Answer to Case 739
Answer toParasite Case of the Week 739:Loa loamicrofilariaeThanks to everyone who wrote in with comments. We received a lot of different responses including some of the sheathed and unsheathed microfilariae. Therefore, this is a great time to review my approach to identifying microfilariae in blood specimens. You can also readthis articleI wrote with Blaine Mathison and Marc Couturier that provides a diagnostic algorithm for microfilariae in blood. In this algorithm, we recommend first measuring the length of the microfilariae. If they are small (<200 micrometers long), then it is likely to be one of theMansonella...
Source: Creepy Dreadful Wonderful Parasites - March 2, 2024 Category: Parasitology Source Type: blogs
NPTX2 Involved in Neurodegeneration Driven by TDP-43 Aggregation
Altered, misfolded forms of TDP-43 are thought to contribute to neurodegeneration in a number of age-related conditions, primarily amyotrophic lateral sclerosis and frontotemporal dementia. As is the case for other misfolded proteins associated with neurodegeneration, aberrant TDP-43 may accumulate in much of the older population to levels sufficient to meaningfully contribute to cognitive decline. That TDP-43 has this negative impact is a relatively recent discovery, and in comparison to amyloid-β, tau, and α-synuclein little is known of the mechanisms by which TDP-43 aggregation causes dysfunction and death in brain ce...
Source: Fight Aging! - February 29, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Gut Microbiome and Alzheimer's Disease
The balance of microbial populations making up the gut microbiome changes with age, both a loss of microbes generating beneficial metabolites and an increase in the number of inflammatory microbes. Separately from this harmful process, a number of studies have shown that that aged gut microbiome is distinctly different in patients with Alzheimer's disease, suggesting that there may be a meaningful contribution to disease onset and progression arising from the gut. The precise mechanisms involved have yet to be identified. While inflammation has an important role in Alzheimer's disease, the contribution of an Alzheimer's-li...
Source: Fight Aging! - February 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Correlations with Mortality in Levels of Proteins Secreted by Senescent Cells
Here, researchers investigate correlations between late life mortality and levels of specific proteins produced by senescent cells as a part of the senescence-associated secretory phenotype (SASP). While looking over the paper, it is worth bearing in mind that circulating levels of many of the molecules thought to be important components of the SASP do not appear to correlate well with senescent cell burden. Why this is the case remains to be understood on a molecule by molecule basis, but note that many of the SASP molecules are widely used for signaling by other cell types and in other circumstances.
A robust an...
Source: Fight Aging! - February 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Circulating Claudin-5 Correlates with Age and Alzheimer's Disease
In this study, we developed a blood-based assay for CLDN-5 and investigated its diagnostic utility using 100 cognitively normal (control) subjects, 100 patients with MCI, and 100 patients with AD. Plasma CLDN-5 levels were increased in patients with AD (3.08 ng/mL) compared with controls (2.77 ng/mL).
The BBB functions as a selective gate for the uptake of essential molecules from blood into the brain and the excretion of harmful molecules from the brain into blood via transporters and receptors on cellular membranes. In addition, the BBB prevents the influx of blood-borne neurotoxins, cells, and pathogens into the ...
Source: Fight Aging! - February 21, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Astrocyte Reactivity in the Development of Alzheimer's Disease
Glial fibrillary acidic protein (GFAP) consistently shows up in proteomic analyses of age-related neurodegenerative processes, particularly now that more research groups are engaged in building early warning biomarker profiles for the later development of Alzheimer's disease. Such studies are usually focused on Alzheimer's disease because that is where most neuroscience funding is directed, but the presence of GFAP as a marker is more generally applicable to the aging of the brain and its supporting cell populations.
Astrocyte cells exhibit increased expression of GFAP when they become reactive, it is a well-known m...
Source: Fight Aging! - February 20, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why ICDs are less effective in Non Ischemic DCM ?
We wish, our understanding about cardiac contractile physiology is deep and nearly complete. Heart is an irreversibly coupled electro-mechanical organ , right from the fetal days until the final heart beat. In myocardial pathology, the genesis and sustainability of ventricular arrhythmia are intricately related to the degree of LV dysfunction of any cause.
SCD is the leading cause of mortality in heart failure. Tackling SCD was in God’s domain, until the brilliance of Dr. Michel Mirowski shrunk the defibrillator and implanted it under the chest in 1980. (Dr. MM’s s a unique and inspiring story, from Poland a...
Source: Dr.S.Venkatesan MD - February 20, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized crt device crt-p vs crt-d danish trial ischemic dcm madit trial non ischemic dcm Source Type: blogs
Bonus Features – February 18, 2024 – 89% of patients want a single platform for managing their health, 70% of organizations interested in AI plan to adopt solutions from their EHR vendors, plus 27 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
HHS designated two more QHINs: CommonWell Health Alliance and Kno2. This brings the total number of approved QHINs to seven.
eHealth Exchange is launching an incentive program that will waive annual fees for three years to...
Source: EMR and HIPAA - February 18, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Ambulatory Health IT Company Healthcare IT Hospital - Health System Akash Network AWS Health Equity Initiative Canopy CipherHealth CloudWave CommonWell Health Alliance DeepScribe Digital Health New York Discern Health eHealth Exc Source Type: blogs
World ’s Largest Radiology AI Marketplace CARPL Raises $6M to Accelerate the Adoption of AI in Clinical Workflows
Stellaris Venture Partners Leads $6 Million Investment into CARPL, the World’s First Enterprise-Grade Testing, Deployment, and Monitoring Platform for Radiology AI Applications; CARPL is Used by the World’s Leading Healthcare Providers to Improve the Productivity of their Radiologists and the Quality of Care Delivered to their Patients
As people live longer and as emphasis on early detection of disease increases, there is a mounting burden on the healthcare services industry globally. This is being especially felt in radiology teams who are witnessing an acute shortage of radiologists. Currently, there are over 200 com...
Source: EMR and HIPAA - February 15, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Akshant Goyal Alisha Moopen Alok Goyal Arjun Kalyanpur Aster DM Healthcare Bain & Co Boston Consulting Group CARPL Deepinder Goyal Dhruv Sahai Dr. Amit Kakar Dr. Felix Olale Dr. Garry Choy Dr. Source Type: blogs
The 2024 Word of the Year: Missense
By MIKE MAGEE
Not surprisingly, my nominee for “word of the year” involves AI, and specifically “the language of human biology.”
As Eliezer Yudkowski, the founder of the Machine Intelligence Research Institute and coiner of the term “friendly AI” stated in Forbes:
“Anything that could give rise to smarter-than-human intelligence—in the form of Artificial Intelligence, brain-computer interfaces, or neuroscience-based human intelligence enhancement – wins hands down beyond contest as doing the most to change the world. Nothing else is even in the same league.”
Perhaps the ...
Source: The Health Care Blog - February 13, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Biology Crispr DNA Mike Magee Source Type: blogs
Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people.
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Greater Individual Wealth Correlates with Longer Life Expectancy
https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Which doctor treats “ Y-36 ” disease ?
If anyone thinks doctors are the only unique and gifted people, who can treat diseases and mitigate human sufferings , realize how incorrect their understanding of the world, humanity & reality.
The ICD-11 , the latest code lists nearly 15000 diseases. Have a look at this much celebrated (respected ?) list put up by the world health organization There are so many entities in the list , that are man made and solution is right there in our minds.
Zoom your eyes on the red rectangle.
Impact of Y-36
Y-36 is a contagious endemic, transmitted by power, pride and foolishness . Y-36 along with violence i...
Source: Dr.S.Venkatesan MD - February 11, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Chest pain with anterior ST depression: look what happens if you use posterior leads.
Don ' t forget to watch theWebinar: Smith and Pendell Meyers interpret ECGs for OMI or not OMI on Monday Feb 12 at 11 AM U.S. Central time. Register here:https://zoom.us/webinar/register/7617067094184/WN_LMN0vPb1Rz-HZu12K-QuYQWritten by Jesse McLarenA 65 year old
with a history of atrial flutter, CABG and end-stage renal disease on dialysis presented
with 3 days of fluctuating chest pain, which was ongoing at triage. What do you
think? Do you need posterior leads?There ’s atrial
flutter with controlled ventricular response, a non-specific intra-ventricular
conduction delay, borderline right axis, normal R wave...
Source: Dr. Smith's ECG Blog - February 9, 2024 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Glial Cell Senescence Impairs α-Synuclein Clearance, Contributing to Parkinson's Disease
In this study, we investigated how aging and glial senescence affect the capacity of α-syn clearance. We found that following the intra-striatal injection of human α-syn (hu-α-syn) preformed fibril, hu-α-syn pathology persisted more in aged mice compared with younger mice and that aged microglia exhibited greater accumulation of hu-α-syn than younger microglia. Moreover, in vitro assay revealed that the clearance of hu-α-syn was primarily dependent on the autophagy-lysosome system rather than on the ubiquitin-proteasome system and that the capacity of hu-α-syn clearance was diminished in senescent glia because of au...
Source: Fight Aging! - February 8, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs