Morphine + OMI is a bad combination
This is written by Magnus Nossen, with some edits by SmithThis ECG diagnosis will be obvious to the majority of the readers of this blog. It is not obvious for the majority of doctors or even cardiologists. A 50 something male was seen in the emergency room due to typical chest pain. The pain had started the same day about two hours prior to medical contact. Previous medical hx notable for type II DM. The first ECG is shown below.The medical care providers ascribed the patient ' s chest pain to new onset atrial fibrillation with rapid ventricular response after having viewed the ECG. Do you agree?The presentation ECG ...
Source: Dr. Smith's ECG Blog - September 24, 2023 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
Synaptic Dysfunction Precedes the Death of Neurons in Parkinson's Disease
Parkinson's disease is characterized by the loss of dopamine-generating neurons, with the inflammatory pathology leading up to that issue thought to be driven by the spread of misfolded α-synuclein. Dysfunctional mitochondrial quality control can make these dopamine-generating neurons more vulnerable to the underlying pathology, however, and thus a fraction of Parkinson's disease arises in people with mutations that cause this sort of dysfunction. That has directed researchers towards mitochondrial function as an important factor in the progression of the condition, but it will probably turn out to be more useful to focus...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
EEG Headset Could Spot Early Alzheimer ’s Disease
Researchers at the University of Colorado Anschutz Medical Campus have developed a technique that may spot the very early signs of Alzheimer’s disease, years before symptoms arise. The method may alert patients and clinicians to an increased risk of the disease, potentially allowing them to take steps to slow the disease progression. The method involves using a simple EEG headband while sleeping. The researchers have identified EEG signatures in aging adults that may indicate early Alzheimer’s pathology. These EEG phenomena relate to memory reactivation that occurs during sleep, and may reveal aspects of early-stage Al...
Source: Medgadget - September 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Neurology CUAnschutz CUSystem Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Roundup – September 16, 2023
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
Optimize Health Data Sharing to Enhance the Patient Experience. Simply collecting patient data and giving it to providers isn’t enough any more. Clinicians can practice better when they get real-time access to a longitudinal patient record and the insights that come from it, John Lynn learned from a conversation with Scott Alderman at CyncHealth. R...
Source: EMR and HIPAA - September 16, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
Inflammation in Early Alzheimer's Disease
Chronic inflammation is a feature of many age-related conditions, including neurodegenerative diseases such as Alzheimer's disease. Is inflammation secondary to protein aggregation and other features of aging that drive the development of neurodegenerative conditions, or is inflammation of primary importance in the onset of cognitive impairment and Alzheimer's disease? These are complex conditions in which many forms of pathology and damage interact, and only now are there means to selectively reduce age-related chronic inflammation via the selective destruction of senescent cells. The results of clinical trials of therapi...
Source: Fight Aging! - September 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing Evidence for Urolithin A Supplementation
Mitochondria are the power plants of the cell, responsible for generating chemical energy store molecules to power cell processes. Urolithin A is one of a number of supplements shown to improve mitochondrial function, though as for the others it isn't all that impressive when compared to the effects of regular exercise. Nonetheless, this and other approaches to modestly attenuate age-related declines in mitochondrial function are under active development. They are not solutions to the problem of mitochondrial aging, however. For that we must look to more radical approaches to therapy, such as mitochondrial transplantation,...
Source: Fight Aging! - September 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Legal Issues in End-Of-Life Care for Speech-Language Pathologists and Social Workers: A Scoping Review
Rachel Feeney (University of Queensland), Lindy Willmott (Queensland University of Technology), Jill Wilson(University of Queensland), Ben White (Queensland University of Technology), Legal Issues in End-Of-Life Care for Speech-Language Pathologists and Social Workers: A Scoping Review, Int ’l J. of Speech-Language Pathology... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - September 12, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Bonus Features – September 10, 2023 – 77% of clinicians see RPM outpacing traditional inpatient care within five years, Microsoft partnering with Paige on pathology and oncology AI models, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
Executives for Healthcare Innovation is transferring its assets to the American Telemedicine Association, and ATA will extend engagement opportunities to current EHI members through its various Special Interest Groups.
More...
Source: EMR and HIPAA - September 11, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Adrian Agostini Alo American Telemedicine Association Andrea Rowe Anki ATA AVIA Black Book Research Canopy Edifecs Experity Healthcare IT Today Bonus Features HITRUST Ibex Medical Analytics iMerit Inovalon K Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DNA Damage and Consequent Inflammation in Heart Failure
One of the ways in which cell damage characteristic of aging can provoke inflammation is via the mislocalization of DNA. Either nuclear DNA or mitochondrial DNA can find its way to the cytosol, where it can trigger responses evolved to detect bacterial or viral infection, or severe cell damage. This creates a cascade of downstream signaling leading to an inflammatory response. In youth these events occur comparatively rarely, and in circumstances wherein immune response and potentially even cell death are beneficial. With age, however, there is a continued mild but growing level of dysfunction and consequent sustained infl...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
PU.1 Inhibition to Reduce Microglial Inflammation in the Aging Brain
Researchers here report on a drug discovery effort targeting PU.1, a gene implicated in increased inflammation of microglia in the brain. Microglia are innate immune cells of the central nervous system. Like macrophages in the rest of the body, they react to the damage and dysfunction of aging with increased inflammatory behavior, a maladaptive response that worsens pathology. Chronic, unresolved inflammation is clearly disruptive to tissue function wherever it occurs in the body. In the brain, chronic inflammation is a well-studied feature of conditions such as Alzheimer's disease. A greater population of inflammatory mic...
Source: Fight Aging! - September 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why It Is Important To Understand Multimodal Large Language Models In Healthcare
The future of medicine is undoubtedly inextricably linked to the development of artificial intelligence (AI). Although this revolution has been brewing for years, the past few months marked a major change, as algorithms finally moved out of the specialized labs and into our daily lives.
The public debut of Large Language Models (LLMs), like ChatGPT which became the fastest-growing consumer application of all time, has been a roaring success. LLMs are machine learning models trained on a vast amount of text data which enables them to understand and generate human-like text based on the patterns and structures they̵...
Source: The Medical Futurist - September 5, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine large language models multimodal AI multimodal large language models multimodal LLM Source Type: blogs
Is Transfusion of Young Blood Essentially a Form of Extracellular Vesicle Therapy?
In this study, we examined the effect of young serum on the cognitive performance of aged mice. We show that repeated infusions with small volumes of young serum significantly improved age-associated memory deficits and this effect was abrogated after the serum was depleted of circulating EVs. RNA-seq analysis of choroid plexus demonstrated effects on genes involved in barrier function and trans-barrier transport. Interestingly, the hippocampal transcriptome demonstrated a significant upregulation of Klotho (Kl) gene, which codes for the longevity protein Klotho, following young serum treatment. Notably this effect was abr...
Source: Fight Aging! - September 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
