Riddle of the Sphinx: Emerging role of circular RNAs in cervical cancer
Pathol Res Pract. 2024 Apr 17;257:155315. doi: 10.1016/j.prp.2024.155315. Online ahead of print.ABSTRACTCervical cancer is a prominent cause of cancer-related mortality among women, with recent attention directed toward exploring the involvement of circular RNAs (circRNAs) in this particular cancer. CircRNAs, characterized by a covalently closed loop structure, belong to a class of single-stranded non-coding RNA (ncRNA) molecules that play crucial roles in cancer development and progression through diverse mechanisms. The abnormal expression of circRNAs in vivo is significantly associated with the development of cervical c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Caiyan Yin Jianwei Yu Gaohua Liu Jun He Peng Wu Source Type: research
NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway
CONCLUSION: Collectively, our findings show that NUPR1 enhances the progression of ESCC by triggering autophagy and is associated with the MAPK-mTOR signaling pathway.PMID:38653091 | DOI:10.1016/j.prp.2024.155323 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Shiheng Ren Yuxin Chen Qiang Wang Liang Song Zhongwei Xin Mo Shi Xiangyan Liu Source Type: research
Advances in glioblastoma multiforme: Integrating therapy and pathology perspectives
In conclusion, our efforts offer hope for enhanced outcomes and improved quality of life for GBM patients through alkaloid-based therapies. By integrating insights from pathology and therapeutic perspectives, we underscore the significance of a comprehensive approach in addressing this devastating disease.PMID:38653089 | DOI:10.1016/j.prp.2024.155285 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Seyed Hossein Shahcheraghi Maliheh Alimardani Malihe Lotfi Marzieh Lotfi Vladimir N Uversky Stephanie Tamdem Guetchueng Sushesh Shrivastsa Palakurthi Nitin B Charbe Altijana Hromi ć-Jahjefendić Alaa A A Aljabali Manoj M Gadewar Sumira Malik Rohit Goyal Source Type: research
Dendritic cell-derived exosome (DEX) therapy for digestive system cancers: Recent advances and future prospect
Pathol Res Pract. 2024 Apr 6;257:155288. doi: 10.1016/j.prp.2024.155288. Online ahead of print.ABSTRACTTumor-mediated immunosuppression is a fundamental obstacle to the development of dendritic cell (DC)-based cancer vaccines, which despite their ability to stimulate host anti-tumor CD8 T cell immunity, have not been able to generate meaningful therapeutic responses. Exosomes are inactive membrane vesicles that are nanoscale in size and are produced by the endocytic pathway. They are essential for intercellular communication. Additionally, DC-derived exosomes (DEXs) contained MHC class I/II (MHCI/II), which is frequently c...
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Sulieman Ibraheem Shelash Al-Hawary Yasir Qasim Almajidi Pooja Bansal Irfan Ahmad Harpreet Kaur Ahmed Hjazi Mahamedha Deorari Ahmed Hussein Zwamel Hamza Fadhel Hamzah Bahira Abdulrazzaq Mohammed Source Type: research
Progesterone amplifies allergic inflammation and airway pathology in association with higher lung ILC2 responses
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00207.2023. Online ahead of print.ABSTRACTPerimenstrual worsening of asthma occurs in up to 40% of asthmatic women, leading to increased acute exacerbations requiring clinical care. The role of sex hormones during these times remains unclear. In the current study, we used a translational approach to determine whether progesterone exacerbates allergic inflammation in the traditional OVA model in BALB/c mice. Simultaneously, we used PBMC from healthy human donors to assess the effects of progesterone on circulating ILC2. Briefly, lungs of ovarectomized (OV...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Shubhanshi Trivedi Cassandra E Deering-Rice Samuel E Aamodt Thomas P Huecksteadt Elizabeth J Myers Karl A Sanders Robert Paine Kristi J Warren Source Type: research
The Landsteiner lung cancer research platform (LALUCA) : Objectives, methodology and implementation of a real-world clinical lung cancer registry
CONCLUSION: The LALUCA registry is a web-based platform for the collection of real-world clinical data of lung cancer patients. Combining a large number of patients with a focus on gathering comprehensive data on diagnosis and treatment, the LALUCA registry provides a tool for investigation, evaluation, and improvement of the clinical management, survival and quality of care of Austrian lung cancer patients.PMID:38652311 | DOI:10.1007/s00508-024-02351-3 (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - April 23, 2024 Category: General Medicine Authors: Anna Lang-St öberl Hannah Fabikan Maximilan Hochmair Klaus Kirchbacher Vikaela Mania Rodriguez Leya Ay Christoph Weinlinger David Rosenthaler Oliver Illini Nino M üser Georg-Christian Funk Arschang Valipour Source Type: research
Adverse events in biologics for severe asthma
CONCLUSION: Biologics for severe asthma are recent drugs with a favorable safety profile, but with little real-life experience, justifying increased vigilance by prescribing physicians.PMID:38653607 | DOI:10.1016/j.rmr.2024.04.001 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 23, 2024 Category: Respiratory Medicine Authors: G Dargentolle M Georges G Beltramo C Poisson P Bonniaud Source Type: research
Medullary Thyroid Cancer: Single Institute Experience over Three Decades and Risk Factors for Recurrence
CONCLUSION: One of 4 patients undergoing surgery for MTC will recur. Risk factors associated with recurrence are male gender, lateral LN metastasis and high/highest MTC risk level mutations, but not necessarily surgery type. Preoperative calcitonin>2,175 pg/mL is suggestive of advanced disease and should prompt further evaluation.PMID:38651609 | DOI:10.1210/clinem/dgae279 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sara Abou Azar Joseph Tobias Megan Applewhite Peter Angelos Xavier M Keutgen Source Type: research
Radio-Guided Surgery with a New-Generation β-Probe for Radiolabeled Somatostatin Analog, in Patients with Small Intestinal Neuroendocrine Tumors
CONCLUSION: This study reports optimal accuracy in detecting lesions of SI-NETs using the intraoperative RGS approach with a novel β-probe. The method was found to be safe, feasible, and easily reproducible in daily clinical practice, with minimal radiation exposure for the staff. RGS might potentially improve radical resection rates in SI-NETs.CLINICAL TRIALS REGISTRATION: 68Ga-DOTATOC Radio-Guided Surgery with β-Probe in GEP-NET (RGS GEP-NET) [NCT0544815; https://classic.CLINICALTRIALS: gov/ct2/show/NCT05448157 ].PMID:38652200 | DOI:10.1245/s10434-024-15277-x (Source: Ann Oncol)
Source: Ann Oncol - April 23, 2024 Category: Cancer & Oncology Authors: Emilio Bertani Francesco Mattana Francesco Collamati Mahila E Ferrari Vincenzo Bagnardi Samuele Frassoni Eleonora Pisa Riccardo Mirabelli Silvio Morganti Nicola Fazio Uberto Fumagalli Romario Francesco Ceci Source Type: research
Case Report of a Hidden Intruder-Extremely Rare Presentation of Hydatidosis as a Nuchal Tumoural Mass
We report the case of a 68-year-old male patient, a zootechnic, who presented at the hospital with a tumoural mass (dimension: about 12/10 cm) located in the nuchal region. The complex approach needed consisted of surgical therapy along with histopathological confirmation of the diagnostic and antiparasitic medication, which led to a complete recovery with a low probability of recurrence. Discussion: Encounters with patients with primary soft tissue hydatidosis are exceptionally rare, but the surgeon must take into consideration this clinical diagnosis, especially for patients located in an endemic region with occupations ...
Source: British Journal of Biomedical Science - April 23, 2024 Category: Laboratory Medicine Authors: Drago ș F Voicu Constantin Popazu Delia Mihaela R âșnoveanu Daniela Mihalache Alexandra Toma Source Type: research
RIP1 kinase inactivation protects against LPS-induced acute respiratory distress syndrome in mice
This study enhances our understanding of the therapeutic potential of RIPK1 kinase modulation in ARDS, providing insights for the pathogenesis of ARDS.PMID:38652970 | DOI:10.1016/j.intimp.2024.112060 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Emmauel Mago Xunan Zhao Weigao Zhang Qianchao Shao Peiqi Li Shuxian Huang Xinyu Ding Hu Liu Tingzhe Sun Fei He Dan Weng Source Type: research
PD-L1 blockade in mitigating severe acute pancreatitis induced pancreatic damage through modulation of immune cell apoptosis
Int Immunopharmacol. 2024 Apr 22;133:112081. doi: 10.1016/j.intimp.2024.112081. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a prevalent gastrointestinal disorder. The immune response plays a crucial role in AP progression. However, the impact of immune regulatory checkpoint PD-L1 on severe acute pancreatitis (SAP) remains uncertain. Hence, this study aimed to examine the influence of PD-L1 on SAP. We assessed PD-L1 expression in neutrophils and monocytes obtained from SAP patients. We induced SAP in C57BL/6J mice, PD-L1 gene-deficient mice, and PD-L1 humanized mice using intraperitoneal injections of cerulein ...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Du-Jiang Yang Ke-Ling Chen Zhao-Ying Lv Bin Zhou Zong-Guang Zhou Yuan Li Source Type: research
Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF- κB p65 signaling pathway and MMP9
Int Immunopharmacol. 2024 Apr 22;133:112082. doi: 10.1016/j.intimp.2024.112082. Online ahead of print.ABSTRACTPsoriasis is an incurable immune-mediated disease affecting the skin or the joints. There are continuing studies on drugs for psoriasis prevention and treatment. This research found that Geniposide (GE) significantly thinned IMQ mice's skin lesions, reduced the scales, and lowered the presence of inflammatory cells in the pathology in a dose-dependent manner. GE inhibited IL-23, IL-22, IL-17A, IL-12, IL-6, and TNF-α levels in psoriatic mice serum. AKT1, TNF, TLR4, MMP9, MAPK3, and EGFR were selected as the top 6 t...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Lijuan Liu Huiling Zhang Xinran Tang Mengge Zhang Yayun Wu Ya Zhao Chuanjian Lu Ruizhi Zhao Source Type: research
Characteristics of radiotherapy for adolescents and young adults
This article reviews the characteristics to be taken into account in adolescent and young adult patients radiotherapy and more particularly in some of the most common diseases.PMID:38652674 | DOI:10.1016/j.canrad.2023.08.002 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 23, 2024 Category: Cancer & Oncology Authors: L Ollivier A Laprie E Jouglar L Claude V Martin X Muracciole L Padovani S Supiot A Escande Source Type: research
The Transaxillary Approach as a Direct Route in the Management of Upper Thoracic Spine Pathology: A Technical Note with Case Series
Asian Spine J. 2024 Apr 23. doi: 10.31616/asj.2023.0175. Online ahead of print.ABSTRACTThis retrospective case series of prospective data aims to describe the transaxillary approach for the treatment of upper thoracic spine pathology. Various surgical techniques and approaches have been reported across the literature to address upper thoracic spine pathology, including the cervicothoracic approach, anterior transsternal approach, posterolateral approach, supraclavicular approach, and lateral parascapular approaches. These techniques are invasive. A minimally invasive, less morbid, and direct access approach to the patholog...
Source: Asian Spine Journal - April 23, 2024 Category: Orthopaedics Authors: Syed Ifthekar Ju-Wan Seuk Ui Dong Hwang Hyung Chang Lee Sang-Ho Lee Junseok Bae Source Type: research
