World ’s Largest Radiology AI Marketplace CARPL Raises $6M to Accelerate the Adoption of AI in Clinical Workflows
Stellaris Venture Partners Leads $6 Million Investment into CARPL, the World’s First Enterprise-Grade Testing, Deployment, and Monitoring Platform for Radiology AI Applications; CARPL is Used by the World’s Leading Healthcare Providers to Improve the Productivity of their Radiologists and the Quality of Care Delivered to their Patients
As people live longer and as emphasis on early detection of disease increases, there is a mounting burden on the healthcare services industry globally. This is being especially felt in radiology teams who are witnessing an acute shortage of radiologists. Currently, there are over 200 com...
Source: EMR and HIPAA - February 15, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Akshant Goyal Alisha Moopen Alok Goyal Arjun Kalyanpur Aster DM Healthcare Bain & Co Boston Consulting Group CARPL Deepinder Goyal Dhruv Sahai Dr. Amit Kakar Dr. Felix Olale Dr. Garry Choy Dr. Source Type: blogs
The 2024 Word of the Year: Missense
By MIKE MAGEE
Not surprisingly, my nominee for “word of the year” involves AI, and specifically “the language of human biology.”
As Eliezer Yudkowski, the founder of the Machine Intelligence Research Institute and coiner of the term “friendly AI” stated in Forbes:
“Anything that could give rise to smarter-than-human intelligence—in the form of Artificial Intelligence, brain-computer interfaces, or neuroscience-based human intelligence enhancement – wins hands down beyond contest as doing the most to change the world. Nothing else is even in the same league.”
Perhaps the ...
Source: The Health Care Blog - February 13, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Biology Crispr DNA Mike Magee Source Type: blogs
Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people.
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Greater Individual Wealth Correlates with Longer Life Expectancy
https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Which doctor treats “ Y-36 ” disease ?
If anyone thinks doctors are the only unique and gifted people, who can treat diseases and mitigate human sufferings , realize how incorrect their understanding of the world, humanity & reality.
The ICD-11 , the latest code lists nearly 15000 diseases. Have a look at this much celebrated (respected ?) list put up by the world health organization There are so many entities in the list , that are man made and solution is right there in our minds.
Zoom your eyes on the red rectangle.
Impact of Y-36
Y-36 is a contagious endemic, transmitted by power, pride and foolishness . Y-36 along with violence i...
Source: Dr.S.Venkatesan MD - February 11, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Chest pain with anterior ST depression: look what happens if you use posterior leads.
Don ' t forget to watch theWebinar: Smith and Pendell Meyers interpret ECGs for OMI or not OMI on Monday Feb 12 at 11 AM U.S. Central time. Register here:https://zoom.us/webinar/register/7617067094184/WN_LMN0vPb1Rz-HZu12K-QuYQWritten by Jesse McLarenA 65 year old
with a history of atrial flutter, CABG and end-stage renal disease on dialysis presented
with 3 days of fluctuating chest pain, which was ongoing at triage. What do you
think? Do you need posterior leads?There ’s atrial
flutter with controlled ventricular response, a non-specific intra-ventricular
conduction delay, borderline right axis, normal R wave...
Source: Dr. Smith's ECG Blog - February 9, 2024 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Glial Cell Senescence Impairs α-Synuclein Clearance, Contributing to Parkinson's Disease
In this study, we investigated how aging and glial senescence affect the capacity of α-syn clearance. We found that following the intra-striatal injection of human α-syn (hu-α-syn) preformed fibril, hu-α-syn pathology persisted more in aged mice compared with younger mice and that aged microglia exhibited greater accumulation of hu-α-syn than younger microglia. Moreover, in vitro assay revealed that the clearance of hu-α-syn was primarily dependent on the autophagy-lysosome system rather than on the ubiquitin-proteasome system and that the capacity of hu-α-syn clearance was diminished in senescent glia because of au...
Source: Fight Aging! - February 8, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A New Day for Parkinson ’s Disease Research Is Near
By STEVEN ZERCOLA
The U.S. Department of Health and Human Service (“HHS”) is responsible for a wide range of activities relating to medical and public health. It has 60,000 employees and a $1.7 trillion annual budget with approximately $140 billion for discretionary spending. For the past 13 years, HHS has been spearheading a National Plan for addressing Alzheimer’s disease – with some notable successes.
Given its resources, expertise and charter, HHS should launch a National Plan to cure Parkinson’s disease patterned after its approach on Alzheimer’s disease.
Legislation, or Not
The U.S. House of R...
Source: The Health Care Blog - February 6, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Drug discovery FDA Parkinson's Disease steve zecola Source Type: blogs
Further Exploration of Drainage Pathways for Cerebrospinal Fluid
Considerable progress has been made in recent years in mapping the pathways by which cerebrospinal fluid drains from the brain into the body, many of which were only recently discovered. The present consensus is that the progressive loss of this drainage with advancing age is likely important in the development of neurodegenerative conditions, allowing molecular waste such as amyloid-β to build up in the brain. Researchers here discuss a new branch of the system of cerebrospinal fluid drainage that passes behind the nose. Like the related cribriform plate pathway, this makes it off interest in the development of Alzheimer...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Making a Mouse that Exhibits Human Telomere Dynamics
Telomerase acts to extend telomeres, the repeated DNA sequences at the ends of chromosomes. With every cell division, some of the telomere repeats are lost. Cells with critically short telomeres become senescent or undergo programmed cell death, having reached the Hayflick limit on replication. Some cells employ telomerase to adjust the countdown of telomere length. In humans, only stem cells use telomerase. In other species, such as mice, telomerase is much more widely expressed. There has been some interest in the research community in upregulation of telomerase as a way to improve stem cell and tissue function in old ag...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
More on CCL17 as a Target to Reduce Inflammation in Cardiovascular Disease
Atherosclerosis is the buildup of fatty plaques in the walls of blood vessels, impeding blood flow and eventually rupturing to produce a heart attack or stroke. It is the single largest cause of human mortality. Atherosclerosis is in part an inflammatory condition, accelerated by the state of chronic inflammation that arises in later life. In this context, levels of CCL17 have been shown to rise with age, while inhibition of CCL17 has been shown to reduce chronic inflammation and slow the progression of atherosclerosis. This outcome is achieved via effects on T cell behavior; CCL17 is expressed on the surface of dendritic ...
Source: Fight Aging! - January 31, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Amyloid- β Biochemistry as a Cause of Blood-Brain Barrier Leakage in Alzheimer's Disease
Alzheimer's disease is a complex degenerative failure of a complex system, the brain. This complexity is illustrated by the continuing debate over which of the many identified mechanisms are the primary cause. Is it amyloid-β aggregation, or some aspect of the halo of biochemistry associated with that aggregation, or is it chronic inflammation, or cellular senescence in supporting cells of the brain, or vascular dysfunction and leakage of the blood-brain barrier, or neurofibrillary tangles, or the presence of persistent viruses. All of these mechanisms interact with one another, and the direction of causation between any ...
Source: Fight Aging! - January 30, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Current State of Immunotherapy for Alzheimer's Disease
After long years of failure, the treatment of Alzheimer's disease through clearance of protein aggregates in the brain has been reinvigorated by minor degrees of success. The results are poor in the grand scheme of things, and come with risk of severe side-effects, but once a disease can be at least slowed, there is a renewed interest in improving on that starting point. It remains the case that the contributing causes of Alzheimer's disease remain poorly understood, however, and it may turn out to be much more preventable than thought. Assays to detect the earliest stages of the condition are now demonstrated, and promisi...
Source: Fight Aging! - January 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Which Aspects of Inflammation are Important in Alzheimer's Disease?
Researchers are coming to see chronic inflammation as an important driving mechanism of Alzheimer's disease, as well as many other age-related conditions. But inflammation is by no means a single, simple state. The immune system is complex, and inflammation is a complex collection of contributions and behaviors undertaken by varied cell populations. Researchers here find a way to gain some insight into which aspects of the inflammatory state are more or less important in the progression of Alzheimer's disease.
Inflammation is a central component of Alzheimer's disease (AD) pathophysiology, downstream of amyloid be...
Source: Fight Aging! - January 24, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
