Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Modeling a Cellular Cascade of Alzheimer's Disease
Alzheimer's disease is complex and puzzling, and massively funded, high-profile efforts to find treatments for the condition have been failing for decades. The research community has focused on clearance of amyloid-β, as this protein accumulates and misfolds in Alzheimer's patients. Yet some old individuals exhibit high levels of amyloid-β and do not suffer Alzheimer's, while clearance of extracellular amyloid-β fails to meaningfully improve the condition of patients. It may be that intracellular amyloid-β is the real target, or that amyloid-β accumulation is a side-effect of the real pathological mechanisms.
O...
Source: Fight Aging! - March 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reactive Astrocytes in Neurodegenerative Conditions
Chronic, unresolved inflammation in brain tissue is a feature of age-related neurodegenerative conditions, and may even be the most important mechanism in these very complex conditions. The supporting cells of the brain, primarily microglia and astrocytes, become more active and inflammatory in later life. This overlaps with a rising count of senescent cells in these populations. Senescent cells produce an outsized contribution to inflammatory signaling, belying their relatively small numbers compared to non-senescent cells. Active microglia and astrocytes are largely not senescent, however. They are reacting to inflammato...
Source: Fight Aging! - March 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A 40-something with 100 minutes of chest pain
I was reading ECGs on the system, and saw this one:What do you think?I knew that, if the patient had presented with chest discomfort, that this ECG is diagnostic of inferior posterior OMI, even though it is not a STEMI.However, it is difficult to recognize for an interpreter who is does not have special expertise in OMI ECG diagnosis. We taught an AI system fromPM Cardio to recognize patterns of subtle OMI (beware: this version of the app is not available to the public yet). We named the AI app the " Queen of Hearts " This is what the Queen said about this ECG:" OMI with High Confid...
Source: Dr. Smith's ECG Blog - March 27, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Mechanistic Links Between Chronic Kidney Disease and Alzheimer's Disease
When reading about potential mechanistic links between chronic kidney disease and Alzheimer's disease, it is worth considering klotho. Increased expression of klotho has been shown to improve kidney function and better resist the decline of kidney function with age. It also improves cognitive function, though there is some debate over how this is happening. Klotho largely acts in the kidney, and its effects on cognitive function may simply be a compelling demonstration of the point that dysfunction of the kidneys is harmful to organs throughout the body, including the brain.
The mediating mechanisms linking kidney t...
Source: Fight Aging! - March 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing Blood-Brain Barrier Dysfunction in the Context of Alzheimer's Disease
The biochemistry of the central nervous system is separated from the biochemistry of the rest of the body by the blood-brain barrier, a specialized lining of cells that wrap blood vessels that pass through the brain. Only some molecules and cells are permitted to pass into and out of the brain. Like all bodily systems, the blood-brain barrier breaks down with age, leading to leakage of unwanted molecules and cells into the brain, where they can provoke inflammation and dysfunction. This is thought to provide a significant contribution to the onset and further progression of age-related neurodegenerative conditions, given t...
Source: Fight Aging! - March 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Imagene Profiles Cancer Biomarkers in Real Time
Cancer therapies have proliferated over the past few decades, improving outcomes for many patients. But this variety requires accurate diagnostics and appropriate decision making to choose the optimal course of therapy. The current gold standard of identifying which cancer mutation is present is new generation sequencing (NGS), which provides a comprehensive genetic report, but can take up to six weeks to complete, requires a significant tumor sample size, and can only be done in an advanced laboratory at a high cost.
Imagene, a company headquartered in Tel Aviv, Israel, has developed AI-based image analysis software...
Source: Medgadget - March 22, 2023 Category: Medical Devices Authors: Medgadget Editors Tags: Diagnostics Exclusive Oncology Pathology biomarkers cancer biomarkers molecular profiling Source Type: blogs
Senescent Cells Contribute to Chronic Periodontitis
In this study, we examined the pathological roles of cellular senescence in periodontitis. We found localization of senescent cells in periodontal tissue, particularly the periodontal ligament (PDL), in aged mice. Senescent human PDL (HPDL) cells showed irreversible cell cycle arrest and SASP-like phenotypes in vitro. Additionally, we observed age-dependent upregulation of miR-34a in HPDL cells. These results suggest that chronic periodontitis is mediated by senescent PDL cells that exacerbate inflammation and destruction of periodontal tissues through production of SASP proteins. Thus, miR-34a and senescent PDL cells migh...
Source: Fight Aging! - March 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Dr. Diamandis develops network to help pathologists interface with AI computational scientists
A neuropathology colleague in Toronto (Dr. Phedias Diamandis) is developing some amazing AI-based tools for pathology and academia. He helped recently launch a site called " CODIDO " (https://www.codido.co/) which is a cloud-based network that allows computational scientists to share AI and machine learning algorithms with general users/academics who are keen on using AI but may not know how to code sufficiently well to implement them. It ' s a great way to allow people to " Demo " code and will hopefully become a central place for pathologists to access a variety of pathology-related algorithms for image analysis projects...
Source: neuropathology blog - March 21, 2023 Category: Radiology Tags: neuropathologists Source Type: blogs
Ceria Nanoparticles Reduce the Impact of Senescent Cells in Osteoarthritic Joints
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
Link: https://doi.org/10.3390/ijms24055056 (Source: Fight Aging!)
Source: Fight Aging! - March 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Moving Cells Using Ultrasound
Researchers at Caltech have developed a technique that lets them move groups of cells very precisely. It involves genetically modifying cells so that they express small protein air sacs in their interior. The sacs render the cells highly susceptible to manipulation using ultrasound waves, and the researchers can precisely move them into complicated shapes or patterns. The new technology could be very useful for sorting cells for cell therapies or arranging cells on biomaterial constructs to form complex tissue layers. The technique may also allow for control of cell movement within the body using external ultrasound. The s...
Source: Medgadget - March 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Pathology Radiology Caltech Source Type: blogs
Cellular Senescence in Type 2 Diabetes
It has been a few years since researchers suggested a role for senescent cells in mediating the damage done by excess fat tissue in the context of type 2 diabetes. Senescent cells accumulate with age, but accumulate significantly faster in people who are meaningfully overweight or obese. The inflammatory signaling produced by lingering senescent cells is disruptive of tissue structure and function throughout the body, and that includes problems in the insulin-generating regions of the pancreas that take place in diabetes patients. Interestingly, senescent cells may also be important in type 1 diabetes, a completely differe...
Source: Fight Aging! - March 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bonus Features – March 19, 2023 – Info for 81% of physicians is inconsistent in major health plan provider directories, 48% of health systems using AI for workforce management, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Research
A paper from the University of Colorado School of Medicine and HiLabs found inconsistencies for 81% of physicians examined across 5 large national health insurers. Along with the challenge of inaccuracy, resea...
Source: EMR and HIPAA - March 19, 2023 Category: Information Technology Authors: Brian Eastwood Tags: AI/Machine Learning Ambulatory Analytics/Big Data Health IT Company Healthcare IT Hospital - Health System ADP Amazon AWS Avaneer Health Basset Healthcare Network Brightside Health Bristol Advanced Illness Management Caribou REward Source Type: blogs
A 50-Something Male with 2 hours of Chest discomfort
This ECG was texted to me in real time, but I did not notice the message until about an hour after it came. " 50 + yo. Concerning history, known CAD "Recorded 2 hours after pain onset:What do you think?This was my response:" This looks like a worrisome EKG. It looks like an Occlusion MI (OMI), but I am not 100% certain. But by now you must have a repeat ECG. Can I see it? "Pendell Meyers had an identical response when I sent it to him.PM Cardio AI algorithm said " OMI with high confidence "Explanation: There is subtle ST Elevation in inferior leads, with a hyperacute T-wave in III, reciprocal STD in aVL with an ...
Source: Dr. Smith's ECG Blog - March 19, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
