Liver regeneration: biological and pathological mechanisms and implications
Nature Reviews Gastroenterology & Hepatology, Published online: 06 August 2020; doi:10.1038/s41575-020-0342-4The liver has a broad range of regenerative capacities. In this Review, Michalopoulos and Bhushan describe the regenerative mechanisms employed by hepatic cells after liver injury as well as the experimental models used to investigate these mechanisms and discuss the clinical implications. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 6, 2020 Category: Gastroenterology Authors: George K. Michalopoulos Bharat Bhushan Source Type: research

Understanding, predicting and achieving liver transplant tolerance: from bench to bedside
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2020; doi:10.1038/s41575-020-0334-4In this Review, Thomson et al. describe the immunobiology underlying liver graft tolerance and failure, and discuss therapeutic approaches for minimization or withdrawal of anti-rejection immunosuppressive drug therapy post transplantation. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 5, 2020 Category: Gastroenterology Authors: Angus W. Thomson Julien Vionnet Alberto Sanchez-Fueyo Source Type: research

Predicting development of ACLF
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2020; doi:10.1038/s41575-020-0355-zPredicting development of ACLF (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 5, 2020 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Non-canonical cholinergic anti-inflammatory pathway in IBD
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2020; doi:10.1038/s41575-020-0356-yVagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and that α7-nicotinic receptor agonists are a panacea for inflammatory conditions. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - August 5, 2020 Category: Gastroenterology Authors: Alan de Araujo Guillaume de Lartigue Source Type: research

Parkinson disease and the gut: new insights into pathogenesis and clinical relevance
Nature Reviews Gastroenterology & Hepatology, Published online: 31 July 2020; doi:10.1038/s41575-020-0339-zGastrointestinal dysfunction (including dysphagia and constipation) can occur in Parkinson disease (PD), with evidence that they can arise prior to diagnosis of PD. This Review describes new insights into the mechanisms and pathophysiology of the gastrointestinal involvement of PD, including clinical manifestations. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 31, 2020 Category: Gastroenterology Authors: R. Alberto Travagli Kirsteen N. Browning Michael Camilleri Source Type: research

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD
Nature Reviews Gastroenterology & Hepatology, Published online: 24 July 2020; doi:10.1038/s41575-020-0331-7Intestinal epithelial glycosylation is influenced by host genetics, the environment and the gut microbiota. In this Review, Kudelka et al. describe the functions of epithelial glycans and discuss the role of epithelial glycosylation in Crohn’s disease and ulcerative colitis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 24, 2020 Category: Gastroenterology Authors: Matthew R. Kudelka Sean R. Stowell Richard D. Cummings Andrew S. Neish Source Type: research

Microbiome signatures for cirrhosis and diabetes
Nature Reviews Gastroenterology & Hepatology, Published online: 23 July 2020; doi:10.1038/s41575-020-0351-3Microbiome signatures for cirrhosis and diabetes (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 23, 2020 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Progress towards elimination goals for viral hepatitis
Nature Reviews Gastroenterology & Hepatology, Published online: 23 July 2020; doi:10.1038/s41575-020-0332-6Viral hepatitis is a global public health problem. In this Viewpoint, we asked a selection of scientists and clinicians working in the viral hepatitis field to provide their opinions on progress and pitfalls towards the 2030 viral hepatitis elimination goals. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 23, 2020 Category: Gastroenterology Authors: Andrea L. Cox Manal H. El-Sayed Jia-Horng Kao Jeffrey V. Lazarus Maud Lemoine Anna S. Lok Fabien Zoulim Source Type: research

Modern therapeutic approaches for the treatment of malignant liver tumours
Nature Reviews Gastroenterology & Hepatology, Published online: 17 July 2020; doi:10.1038/s41575-020-0314-8Modern therapies for malignant liver tumours integrate neoadjuvant and adjuvant strategies. This broad Review discusses these approaches, including advances in staged surgeries, systemic therapies, ablation therapies and liver transplantation. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 17, 2020 Category: Gastroenterology Authors: Henrik Petrowsky Ralph Fritsch Matthias Guckenberger Michelle L. De Oliveira Philipp Dutkowski Pierre-Alain Clavien Source Type: research

How academia should respond to racism
Nature Reviews Gastroenterology & Hepatology, Published online: 17 July 2020; doi:10.1038/s41575-020-0349-xStructural racism in academia and academic medicine is destructive to science and society. To deny its existence is to fertilize the soil in which it thrives. Uprooting it demands, at the very least, a fundamental transformation in institutional education, policies, practices and resource allocation with sustained anti-racist actions. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 17, 2020 Category: Gastroenterology Authors: Darrell M. Gray II Joshua J. Joseph Autumn R. Glover J. Nwando Olayiwola Source Type: research

The changing approach for identifying hereditary colorectal cancer syndromes
Nature Reviews Gastroenterology & Hepatology, Published online: 10 July 2020; doi:10.1038/s41575-020-0348-yData based on next-generation sequencing (NGS) of colorectal cancers (CRC) clearly show that up to 10% of all cases harbour pathogenic variants. Thus, NGS performed for all patients with CRC under the age of 50 could be a cost-effective strategy, leading to a personalized approach to patients and family members. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 10, 2020 Category: Gastroenterology Authors: Luigi Laghi Luigi Ricciardiello Source Type: research

Cell death in the gut epithelium and implications for chronic inflammation
Nature Reviews Gastroenterology & Hepatology, Published online: 10 July 2020; doi:10.1038/s41575-020-0326-4Evidence points to a crucial role of necroptosis and pyroptosis as important modes of programmed cell death in the intestine in addition to apoptosis. This Review discusses advances in our understanding of apoptosis, necroptosis and pyroptosis as major cell death pathways that can result in pathophysiological outcomes. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 10, 2020 Category: Gastroenterology Authors: Jay V. Patankar Christoph Becker Source Type: research

COVID-19 and liver transplantation
Nature Reviews Gastroenterology & Hepatology, Published online: 10 July 2020; doi:10.1038/s41575-020-0347-zThe effect of coronavirus disease 2019 (COVID-19) on liver transplantation programmes and recipients is still not completely understood but overall involves the risk of donor-derived transmission, the reliability of diagnostic tests, health-care resource utilization and the effect of immunosuppression. This Comment reviews the effect of COVID-19 on liver transplantation and summarizes recommendations for donor and recipient management. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 10, 2020 Category: Gastroenterology Authors: Tommaso Di Maira Marina Berenguer Source Type: research

Gut microbiome, big data and machine learning to promote precision medicine for cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 09 July 2020; doi:10.1038/s41575-020-0327-3Large-scale datasets of increasing size and complexity are being produced in the microbiome and oncology field. This Perspective discusses the potential to harness gut microbiome analysis, big data and machine learning in cancer, and the potential and limitations with this approach. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 9, 2020 Category: Gastroenterology Authors: Giovanni Cammarota Gianluca Ianiro Anna Ahern Carmine Carbone Andriy Temko Marcus J. Claesson Antonio Gasbarrini Giampaolo Tortora Source Type: research

The oral–gut axis in IBD
Nature Reviews Gastroenterology & Hepatology, Published online: 07 July 2020; doi:10.1038/s41575-020-0346-0The oral–gut axis in IBD (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 7, 2020 Category: Gastroenterology Authors: Katrina Ray Source Type: research

NETs promote liver metastasis via CCDC25
Nature Reviews Gastroenterology & Hepatology, Published online: 07 July 2020; doi:10.1038/s41575-020-0345-1NETs promote liver metastasis via CCDC25 (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 7, 2020 Category: Gastroenterology Authors: Iain Dickson Source Type: research

Development of AI-based pathology biomarkers in gastrointestinal and liver cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 03 July 2020; doi:10.1038/s41575-020-0343-3Deep learning can mine clinically useful information from histology. In gastrointestinal and liver cancer, such algorithms can predict survival and molecular alterations. Once pathology workflows are widely digitized, these methods could be used as inexpensive biomarkers. However, clinical translation requires training interdisciplinary researchers in both programming and clinical applications. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 3, 2020 Category: Gastroenterology Authors: Jakob N. Kather Julien Calderaro Source Type: research

Sleep loss lethality is caused by gut ROS in mice and flies
Nature Reviews Gastroenterology & Hepatology, Published online: 01 July 2020; doi:10.1038/s41575-020-0340-6Sleep loss lethality is caused by gut ROS in mice and flies (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - July 1, 2020 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Nature Reviews Gastroenterology & Hepatology, Published online: 30 June 2020; doi:10.1038/s41575-020-0310-zCholangiocarcinoma (CCA) comprises heterogeneous biliary malignant tumours, and their incidence is increasing worldwide. This expert Consensus Statement, endorsed by the ENS-CCA, summarizes the latest advances in CCA, including classification, genetics and treatment, and provides recommendations for CCA management and priorities across basic, translational and clinical research. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 30, 2020 Category: Gastroenterology Authors: Jesus M. Banales Jose J. G. Marin Angela Lamarca Pedro M. Rodrigues Shahid A. Khan Lewis R. Roberts Vincenzo Cardinale Guido Carpino Jesper B. Andersen Chiara Braconi Diego F. Calvisi Maria J. Perugorria Luca Fabris Luke Boulter Rocio I. R. Macias Eugenio Source Type: research

Publisher Correction: Early-onset colorectal cancer: initial clues and current views
Nature Reviews Gastroenterology & Hepatology, Published online: 29 June 2020; doi:10.1038/s41575-020-0338-0Publisher Correction: Early-onset colorectal cancer: initial clues and current views (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 29, 2020 Category: Gastroenterology Authors: Lorne J. Hofseth James R. Hebert Anindya Chanda Hexin Chen Bryan L. Love Maria M. Pena E. Angela Murphy Mathew Sajish Amit Sheth Phillip J. Buckhaults Franklin G. Berger Source Type: research

Interfering with acute intermittent porphyria
Nature Reviews Gastroenterology & Hepatology, Published online: 26 June 2020; doi:10.1038/s41575-020-0335-3Interfering with acute intermittent porphyria (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 26, 2020 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Ripretinib for advanced gastrointestinal stromal tumours
Nature Reviews Gastroenterology & Hepatology, Published online: 25 June 2020; doi:10.1038/s41575-020-0336-2Ripretinib for advanced gastrointestinal stromal tumours (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 25, 2020 Category: Gastroenterology Authors: Katrina Ray Source Type: research

A combination therapy to keep hepatocellular carcinoma in check
Nature Reviews Gastroenterology & Hepatology, Published online: 25 June 2020; doi:10.1038/s41575-020-0337-1A combination therapy to keep hepatocellular carcinoma in check (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 25, 2020 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Chemokines: the (un)usual suspects in pancreatic cancer neural invasion
Nature Reviews Gastroenterology & Hepatology, Published online: 19 June 2020; doi:10.1038/s41575-020-0329-1Pancreatic cancer is notorious for its affinity for invading nerves. A new study using a systematic unbiased RNA-interference screen of neuronal chemokines in cocultures of mouse sensory neurons and pancreatic cancer cells has now identified CCL21 and CXCL10 as key mediators of neural invasion, neural remodelling and pain in pancreatic cancer. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 19, 2020 Category: Gastroenterology Authors: Ihsan Ekin Demir Carmen Mota Reyes Source Type: research

IBD in the time of corona — vigilance for immune-mediated diseases
Nature Reviews Gastroenterology & Hepatology, Published online: 18 June 2020; doi:10.1038/s41575-020-0333-5The gastrointestinal tract represents a target organ for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting a thorough discussion on the consequences, particularly regarding inflammatory bowel diseases. Here, aspects of gastrointestinal involvement with SARS-CoV-2, the role of viruses as modulators of mucosal immunity and as treatment-related safety hazards, and the current clinical evidence will be discussed. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 18, 2020 Category: Gastroenterology Authors: Alexander R. Moschen Source Type: research

COVID-19 and the other pandemic: populations made vulnerable by systemic inequity
Nature Reviews Gastroenterology & Hepatology, Published online: 15 June 2020; doi:10.1038/s41575-020-0330-8Greater than the coronavirus disease 2019 (COVID-19) crisis, systemic inequity in social determinants of health is the pandemic that has long fostered vulnerability to disease and poor health outcomes in the USA. Our response has major implications for the health of our nations. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 15, 2020 Category: Gastroenterology Authors: Darrell M. Gray II Adjoa Anyane-Yeboa Sophie Balzora Rachel B. Issaka Folasade P. May Source Type: research

SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience
Nature Reviews Gastroenterology & Hepatology, Published online: 11 June 2020; doi:10.1038/s41575-020-0319-3The COVID-19 pandemic has resulted in changes to the management of patients with inflammatory bowel disease, including major disruptions to endoscopy. This Perspective provides a guide and recommendations for inflammatory bowel disease endoscopy during a global health emergency based on expert experience in Italy and France. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 11, 2020 Category: Gastroenterology Authors: Federica Furfaro Lucine Vuitton Gionata Fiorino Stephane Koch Mariangela Allocca Daniela Gilardi Alessandra Zilli Ferdinando D ’Amico Simona Radice Jean-Baptiste Chevaux Marion Schaefer Stanislas Chaussade Silvio Danese Laurent Peyrin-Biroulet Source Type: research

COVID-19 and the liver-related deaths to come
Nature Reviews Gastroenterology & Hepatology, Published online: 11 June 2020; doi:10.1038/s41575-020-0328-2Coronavirus disease 2019 (COVID-19) itself and/or the use of hepatotoxic drugs might negatively affect the course and management of patients with pre-existing chronic liver diseases. However, the greatest effect of COVID-19 on liver diseases will be indirect and delayed, resulting from the impending global economic crisis. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 11, 2020 Category: Gastroenterology Authors: Jean-Michel Pawlotsky Source Type: research

NAFLD — sounding the alarm on a silent epidemic
Nature Reviews Gastroenterology & Hepatology, Published online: 08 June 2020; doi:10.1038/s41575-020-0315-7On ‘International NASH Day’, we launch a call for the global health community to collaboratively shape and deliver a comprehensive, long-term public health agenda for NAFLD. A global multidisciplinary coalition is needed to guide our response to this increasingly prevalent, yet underaddressed disease. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 8, 2020 Category: Gastroenterology Authors: Jeffrey V. Lazarus Massimo Colombo Helena Cortez-Pinto Terry T. -K. Huang Veronica Miller Michael Ninburg J örn M. Schattenberg Lynn Seim Vincent W. S. Wong Shira Zelber-Sagi Source Type: research

The day after COVID-19 in IBD: how to go back to ‘normal’
Nature Reviews Gastroenterology & Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0322-8During the coronavirus disease 2019 (COVID-19) pandemic, inflammatory bowel disease (IBD) practices have been disrupted. This Comment summarizes the key strategies that should be implemented for both patients and IBD specialists to provide optimal care while avoiding new outbreaks for the first 6–12 months after the peak of the COVID-19 pandemic. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 1, 2020 Category: Gastroenterology Authors: Silvio Danese Bruce Sands Siew C. Ng Laurent Peyrin-Biroulet Source Type: research

Endocrine–exocrine signals in obesity-associated pancreatic cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0324-6Obesity is a known risk factor for pancreatic cancer. Now, a new study reports that obesity accelerates early pancreatic cancer development and growth in mice through local perturbations in the pancreatic microenvironment and implicates pancreatic islet-derived cholecystokinin as a driving factor. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 1, 2020 Category: Gastroenterology Authors: Guido Eibl Source Type: research

Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis
Nature Reviews Gastroenterology & Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0304-xSingle-cell transcriptomic technologies are transforming our understanding of cellular diversity and function in health and disease. This Review discusses how these technologies have been applied in hepatology, advancing our understanding of cellular heterogeneity and providing novel insights into liver biology such as metabolic zonation and the mechanisms underpinning liver regeneration. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 1, 2020 Category: Gastroenterology Authors: Prakash Ramachandran Kylie P. Matchett Ross Dobie John R. Wilson-Kanamori Neil C. Henderson Source Type: research

A smart toilet for personalized health monitoring
Nature Reviews Gastroenterology & Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0320-xA mountable ‘smart’ toilet system has been developed to personalize health monitoring. The system uses excretion data, including urinalysis, urodynamics, stool form and defecation timing, stored in a cloud server. This smart toilet system has the potential to provide useful information to characterize symptoms of patients with bowel dysfunction or defecatory disorders. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 1, 2020 Category: Gastroenterology Authors: Xiao Jing Wang Michael Camilleri Source Type: research

The genomic landscape of recurrent pancreatic cancer is modified by treatment
Nature Reviews Gastroenterology & Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0321-9Most patients who undergo curative intent surgery for pancreatic cancer will still die of recurrent disease. A new study shows that pancreatic tumours that pass through the genetic bottlenecks of surgery and additional chemoradiotherapy have altered mutational signatures, driver genes and subclonal architecture. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 1, 2020 Category: Gastroenterology Authors: Irene Y. Xie Steven Gallinger Source Type: research

Medical and gastroenterological education during the COVID-19 outbreak
Nature Reviews Gastroenterology & Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0323-7The outbreak of coronavirus disease 2019 has undeniably affected modalities of medical and gastroenterology training in all endemic areas. Indeed, the adoption of various distance-learning techniques has been mandatory to facilitate education and enhance skills such as problem-solving, self-directed learning, open communication and also holistic non-cognitive attributes such as adaptability and collaboration. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 1, 2020 Category: Gastroenterology Authors: Brigida Barberio Davide Massimi Anna Dipace Fabiana Zingone Fabio Farinati Edoardo V. Savarino Source Type: research

Microbiota modulates aspirin chemoprevention in CRC
Nature Reviews Gastroenterology & Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0325-5Microbiota modulates aspirin chemoprevention in CRC (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - June 1, 2020 Category: Gastroenterology Authors: Katrina Ray Source Type: research

The evolution and clinical impact of hepatitis B virus genome diversity
Nature Reviews Gastroenterology & Hepatology, Published online: 28 May 2020; doi:10.1038/s41575-020-0296-6Hepatitis B virus (HBV) infection remains a global public health issue. This Review provides insights into the evolution of HBV and discusses the mechanisms by which HBV and hepatitis delta virus diversity occurs and the influence of this diversity on disease progression and treatment response. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 28, 2020 Category: Gastroenterology Authors: Peter A. Revill Thomas Tu Hans J. Netter Lilly K. W. Yuen Stephen A. Locarnini Margaret Littlejohn Source Type: research

From NAFLD to MAFLD: when pathophysiology succeeds
Nature Reviews Gastroenterology & Hepatology, Published online: 27 May 2020; doi:10.1038/s41575-020-0316-6Two new position papers convincingly propose that nonalcoholic fatty liver disease needs a new name — metabolic associated fatty liver disease (MAFLD). A new name for this disease affecting nearly one billion people globally is overdue, as knowledge gained from the past decades has assuringly demonstrated that MAFLD is a purely metabolic disorder. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 27, 2020 Category: Gastroenterology Authors: Herbert Tilg Maria Effenberger Source Type: research

PDAC resistance to immunotherapy — a role for autophagy?
Nature Reviews Gastroenterology & Hepatology, Published online: 20 May 2020; doi:10.1038/s41575-020-0318-4PDAC resistance to immunotherapy — a role for autophagy? (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 20, 2020 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Organoids demonstrate gut infection by SARS-CoV-2
Nature Reviews Gastroenterology & Hepatology, Published online: 19 May 2020; doi:10.1038/s41575-020-0317-5Organoids demonstrate gut infection by SARS-CoV-2 (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 19, 2020 Category: Gastroenterology Authors: Iain Dickson Source Type: research

COVID-19 and endoscopy: implications for healthcare and digestive cancer screening
Nature Reviews Gastroenterology & Hepatology, Published online: 13 May 2020; doi:10.1038/s41575-020-0312-xThe coronavirus disease 2019 (COVID-19) pandemic is affecting and changing the daily practice of gastrointestinal endoscopy worldwide. To protect patients and endoscopy unit personnel, endoscopy units have had to postpone a large proportion of endoscopic procedures. These delays might have an effect on the screening for and surveillance of digestive cancers. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 13, 2020 Category: Gastroenterology Authors: Ian M. Gralnek Cesare Hassan Mario Dinis-Ribeiro Source Type: research

Another Notch in the mechanism of Barrett oesophagus progression
Nature Reviews Gastroenterology & Hepatology, Published online: 12 May 2020; doi:10.1038/s41575-020-0313-9Another Notch in the mechanism of Barrett oesophagus progression (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 12, 2020 Category: Gastroenterology Authors: Iain Dickson Source Type: research

IgE producers in the gut expand the gut’s role in food allergy
Nature Reviews Gastroenterology & Hepatology, Published online: 11 May 2020; doi:10.1038/s41575-020-0309-5Details about IgE-producing B cells in the gut in the context of food allergy are scarce, despite the frequent exposure of the gut and its associated lymphoid tissues to dietary antigens. A new study finds that IgE-producing B cells are enriched in gut tissues and are probably generated from local antibody isotype switching. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 11, 2020 Category: Gastroenterology Authors: Onyinye I. Iweala A. Wesley Burks Source Type: research

Pancreatic cancer stroma: an update on therapeutic targeting strategies
Nature Reviews Gastroenterology & Hepatology, Published online: 11 May 2020; doi:10.1038/s41575-020-0300-1The neoplastic epithelium of pancreatic cancer exists within a dense stroma that is recognized as a critical mediator of disease progression. This Review discusses our current understanding of the three principal constituents of pancreatic cancer stroma, their effect on the prevalent immune landscape and promising therapeutic targets within this compartment. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 11, 2020 Category: Gastroenterology Authors: Abdel N. Hosein Rolf A. Brekken Anirban Maitra Source Type: research

Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities
Nature Reviews Gastroenterology & Hepatology, Published online: 06 May 2020; doi:10.1038/s41575-020-0311-yAuthor Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - May 6, 2020 Category: Gastroenterology Authors: Silvio Danese Maurizio Cecconi Antonino Spinelli Source Type: research

Ironing out mucosal healing
Nature Reviews Gastroenterology & Hepatology, Published online: 29 April 2020; doi:10.1038/s41575-020-0308-6Ironing out mucosal healing (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 29, 2020 Category: Gastroenterology Authors: Katrina Ray Source Type: research

Universal screening for hepatitis C virus infection should be linked to universal treatment access
Nature Reviews Gastroenterology & Hepatology, Published online: 29 April 2020; doi:10.1038/s41575-020-0306-8New national hepatitis C virus (HCV) screening guidance from the United States Preventive Services Task Force includes a recommendation for one-time testing for all adults aged 18 to 79 years. Implicit in the new guidance is that all people diagnosed with chronic HCV infection should be offered HCV treatment. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 29, 2020 Category: Gastroenterology Authors: Gregory J. Dore Gail V. Matthews Source Type: research

Inducing senescence sensitizes pancreatic tumours to therapies
Nature Reviews Gastroenterology & Hepatology, Published online: 28 April 2020; doi:10.1038/s41575-020-0305-9Inducing senescence sensitizes pancreatic tumours to therapies (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 28, 2020 Category: Gastroenterology Authors: Jordan Hindson Source Type: research

Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions
Nature Reviews Gastroenterology & Hepatology, Published online: 22 April 2020; doi:10.1038/s41575-020-0302-zThe microbial communities that occupy the intestinal tract are shaped by a variety of different factors, including the immune system. A new study has observed and quantified, at unprecedented depth, regionally distinct microbial and immune niches along the human colon using simultaneous analyses of the gut microbiota and neighbouring immune cells. (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 22, 2020 Category: Gastroenterology Authors: Rebecca N. Culver Sean P. Spencer Kerwyn Casey Huang Source Type: research

Feeding back on ingestion
Nature Reviews Gastroenterology & Hepatology, Published online: 21 April 2020; doi:10.1038/s41575-020-0307-7Feeding back on ingestion (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 21, 2020 Category: Gastroenterology Authors: Katrina Ray Source Type: research