Anhydroparthenin as a dual-target inhibitor against Sterol C-24 methyltransferase and Sterol 14- α demethylase of Leishmania donovani: A comprehensive in vitro and in silico study
Int J Biol Macromol. 2024 May 1:132034. doi: 10.1016/j.ijbiomac.2024.132034. Online ahead of print.ABSTRACTParthenium hysterophorus plant has a diverse chemical profile and immense bioactive potential. It exhibits excellent pharmacological properties such as anti-cancer, anti-inflammatory, anti-malarial, microbicidal, and anti-trypanosomal. The present study aims to evaluate the anti-leishmanial potential and toxicological safety of anhydroparthenin isolated from P. hysterophorus. Anydroparthenin was extracted from the leaves of P. hysterophorus and characterized through detailed analysis of 1H, 13C NMR, and HRMS. Dye-base...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Diksha Kumari Parampreet Kour Chetan Paul Singh Rinku Choudhary Syed Mudassir Ali Sagar Bhayye Yogesh P Bharitkar Kuljit Singh Source Type: research
Redescription of adults and first description of the larva of Haemaphysalis (Rhipistoma) adleri Feldman-Muhsam, 1951 (Acari: Ixodidae), parasite of carnivorans in Western Asia
Syst Parasitol. 2024 May 3;101(3):36. doi: 10.1007/s11230-024-10156-1.ABSTRACTThe adults of Haemaphysalis (Rhipistoma) adleri Feldman-Muhsam, 1951 (Acari: Ixodidae) are redescribed and the larva of this species is described for the first time here. The adults of H. adleri that we studied were collected from various canid, felid and hyaenid carnivorans (Carnivora: Canidae, Felidae, Hyaenidae) as well as a hedgehog (Erinaceomorpha: Erinaceidae) in Iraq, Israel and West Bank. The males, females and larvae of H. adleri can be differentiated from Haemaphysalis (Rhipistoma) species occurring in the Palearctic portion of West Asi...
Source: Systematic Parasitology - May 3, 2024 Category: Parasitology Authors: Cole C Anderson Maria A Apanaskevich Kosta Y Mumcuoglu Dmitry A Apanaskevich Source Type: research
Integrative Taxonomy of Urocleidoides spp. (Monogenoidea, Dactylogyridae) Parasites of Pseudanos trimaculatus (Characiformes: Anostomidae) from Eastern Amazon, Brazil
This study represents the first record of monogenoids from the gills of P. trimaculatus for the Eastern Amazon.PMID:38700732 | DOI:10.1007/s11230-024-10154-3 (Source: Systematic Parasitology)
Source: Systematic Parasitology - May 3, 2024 Category: Parasitology Authors: Jo ão F Santos-Neto Marcus V Domingues Source Type: research
Nomenclatural stability and the longevity of helminth species names
Syst Parasitol. 2024 May 3;101(3):34. doi: 10.1007/s11230-024-10161-4.ABSTRACTAlthough most Latin binomial names of species are valid, many are eventually unaccepted when they are found to be synonyms of previously described species, or superseded by a new combination when the species they denote are moved to a different genus. What proportion of parasite species names become unaccepted over time, and how long does it take for incorrect names to become unaccepted? Here, we address these questions using a dataset comprising thousands of species names of parasitic helminths from four higher taxa (Acanthocephala, Nematoda, Ce...
Source: Systematic Parasitology - May 3, 2024 Category: Parasitology Authors: Robert Poulin Bronwen Presswell Source Type: research
Not that many leech species after all: Myzobdella lugubris and Myzobdella patzcuarensis (Annelida: Hirudinida) are the same species
Syst Parasitol. 2024 May 3;101(3):38. doi: 10.1007/s11230-024-10160-5.ABSTRACTThe genus Myzobdella groups five species of leeches parasites of fishes mainly of freshwater but with tolerance to brackish waters. Native distribution of these species includes the New World from North to South America. Myzobdella lugubris Leidy, 1851, the type species of the genus, was briefly described based on specimens from the USA, but subsequently their morphology, known distribution and host range were expanded; however, less is known about the other four species of the genus. As part of a survey focusing on characterizing the diversity o...
Source: Systematic Parasitology - May 3, 2024 Category: Parasitology Authors: Gerardo Torres-Carrera Yanet Vel ázquez-Urrieta Ana Santacruz Source Type: research
Anhydroparthenin as a dual-target inhibitor against Sterol C-24 methyltransferase and Sterol 14- α demethylase of Leishmania donovani: A comprehensive in vitro and in silico study
Int J Biol Macromol. 2024 May 1:132034. doi: 10.1016/j.ijbiomac.2024.132034. Online ahead of print.ABSTRACTParthenium hysterophorus plant has a diverse chemical profile and immense bioactive potential. It exhibits excellent pharmacological properties such as anti-cancer, anti-inflammatory, anti-malarial, microbicidal, and anti-trypanosomal. The present study aims to evaluate the anti-leishmanial potential and toxicological safety of anhydroparthenin isolated from P. hysterophorus. Anydroparthenin was extracted from the leaves of P. hysterophorus and characterized through detailed analysis of 1H, 13C NMR, and HRMS. Dye-base...
Source: International Journal of Biological Macromolecules - May 3, 2024 Category: Biochemistry Authors: Diksha Kumari Parampreet Kour Chetan Paul Singh Rinku Choudhary Syed Mudassir Ali Sagar Bhayye Yogesh P Bharitkar Kuljit Singh Source Type: research
NKG2C+CD57+ natural killer with senescent features cells are induced in cutaneous leishmaniasis and accumulate in patients with lesional healing impairment
This study provides a broad understanding of the NK cell biology during Leishmania infection and reinforces the role of senescent cells in the adverse clinical outcomes of cutaneous leishmaniasis.PMID:38700066 | DOI:10.1093/cei/uxae040 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Luciana Polaco Covre Carlos Henrique Fantecelle Ariadne Mendes Queiroz Julia Miranda Fardin Pedro Henrique Miranda Sian Henson Alessandra Marcia da Fonseca-Martins Herbert Leonel de Matos Guedes David Mosser Aloisio Falqueto Arne Akbar Daniel Claudio Oliv Source Type: research
GSE266399 Cytoadhesion of Plasmodium falciparum-infected red blood cells changes the expression of cytokine-, histone- and antiviral protein-encoding genes in brain endothelial cells
Conclusion The presence of iRBCs leads to the stimulation of ECs, activating several immunological signaling pathways and affecting antiviral (-parasitic) mechanism s and angiogenesis. Furthermore, to our knowledge, the induction of the interferon-alpha/beta signaling pathway in ECs in response to iRBCs has been described for the first time. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Comparative genomics of Ascetosporea gives new insight into the evolutionary basis for animal parasitism in Rhizaria
Ascetosporea (Endomyxa, Rhizaria) is a group of unicellular parasites infecting aquatic invertebrates. They are increasingly being recognized as widespread and important in marine environments, causing large a... (Source: BMC Biology)
Source: BMC Biology - May 3, 2024 Category: Biology Authors: Markus Hiltunen Thor én, Ioana Onuț-Brännström, Anders Alfjorden, Hana Pecková, Fiona Swords, Chantelle Hooper, Astrid S. Holzer, David Bass and Fabien Burki Tags: Research article Source Type: research
Year-round monitoring of three water sources in Qu ébec, Canada, reveals site-specific differences in conditions for Cryptosporidium and Giardia contamination
Canadian Journal of Microbiology, Ahead of Print. Cryptosporidium and Giardia are protozoan parasites responsible for gastrointestinal illnesses in humans and in animal species. The main way these parasites are transmitted is by ingestion of their (oo)cysts in drinking water. Monitoring (oo)cysts in water sources is beneficial to evaluate the quality of raw water supplying treatment plants. Currently, the only standardized protocol to enumerate these parasites from water samples is United States Environmental Protection Agency (USEPA) Method 1623.1. With this method, we monitored three major water sources in Quebec over a ...
Source: Canadian Journal of Microbiology - May 3, 2024 Category: Microbiology Authors: Marie-St éphanie Fradette Sandrinne L. Bourque Manuel J. Rodriguez Steve J. Charette Source Type: research
Transcriptome profiles of < i > Trypanosoma brucei rhodesiense < /i > in Malawi reveal focus specific gene expression profiles associated with pathology
ConclusionOur results suggest that the differences in disease presentation in the two foci is mainly driven by genetic differences in the parasites in the two major endemic foci of Rumphi and Nkhotakota rather than differences in the environment or host response. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - May 3, 2024 Category: Tropical Medicine Authors: Peter Nambala Source Type: research
Mitochondrial genome fragmentation is correlated with increased rates of molecular evolution
by Tom áš Najer, Jorge Doña, Aleš Buček, Andrew D. Sweet, Oldřich Sychra, Kevin P. Johnson
While mitochondrial genome content and organization is quite diverse across all Eukaryotes, most bilaterian animal mitochondrial genomes (mitogenomes) exhibit highly conserved gene content and organisation, with genes typically encoded on a single circular chromosome. However, many species of parasitic lice (Insecta: Phthiraptera) are among the notable exceptions, having mitogenomes fragmented into multiple circular chromosomes. To better understand the process of mitogenome fragmentation, we conducted a large-scale genomic st...
Source: PLoS Genetics - May 3, 2024 Category: Genetics & Stem Cells Authors: Tom áš Najer Source Type: research
A single cell atlas of sexual development in Plasmodium falciparum | Science
The developmental decision made by malaria parasites to become sexual underlies all malaria transmission. Here, we describe a rich atlas of short- and long-read single-cell transcriptomes of over 37,000 Plasmodium falciparum cells across ... (Source: Science: Current Issue)
Source: Science: Current Issue - May 2, 2024 Category: Science Source Type: research
Zombie malaria parasites | Science
Natural infections are distinct from those of laboratory —or zombie—strains (Source: Science: Current Issue)
Source: Science: Current Issue - May 2, 2024 Category: Science Source Type: research
The Transmission of Animal African Trypanosomiasis in Two Districts in the Forest Zone of Ghana
Am J Trop Med Hyg. 2024 May 2:tpmd230329. doi: 10.4269/ajtmh.23-0329. Online ahead of print.ABSTRACTAnimal African trypanosomiasis, also known as nagana, is caused by Trypanosoma species, which cause significant clinical diseases and lead to losses in animal production. We carried out a cross-sectional survey to investigate the composition of vectors and parasite diversity in two districts in the eastern region of Ghana where pigs and cattle were exposed to tsetse bites. We performed cytochrome c oxidase subunit 1 polymerase chain reaction (PCR) to identify tsetse species and internal transcribed spacer 1 PCR to identify T...
Source: The American Journal of Tropical Medicine and Hygiene - May 2, 2024 Category: Tropical Medicine Authors: Austine Tweneboah Jana Rosenau Kofi Agyapong Addo Thomas Kwame Addison Mahamat Alhadj Moussa Ibrahim Judith Sophie Weber Soerge Kelm Kingsley Badu Source Type: research
