Does Peripheral Blood Amyloid- β Contribute to Alzheimer's Disease via Inflammatory Mechanisms?
Amyloid-β is found in the bloodstream and blood vessels as well as in the brain, and an increase in this peripheral amyloid-β is noted in Alzheimer's disease patients who exhibit the characteristic amyloid-β aggregates in their brains. Current thinking is that there is a dynamic equilibrium between amyloid-β in the brain and body, and based on this view some success has been achieved in reducing amyloid-β in the brain by clearing amyloid-β in the rest of the body. Does this peripheral amyloid-β contribute to the onset of Alzheimer's disease in other ways, however? Researchers here suggest that it may increase the bu...
Source: Fight Aging! - January 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
HDL dysfunction & It ’ s clinical Implication
High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions .The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.(Article will be linked)
We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. After reaching the liver, HDL receptors in the hepatocellular surface, metabolize it into bile acid or neutral lipids, which are ...
Source: Dr.S.Venkatesan MD - January 21, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Inflammasome as a Target for the Next Generation of Anti-Inflammatory Therapies
With advancing age, a wide range of mechanisms act to provoke the immune system into a state of constant inflammatory signaling and activation. Age-related mitochondrial dysfunction leads to mislocalized mitochondrial DNA fragments that trigger the cGAS-STING pathway to provoke inflammation. Senescent cells produce pro-inflammatory signaling, and their numbers increase with age. Visceral fat tissue produces signaling similar that resulting from infected cells. The increased presence of protein aggregates aggravates immune cells inside and outside of the brain. And so forth. Given all of this, actually fixing the issue of a...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Uses of AI in Healthcare – 2024 Health IT Predictions
As we kick off 2024, we wanted to start the new year with a series of 2024 Health IT predictions. We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes. In fact, we got so many that we had to narrow them down to just the best and most interesting. Check out our community’s predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media.
All of this year’s 2024 health IT predictions (updated as they’re shared):
John and ...
Source: EMR and HIPAA - January 17, 2024 Category: Information Technology Authors: John Lynn Tags: Administration AI/Machine Learning Ambulatory C-Suite Leadership Clinical Health IT Company Healthcare IT Hospital - Health System LTPAC 2024 Health IT Predictions 2bPrecise Alexander Nazem Anish Sebastian Arascia Arun Nagdev Source Type: blogs
Suppressing Inflammatory Activity of Supporting Cells in the Brain as a Treatment for ALS
Constant, unresolved inflammatory behavior in the supporting cells of the brain is implicated in the pathology of diverse neurodegenerative conditions. Here, researchers find that dampening this inflammation can help restore function in animal models of amyotrophic lateral sclerosis (ALS). This joins many other conceptually similar demonstrations conducted in the laboratory for a range of different neurodegenerative diseases. It remains to be seen as to how well these anti-inflammatory strategies will perform in human clinical trials.
ALS is caused by the loss of upper motor neurons, located in the brain, and lowe...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Evidence for the Unfolded Protein Response to be Involved in Age-Related Deafness
Researchers have found that deafness-associated gene TMTC4 causes pathology via an excessive increase in the unfolded protein response in sensory hair cells of the inner ear, and loud noise does much the same. This suggests that inhibition of the unfolded protein response in these cells might be a way to slow loss of hearing capacity, or protect against the effects of loud noise and drugs that can harm hair cells. Still, this isn't a path to restoration of hearing capacity. That would require some way to replace lost hair cells and their connections to the brain.
Mutations to the TMTC4 gene trigger a molecular dom...
Source: Fight Aging! - January 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bonus Features – January 14, 2024 – Epic Research shows telehealth results in more follow-up visits that in-office care, Elevance Health to offer smartphones to qualified Medicaid beneficiaries, plus 21 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
Follow-up rates for telehealth and in-office visits have remained consistent since 2020, according to analysis from Epic Research. That said, telehealth visits are more likely to result in follow-ups at the 7-, ...
Source: EMR and HIPAA - January 14, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Ambulatory Health IT Company Healthcare IT Hospital - Health System LTPAC Abbott Alliance for Pediatric Device Innovation American Telemedicine Association Atropos Health Butterfly Network Caregility Cedar Gate Technologies Childre Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Case of the Week 734
Welcome to the first blog post of 2024! I had been particularly busy last year as I was serving as the Interim Chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic. Now that the permanent Department Chair has arrived, I can go back to my ' day job ' of Chair of Clinical Microbiology and Director of the Clinical Parasitology laboratory. I anticipate being able to go back to regular posting again as well. So without further ado, here is our case this week, courtesy of Heather Morris, the Parasitology Technical Specialist in my laboratory. The following objects were found in a concentrated wet prep...
Source: Creepy Dreadful Wonderful Parasites - January 11, 2024 Category: Parasitology Source Type: blogs
This Is An Important Statement Of A Perfectly Sensible Position On Health Information Access.
This was
released a day or so ago.
GPs and
pathologists raise concerns over plans to remove 7-day delay for all pathology
results on My Health Record
Royal
Australian College of GPs and Royal College of Pathologists of Australasia
The Royal College of Pathologists of Australasia (RCPA)
and the Royal Australian College of General Practitioners (RACGP)
have warned the Government ’s (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - January 11, 2024 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
NRF1 is Neuroprotective via Proteasomal Function
Cells maintain themselves against damage and stress via a range of maintenance processes. These include autophagy, in which proteins and structures are transported to the lysosome to be broken down by enzymes, and the ubiquitin-proteasome system, in which specific proteins are dismantled in the proteasome, among others. It is well demonstrated that upregulation of these processes improves resistance to cell stress, and can also improve long-term health, reducing risk of age-related disease and slowing progression of those conditions. Upregulation of autophagy, for example, is a feature of many interventions that modestly s...
Source: Fight Aging! - January 10, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Hallmarks of Aging in the Context of Sarcopenia
Researchers have implicated numerous mechanisms in the age-related loss of muscle mass and strength leading to the condition known as sarcopenia. While not everyone arrives at a diagnosis of sarcopenia, everyone is subject to the progressive deterioration of muscle tissue. One of the challenges facing attempts to understand age-related disease in detail is that the noteworthy mechanisms of aging form a complex, interacting web of cause and consequence. It is next to impossible to determine which mechanisms are more or less important from observation alone. So while one can mount a good argument for sarcopenia to be driven ...
Source: Fight Aging! - January 8, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bonus Features – January 7, 2024 – New executives at CitiusTech, MultiPlan, and NextGen, plus 15 other stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
A study from Epic Research found women screened for breast cancer annually have a 17% lower risk of mortality after a breast cancer diagnosis than those screened every two years. Women who are Black, over 60, o...
Source: EMR and HIPAA - January 7, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT ACO REACH Amenities Health Arcadia Healthcare Solutions athenahealth Atropos Health BioProcure Bloomlife CitiusTech Corti Deciphex directtrust Epic Research Equality Health Eric Meizlish Healthcare IT Today Bonu Source Type: blogs
Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
