VCAM1 and APOE Involved in Microglial Clearance of Amyloid- β
One of the characteristics of neurodegenerative conditions such as Alzheimer's disease is the inflammatory activation and dysfunction of microglia. These are cells of the innate immune system distinct to the brain, analogous to macrophages elsewhere in the body. They undertake a similar portfolio of tasks, including chasing down pathogens, destroying errant cells, cleaning up waste and debris such as toxic aggregated proteins found outside cells, and aiding in tissue maintenance and repair. When microglia are in an inflammatory state, they are less inclined to aid in tissue maintenance and clearance of harmful metabolic wa...
Source: Fight Aging! - December 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
In Alzheimer's Patients, Neuropsychiatric Symptoms Correlate with Neuroinflammation
Chronic, unresolved inflammation is a feature of aging. It emerges from mitochondrial dysfunction and mislocalization of mitochondrial DNA, from visceral fat tissue, from senescent cells, and from a range of other maladaptive processes. Sustained inflammatory signaling is disruptive of cell and tissue function. In recent years, researchers have come to put a greater emphasis on the role of chronic inflammation in the onset and progression of Alzheimer's disease. While it remains the case that protein aggregation (of altered amyloid-β and tau) is the primary point of focus in Alzheimer's research and the development of tre...
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bonus Features – December 3, 2023 – Only 40% of orgs say EHRs help manage burnout, cost optimization is top strategy for 70% of payers, plus 19 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
The 2023 Fierce Healthcare Innovation Awards have been announced, and the winners are GoodRx, Hinge Health, ISeeYouCare, PointClickCare, and Ventric Health.
Only 40% of healthcare organizations said their EHRs ...
Source: EMR and HIPAA - December 3, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Health IT Company Healthcare IT Hospital - Health System 3M Health Information Systems Caregility Dr. David Shulkin DrFirst eClinicalWorks Ernst & Young GoodRx Healthcare IT Today Bonus Features Hinge Health InteliChart ISeeYouCa Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Can you try these two questions on Amyloid ?
Is it a physiological molecule ?
1.Yes, It is a physiological molecule.
2.No, Amyloid is always pathological.
Where does it gets deposited ?
A .Extracellular*
B. Intracellular
C. Both
Answer : Q 1: A / Q 2: C. It is indeed a physiological molecule in small amounts that help carry hormones across the blood. In pathology, it accumulates in huge amounts. It is a disorder of protein folding, making them thick, stiff , sheets of peptide, hence mis-behaving with adjacent cells, injuring them in the process. This is responsible for the systemic nature of disorder right from the brain to peripheral nerves, H...
Source: Dr.S.Venkatesan MD - December 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Alzheimer disease amyloidosis ttr amyloid what is amyloid Source Type: blogs
IsoDGR as a Form of Molecular Damage Contributing to Degenerative Aging
Proteins can become modified in a wide range of ways via addition or removal of various motifs. This is a necessary part of our biochemistry, but some modifications are harmful rather than useful. The pattern of protein modifications present in cells changes with age, and some pathological modifications begin to appear more often. The underlying reasons for these changes are usually poorly understood, at least once stepping beyond the immediate causal chemical reactions, as cellular biochemistry is very complex. As researchers here demonstrate, given a problematic modified protein that exists outside cells, it is possible ...
Source: Fight Aging! - December 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Even The College Is Worried About The Damage Possible By Uncrated Results!
This also on the topic of the week:
22 November 2023
Real-time diagnostics may prompt patient panic: RACGP
Diagnosis pathology Political RACGP
By Laura
Woodrow
The college is worried that
providing real-time results to patients on My Health Record will prompt a
barrage of concerned calls to GPs and lead to misinterpretation.
While
the RACGP supports pushing providers to upload (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - December 1, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
It Seems The Government Can ’t Stop Fiddling With Its Near To Useless Toy! They Really Are Stubborn To Persist With It!
It looks like the Government has not
thought its plans through again.
This appeared last week.
Should patients be able to immediately access results via MHR?
The DoH is looking to modernise My
Health Record to include the default sharing of pathology and imaging reports,
but the RACGP has concerns.
Matt Woodley
22 Nov 2023
The seven-day delay rule for uploading
pathology and diagnostic (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - November 30, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Intestinal Inflammation Increases with Age, and is Greater Still in Patients with Alzheimer's Disease
16s rRNA sequencing allows the microbial populations resident in the gut to be catalogued in detail: which species are present, and relative numbers by species. In the years since this assay became cheap, reliable, and readily available, researchers have built increasingly large human gut microbiome databases from samples obtained over the course of epidemiological studies. The research community has found that the gut microbiome exhibits characteristic differences in older people, marked by a growth in populations of inflammatory microbes and a loss of those species that produce beneficial metabolites. Further, some age-r...
Source: Fight Aging! - November 29, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Visceral Fat Increases Brain Inflammation and Amyloid Aggregation
The correlation between being overweight and risk of developing Alzheimer's disease is nowhere near as strong as, say, between being overweight and risk of developing type 2 diabetes. Given the evidence for chronic inflammation to be important in the development of Alzheimer's disease, and the many ways in which excess visceral fat tissue promotes chronic inflammation, it is somewhat puzzling that Alzheimer's isn't more of a lifestyle disease, similar to the way in which type 2 diabetes derives from lifestyle choices. That said, there is a contribution to Alzheimer's risk, and carrying excess weight is unwise, for this and...
Source: Fight Aging! - November 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bonus Features – November 26, 2023 – 85% of healthcare orgs boosting IT spending in 2024, 70% of orgs actively considering generative AI, plus 18 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
The latest Hospital Vitals report from Syntellis and the AHA found that hospitals have seen a 28% decline in cash reserves over the last 19 months. This is due in large part to increased expenses (from 25$ for...
Source: EMR and HIPAA - November 26, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Aerin Medical Akasa American Hospital Association Artera AvaSure BrightSpring Health Services CancerIQ Carestream Health Clue CodaMetrix Da Vinci Project Derrick Sung eHealth Exchange EHR Association First Healt Source Type: blogs
A Novel Mitophagy Inducing Compound
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis woul...
Source: Fight Aging! - November 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
USP30 Inhibition Stops Progression of Parkinson's Disease in Mice
Parkinson's disease arises from the spread of misfolded α-synuclein proteins in the nervous system. This produces a wide array of dysfunction, but the most vulnerable cell population to this particular form of neurodegenerative pathology are domaminergenic cells. Their loss provokes the most evident symptoms of the condition. As noted here, this vulnerability appears to have something to do with clearance of damaged mitochondria, and thus with mitochondrial function more generally. Researchers are investigating ways to improve the situation, such as this representative small molecule approach.
Parkinson's disease...
Source: Fight Aging! - November 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Redrick Technologies: Innovating Radiology Workstations with User-Centric Design
Healthcare IT Today recently visited Redrick Technologies in London, Ontario, to explore their cutting-edge radiology workstations. Redrick’s unique approach involves constantly listening to and incorporating customer feedback. The company is a shining example of user-centric design. Their many happy customers are proof that this is not only helps them stand out in a competitive market, but also ensures they remain ahead of their competitors in terms of product design.
Healthcare IT Today first profiled Redrick after seeing their workstations at RSNA22. A video of their workstation is available here on our YouTube ch...
Source: EMR and HIPAA - November 20, 2023 Category: Information Technology Authors: Colin Hung Tags: Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops customer feedback ergonomic workstations Greg Patrick Healthcare Ergonomics Josh Patrick Radiologists Radiology Radiology Ergonomics radiology w Source Type: blogs
