Stronger control-surveillance systems for vector-borne Chagas disease
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e210130chgsb. doi: 10.1590/0074-02760210130chgsb. eCollection 2023.NO ABSTRACTPMID:36700577 | DOI:10.1590/0074-02760210130chgsb (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Rodrigo Gurgel-Gon çalves Source Type: research

Coagulopathy and the humoral response against viral proteins in patients at different stages of COVID-19
CONCLUSIONS: Our data suggest that IgG against NP and RBD participates in the worsening of COVID-19. Although the humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is partially understood, and more efforts are needed to clarify gaps in the knowledge of this process.PMID:36700578 | DOI:10.1590/0074-02760220072 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Fernanda Pereira Monteiro Victor de Souza Tavares Rayane da Silva Oliveira Souza Larissa Paola Rodrigues Ven âncio Mary Hellen Fabres-Klein Rodrigo Feliciano do Carmo Raphael Contelli Klein Jonilson Berlink Lima Th éo Araújo-Santos Source Type: research

Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective
CONCLUSIONS: These findings are important for the understanding of the origin and dynamics of the F1 sub-subtype and a consequent better and greater understanding of the HIV-1 F1 and BF epidemic that still spreads from Brazil to other countries.PMID:36700579 | DOI:10.1590/0074-02760220109 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Gabriela Porto Santos Almeida Silva Rodrigo Cunha Oliveira Juliana Sacramento Mota de Souza Marta Giovanetti Monick Lindenmeyer Guimar ães Carlos Brites Joana Paix ão Monteiro-Cunha Source Type: research

Clinical and epidemiological aspects of Delta and Gamma SARS-CoV-2 variant of concern from the western Brazilian Amazon
CONCLUSIONS: This study highlighted the presence of Gamma and Delta variants of SARS-CoV-2 in RO. Furthermore, we observed the replacement of the Gamma VOC with the Delta VOC and its lineages.PMID:36700580 | DOI:10.1590/0074-02760220155 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Gabriella Sgorlon Jackson Alves da Silva Queiroz T árcio Peixoto Roca Ana Maisa Passos da Silva Nadson Willian Felipe Gasparelo Karolaine Santos Teixeira Andreia Souza da N óbrega Oliveira Aline Linhares Ferreira de Melo Mendon ça Adriana Cristina Salv Source Type: research

Genomic surveillance: a potential shortcut for effective Chagas disease management
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e220164. doi: 10.1590/0074-02760220164. eCollection 2023.ABSTRACTChagas disease is an enduring public health issue in many Latin American countries, receiving insufficient investment in research and development. Strategies for disease control and management currently lack efficient pharmaceuticals, commercial diagnostic kits with improved sensitivity, and vaccines. Genetic heterogeneity of Trypanosoma cruzi is a key aspect for novel drug design since pharmacological technologies rely on the degree of conservation of parasite target proteins. Therefore, there is a need to expand the kn...
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Sophia Lincoln Cardoso de Azevedo Marcos Catanho Ana Carolina Ramos Guimar ães Teca Calcagno Galv ão Source Type: research

Intravenous whole blood transfusion results in faster recovery of vascular integrity and increased survival in experimental cerebral malaria
CONCLUSIONS: The outcome of artemether-treated ECM was improved by intravenous whole blood but worsened by intravenous plasma. Compared to prior studies of transfusion via the intraperitoneal route, intravenous administration was more efficacious.PMID:36700582 | DOI:10.1590/0074-02760220184 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Saba Gul Hans C Ackerman Cl áudio Tadeu Daniel-Ribeiro Leonardo Jm Carvalho Source Type: research

Animal models and SARS-CoV-2-induced pulmonary and neurological injuries
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e220239. doi: 10.1590/0074-02760220239. eCollection 2023.ABSTRACTLaboratory animals are essential mainly for experiments aiming to study pathogenesis and evaluate antivirals and vaccines against emerging human infectious diseases. Preclinical studies of coronavirus disease 19 (COVID-19) pathogenesis have used several animal species as models: transgenic human ACE2 mice (K18 mice), inbred BALB/c or C57BL/6N mice, ferrets, minks, domestic cats and dogs, hamsters, and macaques. However, the choice of an animal model relies on several limitations. Besides the host susceptibility, the rese...
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Marcelo Alves Pinto Alexandre Dos Santos da Silva Daniela Del Rosario Flores Rodrigues Rodrigo M üller Gentil Arthur Lins Bentes Mendon ça de Vasconcelos Patr ícia Cristina da Costa Neves Jaqueline Mendes de Oliveira Renato Sergio Marchevsky Source Type: research

Stronger control-surveillance systems for vector-borne Chagas disease
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e210130chgsb. doi: 10.1590/0074-02760210130chgsb. eCollection 2023.NO ABSTRACTPMID:36700577 | DOI:10.1590/0074-02760210130chgsb (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Rodrigo Gurgel-Gon çalves Source Type: research

Coagulopathy and the humoral response against viral proteins in patients at different stages of COVID-19
CONCLUSIONS: Our data suggest that IgG against NP and RBD participates in the worsening of COVID-19. Although the humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is partially understood, and more efforts are needed to clarify gaps in the knowledge of this process.PMID:36700578 | DOI:10.1590/0074-02760220072 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Fernanda Pereira Monteiro Victor de Souza Tavares Rayane da Silva Oliveira Souza Larissa Paola Rodrigues Ven âncio Mary Hellen Fabres-Klein Rodrigo Feliciano do Carmo Raphael Contelli Klein Jonilson Berlink Lima Th éo Araújo-Santos Source Type: research

Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective
CONCLUSIONS: These findings are important for the understanding of the origin and dynamics of the F1 sub-subtype and a consequent better and greater understanding of the HIV-1 F1 and BF epidemic that still spreads from Brazil to other countries.PMID:36700579 | DOI:10.1590/0074-02760220109 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Gabriela Porto Santos Almeida Silva Rodrigo Cunha Oliveira Juliana Sacramento Mota de Souza Marta Giovanetti Monick Lindenmeyer Guimar ães Carlos Brites Joana Paix ão Monteiro-Cunha Source Type: research

Clinical and epidemiological aspects of Delta and Gamma SARS-CoV-2 variant of concern from the western Brazilian Amazon
CONCLUSIONS: This study highlighted the presence of Gamma and Delta variants of SARS-CoV-2 in RO. Furthermore, we observed the replacement of the Gamma VOC with the Delta VOC and its lineages.PMID:36700580 | DOI:10.1590/0074-02760220155 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Gabriella Sgorlon Jackson Alves da Silva Queiroz T árcio Peixoto Roca Ana Maisa Passos da Silva Nadson Willian Felipe Gasparelo Karolaine Santos Teixeira Andreia Souza da N óbrega Oliveira Aline Linhares Ferreira de Melo Mendon ça Adriana Cristina Salv Source Type: research

Genomic surveillance: a potential shortcut for effective Chagas disease management
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e220164. doi: 10.1590/0074-02760220164. eCollection 2023.ABSTRACTChagas disease is an enduring public health issue in many Latin American countries, receiving insufficient investment in research and development. Strategies for disease control and management currently lack efficient pharmaceuticals, commercial diagnostic kits with improved sensitivity, and vaccines. Genetic heterogeneity of Trypanosoma cruzi is a key aspect for novel drug design since pharmacological technologies rely on the degree of conservation of parasite target proteins. Therefore, there is a need to expand the kn...
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Sophia Lincoln Cardoso de Azevedo Marcos Catanho Ana Carolina Ramos Guimar ães Teca Calcagno Galv ão Source Type: research

Intravenous whole blood transfusion results in faster recovery of vascular integrity and increased survival in experimental cerebral malaria
CONCLUSIONS: The outcome of artemether-treated ECM was improved by intravenous whole blood but worsened by intravenous plasma. Compared to prior studies of transfusion via the intraperitoneal route, intravenous administration was more efficacious.PMID:36700582 | DOI:10.1590/0074-02760220184 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Saba Gul Hans C Ackerman Cl áudio Tadeu Daniel-Ribeiro Leonardo Jm Carvalho Source Type: research

Animal models and SARS-CoV-2-induced pulmonary and neurological injuries
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e220239. doi: 10.1590/0074-02760220239. eCollection 2023.ABSTRACTLaboratory animals are essential mainly for experiments aiming to study pathogenesis and evaluate antivirals and vaccines against emerging human infectious diseases. Preclinical studies of coronavirus disease 19 (COVID-19) pathogenesis have used several animal species as models: transgenic human ACE2 mice (K18 mice), inbred BALB/c or C57BL/6N mice, ferrets, minks, domestic cats and dogs, hamsters, and macaques. However, the choice of an animal model relies on several limitations. Besides the host susceptibility, the rese...
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Marcelo Alves Pinto Alexandre Dos Santos da Silva Daniela Del Rosario Flores Rodrigues Rodrigo M üller Gentil Arthur Lins Bentes Mendon ça de Vasconcelos Patr ícia Cristina da Costa Neves Jaqueline Mendes de Oliveira Renato Sergio Marchevsky Source Type: research

Stronger control-surveillance systems for vector-borne Chagas disease
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e210130chgsb. doi: 10.1590/0074-02760210130chgsb. eCollection 2023.NO ABSTRACTPMID:36700577 | DOI:10.1590/0074-02760210130chgsb (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Rodrigo Gurgel-Gon çalves Source Type: research