Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines
Nature Reviews Gastroenterology & Hepatology, Published online: 16 September 2019; doi:10.1038/s41575-019-0195-xPancreatic cystic neoplasms are a heterogeneous group of pancreatic cysts with different biological behaviours and variable risk of progression to malignancy. This Review summarizes the latest developments in the diagnosis and management of pancreatic cysts, including the quality of available evidence. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 16, 2019 Category: Gastroenterology Authors: Nadine C. M. van Huijgevoort Marco del Chiaro Christopher L. Wolfgang Jeanin E. van Hooft Marc G. Besselink Source Type: research

Evolving therapeutic goals in ulcerative colitis: towards disease clearance
Nature Reviews Gastroenterology & Hepatology, Published online: 13 September 2019; doi:10.1038/s41575-019-0211-1In ulcerative colitis, treating beyond endoscopic healing has shown a reduction of relapse and hospitalization, pushing for histological remission to be embraced in clinical practice and clinical trials. Here, we propose the concept of disease clearance (symptomatic, endoscopic and histological remission) as the ultimate goal in the treatment of ulcerative colitis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 13, 2019 Category: Gastroenterology Authors: Silvio Danese Giulia Roda Laurent Peyrin-Biroulet Source Type: research

Intestinal gases: influence on gut disorders and the role of dietary manipulations
Nature Reviews Gastroenterology & Hepatology, Published online: 13 September 2019; doi:10.1038/s41575-019-0193-zThere is an emerging understanding of the roles of intestinal gases, generated via chemical interactions or the microbial metabolism of dietary substrates, in gut homeostasis and pathophysiology. In this Review, the authors discuss these emerging data, highlighting links with dietary intake and new gas profiling methods. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 13, 2019 Category: Gastroenterology Authors: Kourosh Kalantar-Zadeh Kyle J. Berean Rebecca E. Burgell Jane G. Muir Peter R. Gibson Source Type: research

Anonymous live liver donor: the Good Samaritan Stranger
Nature Reviews Gastroenterology & Hepatology, Published online: 09 September 2019; doi:10.1038/s41575-019-0207-xLiving donor liver transplantation is a proven option for end-stage liver disease. In a new study, a pioneering multi-organ transplantation programme in Canada critically reviews the motivations and facilitators of anonymous adult living liver donors over a 12-year period, providing insights into how we can push forward ethical living organ donation for transplantation. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 9, 2019 Category: Gastroenterology Authors: Robert A. Fisher Source Type: research

Clinical utility of HBV surface antigen quantification in HBV e antigen-negative chronic HBV infection
Nature Reviews Gastroenterology & Hepatology, Published online: 02 September 2019; doi:10.1038/s41575-019-0197-8Chronic HBV infection is a serious problem; few patients achieve the ultimate goal of hepatitis B surface antigen loss. This Review integrates findings from research in HBV infection kinetics and discusses how they can aid understanding and management of HBV infection. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 2, 2019 Category: Gastroenterology Authors: Yun-Fan Liaw Source Type: research

Tumour microbiome defines outcomes
Nature Reviews Gastroenterology & Hepatology, Published online: 02 September 2019; doi:10.1038/s41575-019-0208-9Tumour microbiome defines outcomes (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - September 2, 2019 Category: Gastroenterology Authors: Conor A. Bradley Source Type: research

Closing in on C. difficile infection
Nature Reviews Gastroenterology & Hepatology, Published online: 29 August 2019; doi:10.1038/s41575-019-0206-yClosing in on C. difficile infection (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 29, 2019 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Gallstones formed by NETs
Nature Reviews Gastroenterology & Hepatology, Published online: 28 August 2019; doi:10.1038/s41575-019-0205-zGallstones formed by NETs (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 28, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
Nature Reviews Gastroenterology & Hepatology, Published online: 27 August 2019; doi:10.1038/s41575-019-0189-8Colorectal cancer is one of the most common cancers worldwide. This Review provides a comprehensive summary of colorectal cancer epidemiology, with emphasis on modifiable lifestyle and nutritional factors, chemoprevention and screening. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 27, 2019 Category: Gastroenterology Authors: NaNa Keum Edward Giovannucci Source Type: research

A global view of hepatocellular carcinoma: trends, risk, prevention and management
Nature Reviews Gastroenterology & Hepatology, Published online: 22 August 2019; doi:10.1038/s41575-019-0186-yHepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. This Review summarizes the epidemiology, risk factors (including viral hepatitis and NAFLD), molecular profiles and treatment of HCC, providing insights into how the global burden of HCC can be reduced. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 22, 2019 Category: Gastroenterology Authors: Ju Dong Yang Pierre Hainaut Gregory J. Gores Amina Amadou Amelie Plymoth Lewis R. Roberts Source Type: research

Preventing the development of hepatitis C in uninfected transplant recipients
Nature Reviews Gastroenterology & Hepatology, Published online: 20 August 2019; doi:10.1038/s41575-019-0203-1Preventing the development of hepatitis C in uninfected transplant recipients (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 20, 2019 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Increasing survival in HCV-related hepatocellular carcinoma
Nature Reviews Gastroenterology & Hepatology, Published online: 20 August 2019; doi:10.1038/s41575-019-0202-2Increasing survival in HCV-related hepatocellular carcinoma (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 20, 2019 Category: Gastroenterology Authors: Katrina Ray Source Type: research

PITCHing ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo
Nature Reviews Gastroenterology & Hepatology, Published online: 20 August 2019; doi:10.1038/s41575-019-0201-3PITCHing ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 20, 2019 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Does early metastatic seeding occur in colorectal cancer?
Nature Reviews Gastroenterology & Hepatology, Published online: 15 August 2019; doi:10.1038/s41575-019-0200-4During the metastatic process, cancer cells spread from the primary tumour to distant organs. Although metastases are the primary cause of cancer mortality, the dynamics of the metastatic process remain largely unknown. A new study suggests that during colorectal cancer progression, metastatic seeding might occur before clinical detectability. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 15, 2019 Category: Gastroenterology Authors: Alessandro Magr ì Alberto Bardelli Source Type: research

Guiding pancreatic cyst management
Nature Reviews Gastroenterology & Hepatology, Published online: 13 August 2019; doi:10.1038/s41575-019-0198-7Guiding pancreatic cyst management (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 13, 2019 Category: Gastroenterology Authors: Conor A. Bradley Source Type: research

Author Correction: Probiotics and prebiotics in intestinal health and disease: from biology to the clinic
Nature Reviews Gastroenterology & Hepatology, Published online: 09 August 2019; doi:10.1038/s41575-019-0199-6Author Correction: Probiotics and prebiotics in intestinal health and disease: from biology to the clinic (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 9, 2019 Category: Gastroenterology Authors: Mary Ellen Sanders Daniel J. Merenstein Gregor Reid Glenn R. Gibson Robert A. Rastall Source Type: research

Improving hepatic ischaemia–reperfusion injury outcomes
Nature Reviews Gastroenterology & Hepatology, Published online: 06 August 2019; doi:10.1038/s41575-019-0194-yImproving hepatic ischaemia–reperfusion injury outcomes (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 6, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Insights into the success and failure of systemic therapy for hepatocellular carcinoma
Nature Reviews Gastroenterology & Hepatology, Published online: 01 August 2019; doi:10.1038/s41575-019-0179-xThe design of clinical trials for hepatocellular carcinoma is complicated by a number of obstacles. In this Review, the authors discuss the advances in systemic therapy for hepatocellular carcinoma and critically discuss trial designs in the context of past successes and failures. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 1, 2019 Category: Gastroenterology Authors: Jordi Bruix Leonardo G. da Fonseca Mar ía Reig Source Type: research

Mapping the cells in the liver — unchartered subtypes and heterogeneity
Nature Reviews Gastroenterology & Hepatology, Published online: 30 July 2019; doi:10.1038/s41575-019-0192-0Mapping the cells in the liver — unchartered subtypes and heterogeneity (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 30, 2019 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Microbiota supplements to improve metabolic health
Nature Reviews Gastroenterology & Hepatology, Published online: 23 July 2019; doi:10.1038/s41575-019-0190-2Microbiota supplements to improve metabolic health (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 23, 2019 Category: Gastroenterology Authors: Anna Kriebs Source Type: research

CD11b agonism overcomes PDAC immunotherapy resistance
Nature Reviews Gastroenterology & Hepatology, Published online: 22 July 2019; doi:10.1038/s41575-019-0191-1CD11b agonism overcomes PDAC immunotherapy resistance (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 22, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Too many people with viral hepatitis are diagnosed late — with dire consequences
Nature Reviews Gastroenterology & Hepatology, Published online: 19 July 2019; doi:10.1038/s41575-019-0177-zLate presentation to hepatitis B virus and hepatitis C virus care is common, hindering global efforts to reduce the morbidity and mortality associated with liver disease. Models of care promoting and simplifying early testing of viral hepatitis are needed if we are to eliminate viral hepatitis as a major public health threat by 2030. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 19, 2019 Category: Gastroenterology Authors: Jeffrey V. Lazarus Camila Picchio John F. Dillon J ürgen K. Rockstroh Nina Weis Maria Buti Source Type: research

Multi-omics in IBD biomarker discovery: the missing links
Nature Reviews Gastroenterology & Hepatology, Published online: 16 July 2019; doi:10.1038/s41575-019-0188-9Multi-omics technologies in gut microbiome research provide a global view of changes in genetic, metabolic and biochemical processes. This approach has now been applied to the gut microbiota in the context of IBD, providing first steps towards a functional understanding of host–microbe interactions during disease pathogenesis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: Amira Metwaly Dirk Haller Source Type: research

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Nature Reviews Gastroenterology & Hepatology, Published online: 16 July 2019; doi:10.1038/s41575-019-0172-4Macrophages are the gatekeepers of intestinal immune homeostasis. This Review discusses the molecular and cellular mechanisms involved in the differentiation and function of intestinal macrophages in homeostasis and inflammation, and their role in resolving the inflammatory process. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: Yi Rang Na Michelle Stakenborg Seung Hyeok Seok Gianluca Matteoli Source Type: research

Metabolic and bariatric surgery in adolescents
Nature Reviews Gastroenterology & Hepatology, Published online: 15 July 2019; doi:10.1038/s41575-019-0187-xA new study has added valuable outcome data from adolescents 5 years after undergoing Roux-en-Y gastric bypass. By comparing outcomes from adolescents and adults, the study adds to the existing evidence base, highlighting metabolic and bariatric surgery as an increasingly valuable tool in the multidisciplinary management of adolescents with severe obesity. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 15, 2019 Category: Gastroenterology Authors: Andrew J. Beamish Torsten Olbers Source Type: research

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques
Nature Reviews Gastroenterology & Hepatology, Published online: 11 July 2019; doi:10.1038/s41575-019-0167-1This Consensus Statement provides a conceptual and methodological framework to expand research on colonic motility in experimental animals and humans. The work is intended to facilitate the development of new drugs for common colonic motility disorders and of appropriate diagnostic and therapeutic algorithms for the management of paediatric and adult patients. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 11, 2019 Category: Gastroenterology Authors: Maura Corsetti Marcello Costa Gabrio Bassotti Adil E. Bharucha Osvaldo Borrelli Phil Dinning Carlo Di Lorenzo Jan D. Huizinga Marcel Jimenez Satish Rao Robin Spiller Nick J. Spencer Roger Lentle Jasper Pannemans Alexander Thys Marc Benninga Jan Tack Source Type: research

The jigsaw of dual hepatocellular–intrahepatic cholangiocarcinoma tumours
Nature Reviews Gastroenterology & Hepatology, Published online: 11 July 2019; doi:10.1038/s41575-019-0185-zA new study involving integrative genomic and transcriptomic analysis of dual hepatocellular–intrahepatic cholangiocarcinoma tumours has identified distinct subtypes that display different clinical and molecular features, and that could be used to guide therapeutic decisions. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 11, 2019 Category: Gastroenterology Authors: Patricia Munoz-Garrido Pedro M. Rodrigues Source Type: research

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic
Nature Reviews Gastroenterology & Hepatology, Published online: 11 July 2019; doi:10.1038/s41575-019-0173-3The gut microbiota has been implicated in a range of diseases. This Review describes current understanding of probiotics and prebiotics as a means to manage the microbiota to improve host health, including mechanisms of actions and potential for clinical use. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 11, 2019 Category: Gastroenterology Authors: Mary Ellen Sanders Daniel J. Merenstein Gregor Reid Glenn R. Gibson Robert A. Rastall Source Type: research

NAFLD in children: new genes, new diagnostic modalities and new drugs
Nature Reviews Gastroenterology & Hepatology, Published online: 05 July 2019; doi:10.1038/s41575-019-0169-zNonalcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in children and adolescents. In this Review, the authors summarize current knowledge and new advances related to the epidemiology, pathogenesis and management of paediatric NAFLD. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 5, 2019 Category: Gastroenterology Authors: Valerio Nobili Anna Alisi Luca Valenti Luca Miele Ariel E. Feldstein Naim Alkhouri Source Type: research

Artificial intelligence — upping the game in gastrointestinal endoscopy?
Nature Reviews Gastroenterology & Hepatology, Published online: 05 July 2019; doi:10.1038/s41575-019-0178-yArtificial intelligence (AI) has the potential to change many aspects of health-care practice. Two newly published trials explore the potential applications of AI to improve polyp detection and mucosal visualization in gastrointestinal endoscopy — both show the benefits of AI to improve detection in gastrointestinal endoscopy. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 5, 2019 Category: Gastroenterology Authors: Colin J. Rees Sara Koo Source Type: research

HAstening the development of liver fibrosis
Nature Reviews Gastroenterology & Hepatology, Published online: 04 July 2019; doi:10.1038/s41575-019-0184-0HAstening the development of liver fibrosis (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Organoid modelling of NAFLD
Nature Reviews Gastroenterology & Hepatology, Published online: 02 July 2019; doi:10.1038/s41575-019-0181-3Organoid modelling of NAFLD (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 2, 2019 Category: Gastroenterology Authors: Hugh Thomas Source Type: research

Exclusion diet plus partial enteral nutrition sustains remission in children with Crohn’s disease
Nature Reviews Gastroenterology & Hepatology, Published online: 01 July 2019; doi:10.1038/s41575-019-0183-1Exclusion diet plus partial enteral nutrition sustains remission in children with Crohn’s disease (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 1, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Maternal IgA is necessary for preventing necrotizing enterocolitis
Nature Reviews Gastroenterology & Hepatology, Published online: 01 July 2019; doi:10.1038/s41575-019-0180-4Maternal IgA is necessary for preventing necrotizing enterocolitis (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 1, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Pregnancy safe and beneficial for women with IBD
Nature Reviews Gastroenterology & Hepatology, Published online: 01 July 2019; doi:10.1038/s41575-019-0182-2Pregnancy safe and beneficial for women with IBD (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 1, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

The role of telomeres and telomerase in cirrhosis and liver cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 28 June 2019; doi:10.1038/s41575-019-0165-3Telomerase is a key enzyme for cell survival that prevents telomere shortening. In this Review, the roles of telomeres and telomerase in cirrhosis and liver carcinogenesis are discussed, in addition to their potential in clinical practice as biomarkers and therapeutic targets. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 28, 2019 Category: Gastroenterology Authors: Jean-Charles Nault Massih Ningarhari Sandra Rebouissou Jessica Zucman-Rossi Source Type: research

Cognitive behavioural therapy for IBS: results or treatment as usual?
Nature Reviews Gastroenterology & Hepatology, Published online: 26 June 2019; doi:10.1038/s41575-019-0174-2Telephone or web-based psychotherapy has been suggested to be as effective as face-to-face psychotherapy while lowering access restrictions and improving patient acceptability. A large new study in patients with IBS shows the superiority of such an approach in comparison with treatment as usual. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 26, 2019 Category: Gastroenterology Authors: Paul Enck Jeffrey M. Lackner Source Type: research

TCR-grafted T cells restore antiviral immunity
Nature Reviews Gastroenterology & Hepatology, Published online: 25 June 2019; doi:10.1038/s41575-019-0176-0TCR-grafted T cells restore antiviral immunity (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 25, 2019 Category: Gastroenterology Authors: Conor A. Bradley Source Type: research

Stroma-shaped pancreatic intratumoural tissue heterogeneity and architecture linked to clinical outcomes
Nature Reviews Gastroenterology & Hepatology, Published online: 25 June 2019; doi:10.1038/s41575-019-0175-1Stroma-shaped pancreatic intratumoural tissue heterogeneity and architecture linked to clinical outcomes (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 25, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Symptoms and the small intestinal microbiome — the unknown explored
Nature Reviews Gastroenterology & Hepatology, Published online: 18 June 2019; doi:10.1038/s41575-019-0171-5Small intestinal bacterial overgrowth (SIBO) has been linked to common gastrointestinal symptoms; yet its precise definition remains elusive. A new study shows that, when it comes to symptom prediction in functional gastrointestinal disorders, high-throughput sequencing analysis of the microbiome and not jejunal aspiration and culture is the clear winner. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 18, 2019 Category: Gastroenterology Authors: Eamonn M. M. Quigley Source Type: research

The diagnosis of nonalcoholic fatty liver disease should carry important prognostic information
Nature Reviews Gastroenterology & Hepatology, Published online: 13 June 2019; doi:10.1038/s41575-019-0168-0The diagnostic reach of nonalcoholic fatty liver disease (NAFLD) is broad, stretching from simple steatosis to cirrhosis. Expanded disease definitions are an important cause of waste in health care. Now is the time to revise the definition of NAFLD to include only those who have developed advanced fibrosis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Ian A Rowe Richard Parker Source Type: research

Publisher Correction: Language, numeracy and logic in microbiome science
Nature Reviews Gastroenterology & Hepatology, Published online: 12 June 2019; doi:10.1038/s41575-019-0170-6Publisher Correction: Language, numeracy and logic in microbiome science (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 12, 2019 Category: Gastroenterology Authors: Fergus Shanahan Colin Hill Source Type: research

Language, numeracy and logic in microbiome science
Nature Reviews Gastroenterology & Hepatology, Published online: 05 June 2019; doi:10.1038/s41575-019-0163-5To deliver precision therapeutics, microbiome-based medicine will require precision of language, logic and numerical accuracy. Epidemiological lessons of the past suggest that attempts to link almost everything in modern life with the microbiome as a risk factor for disease, without rapprochement with plausible mechanisms, will generate controversy rather than consensus. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 5, 2019 Category: Gastroenterology Authors: Fergus Shanahan Colin Hill Source Type: research

Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases
Nature Reviews Gastroenterology & Hepatology, Published online: 05 June 2019; doi:10.1038/s41575-019-0156-4New knowledge has been steadily acquired in genetic and congenital cholangiopathies. Here, the authors discuss Alagille syndrome, polycystic liver diseases, fibropolycystic liver diseases and cystic fibrosis-related liver disease and the insights that these conditions provide into the mechanisms of acquired cholangiopathies. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 5, 2019 Category: Gastroenterology Authors: Luca Fabris Romina Fiorotto Carlo Spirli Massimiliano Cadamuro Valeria Mariotti Maria J. Perugorria Jesus M. Banales Mario Strazzabosco Source Type: research

Origins of intestinal stem cells — all in it together?
Nature Reviews Gastroenterology & Hepatology, Published online: 04 June 2019; doi:10.1038/s41575-019-0166-2Origins of intestinal stem cells — all in it together? (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Cellular diversity in the colon: another brick in the wall
Nature Reviews Gastroenterology & Hepatology, Published online: 03 June 2019; doi:10.1038/s41575-019-0161-7Single-cell RNA profiling of colonic epithelial crypts from healthy volunteers and patients with ulcerative colitis adds pH-regulating colonocytes and goblet cells expressing a major determinant of barrier maintenance to the current arsenal of uncovered colonic epithelial cell types. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 3, 2019 Category: Gastroenterology Authors: Isabelle Cleynen Debby Laukens Source Type: research

Engaging primary care clinicians in the assessment of NAFLD
Nature Reviews Gastroenterology & Hepatology, Published online: 29 May 2019; doi:10.1038/s41575-019-0164-4A new study shows that a real-world care pathway for patients with NAFLD in primary care can increase the detection of patients with clinically significant liver disease and decrease referrals for patients who could be managed in the community. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 29, 2019 Category: Gastroenterology Authors: Patricia C. Valery Elizabeth E. Powell Source Type: research

New insights into acute pancreatitis
Nature Reviews Gastroenterology & Hepatology, Published online: 28 May 2019; doi:10.1038/s41575-019-0158-2The incidence of acute pancreatitis is increasing worldwide, and it is one of the most common gastrointestinal causes for hospital admission. In this Review, the authors provide a summary of advances in acute pancreatitis with an emphasis on pathophysiological mechanisms and clinical management. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 28, 2019 Category: Gastroenterology Authors: Peter J. Lee Georgios I. Papachristou Source Type: research

Anaerobic intestine-on-a-chip system enables complex microbiota co-culture
Nature Reviews Gastroenterology & Hepatology, Published online: 24 May 2019; doi:10.1038/s41575-019-0162-6Anaerobic intestine-on-a-chip system enables complex microbiota co-culture (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 24, 2019 Category: Gastroenterology Authors: Iain Dickson Source Type: research

The role of short-chain fatty acids in microbiota–gut–brain communication
Nature Reviews Gastroenterology & Hepatology, Published online: 23 May 2019; doi:10.1038/s41575-019-0157-3Short-chain fatty acids (SCFAs) are speculated to have a key role in microbiota–gut–brain crosstalk, but the pathways influencing psychological functioning have not been fully elucidated. This Review summarizes existing knowledge of how SCFAs might indirectly or directly mediate psychological processes. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 23, 2019 Category: Gastroenterology Authors: Boushra Dalile Lukas Van Oudenhove Bram Vervliet Kristin Verbeke Source Type: research