Leishmania vaccine development: A comprehensive review
Cell Immunol. 2024 Apr 23;399-400:104826. doi: 10.1016/j.cellimm.2024.104826. Online ahead of print.ABSTRACTInfectious diseases like leishmaniasis, malaria, HIV, tuberculosis, leprosy and filariasis are responsible for an immense burden on public health systems. Among these, leishmaniasis is under the category I diseases as it is selected by WHO (World Health Organization) on the ground of diversity and complexity. High cost, resistance and toxic effects of Leishmania traditional drugs entail identification and development of therapeutic alternative. Since the natural infection elicits robust immunity, consistence efforts ...
Source: Cellular Immunology - April 26, 2024 Category: Allergy & Immunology Authors: Isha Saini Jyoti Joshi Sukhbir Kaur Source Type: research
Lysosomal diacylglycerol pyrophosphate phosphatase is not essential in Trypanosoma brucei
In this study through RNAi suppression, we have demonstrated that Trypanosoma brucei diacylglycerol pyrophosphate phosphatase 1 (TbDpp1) procyclic form production is not required for parasite survival in culture. The steady-state levels of triacylglycerol (TAG), the number of lipid droplets, and the PA content are all maintained constant through the inducible down-regulation of TbDpp1. Furthermore, the localization of C-terminally tagged variants of TbDpp1 in the lysosome was demonstrated by immunofluorescence microscopy.PMID:38668789 | DOI:10.1007/s11033-024-09547-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 26, 2024 Category: Molecular Biology Authors: Ladan Dawoody Nejad Tiziana Annese Domenico Ribatti Source Type: research
Leishmania vaccine development: A comprehensive review
Cell Immunol. 2024 Apr 23;399-400:104826. doi: 10.1016/j.cellimm.2024.104826. Online ahead of print.ABSTRACTInfectious diseases like leishmaniasis, malaria, HIV, tuberculosis, leprosy and filariasis are responsible for an immense burden on public health systems. Among these, leishmaniasis is under the category I diseases as it is selected by WHO (World Health Organization) on the ground of diversity and complexity. High cost, resistance and toxic effects of Leishmania traditional drugs entail identification and development of therapeutic alternative. Since the natural infection elicits robust immunity, consistence efforts ...
Source: Cellular Immunology - April 26, 2024 Category: Allergy & Immunology Authors: Isha Saini Jyoti Joshi Sukhbir Kaur Source Type: research
Lysosomal diacylglycerol pyrophosphate phosphatase is not essential in Trypanosoma brucei
In this study through RNAi suppression, we have demonstrated that Trypanosoma brucei diacylglycerol pyrophosphate phosphatase 1 (TbDpp1) procyclic form production is not required for parasite survival in culture. The steady-state levels of triacylglycerol (TAG), the number of lipid droplets, and the PA content are all maintained constant through the inducible down-regulation of TbDpp1. Furthermore, the localization of C-terminally tagged variants of TbDpp1 in the lysosome was demonstrated by immunofluorescence microscopy.PMID:38668789 | DOI:10.1007/s11033-024-09547-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 26, 2024 Category: Molecular Biology Authors: Ladan Dawoody Nejad Tiziana Annese Domenico Ribatti Source Type: research
Transcriptome analysis reveals that gga-miR-2954 inhibits the inflammatory response against Eimeria tenella infection
In conclusion, our study was the first to identify differentially expressed miRNAs in chicken cecal tissue during E. tenella infection and found that gga-miR-2954 regulates the host immune response to coccidial infection in chickens by targeting the RORC gene.PMID:38670189 | DOI:10.1016/j.ijbiomac.2024.131807 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 26, 2024 Category: Biochemistry Authors: Hailiang Yu Jianqiang Tang Liyue Dong Meihui Tang AreeJ Arif Tao Zhang Genxi Zhang Kaizhou Xie Zhenhua Zhao Guojun Dai Source Type: research
Seroprevalence and molecular detection of Toxoplasma gondii and Neospora caninum in beef cattle and goats in Hunan province, China
Toxoplasma gondii and Neospora caninum are closely related protozoan parasites that are considered important causes of abortion in livestock, causing huge economic losses. Hunan Province ranks 12th in the product... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 26, 2024 Category: Microbiology Authors: Xi-Long Yi, Wen-He Yang, He-Liang Zheng, Mei-Ling Cao, Jun Xiong, Wen-Cheng Chen, Yu-Jing Zhou, Fen Li, Xing-Quan Zhu and Guo-Hua Liu Tags: Research Source Type: research
Human and camel cystic echinococcosis – a polyclonal antibody-based sandwich ELISA for its serodiagnosis with molecular identification
In conclusion, Sandwich ELISA technique was found to be a potent and sensitive assay for detection of hydatid antigen in both human and camel samples. (Source: Veterinary Research Communications)
Source: Veterinary Research Communications - April 26, 2024 Category: Veterinary Research Source Type: research
Phenotypic and functional characteristics of monocyte subsets in the blood and bone marrow of Indian subjects with Visceral Leishmaniasis
We examined monocyte subsets in the blood and bone marrow of patients with VL from an endemic site in Bihar, India, and found these contrasted with the roles of monocytes in CL. During VL, intermediate and non-clas sical CD16+ monocyte subsets expressed instead a non-inflammatory phenotype with low CCR2, high CX3CR1 and low microbicidal oxidant generation, making them more similar to patrolling monocytes than inflammatory cells. Bone marrow CD16+ monocyte subsets expressed a phenotype that might be more simila r to the inflammatory subsets of CL, although our inability to obtain bone marrow from healthy donors in the endem...
Source: PLoS Neglected Tropical Diseases - April 26, 2024 Category: Tropical Medicine Authors: Gulafsha Kausar Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
