Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions.
Plasma Transfer Lowers Epigenetic Age and Mortality in Rats
https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains m...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in Aging Skin
In one sense, the accumulation of senescent cells with age is the same story in every tissue. These cells secrete pro-inflammatory, disruptive signaling that actively degrades tissue structure and function. The targeted destruction of lingering senescent cells produces aspects of rapid rejuvenation in aged mice. In another sense, every tissue is different and senescence in that tissue likely worthy of at least some degree of distinct study, perhaps leading to optimized therapies for clearance of senescent cells on a tissue by tissue basis, for example. Here, find a review that looks at cellular senescence in the context of...
Source: Fight Aging! - April 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Role for Cellular Senescence in Medin Amyloidoisis
Medin is one of a small number of proteins that can misfold in ways that encourage other molecules of the same protein to also misfold, linking to form solid aggregates. While medin aggregation seems near ubiquitous in old people, the harms caused by this form of amyloidosis are far less well studied than is the case for, say, the amyloid-β characteristic of Alzheimer's disease. Still, evidence supports a role for medin in causing age-related dysfunction of the cerebral vasculature, and it is also suggested that this can provoke greater pathology in neurodegenerative conditions such as Alzheimer's disease.
In the o...
Source: Fight Aging! - April 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved.
Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting a Mechanism of Hyperphosphorylation in Alzheimer's Disease Pathology
Hyperphosphorylation of tau protein produces aggregation and neurofibrillary tangles in later stage Alzheimer's disease. Researchers here use a peptide to inhibit one of the mechanisms by which increased phosphorylation occurs in neurons in older individuals. The approach produces promising results in a mouse model of Alzheimer's disease, but - as is usually the case - one has to wonder as to whether or not this interaction of model and treatment in mice is relevant to the human condition. Old mice do not naturally develop any pathology resembling Alzheimer's disease, so all of the models are by their nature very artificia...
Source: Fight Aging! - April 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Detection of Small Amounts of Misfolded α-Synuclein Identifies Early Parkinson's Disease
Parkinson's disease is characterized by misfolding and aggregation of α-synuclein, a pathology that spreads from where it initially starts, frequently in the intestinal nervous system, spreading between nerve cells. Researchers here report on a technique to identify the presence of small amounts of misfolded α-synuclein, demonstrating that it allows for early detection of the condition. Near every disease is easier to treat or at least slow down in its earlier stages, and early detection may well be an essential part of efforts to prevent the development of common age-related neurodegenerative conditions, such as Parkins...
Source: Fight Aging! - April 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Theorizing that the APOE ε4 Variant Increases Alzheimer's Risk Through Increased Microglial Inflammation
It is well established that the ε4 variant of APOE increases the risk of Alzheimer's disease, but there is no firm consensus as to why this is the case. Theories abound. Researchers here suggest that the mechanism of interest is increased neuroinflammation, as APOEε4 increases the tendency for the innate immune cells known as microglia to become activated and inflammatory in the aging brain. There has been an increased focus on chronic inflammation in Alzheimer's disease in recent years, particularly given the continued failure to produce meaningful patient benefits via clearance of amyloid-β, with some researchers goin...
Source: Fight Aging! - April 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Preparing For AI-Driven Medicine: 6 Crucial Questions For Tomorrow ’ s Doctors
This article will discuss some critical questions that medical professionals must be able to answer in order to navigate the AI revolution successfully.
1. Do you know enough about AI?
As a medical student or a young doctor, it is crucial to have a fundamental understanding of AI, its applications, and potential implications. The Medical Futurist’s paper, A short guide for medical professionals in the era of artificial intelligence provides a high-level overview of AI, its definitions, methods, levels, dangers, and advantages.
To stay relevant in the evolving healthcare landscape, medical professionals shoul...
Source: The Medical Futurist - April 18, 2023 Category: Information Technology Authors: Andrea Koncz Tags: Artificial Intelligence in Medicine Medical education AI digital health Source Type: blogs
Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context.
Glycine Supplementation as a Methionine Restriction Mimetic
https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/
Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Excess Visceral Fat Generates Inflammatory Signaling that Harms Joint Health
In conclusion, these findings demonstrate the significance of obesity in changing the inflammatory landscape of synovial fibroblasts in both load bearing and non-load bearing joints.
Link: https://doi.org/10.1002/ctm2.1232 (Source: Fight Aging!)
Source: Fight Aging! - April 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 10th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of TDP-43 Aggregation in Neurodegeneration
TDP-43 is one of the more recently discovered protein aggregates involved in neurodegenerative conditions. A few proteins in the body are capable of misfolding or otherwise becoming altered in ways that encourage other molecules of the same protein to do the same. Toxicity results, and it can spread as these altered proteins move from cell to cell. The condition most clearly associated with TDP-43 pathology is amyotrophic lateral sclerosis (ALS), but it appears to be involved in other forms of neurodegenerative disease as well. Researchers have made inroads into understanding how these aggregates form and disrupt normal ce...
Source: Fight Aging! - April 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
RBBB and LAFB. Is it trifascicular block? The complexities of Wenckebach, with Ken Grauer analysis.
This patient presented with complications of his dialysis fistula.Medical history:History of Ischemic Heart DiseaseHistory of Congestive Heart FailureDiabetes Mellitus requiring treatment with insulinPre-operative serum creatinine>2 mg/dLHe had this ECG recorded:What do you think?There is AV 2nd degree AV Block (Mobitz I, Wenckebach) with RBBB and LAFBThe physicians recognized the RBBB and LAFB, but not the Wenckebach. They compared to a previous ECG and thought they were identical. Here is the previous ECG from 2 months prior for pre-op for cataract surgeryThis appears to be atrial fibrillation with RBB...
Source: Dr. Smith's ECG Blog - April 6, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
The profoundest mystery
To me, and everybody who I consider to be in contact with reality, the nature of Donald J. Trump is completely obvious. He is morally depraved and functionally deranged. There are specific labels in the DSM-5 (the manual of psychiatric diagnoses) for his pathologies, of which I am usually skeptical but of which he is absolutely paradigmatic. These are malignant narcissism and sadistic psychopathy. In other words, the only person in the universe is himself. He has an insatiable, bottomless need for adoration and obeisance. The interests and feelings of others mean absolutely nothing to him except insofar as he revels i...
Source: Stayin' Alive - April 3, 2023 Category: American Health Source Type: blogs
A Glial Cell Senescence Hypothesis for Alzheimer's Disease
Senescent cells accumulate with age throughout the body, and evidence is increasingly supportive of a role for cellular senescence in the development of Alzheimer's disease. This is particularly the case for senescent supporting cells in the brain, such as microglia and astrocytes, but the inflammatory signaling produced by senescent cells elsewhere in the body may well be just as influential on dysfunction in brain tissue. Given the capacity to clear senescent cells, and at least one recently launched trial of senolytic therapies to clear senescent cells in Alzheimer's patients, we should see some progress in the years ah...
Source: Fight Aging! - April 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
