Rectal gastric heterotopia with fundic gland polyps, mimicking a high-risk primary anorectal neoplasm: histological evidence of the effects of gastric acid-suppressing medication in a rectal ‘outlet patch’
Gastric heterotopia can occur in any part of the gastrointestinal tract but is rare in the rectum. This case of rectal gastric heterotopia is novel as the heterotopic mucosa contained fundic gland polyps, and there were histological changes in the gastric glands characteristic of proton pump inhibitor-related changes. These changes included apocrine-like luminal cytoplasmic protrusions in cystically dilated oxyntic gland parietal cells. These are well described in the native stomachs of PPI treated patients, but this is the first report of these changes in heterotopic gastric mucosa to our knowledge. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 17, 2024 Category: Pathology Authors: Ethan Clarke, Khine Thu, Tim Bracey Tags: Short case Source Type: research
Evaluation of false-positive Rhodotorula detections by a multiplex PCR-based fungal panel performed on positive blood culture bottles
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - April 17, 2024 Category: Microbiology Authors: Robert Hamilton-SethVincent StrevaNatalie GammelVictoria L. Campod ónicoPatricia J. SimnerSean X. ZhangKaren C. Carroll1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA2Pathology and Laboratory Medicine, Nort Source Type: research
Development of advanced control material for reverse transcription-mediated bacterial nucleic acid amplification tests
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - April 17, 2024 Category: Microbiology Authors: Janessa D. LewisStephen J. Salipante1Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA Nathan A. Ledeboer Source Type: research
Cancers, Vol. 16, Pages 1537: Recent Advances in Pathology of Intrahepatic Cholangiocarcinoma
This article provides an updated overview of ICCA pathology, focusing particularly on molecular features, histological subtypes, and diagnostic approaches. (Source: Cancers)
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Choi Thung Tags: Review Source Type: research
Inflammatory Causes of Dysphagia in Children
Gastroesophageal reflux (GER) and eosinophilic esophagitis (EoE) are the most common inflammatory causes of pediatric dysphagia, but several other less prevalent conditions should be considered. These conditions can affect one or several aspects of the swallowing process. In some inflammatory conditions dysphagia may be an early symptom. Esophagoscopy and instrumental swallow studies are often needed to determine the underlying diagnosis and best treatment plan. In some inflammatory conditions dysphagia can portend a worse outcome and need for more aggressive treatment of the underlying condition. Consultations with speech...
Source: Otolaryngologic clinics of North America - April 17, 2024 Category: ENT & OMF Authors: Marisa A. Ryan, Anna Ermarth Source Type: research
Focusing on mitochondria in the brain: from biology to therapeutics
AbstractMitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of many organs and tissues, among which the brain is particularly prominent. The brain demands 20% of the resting metabolic rate and holds highly active mitochondrial activities. Considerable research shows that mitochondria are closely related to brain function, while mitochondrial defects induce or exacerbate pathology in the brain. In this review, we provide comprehensive research advances of mitochondrial bio...
Source: Translational Neurodegeneration - April 17, 2024 Category: Neurology Source Type: research
Diagnostic Approach to Interstitial Lung Diseases Associated with Connective Tissue Diseases
Semin Respir Crit Care Med DOI: 10.1055/s-0044-1785674Interstitial lung disorders are a group of respiratory diseases characterized by interstitial compartment infiltration, varying degrees of infiltration, and fibrosis, with or without small airway involvement. Although some are idiopathic (e.g., idiopathic pulmonary fibrosis, idiopathic interstitial pneumonias, and sarcoidosis), the great majority have an underlying etiology, such as systemic autoimmune rheumatic disease (SARD, also called Connective Tissue Diseases or CTD), inhalational exposure to organic matter, medications, and rarely, genetic disorders. This review ...
Source: Seminars in Respiratory and Critical Care Medicine - April 17, 2024 Category: Respiratory Medicine Authors: Zamora, Ana C. Wesselius, Lewis J. Gotway, Michael B. Tazelaar, Henry D. Diaz-Arumir, Alejandro Nagaraja, Vivek Tags: Review Article Source Type: research
Anal and perianal disorders
Most anal diseases can be diagnosed by a careful history and examination. Management of haemorrhoids involves exclusion of more serious pathology, adequate explanation of the disorder, and dietary and defecatory advice; most do not require additional treatment. Outpatient procedures or surgical intervention can be required for more symptomatic cases. Anal fissures are initially managed with bulking laxatives and non-constipating analgesics; glyceryl trinitrate ointment is standard first-line treatment. (Source: Medicine)
Source: Medicine - April 17, 2024 Category: Internal Medicine Authors: Bruce D. George, Jonathan Gosling Tags: Anal disease Source Type: research
Metastatic cutaneous squamous cell carcinoma accounts for nearly all squamous cell carcinomas of the parotid gland
AbstractPrimary squamous cell carcinoma of the parotid gland (pSCCP) has long been recognized as a separate entity and is included in the WHO classifications of salivary gland tumors. However, it is widely accepted among head and neck pathologists that pSCCP is exceptionally rare. Yet, there are many publications describing series of pSCCP and data from SEER and other cancer register databases indicate erroneously an increasing incidence of pSCCP. Importantly, pSCCP and metastatic (secondary) squamous cell carcinoma to the parotid gland (mSCCP) have nearly identical histological features, and the diagnosis of pSCCP should ...
Source: Virchows Archiv - April 17, 2024 Category: Pathology Source Type: research
Severe Transfusion-Dependent Thalassemia in Compound Heterozygote Palestinian Siblings with Two α-Globin Gene Defects, Hb Taybe D HBA1: C.119_121delCCA Mutation and HBA2: C.*94A > G Mutation
. (Source: Hemoglobin)
Source: Hemoglobin - April 17, 2024 Category: Hematology Authors: Nada AssafRoba El ZibaouiCarla MonsefTania Abi NassifMiguel AbboudSoha Yazbeka Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanonb Faculty of Medicine, American University of Beirut, Beirut, Leba Source Type: research
Marchiafava-Bignami disease: why not Marchiafava-Bignami-Carducci disease?
AbstractThe Marchiafava-Bignami disease has a curious backstory, namely, the publication in 1898 of theContribution to the Study of Nonsuppurative Encephalitis (Carducci A in Riv Psicol Psichiat Neuropat 8-9:125-135,1898), in which the neo-graduate Agostino Carducci described the disease that the pathologists Ettore Marchiafava and Amico Bignami would report 5 years later. (Source: Neurological Sciences)
Source: Neurological Sciences - April 16, 2024 Category: Neurology Source Type: research
Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research
Poststroke Communication Ability Predicts Patient-Informant Discrepancies in Reported Activities and Participation
DISCUSSION: These findings highlight the importance of measuring participation by PROM. The PWA's experience of participation is not related to their level of language impairment and is predictably different from their care partners' perspective. As others have also reported, "mild" aphasia is not so mild to the PWA. Similarly, "severe" may not be so severe to the PWA. Further research is needed to connect these findings with counseling and caregiver education. Research on response processes (e.g., response shift) is also warranted.PMID:38625105 | DOI:10.1044/2024_AJSLP-23-00322 (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - April 16, 2024 Category: Speech-Language Pathology Authors: Courtney C Jewell Stacy M Harnish Jennifer Brello Alyssa M Lanzi Matthew L Cohen Source Type: research
Gesture's Role in the Communication of Adults With Different Types of Aphasia
CONCLUSIONS: Overall, our results provide evidence for a compensatory role of gesture in aphasia communication. Adults with Broca's aphasia, who showed the greatest speech production difficulties, also relied most on gesture, and this pattern was particularly pronounced in the third-person narrative context.PMID:38625101 | DOI:10.1044/2024_AJSLP-23-00046 (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - April 16, 2024 Category: Speech-Language Pathology Authors: Sumeyra Ozturk Şeyda Özçalışkan Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
