Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani
CONCLUSION: To our knowledge, this is the first study to report in vitro amyloid-like behaviour of Rab proteins in L donovani. This study provides a novel opportunity to understand the complete biophysical characteristics of Rab2 protein of the lower eukaryote, L. donovani.PMID:38661034 | DOI:10.2174/0109298665299157240327084614 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 25, 2024 Category: Biochemistry Authors: None Roshanara Shivani A Muthu None Gulafsha Rati Tandon Angamuthu Selvapandiyan Basir Ahmad Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease
World J Gastroenterol. 2024 Apr 7;30(13):1836-1850. doi: 10.3748/wjg.v30.i13.1836.ABSTRACTThe term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently c...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rodrigo V Motta Francesca Saffioti Vasileios K Mavroeidis Source Type: research
Sampling is decisive to determination of < i > Leishmania (Viannia) < /i > species
ConclusionsThe type of clinical sample can directly influence the detection and identification ofLeishmania (Viannia) species. Here, we demonstrated that lancet scraping samples consistently allowed the identification of more leishmaniasis cases compared to filter paper imprints or biopsies. This procedure is inexpensive, painless, and easy to implement at the point of care and avoids the need for anesthesia, surgery, and hospitalization and therefore could be used in resource limited settings for both military and civilian populations. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 25, 2024 Category: Tropical Medicine Authors: Maxy B. De los Santos Source Type: research
Spatio-temporal distribution of hospitalizations for chronic Chagas disease and risk factors associated with in-hospital mortality and surgical intervention in Chile
by Nicolhole Atero, Marisa Torres, Ang élica Domínguez, Benjamín Diethelm-Varela, Francisca Córdova-Bührle, Fernando O. Mardones
Chagas disease (CD) is a neglected parasitic zoonotic disease that affects over 6 million people worldwide. We conducted a retrospective study to analyze the spatiotemporal trends and risk factors for hospitalization rates of CD with cardiac and digestive diagnoses in Chile. We used the Mann-Kendall analysis for temporal trends, Global Moran ’s Index, and Local Indicators of Spatial Association to identify spatial autocorrelation, and regression models to determine the risk factors associ...
Source: PLoS Neglected Tropical Diseases - April 25, 2024 Category: Tropical Medicine Authors: Nicolhole Atero Source Type: research
Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites [RESEARCH]
Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually associated with adaptation to stress conditions. Chromosomal duplication stability is a tradeoff between the fitness cost of having unbalanced gene copies and the potential fitness gained from increased dosage of specific advantageous genes. Trypanosomatids, a family of protozoans that include species that cause neglected tropical diseases, are a relevant group to study aneuploidies. Their life cycle has several stressors that could select for different patterns of chromosomal duplications and/or losses, and their nearly universal use o...
Source: Genome Research - April 25, 2024 Category: Genetics & Stem Cells Authors: Reis-Cunha, J. L., Pimenta-Carvalho, S. A., Almeida, L. V., Coqueiro-dos-Santos, A., Marques, C. A., Black, J. A., Damasceno, J., McCulloch, R., Bartholomeu, D. C., Jeffares, D. C. Tags: RESEARCH Source Type: research
Global distribution patterns and geographic range of Cymothoa Fabricius, 1793 (Isopoda: Cymothoidae) associated with host fish
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230706. doi: 10.1590/0001-3765202420230706. eCollection 2024.ABSTRACTOver recent years, fish parasites of the genus Cymothoa Fabricius, 1793, have received increased attention due to both their ecological and their economic importance to aquaculture and fishery. As the studies about Cymothoa have increased this improve our understanding on the host specificity and distribution of these parasites. The aim of this paper was to review the current global geographic distribution, distribution patterns and parasite-host interactions patterns of Cymothoa spp. associated with fish from mari...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Marcos Tavares-Dias Marcos Sidney B Oliveira Source Type: research
Infected pulmonary hydatid cyst: A challenging diagnosis
Saudi Med J. 2024 Apr;45(4):433-436. doi: 10.15537/smj.2024.45.4.20230078.ABSTRACTEchinococcosis is a parasitic infection that is distributed worldwide. Its clinical presentation depends on the size and location of the cyst. A 7-year-old was found with a superimposed infected pulmonary hydatid cyst that was initially misdiagnosed as complicated pneumonia. Our case underscores the challenges of diagnosing and managing echinococcosis, emphasizes the need for a high index of suspicion, and describes the disease's ability to mimic other clinical entities.PMID:38657978 | DOI:10.15537/smj.2024.45.4.20230078 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - April 24, 2024 Category: Middle East Health Authors: Fahad M AlRashed Dayel A AlShahrani Source Type: research
In silico identification of drug targets and vaccine candidates against Bartonella quintana: a subtractive proteomics approach
CONCLUSIONS: This insight prioritises such proteins as novel putative targets for further investigations on their potential as drug and vaccine candidates.PMID:38655925 | DOI:10.1590/0074-02760230040 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - April 24, 2024 Category: Infectious Diseases Authors: Shabir Ahmad Hugo Verli/ Source Type: research
Immune targeting of filarial glutaredoxin through a multi-epitope peptide-based vaccine: A reverse vaccinology approach
Int Immunopharmacol. 2024 Apr 23;133:112120. doi: 10.1016/j.intimp.2024.112120. Online ahead of print.ABSTRACTDespite the efforts of global programme to eliminate lymphatic filariasis (GPELF), the threat of lymphatic filariasis (LF) still looms over humanity in terms of long-term disabilities, and morbidities across the globe. In light of this situation, investigators have chosen to focus on the development of immunotherapeutics targeting the physiologically important filarial-specific proteins. Glutaredoxin (16.43 kDa) plays a pivotal role in filarial redox biology, serving as a vital contributor. In the context of the in...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Nabarun Chandra Das Sampa Gorai Parth Sarthi Sen Gupta Saroj Kumar Panda Malay Kumar Rana Suprabhat Mukherjee Source Type: research
Intestinal Parasitic Infections in People Referring to the Central Laboratory of Meshkin Shahr County, Ardabil Province, Iran
CONCLUSION: In- spite of betterment of the health condition in Iran and reduction of parasitic infection, intestinal parasitic infections are still a considerable public health issue in some parts of Iran.PMID:38654952 | PMC:PMC11033542 | DOI:10.18502/ijpa.v19i1.15217 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Pooria Asadi Zabihollah Zarei Mehdi Mohebali Zahra Alizadeh Faezeh Najafi Shahrokh Izadi Zahra Heidari Source Type: research
Expression of Heat Shock Protein 70 (HSP70) and Astacin Genes of < em > Strongyloides stercoralis < /em > as well as HSP70 and HSP17.1 Genes of < em > S. ratti < /em > in Adult and Larval Stages of < em > S. stercoralis < /em >
CONCLUSION: Higher expression levels of Sst-ast, Sst-hsp-70, and Sra-hsp-70 genes in the larval stages of S. stercoralis suggest the potential role of these enzymes in parasite cutaneous invasion and pathogenesis. However, higher expression of Srahsp-17.1 in adult forms is probably involved in resistance and survival mechanisms. The similarity in gene expression between S. stercoralis and S. ratti can provide helpful hints to better understand strongyloidiasis from various perspectives, including pathogenesis, proper diagnosis, and targeted treatment.PMID:38654956 | PMC:PMC11033530 | DOI:10.18502/ijpa.v19i1.15187 (Source: ...
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Maryam Alipour Leila Masoori Mohammad Davoodzadeh Gholami Majid Khoshmirsafa Elham Razmjou Nahid Jalallou Farzane Jafarian Reza Falak Ahmad Reza Meamar Source Type: research
Molecular Characterization of < em > Giardia intestinalis < /em > and < em > Cryptosporidium < /em > spp. Detected in Humans in A ğrı, Türkiye
CONCLUSION: Assemblage A, which is associated with diarrhea, is responsible for giardiasis and C. parvum IId subtype, often found in sheep, goats and cattle, is responsible for cryptosporidiosis in Ağrı, Türkiye.PMID:38654951 | PMC:PMC11033538 | DOI:10.18502/ijpa.v19i1.15188 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Selahattin Aydemir Fethi Barl ık Abdurrahman Ekici Dilara Hande Barl ık Sevil Alkan Esra G ürbüz Hasan Y ılmaz Source Type: research
Visceral Leishmaniasis (VL) Clinical Presentation, Laboratory Findings, Treatment Options and Outcome
CONCLUSION: VL should be included in the differential diagnosis of any child who presents with fever, splenomegaly, and anemia. Concerning the treatment strategy in this study, liposomal amphotericin B had more efficiency and shorter hospitalization duration.PMID:38654944 | PMC:PMC11033536 | DOI:10.18502/ijpa.v19i1.15190 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Mahmoud Khodabandeh Elham Moradian Maedeh Sarvari Mahsa Soti Khiabani Source Type: research
Isolation of < em > Schistosoma haematobium < /em > in Bronchoalveolar Lavage in an Immunocompromised Individual: A Case Report
We report a rare case of a 51-year-old People Living with HIV male, managed in a tertiary care hospital in west India in May 2023, vegetable vendor who was admitted with complaints of dysphagia, odynophagia, fever and chest pain for 3 days, cough and breathlessness for 1 month. Chest x-ray and CT scan were suggestive of hypodense fluid collection with rim enhancement along right lateral and posterior aspect of thoracic esophagus. All routine investigations and urine cultures were sent, which turned to be inconclusive. Upper Gastrointestinal scopy was suggestive of pangastritis. Fiberoptic bronchoscopy was done with no stru...
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Shailesh Bhanudas Meshram Hiral Gulab Ramnani Spandana Chaudhury Source Type: research
