Innate Immune cGAS/STING Signaling is Both Necessary and Pathological
Chronic, unresolved inflammation is a feature of aging. When the immune system is constantly active in this way, the consequent altered cell behavior throughout the body becomes disruptive to tissue and organ function, harmful to the individual. Chronic inflammation accelerates the onset and progression of all of the common fatal age-related conditions. This unwanted inflammatory signaling arises from many different roots, including the growing presence of senescent cells, but also the interaction of innate immune sensors with other forms of age-related dysfunction. For example, damage-associated molecular patterns such as...
Source: Fight Aging! - May 7, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Will AI Revolutionize Surgical Care? Yes, But Maybe Not How You Think
By MIKE MAGEE
If you talk to consultants about AI in Medicine, it’s full speed ahead. GenAI assistants, “upskilling” the work force, reshaping customer service, new roles supported by reallocation of budgets, and always with one eye on “the dark side.”
But one area that has been relatively silent is surgery. What’s happening there? In June, 2023, the American College of Surgeons (ACS) weighed in with a report that largely stated the obvious. They wrote, “The daily barrage of news stories about artificial intelligence (AI) shows that this disruptive technology is here to stay and on the verge of revol...
Source: The Health Care Blog - May 7, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI Mike Magee Surgery Source Type: blogs
In Neurodegenerative Disease, More Neurons Return to the Cell Cycle
Researchers have found evidence of cellular senescence in neurons in the aging brain. How do neurons become senescent, given that they are post-mitotic, non-dividing cells? Cellular senescence is state primarily associated with excessive cell division, in which a cell reaches the Hayflick limit, though cells can become senescent in response to damage or toxicity. Here, researchers provide evidence to show that in the aging brain, and particularly in the context of neurodegenerative conditions, ever more neurons re-enter the cell cycle, which inevitably leads to senescence. This is an interesting line of research, adding an...
Source: Fight Aging! - May 7, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
It Seems There Has Been A Major Policy Change With The MyHealthRecord,
This appeared last week:
Patients given immediate access to results on MHR
The DoHAC has scrapped a seven-day delay in patients viewing
pathology and diagnostic imaging results, against the advice of medical
colleges.
The My Health Record changes were one recommendation of the
Strengthening Medicare Taskforce.
Patients
will be able to access certain test results immediately and (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - May 6, 2024 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, May 6th 2024
In conclusion, we found that elevated central aortic stiffness is associated with a greater decline in kidney function in old age. Since aPWV and cSBP both appear to be predictors of eGFR decline, it might be of interest to identify older individuals with elevated aortic stiffness. In this specific population, intensive blood pressure reduction might be justified in order to slow down the process of vascular aging and prevent kidney function decline.
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Cellular Senescence in Neurodegenerative Conditions
https://www.fightaging.org/archives/2024/04/cellular-senescence-in-neurodegenera...
Source: Fight Aging! - May 5, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in Neurodegenerative Conditions
This open access review paper covers the high points of what is presently known of the contribution of senescent cells to neurodegenerative conditions. Somatic cells become senescent throughout life, largely as they reach the Hayflick limit to replication, but also due to damage or a toxic local environment. Senescent cells halt replication and begin to secrete pro-inflammatory signals to attract the immune system. In youth, senescent cells are rapidly cleared by programmed cell death or by immune cells. With age, the immune system becomes less efficient. As a consequence senescent cells begin to accumulate, and they help ...
Source: Fight Aging! - April 30, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Progressive Failure of Glucose Regulation in the Aging Brain
There has long been a school of thought on Alzheimer's disease that consideres it a form of diabetes, in which dysregulated glucose metabolism features prominently. This dysregulation certainly occurs; the study noted here isn't the only one to show that the aging brain no longer manages glucose adequately. The question is whether this mechanism is important relative to all of the other processes thought to contribute to the pathology of Alzheimer's disease and other neurodegenerative conditions, and where it fits in a chain of cause and consequence. Finding ways to demonstrate the relative importance of different mechanis...
Source: Fight Aging! - April 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Catastrophising – the views of people with pain
Last week I posted the first in a series on pain catastrophizing. This week, instead of looking at the measurement instruments, I thought it worthwhile seeing what people with pain feel when looking at this construct. After all, when we’re talking about us (people with pain) shouldn’t our perspectives be taken into account? Nothing about us without us.
Webster and a large team of collaborators (Webster et al., 2022) conducted possibly the largest study examining the responses of people living with pain to the terms associated with catastrophising. Now the number of collaborators on this project tells you on...
Source: HealthSkills Weblog - April 28, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Cognitive skills Professional topics Psychology Research Science in practice catastrophising catastrophizing Clinical reasoning pain management Source Type: blogs
Fight Aging! Newsletter, April 29th 2024
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging.
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The Role of Immune Aging in Neurodegenerative Conditions
https://www.fightaging.org/archives/2024/04/the-role-of-immune-aging-in-neurodegenerative-conditions/
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is n...
Source: Fight Aging! - April 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Atrial dilatation in Atrial fibrillation : A query with multiple twists!
(This is supposed to be a poll. Sorry, readers, you can’t select the answer. WordPress is not kind enough and suddenly made the poll service payable extra. I am already paying nearly a $100 fee to maintain this site. I can’t afford any more.)
We have been taught Bi-Atrial enlargement is the rule in AF .It is still true in most situations. But, we rarely dispute it , & ask which atrium dilates more in AF ?
Let us see few factors.
Both atria develop from a combination of the primitive atrium, sinus venous, and pulmonary veins.It is logical to presume there must be a hidden morpho-electrical ...
Source: Dr.S.Venkatesan MD - April 28, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized atrial cardiomyopathy atrial fibrillation biatrial enlargement in af dispropotinate atrial enlargement in af left atrial cardiomyopathy left atrial fibrillation left atrial vs right atrial fibrillation lone af non pulmonary Source Type: blogs
The Role of Immune Aging in Neurodegenerative Conditions
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is necessary for defense against pathogens and regeneration following injury. Unresolved, constant inflammation is harmful to tissue structure and function, however, changing cell behavior for the worse. In brain tissue, the effects of inflammatory signaling on the behavior of innate immune cells called microglia appears particularly important. Neurogenerative conditions are characterized by activated microglia. These microglia ar...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fulfilling fatherhood and a thriving medical practice: my story
I started having children towards the end of my medical school. By the time I became a resident, I already had two young boys. My wife was also a pathology resident at that time. We worked hard and were fortunate to have parents who helped us occasionally. However, we still missed out on a lot
Read more…
Fulfilling fatherhood and a thriving medical practice: my story originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 23, 2024 Category: General Medicine Authors: Francisco M. Torres, MD Tags: Physician Primary Care Source Type: blogs
Bonus Features – April 21, 2024 – 89% of physicians said generative AI vendors need to be transparent about where info comes from, 73% of consumers expect a 4-star rating before they ’ ll engage with a provider, plus 21 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
Studies
According to a Wolters Kluwer survey, 68% of physicians think generative AI will benefit healthcare – but to trust the technology, 89% said vendors need to be transparent about where information was sourced and wh...
Source: EMR and HIPAA - April 21, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Brand Engagement Network Butterfly Network CharmHealth CHG Healthcare Clarify Health Cured Databricks Donna Boyer eClinicalWorks Epic Research Google Cloud Harvard Medical School HCTec Healthcare IT Today Bonus Fe Source Type: blogs
Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Parkinson's Disease in the SENS View of Damage Repair
The Strategies for Engineered Negligible Senescence (SENS) is a view of aging as accumulated damage. Drawing from the extensive scientific literature on aging, the originators of SENS created an outline of the forms of cell and tissue damage that are fundamental causes of aging, in that they occur as a natural side-effect of the normal operation of our cellular biochemistry. So we might consider the loss of vital cells due to declining stem cell function, mutations to nuclear DNA and mitochondrial DNA, cross-linking of vital molecules in the extracellular matrix, accumulated metabolic waste in long-lived cells, generation ...
Source: Fight Aging! - April 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
