Defining distal splenopancreatectomy by the mesopancreas
CONCLUSION: While resection margin status was not affected by the MP status in dPDAC patients, the high MP infiltration rate, as well as improved survival in MP- dPDAC patients after R0CRM- resection, justify mesopancreatic excision during splenopancreatectomy. Larger scale studies are urgently needed to validate our results and to study the effect on neoadjuvant treatment in dPDAC patients.PMID:38625602 | DOI:10.1007/s00423-024-03320-0 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: S-A Safi A Alexander W Neuhuber L Haeberle A Rehders T Luedde I Esposito G Fluegen W T Knoefel Source Type: research
Comprehensive Assessment of the Intrinsic Pancreatic Microbiome
CONCLUSIONS: Our analysis of the pancreatic microbiome demonstrated very low intrinsic biomass that is relatively conserved across diverse neoplastic conditions and thus unlikely to drive malignant transformation.PMID:38623754 | DOI:10.1097/SLA.0000000000006299 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Austin M Eckhoff Ashley A Fletcher Matthew S Kelly Anders Dohlman Caitlin A McIntyre Xiling Shen Matthew K Iyer Daniel P Nussbaum Peter J Allen Source Type: research
Peripheral HMGB1 is linked to O < sub > 3 < /sub > pathology of disease-associated astrocytes and amyloid
DISCUSSION: Astrocytes and peripheral myeloid cells are critical lung-brain axis interactors. HMGB1 loss in peripheral myeloid cells regulates the O3-induced DAA phenotype. These findings demonstrate a mechanism and potential intervention target for air pollution-induced AD pathobiology.HIGHLIGHTS: Astrocytes are part of the lung-brain axis, regulating how air pollution affects plaque pathology. Ozone (O3) astrocyte effects are associated with increased plaques and modified by plaque localization. O3 uniquely disrupts the astrocyte transcriptomic and proteomic disease-associated astrocyte (DAA) phenotype in plaque associat...
Source: The Journal of Alzheimers Association - April 16, 2024 Category: Psychiatry Authors: Chandrama Ahmed Hendrik J Greve Carla Garza-Lombo Jamie A Malley James A Johnson Adrian L Oblak Michelle L Block Source Type: research
GSE253476 Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Contributors : Andrew S Mendiola ; Katerina Akassoglou ; Jae K RyuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTraumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into the brain. The impact of blood proteins, especially fibrinogen, on inflammation and neurodegeneration post-TBI is not fully understood, highlighting a critical gap in our comprehension of TBI pathology and its connection to innate immune activation. We combined vascular casting with 3D imaging of solvent-cleared organs (uDISCO) to stud...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
The role of teledermatology in Mohs micrographic surgery: a review
This study underscores TD’s multifaceted benefits in MMS: enhanced patient experience preopera tively, improved communication during surgery, and cost-effective postoperative follow-up. Limitations include the financial expense and technical issues that can arise with TD (connectivity problems, delays in video/audio transmission, etc.). Further studies are needed to explore emerging TD modali ties in post-operative patient management. The integration of TD into MMS signifies a progressive step in dermatological care, offering convenient, cost-effective, and better solutions with the potential to enhance patient experienc...
Source: Archives of Dermatological Research - April 16, 2024 Category: Dermatology Source Type: research
