Can you try these two questions on Amyloid ?

Is it a physiological molecule ? 1.Yes, It is a physiological molecule. 2.No, Amyloid is always pathological. Where does it gets deposited ? A .Extracellular* B. Intracellular C. Both Answer : Q 1: A / Q 2: C. It is indeed a physiological molecule in small amounts that help carry hormones across the blood. In pathology, it accumulates in huge amounts. It is a disorder of protein folding, making them thick, stiff , sheets of peptide, hence mis-behaving with adjacent cells, injuring them in the process. This is responsible for the systemic nature of disorder right from the brain to peripheral nerves, Heart, kidneys, liver, spleen, etc. (Ref 1) (*It should be stressed , majority of deposition occurs in extracellular space.They clog the interstitial space, also can invade the cell, especially in neurons in Alzheimer’s disease . Now we have evidence that Aβ (A beta) get into the myocytes as well. (Troncone L, J Am Coll Cardiol. 2016) Fellows, better say amyloid is primarily extracellular, but, by pressure effect and injury of cell membrane it results in cell death.) Ultrastructural Organization of Amyloid Fibrils byAtomic Force Microscopy Image source Chamberlain AK, . Biophys J. 2000 Dec;79(6):3282-93. Can we dissolve it or get rid of it ? Till now, these disorders has been termed as a degenerative disease with no viable options. Now, we have made a breakthrough. A group of drugs genetically created work by unfolding the proteins b...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized Alzheimer disease amyloidosis ttr amyloid what is amyloid Source Type: blogs