AZGP1 deficiency promotes angiogenesis in prostate cancer

CONCLUSION: AZGP1 is a negative regulator of angiogenesis, such that loss of AZGP1 promotes angiogenesis in prostate cancer. AZGP1 likely exerts heterotypical effects on cells in the tumor microenvironment, such as stromal and endothelial cells. This study sheds light on the anti-angiogenic characteristics of AZGP1 in the prostate and provides a rationale to target AZGP1 to inhibit prostate cancer progression.PMID:38659028 | DOI:10.1186/s12967-024-05183-x

Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Ru M Wen Zhengyuan Qiu G Edward W Marti Eric E Peterson Fernando Jose Garcia Marques Abel Bermudez Yi Wei Rosalie Nolley Nathan Lam Alex LaPat Polasko Chun-Lung Chiu Dalin Zhang Sanghee Cho Grigorios Marios Karageorgos Elizabeth McDonough Chrystal Chadwic Source Type: research