Profile of metacaspase gene expression in Plasmodium vivax field isolates from the Brazilian Amazon
CONCLUSION: The detection of metacaspases in P. vivax blood-stage parasites reported herein, allows the inclusion of these proteases as a potential candidate drug target for vivax malaria, while further investigations are still required to evaluate the activity, role and essentiality of metacaspases in P. vivax biology.PMID:38683374 | DOI:10.1007/s11033-024-09538-x (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Carolina Moreira Blanco Hugo Amorim Dos Santos de Souza Priscilla da Costa Martins Camila Fabbri Fernanda Souza de Souza Josu é da Costa Lima-Junior Stefanie Costa Pinto Lopes Lilian Rose Pratt-Riccio Cl áudio Tadeu Daniel-Ribeiro Paulo Renato Rivas Tot Source Type: research
Inside the Host: Understanding the Evolutionary Trajectories of Intracellular Parasitism
Annu Rev Microbiol. 2024 Apr 29. doi: 10.1146/annurev-micro-041222-025305. Online ahead of print.ABSTRACTThis review explores the origins of intracellular parasitism, an intriguing facet of symbiosis, where one organism harms its host, potentially becoming deadly. We focus on three distantly related groups of single-celled eukaryotes, namely Kinetoplastea, Holomycota, and Apicomplexa, which contain multiple species-rich lineages of intracellular parasites. Using comparative analysis of morphological, physiological, and molecular features of kinetoplastids, microsporidians, and sporozoans, as well as their closest free-livi...
Source: Annual Review of Microbiology - April 29, 2024 Category: Microbiology Authors: Pavla Barto šová-Sojková Anzhelika Butenko Jitka Richtov á Ivan Fiala Miroslav Oborn ík Julius Luke š Source Type: research
Seroprevalence of < em > Toxocara < /em > spp. in Pregnant Women: A Systematic Review and Meta-Analysis
CONCLUSIONS: In the present study, significant prevalence was reported; however, considering the limited number of studies, it seems that the actual prevalence of the disease is higher. Therefore, it seems necessary to monitor this health problem in pregnant women.PMID:38682081 | PMC:PMC11055642 | DOI:10.1155/2024/1943353 (Source: Infectious Diseases in Obstetrics and Gynecology)
Source: Infectious Diseases in Obstetrics and Gynecology - April 29, 2024 Category: OBGYN Authors: Sara Shayanfar Saeed Bahadory Ali Taghipour Masoud Foroutan Amir Abdoli Source Type: research
Profile of metacaspase gene expression in Plasmodium vivax field isolates from the Brazilian Amazon
CONCLUSION: The detection of metacaspases in P. vivax blood-stage parasites reported herein, allows the inclusion of these proteases as a potential candidate drug target for vivax malaria, while further investigations are still required to evaluate the activity, role and essentiality of metacaspases in P. vivax biology.PMID:38683374 | DOI:10.1007/s11033-024-09538-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Carolina Moreira Blanco Hugo Amorim Dos Santos de Souza Priscilla da Costa Martins Camila Fabbri Fernanda Souza de Souza Josu é da Costa Lima-Junior Stefanie Costa Pinto Lopes Lilian Rose Pratt-Riccio Cl áudio Tadeu Daniel-Ribeiro Paulo Renato Rivas Tot Source Type: research
Infections and fever
Z Rheumatol. 2024 Apr 29. doi: 10.1007/s00393-024-01503-0. Online ahead of print.ABSTRACTFever can be due to infectious or noninfectious causes and results from the body's natural response to exogenous or endogenous pyrogens. Laboratory tests including complete blood count, differential blood count, C‑reactive protein, erythrocyte sedimentation rate and procalcitonin do not have sufficient sensitivity and specificity to definitively detect or rule out an infectious (bacterial, viral, parasitic) cause of fever. Blood cultures should be carried out when bacteremic or septic illnesses are suspected. Fever is not always pres...
Source: Zeitschrift fur Rheumatologie - April 29, 2024 Category: Rheumatology Authors: Stefan Schmiedel Source Type: research
Italian peninsula as a hybridization zone of Ixodes inopinatus and I. ricinus and the prevalence of tick-borne pathogens in I. inopinatus, I. ricinus, and their hybrids
Ixodes inopinatus was described from Spain on the basis of morphology and partial sequencing of 16S ribosomal DNA. However, several studies suggested that morphological differences between I. inopinatus and Ixode... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 29, 2024 Category: Microbiology Authors: Ond řej Daněk, Alena Hrbatová, Karolina Volfová, Sylvie Ševčíková, Paulina Lesiczka, Markéta Nováková, Sajjad Ghodrati, Kristyna Hrazdilova, Vincenzo Veneziano, Ettore Napoli, Domenico Otranto, Fabrizio Montarsi, Andrei Daniel Mihalca, Noureddi Tags: Research Source Type: research
Efficacy of monthly treatment with oral fluralaner (Bravecto ® 1-Month) against Tunga penetrans in dogs in Brazil: a randomized, double-blind, controlled field study
Tungiasis is a neglected tropical disease caused by the adult female sand flea (Tunga penetrans). Dogs are considered important reservoirs of T. penetrans in Brazil. The aim of this study was to determine the mon... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 29, 2024 Category: Microbiology Authors: Katharine Costa dos Santos, Paula Elisa Brand ão Guedes, George Rêgo Albuquerque, Anderson Vieira de Jesus, Anaiá da Paixão Sevá, Joana Thaisa Santos de Oliveira, Jamille Bispo de Carvalho Teixeira, Thammy Vieira Bitar, Tatiani Vitor Harvey, Sofia Na Tags: Research Source Type: research
A 11-year-old boy with Blastocystis hominis infection, presents as immune thrombocytopenia
Some causes of first-line treatment failure for ITP are often closely related to infections. But parasitic infections are rarely mentioned and easily overlooked. The case is the first to describe a boy with im... (Source: Thrombosis Journal)
Source: Thrombosis Journal - April 29, 2024 Category: Hematology Authors: Fajuan Tang, Dongqiong Xiao, Lin Chen, Xihong Li and Lina Qiao Tags: Case Report Source Type: research
Molecular diagnosis of human toxoplasmosis: the state of the art
AbstractToxoplasma gondii (T. gondii) is an obligate intracellular apicomplexan protozoan that causes toxoplasmosis. Approximately one-third of the world ’s population is currentlyT. gondii-seropositive. Although most infections are symptomless, a few can produce retinal lesions and, in immunocompromised persons or when congenitally contracted, can progress to life-threatening central nervous system disseminated infections. Therefore, quick, and precise diagnosis is a must. Molecular techniques nowadays play a crucial role in toxoplasmosis diagnosis, particularly in immunocompromised patients or congenital toxoplasmosis....
Source: Journal of Parasitic Diseases - April 29, 2024 Category: Parasitology Source Type: research
An insight into the epidemiology of foodborne zoonotic fascioliasis in small ruminants in northwestern region of Bangladesh
AbstractFascioliasis is one of the most common foodborne zoonotic infection of ruminants in Bangladesh. To estimate the prevalence and associated risk factors of fascioliasis and extent of liver damage, 825 livers of sheep and goats were randomly inspected during onsite slaughterhouse visiting in Naogaon, Natore, Rajshahi and Joypurhat districts. The overall prevalence of fascioliasis was 25.09% and significantly (P = 0.008) higher in goats (26.11%) than sheep (24.00%). During gross inspection,Fasciola infected livers were increased in size, fibrosed, fatty, multiple white or reddish necrotic foci on the parietal surfa...
Source: Journal of Parasitic Diseases - April 29, 2024 Category: Parasitology Source Type: research
Tick species diversity and potential distribution alternation of dominant ticks under different climate scenarios in Xinjiang, China
This study constructed a dataset of tick species distribution in Xinjiang for 60 years based on literature database retrieval and historical data collection (January 1963-January 2023). The distribution data were extracted, corrected, and deduplicated. The dominant tick species were selected for analysis using the MaxEnt model to assess their potential distribution in different periods under the current and BCC-CSM2.MR mode scenarios. The results indicated that there are eight genera and 48 species of ticks in 108 cities and counties of Xinjiang, withHyalomma asiaticum,Rhipicephalus turanicus,Dermacentor marginatus, andHae...
Source: PLoS Neglected Tropical Diseases - April 29, 2024 Category: Tropical Medicine Authors: Rui Ma Source Type: research
Validation of deep amplicon sequencing of < i > Dicrocoelium < /i > in small ruminants from Northern regions of Pakistan
In conclusion each sample was identified asD.dendriticum based on the proportion of MiSeq reads and validated the presence of this group of parasites in the Gilgit Baltistan and Khyber Pakhtunkhwa provinces of Pakistan. The metabarcoding deep amplicon sequencing technology and bioinformatics pathway have several potential applications, including species interactions during co-infections, identifying the host and geographical distribution ofDicrocoelium in livestock, drug therapy response evaluation and understanding of the emergence and spread of drug resistance. (Source: PLoS One)
Source: PLoS One - April 29, 2024 Category: Biomedical Science Authors: Muhammad Asim Khan Source Type: research
Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline
Eur J Pharm Biopharm. 2024 Apr 26:114306. doi: 10.1016/j.ejpb.2024.114306. Online ahead of print.ABSTRACTIn the context of neglected diseases, tegumentary leishmaniasis (TL) presents an emerging and re-emerging character in the national territory and in the world. The treatment of TL has limitations, such as intravenous administration route, high toxicity, and high treatment costs. Thus, several researchers work on new therapeutic strategies to improve the effectiveness of the treatment of leishmaniasis. In this light, the present study used a topical formulation, containing 8-hydroquinoline (8-HQN), for the treatment of B...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 28, 2024 Category: Drugs & Pharmacology Authors: Naianda Rezende Ribeiro Lucas Magno Oliveira Santos Scarleth Silva Costa Carolina Kei Myasaki Daniela Pagliara Lage Vivian Tamietti Martins Rory Cristiane Fortes De Brito Larissa Chaves Freire Ana Maria Ravena Severino Carvalho Bryan Victor Serafim Brigid Source Type: research
The impact of miRNA-155 in acute and chronic toxoplasmosis in Iraqi women
The objective of this study is to assess the expression of miR-155 and its targets, Src homology-2 domain-containing inositol 5- phosphatase 1 (SHIP-1) and suppressor of cytokine signaling-1 (SOCS1), in non-pregnant Iraqi women seropositive for toxoplasmosis. The study included 55 non-pregnant women positive for toxoplasmosis (20 in the acute phase and 35 in the chronic phase) and 35 non-pregnant women negative for toxoplasmosis (control group). Serum samples were collected from all participants to investigate the expression of miR-155 by RT‒PCR, in addition to the levels of SOCS1 and SHIP-1 measured by ELISA. The result...
Source: Acta Tropica - April 28, 2024 Category: Infectious Diseases Authors: Hiba A Qassim Sabaa T Mohammed Haider J Muhamed Source Type: research
The impact of miRNA-155 in acute and chronic toxoplasmosis in Iraqi women
The objective of this study is to assess the expression of miR-155 and its targets, Src homology-2 domain-containing inositol 5- phosphatase 1 (SHIP-1) and suppressor of cytokine signaling-1 (SOCS1), in non-pregnant Iraqi women seropositive for toxoplasmosis. The study included 55 non-pregnant women positive for toxoplasmosis (20 in the acute phase and 35 in the chronic phase) and 35 non-pregnant women negative for toxoplasmosis (control group). Serum samples were collected from all participants to investigate the expression of miR-155 by RT‒PCR, in addition to the levels of SOCS1 and SHIP-1 measured by ELISA. The result...
Source: Acta Tropica - April 28, 2024 Category: Infectious Diseases Authors: Hiba A Qassim Sabaa T Mohammed Haider J Muhamed Source Type: research
