Self-mutilation: a systematic review
AbstractSelf-mutilation lesions can represent a clinical diagnosis challenge for healthcare professionals, as patients do not admit to self-mutilation. This leads to failed diagnoses due to the similarity of this condition to other diseases. Searches on the subject were carried out at the PubMed, Peri ódicos Capes, Scopus, Science Direct and WoS databases, according to the following inclusion criteria: articles in English, Portuguese or Spanish, published from 2018 to June 2023, encompassing case reports, case series and literature reviews. Men are slight more affected by self-mutilation injurie s, also presenting the mos...
Source: Forensic Science, Medicine, and Pathology - April 13, 2024 Category: Forensic Medicine Source Type: research
A fatal misdiagnosis of page kidney – case report
AbstractPage kidney is a condition where external compression of the renal artery and renal parenchyma leads to subsequent ischaemia and activation of renin-angiotensin-aldosterone axis. A 42-year-old female with hirsutism, hypertension and diabetes was diagnosed with a right adrenal mass and underwent laparoscopic adrenalectomy. Her hypertension worsened postoperatively and was managed medically. Subsequently she developed a right flank pain on the fifth postoperative day and died suddenly the next day. Autopsy revealed a pale body with cushingoid appearance. Surgical scars were healthy. Internal examination of the abdome...
Source: Forensic Science, Medicine, and Pathology - April 13, 2024 Category: Forensic Medicine Source Type: research
α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
Cell Death & Disease, Published online: 13 April 2024; doi:10.1038/s41419-024-06630-9α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway (Source: Cell death and disease)
Source: Cell death and disease - April 13, 2024 Category: Internal Medicine Authors: Marina I. Oliveira da Silva Miguel Santejo Isaac W. Babcock Ana Magalh ães Laurie S. Minamide Seok-Joon Won Erika Castillo Ellen Gerhardt Christiane Fahlbusch Raymond A. Swanson Tiago F. Outeiro Ricardo Taipa Michael Ruff James R. Bamburg M árcia A. Liz Source Type: research
Platelet –lymphocyte ratio as a predictor of lymph node metastasis in small bowel cancer
AbstractThe purpose of this research was to investigate the potential predictive value of preoperative systemic inflammatory indexes in identifying lymph node metastasis among patients diagnosed with small bowel cancer. A retrospective analysis of clinical data was conducted on small bowel cancer patients who underwent surgical treatment at the gastrointestinal surgery department of our hospital between January 2010 and June 2021. Patients were divided into groups based on the presence or absence of lymph node metastasis as confirmed by postoperative pathological results. The study compared the differences in preoperative ...
Source: Journal of Robotic Surgery - April 13, 2024 Category: Surgery Source Type: research
Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in pediatric opsoclonus myoclonus ataxia syndrome presenting with neuroblastoma
ConclusionIn patients with OMAS,18F-FDG PET/CT has a high diagnostic accuracy in detecting tumors of the neuroblastoma, especially when combined with the independent risk factor serum lactate dehydrogenase.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 13, 2024 Category: Radiology Source Type: research
Neuroimmunology of Cardiovascular Disease
AbstractPurpose of ReviewCardiovascular disease (CVD) is a leading cause of death and chronic disability worldwide. Yet, despite extensive intervention strategies the number of persons affected by CVD continues to rise. Thus, there is great interest in unveiling novel mechanisms that may lead to new treatments. Considering this dilemma, recent focus has turned to the neuroimmune mechanisms involved in CVD pathology leading to a deeper understanding of the brain ’s involvement in disease pathology. This review provides an overview of new and salient findings regarding the neuroimmune mechanisms that contribute to CVD.Rece...
Source: Current Hypertension Reports - April 13, 2024 Category: Primary Care Source Type: research
Isolated Mediastinal Goitre: A Case Report
AbstractRetrosternal goitre is not an uncommon entity owing to various reasons – ignorance, fear, lack of access to safe surgical technique, incomplete thyroid surgery. Retrosternal goitre could have varied presentations, especially in cases with prior thyroid surgery. Fifty-three-year-old female with history of thyroid surgery 20 years back presented with a large neglected anterior neck swelling. Computed tomography imaging revealed the rare entity of an isolated mediastinal goitre type 3 with no communication with the cervical thyroid gland. Careful evaluation of computed tomography and pathology indicated the need for...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 13, 2024 Category: ENT & OMF Source Type: research
Challenging pitfalls in frozen section pathology: a case of mandible ghost cell odontogenic carcinoma and the literature review
Ghost cell odontogenic carcinoma (GCOC) is a rare malignancy characterized by the presence of ghost cells, preferably in the maxilla. Only slightly more than 50 case reports of GCOC have been documented to dat... (Source: BMC Oral Health)
Source: BMC Oral Health - April 13, 2024 Category: Dentistry Authors: Sha-Sha Hu, Jian Yang, Hai-Fei Zhang, Jie Chen, Xin-Nian Li, Fu-Jin Liu and Bo Wang Tags: Case Report Source Type: research
RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer
J Environ Pathol Toxicol Oncol. 2024;43(3):69-80. doi: 10.1615/JEnvironPatholToxicolOncol.2024053012.ABSTRACTThe present study explored that the effects and its possible mechanisms of ring finger protein 20 (RNF20) in Postoperative survival rate of liver cancer in clinical. All the serum samples were collected from our hospital. Quantitative polymerase chain reaction (PCR) and microarray analysis, and RNA pull down assay were used in this study. We found that the serum RNF20 mRNA expression level in patients with liver cancer were down-regulated. Postoperative survival rate of RNF20 high expression was higher than that of ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Deqin Liu Renyin Luo Qian Zhou Mei Li Source Type: research
Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape
This study attempted to delineate potential value of apoptosis and hypoxia-related genes (AHRGs) in prognosis of gastric cancer. Differential expression analysis was performed on GC transcriptomic data from TCGA. Apoptosis-related genes (ARGs) and hypoxia-related genes (HRGs) were obtained from MSigDB, followed by intersecting them with differentially expressed genes (DEGs) in GC. A prognostic model was constructed using univariate, LASSO, and multivariate regression analyses. The model was validated using a Gene Expression Omnibus dataset. DEGs between risk groups were subjected to enrichment analysis. A nomogram was plot...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Jian Zhu Yao Ma Source Type: research
A Review on Protease Inhibitors of Herbal Origin to Combat Malignancy
J Environ Pathol Toxicol Oncol. 2024;43(3):1-11. doi: 10.1615/JEnvironPatholToxicolOncol.2024052872.ABSTRACTProtease is the enzyme accountable for the breakdown of proteins i.e., proteolysis. Proteases are reportedly involved in the events of growth, development, progression and metastasis of cancers. If any agent could inhibit/retard the protease enzyme, i.e., protease inhibitor, it would arrest the cancer; thus indicating the significance of exploring protease inhibitors for latest anti-malignant drug discovery. Higher plants are the rich sources of different protease inhibitors that are effective against several types o...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Sanjib Bhattacharya Source Type: research
Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small-Cell Lung Cancer
This article discusses the molecular genetic landscape of NSCLC and the latest therapy developments, focusing on clinically relevant changes using several schematic and tabular representations.PMID:38608143 | DOI:10.1615/JEnvironPatholToxicolOncol.2024051317 (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Salik Abdullah Ratul Chakraborty Pratiksha Somnath Kumkar Biplab Debnath Asis Bala Source Type: research
Treatment Strategy for Breast Benign Intraductal Papilloma: A Meta-Analysis
This study aims to conduct a meta-analysis to determine the rate of upgrade from breast benign IDP and identify predictive factors associated with the conversion of benign IDP to high-risk lesions or carcinoma, which could guide healthcare practitioners in selecting the appropriate clinical treatment strategy. We conducted a comprehensive search across multiple databases (PubMed, Web Of Science, Cochrane Library, and Embase) for studies published between 2012 and 2023 that evaluated upgrade rates and predictive factors of breast benign IDP diagnosed via biopsy. In addition, we included studies that reported on the clinical...
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Congkun Lou Wenhsin Wang Binggang Zhou Source Type: research
Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma
In conclusion, our findings highlight the predictive role of IMRGs in prognosis and immune treatment of HCC, indicating that ADAMTS13, CRHBP, VIPR1, FCN3, and CLEC1B may serve as potential prognostic biomarkers for HCC.PMID:38608145 | DOI:10.1615/JEnvironPatholToxicolOncol.2024050167 (Source: Journal of Environmental Pathology, Toxicology and Oncology)
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 12, 2024 Category: Environmental Health Authors: Shijing Tang Hao Chen Source Type: research
Inhalation of 2, 4-di-tert-butylphenol-Loaded micelles suppresses respiratory syncytial virus infection in mice
In this study, we explored the anti-RSV potential of 2, 4-Di-tert-butylphenol (2, 4-DTBP), a compound derived from Houttuynia cordata Thunb. To overcome the poor solubility of 2, 4-DTBP, we encapsulated it in polymeric micelles and delivered it by inhalation. We found that 2, 4-DTBP-loaded micelles inhibited RSV infection in vitro and improved survival, lung pathology, and viral clearance in RSV-infected mice. Our results suggested that 2, 4-DTBP-loaded micelle is a promising novel therapeutic agent for RSV infection.PMID:38608838 | DOI:10.1016/j.antiviral.2024.105880 (Source: Antiviral Research)
Source: Antiviral Research - April 12, 2024 Category: Virology Authors: Mingyang Guo Jianqing Peng Pengcheng Guo Qin Wang Lin Zhang Huyan Shen Fang Chen Pingping Zhang Siyu Lin Han Gao Hong Peng Rong Mou Jiandong Huang Jianxin Wang Yu-Si Luo Ke Zhang Source Type: research
