per caput effective radiation dose has been described, partly as a result of medical exposure. External beam radiation therapy of the head and neck region has also been attributed. Thyroid tissue is particularly vulnerable to the carcinogenic effects of ionizing radiation because of its anatom...
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

IgG4-related disease: The utility of (18)F-FDG PET/CT in diagnosis and treatment.
CONCLUSION: In this contribution we present a rare entity of IgG4-RD and discuss the utility of fluorine-18-fluorodeoxyglucose ((18)F-FDG) Positron emission tomography/computed tomography (PET/CT) in the diagnosis and treatment of this condition. PMID: 26672716 [PubMed - in process] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 20, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Can tumor necrosis factor a (TNF-a) and interleukin 6 (IL-6) be used as prognostic markers of infection following ureteroscopic lithrotripsy and extracorporeal shock wave lithotripsy for ureteral stones?
Authors: Bantis A, Tsakaldimis G, Zissimopoulos A, Kalaitzis C, Gianakopoulos S, Pitiakoudis M, Polichronidis A, Touloupidis S Abstract OBJECTIVE: Ureteroscopic lithotripsy (URS) and Extracorporeal shock wave lithotripsy (ESWL) are highly effective for the treatment of uretral lithiasis and remain the treatment option for the majority of patients for more than two decades. In the present study we aimed to evaluate the levels of serum tumor necrosis factor A (TNFa) and interleucin 6 (IL6) in patients undergoing ESWL and URS. SUBJECTS AND METHODS: A total number of seventy patients were involved in our study. Thi...
Source: Hellenic Journal of Nuclear Medicine - December 20, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Application of Kanban System on a hospital pharmacy.
Authors: Mitka E Abstract This is a brief overview of principles, views and methods, of the Kanban System for the pharmacy of a general hospital. The main goal is the reduction of stores managed by the pharmacy, as well as improvement of the mode of operation. Solutions to problems, such as inadequate storage space, the delay in serving patients or clinics and the expiration of various pharmaceutical formulations, stored for so long time, are provided. The philosophy behind the Kanban procurement System and specifically its applicability to a pharmacy underperforming in terms of efficiency, in Greece, are described...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Role of dopaminergic neurotransmission in pathophysiology of action tremor in Parkinson's disease.
Authors: Niccoli Asabella A, Gigante AF, Ferrari C, Di Palo A, Rubini D, Mossa EP, Dagostino S, Pellicciari R, Defazio G, Rubini G Abstract BACKGROUND: Rest tremor (RT), a tremor that occurs in a body part that is completely supported against gravity, is together with rigidity and bradykinesia among the core features of Parkinson's disease (PD). In addition to classical RT, many PD patients also have action tremor (AT) occurring during sustained postures or voluntary movement. Earlier studies showed a good correlation between striatal dopamine transporter (DAT) binding, measured with [(123)I] FP-CIT SPET and bradyk...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Role of (18)F-FDG PET/CT in the evaluation of response to antibiotic therapy in patients affected by infectious spondylodiscitis.
CONCLUSIONS: (18)F-FDG PET/CT is useful to detect the early response to antibiotic therapy in patients affected by infectious spondylodiscitis. (18)F-FDG PET/CT semiquantitative parameters provide critical diagnostic information of the infectious process. (18)F-FDG PET/CT should be considered as first-line exam in the early post-treatment evaluation of spondylodiscitis while MR should be preferred for delayed assessment. PMID: 26665207 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The diagnostic performance of (99m)Tc-HMPAO radiolabeled leucocytes scintigraphy in the investigations of infection. A single center experience.
CONCLUSION: The RL-WBC scan (i) is extremely useful in the diagnosis of perigraft tissue infection and osteomyelitis (except for spine) with high rate of sensitivity and specificity (≈90%) when timely used, and (ii) may provide valuable information in patients with fever of unknown origin, inflammatory bowel disease or vague symptoms. False positive results have been noticed mainly due to artifacts, co-existent skeletal lesions or in the early postoperative course because of the nonspecific radionuclide uptake in the healing tissue. On the other hand, false negative results may appear in delayed aortic graft infectio...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Intravitreal aflibercept (A-IVI) for the treatment of neovascular age-related macular degeneration (nv-AMD): one year experience.
Authors: Papavasileiou E, Zygoura V, Richardson T, Cortis D, Eleftheriadis H, Jackson TL Abstract OBJECTIVE: To report the anatomical and functional results of intravitreal injections of aflibercept (Eylea) (A-IVI) for the treatment of naïve eyes with neovascular age-related macular degeneration (nv-AMD). SUBJECTS AND METHODS: This retrospective, one-center, non-comparative chart review included 26 treatment naïve eyes with nv-AMD of 26 patients (14 male) with a mean age of 80.5 (range 63-91) who had a complete follow-up of 14 months. The morphological analysis included spectral domain optical coheren...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Real-world treatment of diabetic macular oedema: a comparison of combined ranibizumab plus macular LASER with macular LASER monotherapy.
CONCLUSIONS: Combination treatment of intravitreal ranibizumab injections and macular LASER appears safe and effective over two years. The need for injection declines over time. There is an association between higher levels of serum total and LDL cholesterol and the presence and the extent of hard exudates. PMID: 26665210 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Imaging of cardiac amyloidosis by (99m)Tc-PYP scintigraphy.
CONCLUSION: These preliminary results are compatible with current international literature, and demonstrate that scintigraphy with (99m)Tc-PYP may prove a simple, non-invasive and widely available method in the identification of patients with the ATTR subtype, thus optimizing therapeutic decisions. PMID: 26665211 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Exploration of mechanisms in nutriepigenomics: Identification of chromatin-modifying compounds from Olea Europaea.
Authors: Bonvino NP, Ray NB, Luu VT, Liang J, Hung A, Karagiannis TC Abstract Chemical modification of histones represents an important epigenetic mechanism critical for DNA metabolism including, transcription, replication and repair. A well-known example is maintenance of histone acetylation status by the opposing actions of histone acetyltransferase and histone deacetylase enzymes which add and remove acetyl groups on lysine residues on histone tails, respectively. Similarly, histone methyltransferase and histone demethylase enzymes are responsible for adding and removing methyl groups on histone tails, respectiv...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Psychological aspects in brain tumor patients: A prospective study.
CONCLUSION: Depressive symptoms as well as anxious and OCD psychopathology were shown to be prevalent signs among patients with brain tumor. Diagnosis of the previous mentioned symptoms were totally based on DSM-IV criteria and these disorders and the percentiles don't seem to be related to each other. Due to high variability of tumor stages, statistical analysis of whether the mentioned psychiatric symptoms get worsen at the later stages of the tumor genesis was not feasible. Although not measured directly, mentioned psychiatric symptoms seem to get worsen at the later stages of the brain tumor. The associated factors are...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Radioguided surgery using gamma detection probe technology for resection of cerebral glioma.
Authors: Seddighi A, Akbari ME, Seddighi AS, Pirayesh E, Soleymani MM, Baqdashti HR, Nikouei A, Zali A, Tabatabaei SM, Naimian S, Mellati O, Sheikhi A Abstract OBJECTIVE: Using microsurgical procedures without intraoperative imaging, Gross Total Resection (GTR) has so far only been achieved in less than 30% of all cases. Radio-guided surgery was introduced in the clinical setting in 1985 in an attempt to facilitate intraoperative tumor detection. Because of few studies in literature about this subject, we decided to use gamma probe with the hypothesis that we could increase extent of tumor resection. MATERIALS ...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Voxel based internal dosimetry during radionuclide therapy.
CONCLUSION: Patient specific voxel internal dosimetry can be performed accurately with MATLAB. Dose volume histograms and mean dose can be calculated. PMID: 26665215 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

The diagnostic performance and added value of (18)F-FDG PET/CT in the detection of liver metastases in recurrent colorectal carcinoma patients.
CONCLUSION: (18)F-FDG PET/CT was highly sensitive, specific and accurate method in detection of liver metastases in patients with suspected recurrent colorectal carcinoma in our study. This hybrid imaging showed superior diagnostic performance in evaluation of suspected colorectal cancer liver metastases compared to conventional imaging. PMID: 26665216 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Diagnostic medicine: A comprehensive ABCDE algorithm for accurate interpretation of radiology and pathology images and data.
Authors: Zioga CA, Destouni CT Abstract A pathway to the procedure of interpreting radiology images or pathology slides is presented. This simplified mnemonic can be used as a memory aid determining the order in which diagnosis should be approached. First, before we place the radiology image in front of the lightbox or the slide under the microscope we have to be sure that it is adequately labelled and prepared (Correct). It is also necessary to have or gather all available information concerning the patient and if possible his full medical history (A, Available Information). Once we come across the image, two fund...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Radionuclide imaging: Past, present and future outlook in the diagnosis of infected prosthetic joints.
Authors: Brammen L, Palestro C, Sinzinger H Abstract OBJECTIVE: A serious complication of joint replacement surgery is infection, which results in prolonged invalidity as well as removal and subsequent re-implantation after lengthy antibiotic therapy. In terms of diagnostic imaging, nuclear medicine has presented several tracers and imaging modalities over the years to be used in prosthetic joint infection. The PubMed/MEDLINE literature database was systematically examined for publications on infection, arthroplasty, joint replacement, prosthetic joint, gallium, labeled leukocytes, sulfur colloid, antimicrobial pep...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Tumor necrosis factor A and interleucin 6 serum values in patients undergoing extracorporeal shock wave lithotripsy for ureteral stones.
Authors: Tsakaldimis G, Bantis A, Zissimopoulos A, Kalaitzis C, Gianakopoulos S, Pitiakoudis M, Polichronidis A, Touloupidis S Abstract OBJECTIVE: Extracorporeal shock wave lithotripsy (ESWL) is highly effective for the treatment of uretral lithiasis and remains the first treatment option for the majority of patients when ureteral lithiasis can not be treated otherwise for more than two decades. In the present study we aim to evaluate the levels of serum tumor necrosis factor a (TNF-a) and interleucin 6 (IL-6) in patients undergoing ESWL and investigate whether preESWL levels of serum TNF-a and IL-6 correllate with...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Social cognition in adults: the role of cognitive control.
CONCLUSION: The decreased performance that cognitively healthy older adults exhibit, as regards specific complex dimensions of social cognition, could be attributed to negative effects of age on cognitive control. However, it is likely that some other complex dimensions of social cognition are not affected by frontal aging. PMID: 26665220 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Comparing the latent structure of Raven's educational coloured progressive matrices among young children and older adults: A preliminary study.
CONCLUSION: The results support the existence of a different factor structure in [R] Educational CPM between first- to second- grade elementary school students and new-old adults, on the one hand, and kindergarten students and old-old adults, on the other. This difference could possibly reflect the underdevelopment of inductive reasoning and executive functioning in the group of kindergarten students and the disorganization of them in the group of old-old adults. PMID: 26665221 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Our experience with informative and communication technologies (ICT) in dementia.
In conclusion ICT can help health professionals and caregivers to support in a better way the patients with cognitive, functional and behavioral problems. PMID: 26665222 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Assessing an avoidable and dispensable reoperative entity: Self-referred flawed cleft lip and palate repair.
CONCLUSION: The aim of this study was to assess secondary CLP deformity management in an accredited present-day tertiary hospital facility with an existing infrastructure of a specialist teams however not formed in a multidisciplinary group. Equally, to answer questions of specific operation indications and choice as related to prior surgeries, hospitalization time and cost, provision of adequate preoperative information, correlation between paediatric and plastic surgeons and effect of post-plastic surgical care on patients' health and well-being. It also aims at presenting, beyond our current primary cleft lip and palate...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Role of (18)F-DOPA PET/CT and (131)I-MIBG planar scintigraphy in evaluating patients with pheochromocytoma.
CONCLUSIONS: (18)F-DOPA PET/CT seems to be a better modality in comparison to (131)I-MIBG scintigraphy in the evaluation of pheochromocytoma/paraganglioma. At this point both these tracers seem to have mutually additive role in these patients and essential investigations with diagnosis and follow-up of this disease. PMID: 26665224 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

In-111 polyclonal HIG identifies patients but not atherosclerotic lesions at risk - a 5 years follow-up.
Authors: Berent R, Auer J, Granegger S, Sinzinger H Abstract There is a strong need for non-invasive detection of human atherosclerotic lesions. One of the radioisotopic approaches using Indium-111-HIG has been shown to accumulate in oxidized LDL-rich foam cells and inflammatory vascular lesions. Earlier human studies in 200 patients, 100 with peripheral vascular disease and 100 with carotid artery disease comparing In-111-HIG scintigraphy with sonographic data revealed a high sensitivity (70%-77%) but a very low specificity (33%-41%). At this time we concluded the approach "not promising" for human studi...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Validation of numerical outputs of IAEA software by the analysis of diuretic nephrogram in children with antenatally detected hydronephrosis.
CONCLUSION: We have calculated in children by means of the IAEA software the values of three advanced parameters of the (99m)Tc MAG3 F+2 diuresis nephrogram for normal kidneys, hypotonic non-obstructed and obstructed kidneys. The overall results provided evidence of excellent agreement of obtained results with previously reported values of the quantitative parameters of renal washout. The parameters of IAEA software has been shown to be reliable in assessing kidney drainage. The nuclear medicine section of the IAEA should be encouraged to produce final version of the software and to release it through IAEA Web site. PM...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Ebola Check: Delivering molecular diagnostics at the point of need.
Authors: Moschos SA Abstract The 2013-5 global outbreak of Ebolavirus disease brought to sharp focus the need for diagnostic capacity to be equitably available on a global scale: from the most under-developed areas of resource-limited countries in West Africa to high volume international travel hubs in Europe and the USA. Quick detection of the causal agent of disease is pivotal to containment, contact tracing and clinical action to protect healthcare workers, communities and patients. Nucleic acid testing (NAT) by real time reverse transcription quantitative polymerase chain reaction (RT-PCR) has emerged as the pr...
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research