Plasma biomarkers for prediction of Alzheimer ’s disease neuropathologic change
AbstractWhile plasma biomarkers for Alzheimer ’s disease (AD) are increasingly being evaluated for clinical diagnosis and prognosis, few population-based autopsy studies have evaluated their utility in the context of predicting neuropathological changes. Our goal was to investigate the utility of clinically available plasma markers in predict ing Braak staging, neuritic plaque score, Thal phase, and overall AD neuropathological change (ADNC).We utilized a population-based prospective study of 350 participants with autopsy and antemortem plasma biomarker testing using clinically available antibody assay (Quanterix) consis...
Source: Acta Neuropathologica - June 3, 2023 Category: Neurology Source Type: research
Cause of death and the autopsy rate in an elderly population
AbstractAutopsy
rates are declining, while major discrepancies between autopsies and clinical diagnoses remain. Still, little is known about the impact of suspected underlying diseases, for example, a diagnosis of cancer, on the autopsy rate. The aim of this study was to investigate the relation between the clinical cause of death, a history of cancer, and the medical autopsy rate using data from the Netherlands Cohort Study on Diet and Cancer (NLCS), a large prospective cohort study with a long follow-up. The NLCS is a prospective study initiated in 1986 and includes 120,852 persons (58,279 males and 62,573 females), 5...
Source: Virchows Archiv - June 3, 2023 Category: Pathology Source Type: research
Only one beer can be mortal: a case report of two sisters with cardiac arrest due to a homozygous mutation in PPA2 gene
Conclusion: Duo exome sequencing clarified the diagnosis of PPA2-related mitochondriopathy in two sisters with isolated cardiac features and sudden cardiac arrest triggered by minimal amounts of alcohol.What is Known:• Multigene-Panel or exome analysis is a valuable tool to identify genetic causes of hereditary cardiac arrhythmias.• Variants of unknown significance can lead to misinterpretation. PPA2-related mitochondriopathy is a very rare autosomal recessive condition that is normally fatal in infancy.What is New:• Duo exome analysis in two teeenage sisters with cardiac arrest revealed a homozygous mild PPA2 muta...
Source: European Journal of Pediatrics - June 3, 2023 Category: Pediatrics Source Type: research
Deep learning-based subtyping of gastric cancer histology predicts clinical outcome: a multi-institutional retrospective study
ConclusionOur study shows that gastric adenocarcinoma subtyping using pathologist ’s Laurén classification as ground truth can be performed using current state of the art DL techniques. Patient survival stratification seems to be better by DL-based histology typing compared with expert pathologist histology typing. DL-based GC histology typing has potential as an aid in subtyp ing. Further investigations are warranted to fully understand the underlying biological mechanisms for the improved survival stratification despite apparent imperfect classification by the DL algorithm. (Source: Gastric Cancer)
Source: Gastric Cancer - June 3, 2023 Category: Gastroenterology Source Type: research
An Update on Apraxia of Speech
This article reviews recent findings regarding the clinic phenotypes of AOS, neuroimaging correlates, and the underlying disease processes.Recent FindingsTwo clinical subtypes of AOS map onto two underlying 4-repeat tauopathies. New imaging techniques have recently been applied to the study of progressive AOS. There is no data on the impact of behavioral intervention, although studies of nonfluent/agrammatic primary progressive aphasia that include patients with AOS suggest some benefit in speech intelligibility and maintenance.SummaryWhile recent findings suggest subtypes of AOS exist that are linked to molecular patholog...
Source: Current Neurology and Neuroscience Reports - June 3, 2023 Category: Neuroscience Source Type: research
Clinical outcomes of de novo metastatic HER2-positive inflammatory breast cancer
In conclusion, patients with de novo HER2-positive mIBC who undergo surgery have favorable outcomes. More than half of patients received systemic and local therapy with good locoregional control and prolonged survival, suggesting a potential role for local therapy.PMID:37268625 | DOI:10.1038/s41523-023-00555-w (Source: Cancer Control)
Source: Cancer Control - June 2, 2023 Category: Cancer & Oncology Authors: Ana C Garrido-Castro Meredith M Regan Samuel M Niman Faina Nakhlis Claire Remolano Jennifer M Rosenbluth Caroline Block Laura E Warren Jennifer R Bellon Eren Yeh Beth T Harrison Elizabeth Troll Nancy U Lin Sara M Tolaney Beth Overmoyer Filipa Lynce Source Type: research
The Metabolostasis Network and the Cellular Depository of Aggregation-Prone Metabolites
Angew Chem Int Ed Engl. 2023 Jun 2:e202217622. doi: 10.1002/anie.202217622. Online ahead of print.ABSTRACTThe vital role of metabolites across all branches of life and their involvement in various disorders have been investigated for decades. Many metabolites are poorly soluble in water or in physiological buffers and tend to form supramolecular aggregates. On the other hand, in the cell, they should be preserved in a pool and be readily available for the execution of biochemical functions. We thus propose that a quality-control network, termed 'metabolostasis', has evolved to regulate the storage and retrieval of aggregat...
Source: Cancer Control - June 2, 2023 Category: Cancer & Oncology Authors: Shon A Levkovich Ehud Gazit Dana Laor Bar-Yosef Source Type: research
Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease
Neurobiol Dis. 2023 May 31:106175. doi: 10.1016/j.nbd.2023.106175. Online ahead of print.ABSTRACTPlasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) both reflect early changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels and their association with regional β-amyloid (Aβ) pathology and cognitive performance head-to-head in clinically unimpaired elderly (n = 88) at three levels of APOE4-related genetic risk for sporadic AD (APOE4/4 n = 19, APOE3/4 n = 32 or non-carriers n = 37). Concentrations of plasma p-tau181, p-tau231 and GFAP were measured using Single molecule...
Source: Neurobiology of Disease - June 2, 2023 Category: Neurology Authors: Anniina Snellman Laura L Ekblad Nicholas J Ashton Thomas K Karikari Juan Lantero-Rodriguez Elina Pietil ä Mikko Koivum äki Semi Helin Mira Karrasch Henrik Zetterberg Kaj Blennow Juha O Rinne Source Type: research
The Metabolostasis Network and the Cellular Depository of Aggregation-Prone Metabolites
Angew Chem Int Ed Engl. 2023 Jun 2:e202217622. doi: 10.1002/anie.202217622. Online ahead of print.ABSTRACTThe vital role of metabolites across all branches of life and their involvement in various disorders have been investigated for decades. Many metabolites are poorly soluble in water or in physiological buffers and tend to form supramolecular aggregates. On the other hand, in the cell, they should be preserved in a pool and be readily available for the execution of biochemical functions. We thus propose that a quality-control network, termed 'metabolostasis', has evolved to regulate the storage and retrieval of aggregat...
Source: Angewandte Chemie - June 2, 2023 Category: Chemistry Authors: Shon A Levkovich Ehud Gazit Dana Laor Bar-Yosef Source Type: research
Using human induced pluripotent stem cell-derived liver cells to investigate the mechanisms of liver fibrosis in vitro
We describe the utility of these liver models as experimental systems to investigate the mechanism of liver fibrosis and development of drugs for the treatment thereof.PMID:37264940 | DOI:10.1042/BST20221421 (Source: Biochemical Society Transactions)
Source: Biochemical Society Transactions - June 2, 2023 Category: Biochemistry Authors: Yuta Koui Taketomo Kido Source Type: research
Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease
DISCUSSION: The higher concentrations of neuroprotective metabolites KA and picolinic acid suggest that the activation of the KP's neuroprotective branch is an adaptive response in AD and may be a promising target for intervention and treatment. Highlights Patients with Alzheimer's disease (AD) exhibited higher concentrations of kynurenic acid and picolinic acid than controls. Higher concentrations of kynurenic acid were associated with slower progression of AD. Potential neurotoxic kynurenines were not increased among patients with AD. Activation of the kynurenine pathway's neuroprotective branch may be an adaptive respon...
Source: The Journal of Alzheimers Association - June 2, 2023 Category: Psychiatry Authors: Anne-Brita Knapskog Mari Aksnes Trine Holt Edwin Per Magne Ueland Arve Ulvik Evandro Fei Fang Rannveig Sakshaug Eldholm Nathalie Bodd Halaas Ingvild Saltvedt Lasse M Giil Leiv Otto Watne Source Type: research
Tau in dementia with Lewy bodies
CONCLUSIONS: Tau is a common co-pathology in dementia with Lewy bodies. Plasma p-tau181 correlated with abnormal tau and amyloid-beta positron emission tomography and may potentially be used as a marker to identify co-morbid Alzheimer's disease-related pathology in dementia with Lewy bodies. The clinical implications of tau in dementia with Lewy bodies need to be further evaluated in larger longitudinal studies.PMID:37264610 | DOI:10.1177/00048674231177219 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - June 2, 2023 Category: Psychiatry Authors: Kai Sin Chin Leonid Churilov Vincent Dor é Victor L Villemagne Christopher C Rowe Nawaf Yassi Rosie Watson Source Type: research
Systematic dissection of coordinated stromal remodeling identifies Sox10 < sup > + < /sup > glial cells as a therapeutic target in myelofibrosis
Cell Stem Cell. 2023 Jun 1;30(6):832-850.e6. doi: 10.1016/j.stem.2023.05.002.ABSTRACTRemodeling of the tissue niche is often evident in diseases, yet, the stromal alterations and their contribution to pathogenesis are poorly characterized. Bone marrow fibrosis is a maladaptive feature of primary myelofibrosis (PMF). We performed lineage tracing and found that most collagen-expressing myofibroblasts were derived from leptin-receptor-positive (LepR+) mesenchymal cells, whereas a minority were from Gli1-lineage cells. Deletion of Gli1 did not impact PMF. Unbiased single-cell RNA sequencing (scRNA-seq) confirmed that virtually...
Source: Cell Stem Cell - June 2, 2023 Category: Stem Cells Authors: Shawn M Sarkaria Junsong Zhou Suying Bao Wenqi Zhao Yinshan Fang Jianwen Que Govind Bhagat Chaolin Zhang Lei Ding Source Type: research
Regulation of laboratory-developed tests: scoping the issue
Am J Clin Pathol. 2023 Jun 2:aqad060. doi: 10.1093/ajcp/aqad060. Online ahead of print.NO ABSTRACTPMID:37265228 | DOI:10.1093/ajcp/aqad060 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 2, 2023 Category: Pathology Authors: Steven H Kroft Karen L Kaul Source Type: research
Outpatient apheresis billing: A photopheresis model shows that hospital price transparency data remain difficult to interpret
CONCLUSIONS: Despite recent financial penalties, ECP pricing data are often unavailable or inadequate. Current available resources are unlikely to benefit the average health care consumer who requires ECP.PMID:37265164 | DOI:10.1093/ajcp/aqad059 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 2, 2023 Category: Pathology Authors: Brian D Adkins Garrett S Booth Jeremy W Jacobs Heather Jones Morgane C Mouslim Morgan A Henderson Source Type: research
