Characteristics of radiotherapy for adolescents and young adults
This article reviews the characteristics to be taken into account in adolescent and young adult patients radiotherapy and more particularly in some of the most common diseases.PMID:38652674 | DOI:10.1016/j.canrad.2023.08.002 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 23, 2024 Category: Cancer & Oncology Authors: L Ollivier A Laprie E Jouglar L Claude V Martin X Muracciole L Padovani S Supiot A Escande Source Type: research
The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology
In this report, we review the roles that extracellular vesicles can play in biological processes and cellular dysfunction and pathobiology, particularly neurodegenerative diseases. We also examine the potential translational impacts of extracellular vesicles in diagnostics and therapeutic development. ER: endoplasmic reticulum; ROS: reactive oxygen species. AbstractBrain-derived extracellular vesicles (EVs) serve a prominent role in maintaining homeostasis and contributing to pathology in health and disease. This review establishes a crucial link between physiological processes leading to EV biogenesis and their impacts on...
Source: Journal of Neurochemistry - April 23, 2024 Category: Neuroscience Authors: Stephanie Tam,
Darcy Wear,
Christopher D. Morrone,
Wai Haung Yu Tags: SYSTEMATIC REVIEW Source Type: research
Radiomic nomogram based on bi-parametric MRI to predict the International Society of Urological Pathology (ISUP) grading ≥ 3 prostate cancer: a multicenter study
To create a reliable radiomic nomogram for the prediction of the International Society of Urological Pathology (ISUP) grading ≥ 3 PCa patients. (Source: Clinical Radiology)
Source: Clinical Radiology - April 23, 2024 Category: Radiology Authors: Yongsheng Zhang, Zhiping Li, Chen Gao, Liqing Zhang, Yasheng Huang, Hua Qu, Chang Shu, Yuguo Wei, Maosheng Xu, Feng Cui Source Type: research
Arthroscopic Management of the Contact Athlete with Anterior Instability
Anterior glenohumeral instability is one of the most common injuries suffered from sport. Despite padding and conditioning, the shoulder joint remains particularly vulnerable to injury, especially in the setting of contact. The overall rate of anterior instability is reported to be 0.12 injuries per 1000 athlete exposures, although this is increased up to 0.40 to 0.51 in the contact athlete. Successful treatment requires consideration of restoring stability while minimizing loss of glenohumeral motion. Common treatment strategies involve addressing the pathology that results from anterior shoulder dislocation including lab...
Source: Clinics in Sports Medicine - April 23, 2024 Category: Sports Medicine Authors: Joseph C. Brinkman, Elizabeth Damitio, John M. Tokish Source Type: research
Robotic resection of presacral tumors
ConclusionsRobotic resection of select presacral pathology is feasible and safe. Further studies must be conducted to determine complication rates, outcomes, and long-term safety profiles. (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - April 23, 2024 Category: Surgery Source Type: research
A case of fatal poisoning caused by etomidate: evidence from pathological and toxicological analyses
This report describes a rare case of a 47-year-old man who died from acute intoxication after oral ingestion of liquid containing etomidate. The cause of death was conclusively attributed to etomidate based on a comprehensive investigation, including autopsy, histopathological examination, toxicological analysis, and biochemical analysis. This is the first reported case of a fatality solely resulting from the oral ingestion of etomidate, which can provide valuable insights for future forensic investigations involving etomidate poisoning. Therefore, it is imperative to share this case with the scientific community. (Source:...
Source: Forensic Science, Medicine, and Pathology - April 23, 2024 Category: Forensic Medicine Source Type: research
Protective effect of increased O-GlcNAc cycling against 6-OHDA induced Parkinson’s disease pathology
Cell Death & Disease, Published online: 23 April 2024; doi:10.1038/s41419-024-06670-1Protective effect of increased O-GlcNAc cycling against 6-OHDA induced Parkinson’s disease pathology (Source: Cell death and disease)
Source: Cell death and disease - April 23, 2024 Category: Internal Medicine Authors: Dong Yeol Kim Sang-Min Kim Eun-Jeong Cho Hyo-Bum Kwak Inn-Oc Han Source Type: research
Targeted linked-read sequencing for direct haplotype phasing of parental GJB2/SLC26A4 alleles: A universal and dependable noninvasive prenatal diagnosis method applied to autosomal recessive nonsyndromic hearing loss in at-risk families
Noninvasive prenatal diagnosis (NIPD) for autosomal recessive nonsyndromic hearing loss (ARNSHL) has been rarely reported until recent years. However, the previous method could not be performed on challenging genome loci (e.g. CNVs, deletions, inversions, or gene recombinants) or on families without proband genotype. Here, this study assesses the performance of relative haplotype dosage analysis (RHDO)-based NIPD for identifying fetal genotyping in pregnancies at risk of ARNSHL. Fifty couples carrying pathogenic variants associated with ARNSHL in either GJB2 or SLC26A4 were recruited. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - April 23, 2024 Category: Pathology Authors: Bo Gao, Yi Jiang, Mingyu Han, Xiaowen Ji, Dejun Zhang, Lihua Wu, Xue Gao, Shasha Huang, Chaoyue Zhao, Yu Su, Suyan Yang, Xin Zhang, Na Liu, Lu Han, Lihai Wang, Lina Ren, Jinyuan Yang, Jian Wu, Yongyi Yuan, Pu Dai Tags: Regular Article Source Type: research
Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
We examined four cases (one female, three males) of gastric LCH. The affected patients were between 33 and 70 years of age. Endoscopically, three patients presented with a solitary polyp or elevated lesions, whereas one patient showed no abnormalities. Under a microscope, all cases showed abnormal proliferation of histiocytoid cells infiltrating in a nested or sheet-like fashion. The tumor cells were medium-sized, with a slightly eosinophilic cytoplasm, irregular or renal-shaped nuclei, folded nuclear membranes, visible nuclear grooves, and the infiltration of inflammatory cells in the background. Immunohistochemically, al...
Source: Journal of Hematopathology - April 23, 2024 Category: Pathology Source Type: research
Association between coca chewing (Erythroxylum coca) habit and oral squamous cell carcinoma. A case-control study from Argentina
Previous isolated reports have hypothesized that chewing coca leaves, a pre-Columbian tradition found in certain regions of South America, may be associated with the development of oral squamous cell carcinoma (OSCC). Coca chewing (CC) is a habit that shares many characteristics with the well-known practice of betel chewing observed in Asia. The aim of this study is to analyze the association between CC and OSCC among patients who attended the Se ñor del Milagro Hospital in Salta, Argentina. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 23, 2024 Category: ENT & OMF Authors: Ignacio Molina- Ávila, Juan Martín Pimentel-Solá, Emilio Buschiazzo, Adriana Echazú, Eduardo Piemonte, Gerardo Gilligan Source Type: research
Spatial genomics: mapping human steatotic liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 23 April 2024; doi:10.1038/s41575-024-00915-2This Perspective discusses single-cell and single-nuclei RNA sequencing in metabolic dysfunction-associated steatotic liver disease and explains how our understanding of the pathology of the disease will accelerate following the advances in spatial transcriptomics. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Kylie P. Matchett Jasmin Paris Sarah A. Teichmann Neil C. Henderson Source Type: research
REPAIRS Delphi: A UK and Ireland Consensus Statement on the Management of Infected Arterial Pseudoaneurysms Secondary to Groin Injecting Drug Use
This study was designed to establish consensus to promote better management of these patients, drawing on the expert experience of those in a location with a high prevalence of illicit drug use. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - April 23, 2024 Category: Surgery Authors: Caitlin S. MacLeod, John Nagy, Andrew Radley, Faisel Khan, Nikolas Rae, Michael S.J. Wilson, Stuart A. Suttie, REPAIRS Collaborative Source Type: research
The time-dependent expression of FPR2 and ANXA1 in murine deep vein thrombosis model and its relation to thrombus age
In this study, we investigated the time-dependent expressions of formyl peptide receptor 2 (FPR2) and Annexin A1 (ANXA1) in a stasis-induced deep vein thrombosis (DVT) murine model, with the aim of obtaining useful information for thrombus age timing. A total of 75 ICR mice were randomly classified into thrombosis group and control group. In thrombosis group, a DVT model was established by ligating the inferior vena cava (IVC) of mice, and thrombosed IVCs were harvested at 1, 3, 5, 7, 10, 14, and 21 days after modeling. In control group, IVCs without thrombosis were taken as control samples. The expressions of FPR2 and A...
Source: Forensic Science, Medicine, and Pathology - April 23, 2024 Category: Forensic Medicine Source Type: research
Imaging manifestations of papillary glioneuronal tumors
AbstractTo analyse the imaging findings of papillary glioneuronal tumors (PGNTs), in order to improve the accuracy of preoperative diagnosis of this tumor. The clinical and imaging manifestations of 36 cases of PGNT confirmed by pathology were analyzed retrospectively. A total of 17 males and 19 females, averaging 22.47 ( ± 11.23) years. Initial symptoms included epilepsy in ten, headache in seven, and others in 19 cases. 97.2% (35/36) of the lesions were located in the supratentorial area, and 80.5% (29/36) in the intraventricular or deep white matter adjacent to the lateral ventricles. Twenty-four of the lesions (66.7...
Source: Neurosurgical Review - April 23, 2024 Category: Neurosurgery Source Type: research
Elevated skull fractures: an institutional experience and individual participant data meta-analysis
In this study, we present the meta-analysis of outcomes and complications within this patient cohor t, offering a comprehensive synthesis of existing literature on this pathology. However, further investigation is imperative to provide higher-quality evidence and address lingering uncertainties in the classification and management of ESFs. (Source: Neurosurgical Review)
Source: Neurosurgical Review - April 23, 2024 Category: Neurosurgery Source Type: research
