Cancers, Vol. 16, Pages 1590: Unsaturated Fatty Acid Synthesis Is Associated with Worse Survival and Is Differentially Regulated by MYCN and Tumor Suppressor microRNAs in Neuroblastoma
John T. Powers
MYCN amplification (MNA) and disruption of tumor suppressor microRNA (TSmiR) function are key drivers of poor outcomes in neuroblastoma (NB). While MYCN and TSmiRs regulate glucose metabolism, their role in de novo fatty acid synthesis (FAS) and unsaturated FAS (UFAS) remains poorly understood. Here, we show that FAS and UFAS (U/FAS) genes FASN, ELOVL6, SCD, FADS2, and FADS1 are upregulated in high-risk (HR) NB and that their expression is associated with lower overall survival. RNA-Seq analysis of human NB cell lines revealed parallel U/FAS gene expression patterns. Consistent with this, we found tha...
Source: Cancers - April 21, 2024 Category: Cancer & Oncology Authors: Dennis A. Sheeter Secilia Garza Hui Gyu Park Lorraine-Rana E. Benhamou Niharika R. Badi Erika C. Espinosa Kumar S. D. Kothapalli J. Thomas Brenna John T. Powers Tags: Article Source Type: research
Genes, Vol. 15, Pages 519: Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
Jin Li
Post-traumatic stress disorder (PTSD) is the most common psychiatric disorder after a catastrophic event; however, the efficacious treatment options remain insufficient. Increasing evidence suggests that cannabidiol (CBD) exhibits optimal therapeutic effects for treating PTSD. To elucidate the cell-type-specific transcriptomic pathology of PTSD and the mechanisms of CBD against this disease, we conducted single-nucleus RNA sequencing (snRNA-seq) in the hippocampus of PTSD-modeled mice and CBD-treated cohorts. We constructed a mouse model by adding electric foot shocks following exposure to single prolonged st...
Source: Genes - April 21, 2024 Category: Genetics & Stem Cells Authors: Guanbo Xie Yihan Qin Ning Wu Xiao Han Jin Li Tags: Article Source Type: research
Bilateral dens evaginatus and associated cystic pathology: An unusual case report
Key Clinical MessageDens evaginatus (DE) presents a clinical conundrum due to its fragility and propensity to cause pulpal and periapical complications. Clinicians should heed the presence of DE during clinical examinations and avoid unnecessary intervention. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 20, 2024 Category: General Medicine Authors: Haeseong Lee,
Bach Le,
Parish Sedghizadeh Tags: CASE REPORT Source Type: research
Exosome secretion related gene signature predicts chemoresistance in patients with colorectal cancer
CONCLUSIONS: In summary, the gene signature related to exosome formation and secretion could reliably predict patients' chemosensitivity and ICB treatment response, which providing new independent biomarkers for the treatment of CRC.PMID:38642509 | DOI:10.1016/j.prp.2024.155313 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 20, 2024 Category: Pathology Authors: Liang Ming Junhui Tang Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma
CONCLUSIONS: The detection of K17 in 10% or greater of PDAC cells identified patients with shortest survival. Among patients with low K17 PDACs, 5-FU-based treatment was more likely than gemcitabine-based therapies to extend survival.PMID:38642081 | DOI:10.1093/ajcp/aqae038 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 20, 2024 Category: Pathology Authors: Lyanne A Delgado-Coka Lucia Roa-Pe ña Sruthi Babu Michael Horowitz Emanuel F Petricoin Lynn M Matrisian Edik M Blais Natalia Marchenko Felicia D Allard Ali Akalin Wei Jiang Brent K Larson Andrew E Hendifar Vincent J Picozzi Minsig Choi Kenneth R Shroyer Source Type: research
Early identification of patients at risk for iron-deficiency anemia using deep learning techniques
CONCLUSIONS: Our results showcase the feasibility of employing deep learning techniques for early prediction of IDA in the outpatient setting based on sequences of laboratory data, offering a substantial lead time for clinical intervention.PMID:38642073 | DOI:10.1093/ajcp/aqae031 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 20, 2024 Category: Pathology Authors: Nelly Estefanie Garduno-Rapp Yee Seng Ng Jenny L Weon Sameh N Saleh Christoph U Lehmann Chenlu Tian Andrew Quinn Source Type: research
An unusual case of primary splenic soft part alveolar sarcoma: case report and review of the literature with emphasis on the spectrum of TFE3-associated neoplasms
Alveolar soft part sarcoma is a rare tumour of soft tissues, mostly localized in muscles or deep soft tissues of the extremities. In rare occasions, this tumour develops in deep tissues of the abdomen or pelvis. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 20, 2024 Category: Pathology Authors: Ren é Guérin, Anne-Lise Menard, Emilie Angot, Nicolas Piton, Pierre Vera, Lilian Schwarz, Jean-Christophe Sabourin, Marick Laé and Pierre-Alain Thiébaut Tags: Case Report Source Type: research
From quantitative metrics to clinical success: assessing the utility of deep learning for tumor segmentation in breast surgery
ConclusionWe present a clinical evaluation of deep learning models trained for intraoperative tumor segmentation in breast-conserving surgery. We demonstrate that automatic contouring is limited in predicting pathology margins despite achieving high performance on quantitative metrics. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - April 20, 2024 Category: Intensive Care Source Type: research
Clinicopathologic Features and Cytologic Correlation of ALK-Rearranged Papillary Thyroid Carcinoma: A Series of Eight Cases
In conclusion, althoughALK-rearranged PTCs have been associated with neutral gene expression profile from aBRAF-RAS scoring perspective, the “RAS-like ” nuclear features were more commonly identified in this series, resulting in frequent indeterminate diagnosis of preoperative FNA. (Source: Endocrine Pathology)
Source: Endocrine Pathology - April 20, 2024 Category: Pathology Source Type: research
The Role of Verbal Fluency in the Cerebellar Cognitive Affective Syndrome Scale in Friedreich Ataxia
This study explored the relationship between performance on the CCAS-S and clinical metrics of disease severity in 57 adults with FRDA. In addition, this study explored the relationship between measures of intelligibility and naturalness of speech and scores on the CCAS-S in a subgroup of 39 individuals with FRDA. We demonstrated a significant relationship between clinical metrics and performance on the CCAS-S. In addition, we confirmed the items that returned the greatest rate of failure were based on Verbal Fluency Tasks, revealing a significant relationship between these items and measures of speech. Measures of speech ...
Source: The Cerebellum - April 20, 2024 Category: Neurology Source Type: research
Polar lipids modify Alzheimer ’s Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation
Pro-inflammatory processes triggered by the accumulation of extracellular amyloid beta (A β) peptides are a well-described pathology in Alzheimer's disease (AD). Activated astrocytes surrounding Aβ plaques cont... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 20, 2024 Category: Lipidology Authors: Sakshi Hans, Janelle E. Stanton, Ann Katrin Sauer, Katie Shiels, Sushanta Kumar Saha, Ronan Lordan, Alexandros Tsoupras, Ioannis Zabetakis and Andreas M. Grabrucker Tags: Research Source Type: research
Benign metastasizing fumarate hydratase (FH)-deficient uterine leiomyomas: clinicopathological and molecular study with first documentation of multi-organ metastases
AbstractLeiomyoma is the most prevalent benign tumor of the female reproductive system. Benign metastasizing leiomyoma (BML) is a rare phenomenon that presents at distant sites, typically the lungs, exhibiting histopathological features similar to the primary uterine tumor in the absence of malignancy features in both. Fumarate hydratase-deficient uterine leiomyoma (FH-d UL) is an uncommon subtype among uterine smooth muscle tumors (0.5 –2%), showing distinctive histomorphology andFH inactivation. The majority of FH-d ULs are sporadic, caused by somaticFH inactivation, while a minority of cases occur in the context of th...
Source: Virchows Archiv - April 20, 2024 Category: Pathology Source Type: research
M üllerian anomalies in girls with congenital solitary kidney
ConclusionsThe prevalence of MA in patients with congenital SFK was 24% among those age 10 years or older, and 38% were obstructive. This justifies routine screening pelvic ultrasound in girls with congenital SFK to improve early diagnosis.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Fenestrated Physician Modified Endografts for Endovascular Aortic Arch Repair in Zone 0
CONCLUSION: This study demonstrated the efficacy of PMEGs for zone 0 endovascular aortic arch repair, with acceptable technical success and mortality rate. Stroke, RTAD, and re-intervention rates remain a concern for endovascular therapy. A larger population and long term outcomes are required to assess the safety and durability of this technique as a beneficial choice for endovascular aortic arch repair in specialised centres.PMID:38641315 | DOI:10.1016/j.ejvs.2024.04.008 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - April 19, 2024 Category: Surgery Authors: Qinshu Wen Yepeng Zhang Jun Wei Mingyang Shen Guangyan Wu Xiaolong Du Xiaoqiang Li Min Zhou Source Type: research
Contextualized, Multicomponent Language Instruction: From Theory to Randomized Controlled Trial
CONCLUSIONS: There is growing support for the use of multicomponent CLIs to bring about educationally relevant outcomes for students with LLDs. The authors present this review of how SKILL was designed, manualized, and rigorously tested by a team of researchers and practitioners with the hope that this approach will serve as a springboard for the development of future multicomponent CLIs that may meaningfully improve communicative and educational outcomes for students with LLDs.PMID:38640078 | DOI:10.1044/2024_LSHSS-23-00171 (Source: Language, Speech, and Hearing Services in Schools)
Source: Language, Speech, and Hearing Services in Schools - April 19, 2024 Category: Speech-Language Pathology Authors: Sandra L Gillam Ronald B Gillam Beula M Magimairaj Philip Capin Megan Israelsen-Augenstein Greg Roberts Sharon Vaughn Source Type: research
