The Presence of Small-Size Circulating Tumor Cells Predicts Worse Prognosis in Non-Small Cell Lung Cancer Patients
CONCLUSIONS.—: Small-size CTCs are a reliable prognostic indicator and a probable predictor of the severity of disease in NSCLC patients.PMID:38631685 | DOI:10.5858/arpa.2023-0455-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 17, 2024 Category: Laboratory Medicine Authors: Qianqian Sun Weiqing Li Donghua Yang Peter Ping Lin Lina Zhang Huiqin Guo Source Type: research
Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia
In conclusion, the accumulation of lipid droplets and abnormal lipid metabolism may be critical mechanisms in the progression of AD in microglia carrying the APOE4 genotype.PMID:38631884 | DOI:10.5582/bst.2024.01092 (Source: BioScience Trends)
Source: BioScience Trends - April 17, 2024 Category: Biomedical Science Authors: Xiqi Hu Ya-Nan Ma Ying Xia Source Type: research
Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial
We examined plasma amyloid beta 42/40 and positron emission tomography (PET) amyloid eligibility for the ongoing AHEAD Study preclinical AD program (NCT04468659).METHODS: Univariate logistic regression models were used to examine group differences in plasma and PET amyloid screening eligibility.RESULTS: Of 4905 participants screened at time of analysis, 1724 were plasma eligible to continue in screening: 13.3% Hispanic Black, 24.7% Hispanic White, 20.8% non-Hispanic (NH) Asian, 24.7% NH Black, and 38.9% NH White. Plasma eligibility differed across groups in models controlling for covariates (odds ratio from 1.9 to 4.0 comp...
Source: The Journal of Alzheimers Association - April 17, 2024 Category: Psychiatry Authors: Doris Patricia Molina-Henry Rema Raman Andy Liu Oliver Langford Keith Johnson Leona K Shum Crystal M Glover Shobha Dhadda Michael Irizarry Gustavo Jimenez-Maggiora Joel B Braunstein Kevin Yarasheski Venky Venkatesh Tim West Philip B Verghese Robert A Riss Source Type: research
White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old
DISCUSSION: Decreased AQP expression within WMH and proximal NAWM suggest an overwhelmed system wherein water homeostasis is no longer maintained, contributing to WM damage in older individuals.HIGHLIGHTS: Post mortem magnetic resonance imaging (MRI) was used to characterize the pathology of white matter hyperintensities (WMHs) and surrounding normal appearing white matter (NAWM). Stained immunohistochemical (IHC) slides from targeted WMH and NAWM samples were digitized and quantified. WMHs and NAWM were associated with inflammation, demyelination, and gliosis. WMHs and NAWM astrocytic changes included decreased AQP1 and A...
Source: The Journal of Alzheimers Association - April 17, 2024 Category: Psychiatry Authors: Lisa C Silbert Natalie E Roese Victoria Krajbich Justin Hurworth David Lahna Daniel L Schwartz Hiroko H Dodge Randall L Woltjer Source Type: research
Serum levels of sirtuins, leptin and adiponectin in women with pregnancy-induced hypertension
CONCLUSIONS: High leptin levels in PIH women during 3rd trimester might be helpful to predict the necessity for a caesarian section. Blood levels of sirtuins 1, 3 and 6 measured after the 20th week of gestation cannot be regarded as a single diagnostic test for PIH or preeclampsia. More studies to clarify significance of sirtuins in PIH and PE development and diagnosis are needed.PMID:38631184 | DOI:10.1016/j.cyto.2024.156612 (Source: Cytokine)
Source: Cytokine - April 17, 2024 Category: Molecular Biology Authors: Magdalena Gola ńska-Wróblewska Jolanta Fryczak Agnieszka Siejka Source Type: research
Sodium oligomannate's amelioration of reproductive and metabolic phenotypes in a letrozole-induced PCOS-like mouse model depends on the gut microbiome
In conclusion, the hyperinsulinemia and hyperandrogenemia of PCOS-like mice were alleviated by GV-971 intervention, which was associated with mitigating bile acid metabolism and modulating gut microbiota.PMID:38630889 | DOI:10.1093/biolre/ioae058 (Source: Reproductive Biology)
Source: Reproductive Biology - April 17, 2024 Category: Reproduction Medicine Authors: Zhi Li Yan Liu Yang Wang Qingqing Cai Yuhui Wang Yixuan Bai Haiou Liu Congjian Xu Feifei Zhang Source Type: research
Ketamine Use for Palliative Care in the Austere Environment: Is Ketamine the Path Forward for Palliative Care
Am J Hosp Palliat Care. 2024 Apr 17:10499091241246520. doi: 10.1177/10499091241246520. Online ahead of print.ABSTRACTThe goal of palliative care is to focus on the holistic needs of the patient and their family versus the pathology of the patient's diagnosis to reduce the stress of illness. U.S. servicemembers deployed to austere environments worldwide have significantly less access to palliative care than in military treatment facilities in the U.S. Preparation for future conflicts introduces the concept of prolonged medical management for an environment where urgent casualty evacuation is impossible. Ketamine is currentl...
Source: The American Journal of Hospice and Palliative Care - April 17, 2024 Category: Palliative Care Authors: John R Reed Stephanie K Parks Antony Kaniaru Justin Hefley Young Yauger Jeremy V Edwards Derrick C Glymph Source Type: research
Analysis of atypical glandular cells in ThinPrep Pap smear and follow-up histopathology
CONCLUSION: The AGC diagnostic rate at our institution falls within the range given by the College of American Pathologists. A significant number of cases had follow-up histologic results available, and the overall 5-year insignificant AGC rate was 0.12%.PMID:38628324 | PMC:PMC11018051 | DOI:10.1080/08998280.2024.2324656 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - April 17, 2024 Category: Universities & Medical Training Authors: Tengfei Wang Yinan Hua Lina Liu Bing Leng Source Type: research
Diagnostic Approach to Interstitial Lung Diseases Associated with Connective Tissue Diseases
Semin Respir Crit Care Med. 2024 Apr 17. doi: 10.1055/s-0044-1785674. Online ahead of print.ABSTRACTInterstitial lung disorders are a group of respiratory diseases characterized by interstitial compartment infiltration, varying degrees of infiltration, and fibrosis, with or without small airway involvement. Although some are idiopathic (e.g., idiopathic pulmonary fibrosis, idiopathic interstitial pneumonias, and sarcoidosis), the great majority have an underlying etiology, such as systemic autoimmune rheumatic disease (SARD, also called Connective Tissue Diseases or CTD), inhalational exposure to organic matter, medication...
Source: Respiratory Care - April 17, 2024 Category: Respiratory Medicine Authors: Ana C Zamora Lewis J Wesselius Michael B Gotway Henry D Tazelaar Alejandro Diaz-Arumir Vivek Nagaraja Source Type: research
Sodium oligomannate's amelioration of reproductive and metabolic phenotypes in a letrozole-induced PCOS-like mouse model depends on the gut microbiome
In conclusion, the hyperinsulinemia and hyperandrogenemia of PCOS-like mice were alleviated by GV-971 intervention, which was associated with mitigating bile acid metabolism and modulating gut microbiota.PMID:38630889 | DOI:10.1093/biolre/ioae058 (Source: Biology of Reproduction)
Source: Biology of Reproduction - April 17, 2024 Category: Reproduction Medicine Authors: Zhi Li Yan Liu Yang Wang Qingqing Cai Yuhui Wang Yixuan Bai Haiou Liu Congjian Xu Feifei Zhang Source Type: research
Development of an Interpretable Deep Learning Model for Pathological Tumor Response Assessment After Neoadjuvant Therapy
CONCLUSION: This work illustrates deep learning's potential for assisting pathological response assessment. Spatial heatmaps and patch examples provide intuitive explanations of model predictions, engendering clinical trust and adoption (Code and data will be available at https://github.com/WinnieLaugh/ESCC_Percentage once the paper has been conditionally accepted). Integrating interpretable computational pathology could help enhance the efficiency and consistency of tumor response assessment and empower precise oncology treatment decisions.PMID:38632527 | DOI:10.1186/s12575-024-00234-5 (Source: Biological Procedures Online)
Source: Biological Procedures Online - April 17, 2024 Category: Molecular Biology Authors: Yichen Wang Wenhua Zhang Lijun Chen Jun Xie Xuebin Zheng Yan Jin Qiang Zheng Qianqian Xue Bin Li Chuan He Haiquan Chen Yuan Li Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Am J Pathol. 2024 Apr 15:S0002-9440(24)00132-9. doi: 10.1016/j.ajpath.2024.02.023. Online ahead of print.ABSTRACTSince the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pan...
Source: Am J Pathol - April 17, 2024 Category: Pathology Authors: Li-Yun Ding Chia-Jung Chang Szu-Ying Chen Kuan-Lin Chen Yueh-Shan Li Yun-Chieh Wu Ting-Yi Hsu Hsin-Yu Ying Hsin-Yi Wu Michael W Hughes Chia-Yih Wang Chih-Han Chang Ming-Jer Tang Woei-Jer Chuang Yan-Shen Shan Chia-Jung Chang Po-Hsien Huang Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Am J Pathol. 2024 Apr 15:S0002-9440(24)00132-9. doi: 10.1016/j.ajpath.2024.02.023. Online ahead of print.ABSTRACTSince the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pan...
Source: The American Journal of Pathology - April 17, 2024 Category: Pathology Authors: Li-Yun Ding Chia-Jung Chang Szu-Ying Chen Kuan-Lin Chen Yueh-Shan Li Yun-Chieh Wu Ting-Yi Hsu Hsin-Yu Ying Hsin-Yi Wu Michael W Hughes Chia-Yih Wang Chih-Han Chang Ming-Jer Tang Woei-Jer Chuang Yan-Shen Shan Chia-Jung Chang Po-Hsien Huang Source Type: research
Molecular characterization and survival analysis of a cohort of glioblastoma, IDH-wildtype
This study established a cohort of 124 sequential glioblastomas from a tertiary hospital and aimed to find correlations between molecular features and survival outcomes. Comprehensive molecular characterization of the cohort revealed prevalent alterations as previously described, such as TERT promoter mutations and involvement of the PI3K-Akt-mTOR, CK4/6-CDKN2A/B-RB1, and p14ARF-MDM2-MDM4-p53 pathways. MGMT promoter methylation is a significant predictor of improved overall survival, aligned with previous data. Conversely, age showed a marginal association with higher mortality. Multivariate analysis to account for the eff...
Source: Pathology, Research and Practice - April 17, 2024 Category: Pathology Authors: Bilge Dundar Mouaz Alsawas Amr Masaadeh Kyle Conway Anthony N Snow Ramakrishna R Sompallae Aaron D Bossler Deqin Ma Osorio Lopes Abath Neto Source Type: research
Diagnostic investigation of Avian Reovirus Field Variants Circulating in Broiler Chickens in Pennsylvania of United States between 2017-2022
This report provides our diagnostic investigation on monitoring ARV field variants from broiler chickens in Pennsylvania. Genomic characterization findings of 72 ARV field isolates obtained from broiler cases during the last six years indicated that the six distinct cluster variant strains (genotype I-VI) continuously circulated in PA poultry, which were genetically diverse and distant from the vaccine and vaccine-related field strains. Most of the variants clustered within genotype V (24/72, 33.3%), followed by genotype II (16/72, 22.2%), genotype IV (13/72, 18.1%), genotype III (13/72, 18.1%), genotype VI (05/72, 6.94%),...
Source: Avian Pathology - April 17, 2024 Category: Pathology Authors: Muhammad Zubair Shabbir Haiyang Yu Megan E Lighty Patricia Ann Dunn Eva A Wallner-Pendleton Huaguang Lu Source Type: research
