Taxonomy, Phylogeny, and Host Expansion of Powdery Mildew Fungi Parasitic to < em > Veronica < /em > Species
This study aimed to identify the causative agent of powdery mildew on Veronica spp. in Korea through molecular phylogenetic analysis of internal transcribed spacer (ITS) and large subunit (LSU) sequences of rDNA and morphological examination. Our study identified Golovinomyces bolayi as the sole pathogen affecting all nine Veronica species in Korea and confirmed that G. cichoracearum s. str., which was previously identified as the pathogen, was not the causal agent. These results expand the known host range of G. bolayi, including the addition of five Veronica species in Korea: V. hederifolia, V. kiusiana var. glabrifolia,...
Source: Mycobiology - May 1, 2024 Category: Biology Authors: Jun Hyuk Park Young-Joon Choi Hyeon-Dong Shin Source Type: research
First report on prevalence, molecular characterization and phylogenetic study of Toxoplasma gondii infecting sheep of the Malakand Division of Pakistan
Comp Immunol Microbiol Infect Dis. 2024 Apr 18;109:102184. doi: 10.1016/j.cimid.2024.102184. Online ahead of print.ABSTRACTBACKGROUND: Toxoplasma gondii is an apicomplexan protozoan parasite that infects one-third of the population of the world, including humans, animals, birds, and other vertebrates. The present investigation is the first molecular attempt in the Malakand Division of Pakistan to determine the epidemiology and phylogenetic study of Toxoplasma gondii infecting small ruminants.METHODOLOGY: A total of (N = 450) blood samples of sheep were randomly collected during the study period (December 2020 to November 2...
Source: Comparative immunology, microbiology and infectious diseases. - May 1, 2024 Category: Allergy & Immunology Authors: Ahmad Irshad Shumaila Noreen Faisal Nouroz Akhtar Rasool Mingkun Zhu Mohamed Mohany Source Type: research
Lactic Acid Conjugated SLN for Effective Management of Neurocysticercosis
Background: Neurocysticercosis(NCC) is a primary infection of brain, spinal cord or peri-meningeal structures with the larval forms of Taenia solium and associated inflammation, which is aggravated by debris of parasites by anthelminthics. The study aimed to develop Lactic acid(LA)-conjugated solid lipid nanoparticles(SLN-LA) bearing albendazole(ALB) and prednisolone(PRD) for effective management of NCC. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: V. Bhargava, S. Bhargava Source Type: research
Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 29;79:102484. doi: 10.1016/j.mib.2024.102484. Online ahead of print.ABSTRACTLong noncoding RNAs (lncRNA) are emerging as important regulators of gene expression in eukaryotes. In recent years, a large repertoire of lncRNA were discovered in Apicomplexan parasites and were implicated in several mechanisms of gene expression, including marking genes for activation, contributing to the formation of subnuclear compartments and organization, regulating the deposition of epigenetic modifications, influencing chromatin and chromosomal structure and manipulating host gene expression. Here, we aim to u...
Source: Current Opinion in Microbiology - April 30, 2024 Category: Microbiology Authors: Vera Mitesser Karina Simantov Ron Dzikowski Source Type: research
Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 29;79:102484. doi: 10.1016/j.mib.2024.102484. Online ahead of print.ABSTRACTLong noncoding RNAs (lncRNA) are emerging as important regulators of gene expression in eukaryotes. In recent years, a large repertoire of lncRNA were discovered in Apicomplexan parasites and were implicated in several mechanisms of gene expression, including marking genes for activation, contributing to the formation of subnuclear compartments and organization, regulating the deposition of epigenetic modifications, influencing chromatin and chromosomal structure and manipulating host gene expression. Here, we aim to u...
Source: Current Opinion in Microbiology - April 30, 2024 Category: Microbiology Authors: Vera Mitesser Karina Simantov Ron Dzikowski Source Type: research
Deletions of Histidine-Rich Protein 2/3 Genes in Natural Plasmodium falciparum Populations from Cameroon and India: Role of Asymptomatic and Submicroscopic Infections
This study outlines that double deletions that result in false negative RDTs are uncommon in our settings, and highlights the importance of active molecular surveillance for pfhrp2/3 deletions in Cameroon and India.PMID:38688260 | DOI:10.4269/ajtmh.23-0896 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Loick Pradel Kojom Foko Carole Else Eboumbou Moukoko Jahnvi Jakhan Geetika Narang Joseph Hawadak Francine Dorgelesse Kouemo Motse Veena Pande Vineeta Singh Source Type: research
Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review
Am J Trop Med Hyg. 2024 Apr 30:tpmd240047. doi: 10.4269/ajtmh.24-0047. Online ahead of print.ABSTRACTExtralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred vision in his right eye. A small, slender, coiled worm was found and surgically removed from the right anterior chamber. Histopathological examination illustrated predominant eosinophilic inflammation surrounding the parasite, which showed smooth and t...
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Narut Suphap Thanapong Somkijrungroj Wijak Kongwattananon Wajamon Supawatjariyakul Thanapat Pataradool Kanyarat Kraivichian Watsamon Jantarabenjakul Wasee Tulvatana Kanok Preativatanyou Source Type: research
Seroprevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women in Algeria
Am J Trop Med Hyg. 2024 Apr 30:tpmd230187. doi: 10.4269/ajtmh.23-0187. Online ahead of print.ABSTRACTToxoplasma gondii is an obligate intracellular protozoan parasite affecting all warm-blooded vertebrates, including humans. Infections in humans can lead to severe clinical manifestations in pregnant women and immunocompromised patients. The aim of the present study was to assess seroprevalence of T. gondii infection and to identify the associated risk factors among pregnant women from southern Algeria. A cross-sectional study was conducted from March 2021 to May 2022 among 1,345 pregnant women. A structured questionnaire w...
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Soumia Sebaa Jerzy M Behnke Amina Labed Marawan A Abu-Madi Source Type: research
Deletions of Histidine-Rich Protein 2/3 Genes in Natural Plasmodium falciparum Populations from Cameroon and India: Role of Asymptomatic and Submicroscopic Infections
This study outlines that double deletions that result in false negative RDTs are uncommon in our settings, and highlights the importance of active molecular surveillance for pfhrp2/3 deletions in Cameroon and India.PMID:38688260 | DOI:10.4269/ajtmh.23-0896 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 30, 2024 Category: Tropical Medicine Authors: Loick Pradel Kojom Foko Carole Else Eboumbou Moukoko Jahnvi Jakhan Geetika Narang Joseph Hawadak Francine Dorgelesse Kouemo Motse Veena Pande Vineeta Singh Source Type: research
Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review
Am J Trop Med Hyg. 2024 Apr 30:tpmd240047. doi: 10.4269/ajtmh.24-0047. Online ahead of print.ABSTRACTExtralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred vision in his right eye. A small, slender, coiled worm was found and surgically removed from the right anterior chamber. Histopathological examination illustrated predominant eosinophilic inflammation surrounding the parasite, which showed smooth and t...
Source: The American Journal of Tropical Medicine and Hygiene - April 30, 2024 Category: Tropical Medicine Authors: Narut Suphap Thanapong Somkijrungroj Wijak Kongwattananon Wajamon Supawatjariyakul Thanapat Pataradool Kanyarat Kraivichian Watsamon Jantarabenjakul Wasee Tulvatana Kanok Preativatanyou Source Type: research
Seroprevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women in Algeria
Am J Trop Med Hyg. 2024 Apr 30:tpmd230187. doi: 10.4269/ajtmh.23-0187. Online ahead of print.ABSTRACTToxoplasma gondii is an obligate intracellular protozoan parasite affecting all warm-blooded vertebrates, including humans. Infections in humans can lead to severe clinical manifestations in pregnant women and immunocompromised patients. The aim of the present study was to assess seroprevalence of T. gondii infection and to identify the associated risk factors among pregnant women from southern Algeria. A cross-sectional study was conducted from March 2021 to May 2022 among 1,345 pregnant women. A structured questionnaire w...
Source: The American Journal of Tropical Medicine and Hygiene - April 30, 2024 Category: Tropical Medicine Authors: Soumia Sebaa Jerzy M Behnke Amina Labed Marawan A Abu-Madi Source Type: research
Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 29;79:102484. doi: 10.1016/j.mib.2024.102484. Online ahead of print.ABSTRACTLong noncoding RNAs (lncRNA) are emerging as important regulators of gene expression in eukaryotes. In recent years, a large repertoire of lncRNA were discovered in Apicomplexan parasites and were implicated in several mechanisms of gene expression, including marking genes for activation, contributing to the formation of subnuclear compartments and organization, regulating the deposition of epigenetic modifications, influencing chromatin and chromosomal structure and manipulating host gene expression. Here, we aim to u...
Source: Current Opinion in Microbiology - April 30, 2024 Category: Microbiology Authors: Vera Mitesser Karina Simantov Ron Dzikowski Source Type: research
The ecto-3'-nucleotidase activity of Acanthamoeba castellanii trophozoites increases their adhesion to host cells through the generation of extracellular adenosine
Eur J Protistol. 2024 Apr 26;94:126086. doi: 10.1016/j.ejop.2024.126086. Online ahead of print.ABSTRACTAcanthamoeba castellanii, a free-living amoeba, can be pathogenic to humans causing a corneal infection named Acanthamoeba keratitis (AK). The mannose-binding protein (MBP) is well established as the major factor related to Acanthamoeba pathogenesis. However, additional factors that participate in the adhesion process and protect trophozoites from cytolytic effects caused by host immune responses remain unknown. Ectonucleotidases, including 3'-nucleotidase/nuclease (3'-NT/NU), a bifunctional enzyme that was recently repor...
Source: European Journal of Protistology - April 30, 2024 Category: Microbiology Authors: Eduarda de Souza-Maciel Luiz Fernando Carvalho-Kelly Anita Leocadio Freitas-Mesquita Jos é Roberto Meyer-Fernandes Source Type: research
Drugs in preclinical and early clinical development for the treatment of chagas disease: the current status
Expert Opin Investig Drugs. 2024 Apr 30. doi: 10.1080/13543784.2024.2349289. Online ahead of print.ABSTRACTINTRODUCTION: Chagas disease is spreading faster than expected in different countries and little progress has been reported in the discovery of new drugs to combat Trypanosoma cruzi infection in humans. Recent clinical trials have ended with small hope. The pathophysiology of this neglected disease and the genetic diversity of parasites are exceptionally complex. The only two drugs available to treat patients are far from being safe, and their efficacy in the chronic phase is still unsatisfactory.AREAS COVERED: This r...
Source: Expert Opinion on Investigational Drugs - April 30, 2024 Category: Drugs & Pharmacology Authors: Fernanda Karoline Vieira da Silva Torchelsen Ana Lia Mazzeti Vanessa Carla Furtado Mosqueira Source Type: research
Seroprevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women in Algeria
Am J Trop Med Hyg. 2024 Apr 30:tpmd230187. doi: 10.4269/ajtmh.23-0187. Online ahead of print.ABSTRACTToxoplasma gondii is an obligate intracellular protozoan parasite affecting all warm-blooded vertebrates, including humans. Infections in humans can lead to severe clinical manifestations in pregnant women and immunocompromised patients. The aim of the present study was to assess seroprevalence of T. gondii infection and to identify the associated risk factors among pregnant women from southern Algeria. A cross-sectional study was conducted from March 2021 to May 2022 among 1,345 pregnant women. A structured questionnaire w...
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Soumia Sebaa Jerzy M Behnke Amina Labed Marawan A Abu-Madi Source Type: research
