Fight Aging! Newsletter, March 13th 2023
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CodaMetrix Closes $55M Series A to Autonomously Power Medical Coding, Boost Health System Revenue Cycles
Born out of Mass General Brigham, and led by healthtech veterans, CodaMetrix empowers health systems to use Artificial Intelligence to prevent revenue setbacks driven by manual coding inefficiencies
Overhauling medical coding is now crucial for health systems grappling with physician burnout, billing backlogs and claim denials, skilled labor shortages, and a graying medical coding workforce
AI-powered, multi-specialty, autonomous medical coding eliminates human intervention, reduces coding costs, improves coding quality and unlocks clinician capacity
CodaMetrix, the leading AI technology platform transforming healthcare ...
Source: EMR and HIPAA - March 10, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT AI Artificial Intelligence Chris Scoggins CMX CodaMetrix CU Healthcare Innovation Fund EHR Electronic Health Record FCV Frist Cressey Ventures Hamid Tabatabaie Health IT Funding Health IT Funding Source Type: blogs
AI in Healthcare: A Great Add-on, Not a Replacement
There has been this huge rush to implement AI wherever it can be added. And while nothing is wrong with this, it’s important that we don’t loose sight of AI being a tool and not a replacement. There are so many great things that AI can do, such as data gathering, increased pattern recognition, etc. However, it cannot fully nor successfully replace a human. A human touch is very much still needed, not only to get the AI to function as it should but in order for patients to feel comfortable.
So instead of looking for one or the other, it’s important to look for a balance. For a closer look at this balance w...
Source: EMR and HIPAA - March 9, 2023 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning C-Suite Leadership Communication and Patient Experience Healthcare IT Adam Cole Advata Archie Mayani Art Papier athenahealth Ben Zaniello Billy Parrish Brian Fugere Cedar Change Healthcare Charlie Clarke C Source Type: blogs
P wave spotting in AF is not forbidden
Fibrillation is a continuous, chaotic muscular activity. In AF, atrial muscle is expected to lose all coordinated contractions with fibrillatory waves replacing P waves. Have you ever spotted a suspicious P wave in a strip of otherwise explicit AF? If not, this write-up is not for you.
An evolving rare theme in Atrial fibrillation
Have a look at this ECG
Here is an ECG, that was reported as AF, multiple APDs, or Possible AF, Pre AF. I suggested the term AF in transition. While few agreed, many said it is a straightforward SR with APDs, making it appear irregular RR.
But, the fact of ...
Source: Dr.S.Venkatesan MD - March 8, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized cardiology research topics for fellows causes of absent p wabes p vs f waves in af p waves in atrial fibrillation research topics in atrial fibrillation Source Type: blogs
What Would John Henry Rauch Do Today As A HIT Entrepreneur?
BY MIKE MAGEE
Health entrepreneurs today tend to give themselves very high grades, and seem surprised when their creations fall short of expectations due to a disconnect with funders or regulators with legal authority. But Medicine isn’t fair, and genius is not that common.
What other conclusion can you draw from the thousands of references and citations featuring Philadelphia physician Benjamin Rush and his wild ideas on how to heroically treat Yellow Fever in 1793, but likely never heard of Dr. John Henry Rauch. The former signed the Declaration of Independence but directly or indirectly contributed to many an un...
Source: The Health Care Blog - March 8, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Benjamin Rush John Henry Rauch Mike Magee public health sanitation Source Type: blogs
Towards Transplantation of Stem Cell Derived Neurons for Parkinson's Disease
The more obvious manifestations of Parkinson's disease stem from the the loss of a small population of dopamine-generating neurons. These cells are more sensitive to the underlying pathology of α-synuclein protein aggregation that drives the condition. Researchers have been working towards cell therapies that deliver new neurons for a long time now. A variety of clinical trials are underway, using a variety of cell sources; here, one of those programs has advanced to the stage of a first treated patient. None of these programs have yet emerged into widespread clinical practice. Is replacing cells the best way forward in t...
Source: Fight Aging! - March 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Evidence for Reduced Dementia Incidence to be Driven by Improved Vascular Health
Dementia risk for individuals has decreased in recent decades, even as the population grows and ages to the point at which overall number of cases expands. Since individual risk of suffering cardiovascular disease has also decreased over the same period of time, it is reasonable to ask whether reduced dementia risk is a direct consequence of improvements in long term vascular health. Researchers here provide evidence to suggest that this is the case, noting that levels of amyloid-β aggregates in post-mortem brains are much the same across recent decades, while vascular health improves. Misfolding and aggregation of amyloi...
Source: Fight Aging! - March 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What do you think of this ECG?? Is this during pain, or after pain resolution? Also, see the CT image of the heart.
If you saw this ECG only knowing that it is an acute chest pain patient, what would be your interpretation?This is a trick question, as you will see below. But you can make a diagnosis here, and Pendell and I do this all the time when reading ECGs from databases. I sent this to Pendell without any information at all, and he replied " Postero-lateral Reperfusion. "The T-waves in V2-V4appear hyperacute, suggesting LAD occlusion,BUT there is also T-wave inversion that is typical morphology forreperfusion in V5 and V6.Thus, one must think of reperfusion. When there is reperfusion and there are large T-waves in...
Source: Dr. Smith's ECG Blog - March 6, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Bonus Features – March 5, 2023 – Two-thirds of patients connect with regular docs when they need medical care when traveling, half of clinical workflow automation users plan to expand their use, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Research
With the COVID-19 Public Health Emergency due to end on May 11, the Drug Enforcement Administration has proposed restrictions on the remote prescription of controlled substances, with only buprenorphine and Sch...
Source: EMR and HIPAA - March 5, 2023 Category: Information Technology Authors: Brian Eastwood Tags: C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Abridge Alan Swenson ATA Biofourmis canon medical CareCloud Carequality Chugai Phmarceutical DEA Derek Shaw Dustin Spencer eClinicalWorks eCW emt Source Type: blogs
Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult.
Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice
https://www.fightaging.org/archives/20...
Source: Fight Aging! - March 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
As Suspected, Local Clearance of Senescent Cells isn't as Effective as Global Clearance for Osteoporosis
It has long been suspected that removing senescent cells locally is insufficient to treat age-related conditions in which the pro-inflammatory signaling produced by senescent cells contributes to pathology. These signals enter the bloodstream and are carried widely about the body. While the effect of a distant senescent cell on local pathology is more dilute than that of a local senescent cell, there are a lot more distant senescent cells than there are local senescent cells. This issue is likely why Unity Biotechnology's initial clinical trial of localized removal of senescent cells in osteoarthritic knee joints failed to...
Source: Fight Aging! - March 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Greater Thymic Atrophy Correlates with More Rapid Progression of Chronic Kidney Disease
In this study, we explored the impact of T cell senescence on the renal prognosis and mortality of patients with chronic kidney disease (CKD). We found that decreased recent thymic emigrant (RTE) T cells, which corresponds to decreased thymic output, was associated with CKD progression and high mortality, and an increase in highly differentiated CD28-CD4+ T cells, which increases with age, tended to be associated with CKD progression. Thymic atrophy is a characteristic of an aging immune system and has been implicated in age-related diseases such as infection, malignancy, atherosclerosis, and CKD. However, epidemiologic da...
Source: Fight Aging! - February 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
One of the Many Advantages of AI in Healthcare: Data
In the world of Healthcare, there isn’t much room for making guesses. When you’re in charge of someone’s well being, it is critical that all of your decisions are well thought through and based on data. This is where AI can be very useful to your organization. AI, when applied properly, is very helpful in not only gathering data, but in sharing, analyzing, and storing it.
We reached out to our incredibly talented Healthcare IT Today Community for their comments and insights on the impact AI can have on data. This is what they had to say.
Ben Herzberg, Chief Scientist at Satori
From “where we are sta...
Source: EMR and HIPAA - February 21, 2023 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning Ambulatory Analytics/Big Data C-Suite Leadership Clinical Health IT Company Healthcare IT Hospital - Health System LTPAC 4medica Artificial Intelligence Ben Herzberg Charlie Clarke Data Driven Healthcare Dr. Source Type: blogs
Raman-Based Urine Sensor Detects Cancer Metabolites
Researchers at the Korea Institute of Materials Science (KIMS) creaetd a Raman-spectroscopy-based urine test that can detect metabolic compounds that are produced by pancreatic and prostate cancers, potentially allowing for rapid and convenient cancer screening. The technology consists of a paper strip onto which a urine sample can be added. The paper contains ‘coral-shaped’ structures that assist in amplifying the optical signal of cancer metabolites in the urine when the paper strip is illuminated with light, letting the researchers acquire spectral signals for each sample. By analyzing urine samples from cancer pati...
Source: Medgadget - February 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Oncology Pathology Source Type: blogs
