Rochester Regional Health is Achieving Interoperability One Practical Byte at a Time
Rochester Regional Health is using a measured and practical approach to data interoperability. They have focused their efforts on data that clinicians want to use, that fits their workflow, and can be seamlessly incorporated into their Epic system. They started with lab data and this integration, on its own, is having a positive impact on patient care.
Healthcare IT Today sat down with Erik Jacob, Director of Interoperability at Rochester Regional Health (RRH) and Charlie Harp, CEO at Clinical Architecture to discuss how a practical, measured approach to interoperability is preferable to a tsunami of data.
Starting Simple ...
Source: EMR and HIPAA - August 10, 2023 Category: Information Technology Authors: Colin Hung Tags: Analytics/Big Data Health IT Company Healthcare IT Highlighted Hospital - Health System Interoperability ccda Charlie Harp Clinical Architecture Epic EMR Epic System Erik Jacob Health Information Exchange Healthcare Data Quality Source Type: blogs
Evaluation of Prosthetic Aortic Valve Obstruction
This discussion will focus beyond the basic clinical evaluation, ECG, chest X-ray and hematological workup. Hematological workup is important in aortic valve obstruction because of likelihood of associated hemolytic anemia and acquired von Willebrand Syndrome. Former is due to destruction of red blood cells across the narrowed aortic valve, and latter due to loss of the largest multimers of von Willebrand factor. High shear stress across the narrowed aortic valve exposes a region of the von Willebrand factor which is susceptible to a specific von Willebrand protease. This can lead on to gastrointestinal angiodysplasia (He...
Source: Cardiophile MD - August 9, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
A Senolytic Vaccine Targeting SAGP Reduces Pathology in a Mouse Model of Alzheimer's Disease
In this study, the research team created an Alzheimer's disease mouse model that mimics a human brain and simulates amyloid-beta-induced Alzheimer's disease pathology. To test the efficacy of the SAGP vaccine, the mice were treated with a control vaccine or the SAGP vaccine at two and four months old. Usually, people in the late stage of Alzheimer's lack anxiety, which means they are not aware of the things around them. The mice who received the vaccine had anxiety, which means that they were more cautious and more aware of things around them - a sign researcher say could indicate a lessening of the disease. In addition, s...
Source: Fight Aging! - August 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
« Back to Top
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Transplantation as a Treatment for Kidney Damage
It is interesting see an increased focus on assessing the ability of mitochondrial transplantation to be useful in a variety of circumstances, not just as a treatment to reduce the mitochondrial dysfunction that occurs with aging. The limiting factor in bringing mitochondrial transplantation to the clinic is chiefly the speed at which the research and development communities can achieve the logistical advances needed to reliably produce enough mitochondria to deliver to an entire organ (at first), and the whole body (later). It is likely the case that mitochondria will have to be patient-matched by haplotype of mitochondri...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
NRF2 in the Oxidative Stress of Alzheimer's Disease
There are many ways of looking at the pathology of Alzheimer's disease, as it is very complex, layered condition. One of these viewpoints is to note that levels of oxidative stress increase in the Alzheimer's brain, stressing and killing cells. Researchers here report on their investigation of changes in the NRF2-centered regulation of cellular antioxidant systems that take pace in the Alzheimer's brain. A decline in antoxidants accelerates the progression of cell death and dysfunction, but this can be slowed or prevented by suitably targeted intervention aimed at maintaining NRF2 activity. Whether or not this is too far d...
Source: Fight Aging! - August 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
« Back to Top (Source: Fight Aging!)
Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Health IT ’s Role in Fixing Healthcare’s Biggest AI Misconceptions
The following is a guest article by Dave DeCaprio, Co-Founder and Chief Technology Officer at ClosedLoop
No matter where you look – from TikTok filters to the latest ChatGPT release – artificial intelligence (AI) has a profound and growing impact on our daily lives. The market for AI is expected to show strong growth in the coming decade; its current value of nearly $100 billion USD is expected to increase twentyfold by 2030, reaching nearly $2 trillion.
AI has the potential to transform the ever-growing healthcare industry. However, many healthcare organizations don’t know where to start. Leaders struggle to disting...
Source: EMR and HIPAA - July 28, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Clinical Health IT Company Healthcare IT Hospital - Health System AI Solution Algorithmic Bias Artificial Intelligence ChatGPT ClosedLoop Dave DeCaprio EHR Generative AI Healthcare AI Healthcare ChatGPT La Source Type: blogs
The Repair Biotechnologies View of Cholesterol Pathology at the 2023 Foresight Longevity Workshop
I attended the Foresight Institute's 2023 Longevity Frontiers Workshop earlier in the year. This event series provides a chance to make connections with some of the longevity industry figures and academic researchers in the field of aging that are associated with the Bay Area venture and futurist communities. The format this year was rapid-fire seven minute presentations and longer discussions; the presentations are shared online. I presented an informal, abbreviated version of the Repair Biotechnologies viewpoint on the role of cholesterol in aging and disease, trying to cover at least the important points in the time all...
Source: Fight Aging! - July 27, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
The Ketone Body β-hydroxybutyrate is Involved in Clearance of Amyloid-β
Researchers here note an interesting role for one of the common ketone bodies found in mammalian biochemistry, in that it provokes clearance of amyloid-β via its interaction with that molecule. An increase in misfolded amyloid-β is involved in the early stages of Alzheimer's disease, and seems likely to cause some fraction of the pathology of that condition. If comparatively simple approaches could keep amyloid-β levels low in later life, then the incidence of Alzheimer's disease might be reduced. That said, while the mechanism described here is interesting, it doesn't mean that the effect size, relative to other mechan...
Source: Fight Aging! - July 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Donanemab Slows Progression of Earlier, Less Severe Alzheimer's Disease
Several immunotherapies targeting amyloid-β in the brain have now been shown to modestly slow the progression of Alzheimer's disease if applied at an earlier stage of the condition. This is a long way removed from a cure, particularly given the potentially severe side-effects that accompany brain-targeted monoclonal antibody therapies. Alzheimer's is a complicated condition, and it seems clear that removing amyloid-β does too little on its own to reduce pathology in the brain. It is contributing, but it is not the only contribution, or perhaps not even the most important contribution. More will be needed in parallel, suc...
Source: Fight Aging! - July 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A young man with tachycardia. Should We Try Adenosine?
A young man presented with weakness and fever. His pulse was 186. An ECG was recorded:What do you think?There is a regular narrow complex tachycardia. Thus, it is supraventricular tachycardia. It is important to remember thatSVT includes Sinus Tachycardia! That is why I like to call re-entrant SVT " Paroxysmal " SVT, or PSVT). The sinus node is " supraventricular " and in young people it can beat VERY fast. Especially when there is fever.You must look closely for P-waves, and if you do, the P-waves are obvious (if you look at the leads most likely to reveal P-waves: leads II and V1)...
Source: Dr. Smith's ECG Blog - July 19, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Inhibition of Glycolysis as a Treatment for Neurodegeneration
Researchers here discuss a program of drug discovery that led to inhibitors of glycolysis as a potential approach to treatment for neurodegenerative conditions. The researchers note that elevated glycolysis is a characteristic of Alzheimer's disease, for example. There are always many, many mechanisms and altered aspects of cell metabolism one can investigate in aging and age-related disease. The question to ask when looking at any one specific mechanism in isolation is how much of the pathology of the condition lies downstream of this mechanism. It is all to easy to find oneself targeting a side-effect, or a minor mechani...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Microglial Activation as a Consequence of Gum Disease
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
