Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice
AbstractMyeloid neoplasms are a group of bone marrow diseases distinguished by disruptions in the molecular pathways that regulate the balance between hematopoietic stem cell (HSC) self-renewal and the generation of specialized cells. Cytokines and chemokines, two important components of the inflammatory process, also influence hematological differentiation. In this scenario, immunological dysregulation plays a pivotal role in the pathogenesis of bone marrow neoplasms. The STING pathway recognizes DNA fragments in the cell cytoplasm and triggers an immune response by type I interferons. The role of STING in cancer has not ...
Source: Medical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1640: Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations
őző
Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possib...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: G ábor Cserni Rita Bori Éva Ambrózay Orsolya Serf őző Tags: Article Source Type: research
Rethinking the Approach to Nail Disorders
This Viewpoint discusses the need for a broader approach to nail pathology, in which infectious, inflammatory, systemic, and structural factors are considered. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 24, 2024 Category: Dermatology Source Type: research
Modulating PCGF4 stability is an efficient metastasis-regulatory strategy utilized by distinct subtypes of Cancer-Associated Fibroblasts in intrahepatic cholangiocarcinoma
Intrahepatic Cholangiocarcinoma (ICC) is highly malignant neoplasm and prone to metastasis. It is unclear if cancer-associated fibroblasts (CAFs) affect the metastasis of ICC. Here, we have established ICC patient-derived CAF lines and related cancerous cell lines and analyzed the effects of CAFs on the tumor progressive properties of the ICC cancerous cells. Results demonstrated that CAFs can be classified into cancer-restraining or promoting categories (rCAFs or pCAFs) based on distinct tumorigenic effects. (Source: American Journal of Pathology)
Source: American Journal of Pathology - April 24, 2024 Category: Pathology Authors: Jinjing Hu, Hao Xu, Xiaojun Ma, Mingzhen Bai, Yongqiang Zhou, Ruidong Miao, Fanghong Wang, Xun Li, Bo Cheng Tags: Regular Article Source Type: research
Coxa pedis: can calcaneal pronation angle be considered a predictive sign of medial plantar arch overload?
ConclusionIn conclusion, the literature associates medial longitudinal plantar arch overload with posterior tibial tendinopathy and spring ligament complex injuries. Our data show that both injuries are highly correlated with increased calcaneal pronation angle, which could be considered a predictive sign of internal plantar arch overload, prior to the development of the associated signs. (Source: La Radiologia Medica)
Source: La Radiologia Medica - April 24, 2024 Category: Radiology Source Type: research
Trimerization profile of type IV collagen COL4A5 exon deletion in X-linked Alport syndrome
ConclusionExon skipping is advantageous for nonsense mutants in AS with severe phenotypes and early onset of renal failure but applications may be limited to ΔExons capable of normal trimerization and secretion. This study provides information on α5(IV) exon-skipping for possible therapeutic application and the prediction of the trimer behavior associated with exon-skipping in Alport syndrome. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 24, 2024 Category: Urology & Nephrology Source Type: research
Molecules, Vol. 29, Pages 1940: Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
n Kangwan
An excessive inflammatory response of the gastrointestinal tract is recognized as one of the major contributors to ulcerative colitis (UC). Despite this, effective preventive approaches for UC remain limited. Rosmarinic acid (RA), an enriched fraction from Perilla frutescens, has been shown to exert beneficial effects on disease-related inflammatory disorders. However, RA-enriched perilla seed meal (RAPSM) and perilla seed (RAPS) extracts have not been investigated in dextran sulfate sodium (DSS)-induced UC in mice. RAPSM and RAPS were extracted using the solvent-partitioning method and analyzed with high-pre...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Natticha Sumneang Komsak Pintha Sarawut Kongkarnka Maitree Suttajit Napapan Kangwan Tags: Article Source Type: research
Publisher Correction: Epithelial recognition and elimination against aberrant cells
(Source: Seminars in Immunopathology)
Source: Seminars in Immunopathology - April 24, 2024 Category: Pathology Source Type: research
Prospective development study of the Versius Surgical System for use in transoral robotic surgery: an IDEAL stage 1/2a first in human and initial case series experience
ConclusionsTORS is feasible with the Versius Surgical System. The development of TORS-specific instruments would benefit performance and wider adoption of the system. 4-arm surgery is possible however further evaluation is required. Multicentre evaluation (IDEAL stage 2b) is recommended. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 23, 2024 Category: ENT & OMF Source Type: research
Point de vue de l’urologue : apport de la cytologie urinaire dans le diagnostic et la prise en charge des tumeurs urothéliales
Ann Pathol. 2024 Apr 22:S0242-6498(24)00076-2. doi: 10.1016/j.annpat.2024.04.001. Online ahead of print.NO ABSTRACTPMID:38653657 | DOI:10.1016/j.annpat.2024.04.001 (Source: Annales de Pathologie)
Source: Annales de Pathologie - April 23, 2024 Category: Pathology Authors: A-S Bajeot M Roumigui é Source Type: research
Literature highlights
Ann Pathol. 2024 Apr 22:S0242-6498(24)00077-4. doi: 10.1016/j.annpat.2024.04.002. Online ahead of print.NO ABSTRACTPMID:38653658 | DOI:10.1016/j.annpat.2024.04.002 (Source: Annales de Pathologie)
Source: Annales de Pathologie - April 23, 2024 Category: Pathology Authors: Audrey Rousseau Source Type: research
Brystkreft hos menn – histopatologi og biomarkører
Tidsskr Nor Laegeforen. 2024 Mar 27;144(5). doi: 10.4045/tidsskr.23.0438. Print 2024 Apr 23.ABSTRACTBACKGROUND: Breast cancer in men accounts for around 1 % of all cases of the disease. The study aimed to identify histopathological parameters and selected biomarkers in men with breast cancer.MATERIAL AND METHOD: Retrospective study of archival material from 53 men diagnosed with breast cancer at the department of pathology, Haukeland University Hospital, in the period 1996-2020. The prevalence of the oestrogen receptor (ER), progesterone receptor (PGR) and Human Epidermal Growth Factor (HER2) biomarkers was examined.RESULT...
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Ingvild Kathrin Lok øy Inga Sofie Bakken Elisabeth Wik Ingunn Marie Stefansson Source Type: research
Translation and validation of traditional Chinese version of the pediatric eating assessment Tool-10
CONCLUSIONS: The Traditional Chinese version of the Pedi-EAT-10 has fair reliability and validity and can be quickly and easily completed by caregivers. The translated Ped-EAT-10 can be used as a first-line tool for assessing the need for further referral and instrumental examination.PMID:38653676 | DOI:10.1016/j.jfma.2024.04.010 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 23, 2024 Category: General Medicine Authors: Sz-Ting Wang Kun-Tai Kang Wen-Chin Weng Pin-Hung Lu Chi-Fen Chang Yuh-Yu Lin Yu-Chen Lee Chen-Yu Chen Jing-Chun Song Wei-Chung Hsu Source Type: research
Riddle of the Sphinx: Emerging role of circular RNAs in cervical cancer
Pathol Res Pract. 2024 Apr 17;257:155315. doi: 10.1016/j.prp.2024.155315. Online ahead of print.ABSTRACTCervical cancer is a prominent cause of cancer-related mortality among women, with recent attention directed toward exploring the involvement of circular RNAs (circRNAs) in this particular cancer. CircRNAs, characterized by a covalently closed loop structure, belong to a class of single-stranded non-coding RNA (ncRNA) molecules that play crucial roles in cancer development and progression through diverse mechanisms. The abnormal expression of circRNAs in vivo is significantly associated with the development of cervical c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Caiyan Yin Jianwei Yu Gaohua Liu Jun He Peng Wu Source Type: research
NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway
CONCLUSION: Collectively, our findings show that NUPR1 enhances the progression of ESCC by triggering autophagy and is associated with the MAPK-mTOR signaling pathway.PMID:38653091 | DOI:10.1016/j.prp.2024.155323 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Shiheng Ren Yuxin Chen Qiang Wang Liang Song Zhongwei Xin Mo Shi Xiangyan Liu Source Type: research
