Efficacy of sentinel lymph-node biopsy after neoadjuvant chemotherapy in clinically axilla node-negative patients
ConclusionsAxillary lymph-node dissection may not be necessary for patients with cNO confirmed by physical and radiological examination using positron emission tomography (PET) computed tomography (CT), and breast magnetic resonance imaging (MRI) after NACT, if ≥ three negative SLNB are removed. Further studies are needed to confirm our findings. (Source: Surgery Today)
Source: Surgery Today - April 16, 2024 Category: Surgery Source Type: research
Mechanical trauma in children and adolescents in Berlin
This study analyzes trauma mechanisms in deceased pediatric patients. Fatal pediatric trauma cases aged 0 –18 years who underwent forensic autopsy in the Federal State of Berlin, Germany, between 2008 until 2018 were enrolled in this retrospective study. Autopsy protocols were analyzed regarding demographic characteristics, trauma mechanisms, injury patterns, resuscitation measures, survival times as well as place, and cause of death. 71 patients (73% male) were included. Traffic accidents (40%) were the leading cause of trauma, followed by falls from height > 3 m (32%), railway accidents (13%), third party viol...
Source: Forensic Science, Medicine, and Pathology - April 16, 2024 Category: Forensic Medicine Source Type: research
Hysteroscopic Subchorionic Injection of Methotrexate Followed by Laparoscopic Excision of the Gestational Sac for the Management of Cesarean Scar Ectopic Pregnancy: An Innovative Dual Approach of a Challenging Pathology.
This innovative two-step therapeutic approach should be considered a compelling option for managing cesarean scar ectopic pregnancy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 16, 2024 Category: Reproduction Medicine Authors: Maria del Milagro Tejerizo Fe, Paola Elizabeth Benitez, Alejandro Martin Gonzalez, Kyara Marquez, Joelle Mouhanna, Jose Carugno Tags: Video Source Type: research
The role of teledermatology in Mohs micrographic surgery: a review
This study underscores TD’s multifaceted benefits in MMS: enhanced patient experience preopera tively, improved communication during surgery, and cost-effective postoperative follow-up. Limitations include the financial expense and technical issues that can arise with TD (connectivity problems, delays in video/audio transmission, etc.). Further studies are needed to explore emerging TD modali ties in post-operative patient management. The integration of TD into MMS signifies a progressive step in dermatological care, offering convenient, cost-effective, and better solutions with the potential to enhance patient experienc...
Source: Archives of Dermatological Research - April 16, 2024 Category: Dermatology Source Type: research
Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology
Toxoplasma gondii (T. gondii) and Helicobacter pylori (H. pylori) are among the most prevalent foodborne parasitic and bacterial infections worldwide. However, the concurrent impact of coinfection on gastric path... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Marwa A. Gouda, Sara A. Saied, Ahmed Edrees, Rasha Galal Mostafa, Ashraf Elfert, Aya Abdallah seleem, Asmaa Shams and Sameh Afify Tags: Research Source Type: research
The degeneration of locus coeruleus occurring during Alzheimer ’s disease clinical progression: a neuroimaging follow-up investigation
AbstractThe noradrenergic nucleus Locus Coeruleus (LC) is precociously involved in Alzheimer ’s Disease (AD) pathology, and its degeneration progresses during the course of the disease. Using Magnetic Resonance Imaging (MRI), researchers showed also in vivo in patients the disruption of LC, which can be observed both in Mild Cognitively Impaired individuals and AD demented patients. In th is study, we report the results of a follow-up neuroradiological assessment, in which we evaluated the LC degeneration overtime in a group of cognitively impaired patients, submitted to MRI both at baseline and at the end of a 2.5-year ...
Source: Anatomy and Embryology - April 16, 2024 Category: Anatomy Source Type: research
Repair of a fistula between the aorta and right ventricular outflow tract secondary to infective endocarditis of a unicuspid aortic valve and previously repaired ventricular septal defect
Infective endocarditis of the aortic valve can result in a wide range of destructive pathology beyond the valve leaflets and annulus which require careful surgical planning to provide appropriate debridement a... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - April 16, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Rickesh B. Karsan, Katie E. O ’Sullivan, Christopher J. Lockhart and Christopher Austin Tags: Case Report Source Type: research
Development of an automated amplicon-based next-generation sequencing pipeline for rapid detection of bacteria and fungi directly from clinical specimens
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - April 16, 2024 Category: Microbiology Authors: Lucas J. OsbornJohn FisselSamantha GomezJavier MestasJessica Flores-VazquezJaehyeon LeeHesamedin HakimjavadiCristina CostalesJennifer Dien Bard1Department of Pathology and Laboratory Medicine, Children ’s Hospital Los Angeles, Los Angeles, California, U Source Type: research
Evaluation of the prognostic potential of histopathological subtyping in high-grade serous ovarian carcinoma
AbstractHigh-grade serous ovarian carcinoma (HGSOC) can be categorized into four gene expression-based subtypes, with supposedly distinct prognoses and treatment responses. Murakami et al. translated these gene expression-based subtypes into the histopathological mesenchymal, immunoreactive, solid and proliferative, and papilloglandular subtypes, showing differences in survival outcomes. Miyagawa et al. refined these criteria to improve the interobserver concordance. The current retrospective study evaluated the interobserver variability and the prognostic differences between the histopathologic subtypes using the criteria...
Source: Virchows Archiv - April 16, 2024 Category: Pathology Source Type: research
Prevalence and Predictors of Readmissions Among Patients with Hypertrophic Cardiomyopathy and Atrial Fibrillation/Flutter
Atrial fibrillation/flutter (AF) is the most common dysrhythmia in patients with hypertrophic cardiomyopathy (HCM). Unexplained left ventricular hypertrophy and left ventricular outflow tract (LVOT) obstruction are integral components of HCM pathology which can cause increased left atrial pressure and atrial myopathy contributing to the substrate for AF. Our aim was to determine the impact of AF on hospital readmissions in patients with HCM. We conducted a retrospective analysis using the 2015 - 2019 Nationwide Readmission Database to analyze the effect of AF on 30-day readmission and causes of 30-day readmission in patien...
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Muhammad Usman Almani, Khawaja Muhammad Talha, Laibah Arhsad Khan, Ishaque Hameed, Zain Ul Abideen Asad, Marat Fudim, Richard Krasuski, Muhammad Shahzeb Khan Source Type: research
Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL
Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a common cerebral small vessel disease caused by highly stereotyped dominant mutations in NOTCH3. Yet the relationship between NOTCH3 receptor activity, Notch3ECD accumulation, and arterial SMC loss has remained elusive, hampering the development of disease-modifying therapies. Using dedicated histopathological and multiscale imaging modalities, we could detect and quantify previously undetectable CADASIL-driven arterial SMC loss in the CNS of mice expressi...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Nicolas Dupré, Florian Gueniot, Valérie Domenga-Denier, Virginie Dubosclard, Christelle Nilles, David Hill-Eubanks, Christelle Morgenthaler-Roth, Mark T. Nelson, Céline Keime, Lydia Danglot, Anne Joutel Source Type: research
Experience with the utilization of new-generation shared-control robotic system for spinal instrumentation
CONCLUSIONS: From this single-center, single-surgeon series we conclude that robot-assisted spine surgery can be safely and efficiently integrated into the operating room workflow, which improves after a learning curve of approximately 20 operative interventions. We found robot-assisted spinal instrumentation to be reliable, safe, effective and highly precise.PMID:38619188 | DOI:10.23736/S0390-5616.24.06206-4 (Source: Journal of Neurosurgical Sciences)
Source: Journal of Neurosurgical Sciences - April 15, 2024 Category: Neurosurgery Authors: Ghani Haider Vaibhavi Shah Ivan Lopez Katherine E Wagner Martin N Stienen Anand Veeravagu Source Type: research
Cerebral malaria pathogenesis: Dissecting the role of CD4 < sup > + < /sup > and CD8 < sup > + < /sup > T-cells as major effectors in disease pathology
Int Rev Immunol. 2024 Apr 15:1-18. doi: 10.1080/08830185.2024.2336539. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe complication of Plasmodium falciparum (P. falciparum) infection, with complex pathogenesis involving multiple factors, including the host's immunological response. T lymphocytes, specifically CD4+ T helper cells and CD8+ cytotoxic T cells, are crucial in controlling parasite growth and activating cells for parasite clearance via cytokine secretion. Contrary to this, reports also suggest the pathogenic nature of T lymphocytes as they are often involved in disease progression and severity. CD...
Source: International Reviews of Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Indu Sharma Poonam Kataria Jyoti Das Source Type: research
COVID-19 Pandemic: Impact and rapid reaction of Urology
Actas Urol Esp. 2020 Sep;44(7):450-457. doi: 10.1016/j.acuro.2020.04.006. Epub 2020 Apr 24.ABSTRACTThe COVID-19 pandemic caused by the SARS-CoV-2 virus has caused tens of thousands of deaths in Spain and has managed to breakdown the healthcare system hospitals in the Community of Madrid, largely due to its tendency to cause severe pneumonia, requiring ventilatory support. This fact has caused our center to collapse, with 130% of its beds occupied by COVID-19 patients, thus causing the absolute cessation of activity of the urology service, the practical disappearance of resident training programs, and the incorporation of a...
Source: Actas Urologicas Espanolas - April 15, 2024 Category: Urology & Nephrology Authors: V Hevia J Lorca M Hevia A Dom ínguez J L ópez-Plaza A Artiles S Álvarez Á Sánchez A Fraile L L ópez-Fando E Sanz M Ruiz E Alcaraz F J Burgos Source Type: research
Critical Care: What You May Have Missed in 2023
This article highlights 10 important pieces of research from 2023 (and 1 from 2022) in critical care. The literature was screened for new evidence relevant to internal medicine physicians and hospitalists whose focus of practice is not critical care but who may be taking care of seriously ill patients. The articles highlight the diverse spectrum of pathology and interplay of various specialties that go into critical care. Topics include transfusion medicine, fluid resuscitation, safe intubation practices and respiratory failure, and the management of acute ischemic stroke. Several trials are groundbreaking, forcing clinici...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Henry Ajzenberg Mansor Abdalaziz N Binhashr Mark Keith Hewitt Michael Unger Source Type: research
