Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
CONCLUSIONS: We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.PMID:38660806 | DOI:10.1161/ATVBAHA.123.319701 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 25, 2024 Category: Molecular Biology Authors: Frank H Schaftenaar Andrea D van Dam Gerjan de Bruin Marie A C Depuydt Jill de Mol Jacob Amersfoort Hidde Douna Menno Meijer Mara J Kr öner Peter J van Santbrink Mireia N A Bernab é Kleijn Gijs H M van Puijvelde Bogdan I Florea Bram Sl ütter Amanda C F Source Type: research
Analysis of the Complexity of Palliative Care for Cancer Patients
This study aims to describe the degree of complexity of cancer patients in palliative care, to determine which elements of complexity are most prevalent and to determine which other hospital clinical factors are associated with the level of complexity.METHODS: This study is a descriptive, observational, and cross-sectional analysis that included patients diagnosed with advanced oncological pathology undergoing palliative treatment who were admitted to the Medical Oncology ward of the Miguel Servet University Hospital between March and April 2023.RESULT: A total of 100 patients were selected for the study. According to the ...
Source: The American Journal of Hospice and Palliative Care - April 25, 2024 Category: Palliative Care Authors: F átima Mocha Campillo Ana Mar ía Comín Orce Mar ía Luna Monreal Cepero Pablo Trincado Cobos Pablo G ómez Mugarza Susana Barriendos Sanz Natalia Pascual de la Fuente Sofia Ruffini Egea Javier Mart ínez Trufero Source Type: research
Diagnosis: What Is the Structure of Its Reasoning?
Perspect Biol Med. 2024;67(1):88-95. doi: 10.1353/pbm.2024.a919712.ABSTRACTHow does the diagnosis process work? This essay traces the philosophical underpinnings of diagnosis from Hume through Kant, Peirce, and Popper, analyzing how pathologists amalgamate sensibility, intuition, and imagination to form new hypotheses that can be tested by evidence and experience.PMID:38662065 | DOI:10.1353/pbm.2024.a919712 (Source: Perspectives in Biology and Medicine)
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Donald E Stanley Robert Hanna Source Type: research
Exploring potential developmental origins of common neurodegenerative disorders
Biochem Soc Trans. 2024 Apr 25:BST20230422. doi: 10.1042/BST20230422. Online ahead of print.ABSTRACTIn the United States, it is now estimated that 6.7 million people over the age of 65 are afflicted by Alzheimer's disease (AD), over 1 million people are living with Parkinson's disease (PD), and over 200 000 have or are at risk for developing Huntington's disease (HD). All three of these neurodegenerative diseases result in the ultimate death of distinct neuronal subtypes, and it is widely thought that age-related damage is the single biggest contributing factor to this neuronal death. However, recent studies are now sugges...
Source: Biochemical Society Transactions - April 25, 2024 Category: Biochemistry Authors: James P Catlin Christine E Schaner Tooley Source Type: research
Acute pleurisy mimicking neck pain in a young volleyball player: a case report
CONCLUSION: This case report highlights the importance of screening for serious pathology in direct access physiotherapy, irrespective of a prior physician consultation.PMID:38661029 | DOI:10.1080/09593985.2024.2336103 (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - April 25, 2024 Category: Physiotherapy Authors: Gabriele Giannotta Virginia Lillo Matteo Cioeta Filippo Maselli Giuseppe Giovannico John Heick Source Type: research
Efficacy of fat quantification methods used in MRI to distinguish between normal, benign, and malignant bone marrow pathologies in children
CONCLUSION: T1-SIV, OP/IP SR, and FF may potentially distinguish normal from pathological bone marrow. OP/IP SR and FF values detected malignant infiltration with high sensitivity and specificity in this study. However, only OP/IP SR may significantly differentiate benign and malignant bone marrow pathologies which needs to be confirmed in the future study with a larger patient population.PMID:38659300 | DOI:10.1177/02841851241247110 (Source: Acta Radiologica)
Source: Acta Radiologica - April 25, 2024 Category: Radiology Authors: Duygu Erkal Tonkaz Rifat Ozpar Mehmet Tonkaz Zeynep Yazici Source Type: research
Resting state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00423.2023. Online ahead of print.ABSTRACTThe kidneys maintain fluid-electrolyte balance and excrete waste in the presence of constant fluctuations in plasma volume and systemic blood pressure. The kidneys perform these functions to control capillary perfusion and glomerular filtration by modulating the mechanisms of autoregulation. An effect of these modulations are spontaneous, natural fluctuations in nephron perfusion. Numerous other mechanisms can lead to fluctuations in perfusion and flow. The ability to monitor these spontaneous physiological fluctuations...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Edwin J Baldelomar Darya Morozov Leslie D Wilson Cihat Eldeniz Hongyu An Jennifer R Charlton Adam Bauer Shella D Keilholz Monica L Hulbert Kevin M Bennett Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
CONCLUSIONS: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.PMID:38659250 | DOI:10.4166/kjg.2024.003 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - April 25, 2024 Category: Gastroenterology Authors: Jung Ho Lee Hyunseok Cho Sang Hoon Lee Sung Joon Lee Chang Don Kang Dae Hee Choi Jin Myung Park Seung-Joo Nam Tae Suk Kim Ji Hyun Kim Sung Chul Park Source Type: research
Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
CONCLUSIONS: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.PMID:38659250 | DOI:10.4166/kjg.2024.003 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Jung Ho Lee Hyunseok Cho Sang Hoon Lee Sung Joon Lee Chang Don Kang Dae Hee Choi Jin Myung Park Seung-Joo Nam Tae Suk Kim Ji Hyun Kim Sung Chul Park Source Type: research
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
CONCLUSIONS: We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.PMID:38660806 | DOI:10.1161/ATVBAHA.123.319701 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Frank H Schaftenaar Andrea D van Dam Gerjan de Bruin Marie A C Depuydt Jill de Mol Jacob Amersfoort Hidde Douna Menno Meijer Mara J Kr öner Peter J van Santbrink Mireia N A Bernab é Kleijn Gijs H M van Puijvelde Bogdan I Florea Bram Sl ütter Amanda C F Source Type: research
The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association
Circulation. 2024 Apr 25. doi: 10.1161/CIR.0000000000001232. Online ahead of print.ABSTRACTTricuspid valve disease is an often underrecognized clinical problem that is associated with significant morbidity and mortality. Unfortunately, patients will often present late in their disease course with severe right-sided heart failure, pulmonary hypertension, and life-limiting symptoms that have few durable treatment options. Traditionally, the only treatment for tricuspid valve disease has been medical therapy or surgery; however, there have been increasing interest and success with the use of transcatheter tricuspid valve ther...
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Laura J Davidson Gilbert H L Tang Edwin C Ho Marat Fudim Tiberio Frisoli Anton Camaj Margaret T Bowers Sofia Carolina Masri Pavan Atluri Joanna Chikwe Peter J Mason Jason C Kovacic George D Dangas American Heart Association Interventional Committee of the Source Type: research
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
CONCLUSIONS: We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.PMID:38660806 | DOI:10.1161/ATVBAHA.123.319701 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Frank H Schaftenaar Andrea D van Dam Gerjan de Bruin Marie A C Depuydt Jill de Mol Jacob Amersfoort Hidde Douna Menno Meijer Mara J Kr öner Peter J van Santbrink Mireia N A Bernab é Kleijn Gijs H M van Puijvelde Bogdan I Florea Bram Sl ütter Amanda C F Source Type: research
Bowel Resection Margins in Crohn's Disease: Do They Matter?
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786376Many patients with Crohn's disease (CD) will ultimately require surgical intervention for refractory disease despite recognizing that surgery does not cure CD. The initial operation, primarily for ileocolic disease, is focused on resecting the offending pathology and ideally providing a reduced likelihood for subsequent operations and additional bowel loss through surgical techniques. The appropriate margin, macro- vs. microscopic, lays in balance to provide an adequate resection that minimizes bowel loss, compared to an extensive resection which ensures a thorough resectio...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Choi, Beatrix Cohen, David Schwartzberg, David M. Tags: Review Article Source Type: research
