Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
CONCLUSIONS: We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.PMID:38660806 | DOI:10.1161/ATVBAHA.123.319701 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Frank H Schaftenaar Andrea D van Dam Gerjan de Bruin Marie A C Depuydt Jill de Mol Jacob Amersfoort Hidde Douna Menno Meijer Mara J Kr öner Peter J van Santbrink Mireia N A Bernab é Kleijn Gijs H M van Puijvelde Bogdan I Florea Bram Sl ütter Amanda C F Source Type: research
Bowel Resection Margins in Crohn's Disease: Do They Matter?
Clin Colon Rectal Surg DOI: 10.1055/s-0044-1786376Many patients with Crohn's disease (CD) will ultimately require surgical intervention for refractory disease despite recognizing that surgery does not cure CD. The initial operation, primarily for ileocolic disease, is focused on resecting the offending pathology and ideally providing a reduced likelihood for subsequent operations and additional bowel loss through surgical techniques. The appropriate margin, macro- vs. microscopic, lays in balance to provide an adequate resection that minimizes bowel loss, compared to an extensive resection which ensures a thorough resectio...
Source: Clinics in Colon and Rectal Surgery - April 25, 2024 Category: Surgery Authors: Choi, Beatrix Cohen, David Schwartzberg, David M. Tags: Review Article Source Type: research
A cost-effective and labor-saving method for detecting HLA-B27 status via sequence-encoded fluorescence amplification assay
Identification of Human leukocyte antigen B27 (HLA-B27) by flow cytometry (FCM) has been widely applied in clinical practice for auxiliary diagnosis of ankylosing spondylitis (AS). However, FCM requires fresh-prepared samples and relies on expensive equipment, reagents, and experienced operator. To provide a cheaper and more convenient method for HLA-B27 detection, we proposed a new method termed sequence-encoded fluorescence amplification assay (SEFA), which specially recognized sequences of HLA-B27 gene (HLA-B*27) covering current common subtypes in a single closed tube. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - April 25, 2024 Category: Pathology Authors: Nan Sheng, Li Zhao, Shuyun Pang, Wenwen Wang, Panfeng Feng, Jing Zhao, Xiaoxiang Chen, Yingying Gao Tags: Regular Article Source Type: research
CircCOL1A1 promotes proliferation, migration, and invasion of colorectal cancer (CRC) cells and glutamine metabolism through GLS1 up-regulation by sponging miR-214-3p
ConclusionThese findings suggest that circCOL1A1 functions as an oncogenic molecule to promote CRC progression via miR-214-3p/GLS1 axis, hinting on the potential of circCOL1A1 as a therapeutic target for CRC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
Resuscitative thoracotomy
This article provides a detailed review of the relevant pathophysiology, indications and contraindications, necessary equipment and techniques, and factors influencing patient outcomes. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - April 25, 2024 Category: Surgery Authors: Karl Foster, Laura J. Watson, Peter Coyne Tags: Surgery for major incidents Source Type: research
Intestinal carbapenem-resistant Klebsiella pneumoniae undergoes complex transcriptional reprogramming following immune activation
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 25, 2024 Category: Microbiology Authors: Clement DavidAleksander CzaudernaLiqing ChengMarion LaguneHea-Jin JungSohn G. KimEric G. PamerJulien PradosLiang ChenSimone Becattinia Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerlandb Geneva Centre fo Source Type: research
A Streamlined PENK Methylation Test in Urine DNA, EarlyTect BCD, Effectively Detects Bladder Cancer in Hematuria Patients
This study aims to evaluate the validity of a streamlined urine-based PENK methylation test called EarlyTect BCD in detecting BC in hematuria patients scheduled for cystoscopy in Korean and American populations. The test seamlessly integrates two steps, linear target enrichment, and quantitative methylation-specific PCR within a single closed tube. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - April 25, 2024 Category: Pathology Authors: Bo-Ram Bang, Jin Zhong, Tae Jeong Oh, Ji Yong Lee, Yangyei Seo, Min A. Woo, Jae Sung Lim, Yong Gil Na, Ki Hak Song, Ju Hyun Shin, Justin Junguek Lee, Chan Su Im, Seoyong Kim, Safedin Beqaj, Joseph D. Shirk, Katelyn W. Ke, John Vallone, Sungwhan An Tags: Regular Article Source Type: research
PUMC-MB1 is a novel group 3 medulloblastoma preclinical model, sensitive to PI3K/mTOR dual inhibitor
ConclusionsPUMC-MB1, a novel Group 3 (Non-WNT/Non-SHH) MB cell line, is comprehensively characterized for its growth, pathology, and molecular characteristics. Notably, dactolisib demonstrated potent anti-proliferative effects with minimal toxicity, promising a potential therapeutic avenue. PUMC-MB1 could serve as a valuable tool for unraveling MB mechanisms and innovative treatment strategies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
The efficacy of clinicopathological and imaging features in differentiating benign from malignant parotid micro- and minitumors: A retrospective analysis
To compare clinicopathological and imaging and features of micro- and minitumors of the parotid gland and provide a reference for preoperative prediction of benign vs. malignant status. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 25, 2024 Category: ENT & OMF Authors: Yaqing Mao, Byeongwoo Lee, Zhipeng Sun, Zunan Tang, Leihao Hu, Wenbo Zhang, Yao Yu, Xin Peng Source Type: research
Artificial Intelligence in Digital Histopathology for predicting patient prognosis and treatment efficacy in breast cancer
Expert Rev Mol Diagn. 2024 Apr 24. doi: 10.1080/14737159.2024.2346545. Online ahead of print.ABSTRACTINTRODUCTION: Histological images contain phenotypic information predictive of patient outcomes. Due to the heavy workload of pathologists, the time-consuming nature of quantitatively assessing histological features, and human eye limitations to recognize spatial patterns, manually extracting prognostic information in routine pathological workflows remains challenging. Digital pathology has facilitated the mining and quantification of these features utilizing whole-slide image (WSI) scanners and artificial intelligence (AI)...
Source: Expert Review of Molecular Diagnostics - April 24, 2024 Category: Laboratory Medicine Authors: William M Gallagher Christine McCaffrey Chowdhury Jahangir Clodagh Murphy Caoimbhe Burke Arman Rahman Source Type: research
Effect of whole-body vibration stimulation on plasma soluble TNF receptors in elderly with sarcopenia: a randomized controlled trial
In conclusion, an acute session of WBV influenced sTNFr2 levels, with sarcopenic individuals showing a greater effect. This suggested that WBV had a more pronounced impact on sTNFr2 in those with loss of muscle strength and/or physical performance. Additionally, WBV is gaining recognition as an efficient strategy for those with persistent health issues.PMID:38656072 | DOI:10.1590/1414-431X2024e13282 (Source: Brazilian Journal of Medical and Biological Research)
Source: Brazilian Journal of Medical and Biological Research - April 24, 2024 Category: Research Authors: H C Almeida V K S Lage R Taiar J M Santos F A de Paula A Rapin D C S á-Caputo M Bernardo-Filho A C R Lacerda V A Mendon ça Source Type: research
Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF- κB signaling for the treatment of sepsis
Eur J Med Chem. 2024 Apr 23;271:116427. doi: 10.1016/j.ejmech.2024.116427. Online ahead of print.ABSTRACTGlucocorticoids (GCs) have been used in the treatment of sepsis because of their potent anti-inflammatory effects. However, their clinical efficacy against sepsis remains controversial because of glucocorticoid receptor (GR) downregulation and side effects. Herein, we designed and synthesized 30 ocotillol derivatives and evaluated their anti-inflammatory activities. Ocotillol 24(R/S) differential isomers were stereoselective in their pharmacological action. Specifically, 24(S) derivatives had better anti-inflammatory ac...
Source: European Journal of Medicinal Chemistry - April 24, 2024 Category: Chemistry Authors: Gongshan Ma Xiaojin Gao Xin Zhang Haixia Li Zhiyuan Geng Jing Gao Shuxin Yang Zhiruo Sun Yuqi Lin Xiaomei Wen Qingguo Meng Leiming Zhang Yi Bi Source Type: research
Persistent chronic calcific pancreatitis with intraductal calculi associated with secondary diabetes mellitus type 3 and diabetic ketoacidosis - A case report
Endocr Regul. 2024 Apr 24;58(1):101-104. doi: 10.2478/enr-2024-0011. Print 2024 Jan 1.ABSTRACTDiabetes mellitus type 3 refers to diabetes secondary to an existing disease or condition of the exocrine pancreas and is an uncommon cause of diabetes occurring due to pancreatogenic pathology. It accounts for 15-20% of diabetic patients in Indian and Southeast Asian continents. This is case report of a rare case of type 3 diabetes mellitus (T3DM) presenting with diabetic ketoacidosis (DKA). The patient was admitted for DKA along with complaint of hyperglycemia, blood glucose of 405 mg/dl with HbA1c level of 13.7%. Computed tomog...
Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Gurusha Bahl Dinesh K Upadhyay Madhumati Varma Rajveer Singh Subhankar Das Sadique Hussain Source Type: research
Feasibility of EMDR toward Personality Functioning in Older Adults with PTSD
CONCLUSIONS: Observed improvements in personality functioning from pre to post EMDRtreatment were explained by PTSD-severity. Identityintegration improved significantly over time. Results suggest that participants with "othertreatment" showed more severe baseline-pathology and thus lower personality functioning.CLINICAL IMPLICATIONS: EMDR, in addition to being a feasible treatment option for older adults with PTSD, improves personality functioning and reduces the presence of PDs over time.'PMID:38656832 | DOI:10.1080/07317115.2024.2344793 (Source: Clinical Gerontologist)
Source: Clinical Gerontologist - April 24, 2024 Category: Geriatrics Authors: Ellen M J Gielkens Sjacko Sobczak Nienke Gerrits Erlene Rosowsky Lara Stas Gina Rossi Sebastiaan P J van Alphen Source Type: research
